IL109587A - Heparin fractions obtained by nitrous depolymerization, with low nitroso-compound content, method for obtaining them and pharmaceutical compositions containing them - Google Patents

Heparin fractions obtained by nitrous depolymerization, with low nitroso-compound content, method for obtaining them and pharmaceutical compositions containing them

Info

Publication number
IL109587A
IL109587A IL109587A IL10958794A IL109587A IL 109587 A IL109587 A IL 109587A IL 109587 A IL109587 A IL 109587A IL 10958794 A IL10958794 A IL 10958794A IL 109587 A IL109587 A IL 109587A
Authority
IL
Israel
Prior art keywords
nitroso
obtaining
low
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL109587A
Other languages
English (en)
Other versions
IL109587A0 (en
Original Assignee
Choay Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9446915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL109587(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Choay Sa filed Critical Choay Sa
Publication of IL109587A0 publication Critical patent/IL109587A0/xx
Publication of IL109587A publication Critical patent/IL109587A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL109587A 1993-05-07 1994-05-06 Heparin fractions obtained by nitrous depolymerization, with low nitroso-compound content, method for obtaining them and pharmaceutical compositions containing them IL109587A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9305534A FR2704861B1 (fr) 1993-05-07 1993-05-07 Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
IL109587A0 IL109587A0 (en) 1994-08-26
IL109587A true IL109587A (en) 1997-04-15

Family

ID=9446915

Family Applications (1)

Application Number Title Priority Date Filing Date
IL109587A IL109587A (en) 1993-05-07 1994-05-06 Heparin fractions obtained by nitrous depolymerization, with low nitroso-compound content, method for obtaining them and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US5599801A (da)
EP (1) EP0623629B1 (da)
JP (1) JP3529835B2 (da)
KR (1) KR100328095B1 (da)
CN (1) CN1066155C (da)
AT (1) ATE141618T1 (da)
AU (1) AU672291B2 (da)
BR (1) BR9401920A (da)
CA (1) CA2122930C (da)
CZ (1) CZ287889B6 (da)
DE (1) DE69400385T2 (da)
DK (1) DK0623629T3 (da)
ES (1) ES2093494T3 (da)
FI (1) FI107388B (da)
FR (1) FR2704861B1 (da)
GR (1) GR3021648T3 (da)
HK (1) HK1007432A1 (da)
HU (1) HU221595B (da)
IL (1) IL109587A (da)
MY (1) MY110862A (da)
NO (1) NO306952B1 (da)
NZ (1) NZ260460A (da)
PL (1) PL178294B1 (da)
RU (1) RU2133253C1 (da)
TW (1) TW438812B (da)
ZA (1) ZA943152B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5980865A (en) * 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
CA2235223A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
EP1109919A2 (en) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP4824170B2 (ja) * 1999-04-23 2011-11-30 マサチューセッツ インスティテュート オブ テクノロジー ポリマーを表記するためのシステムおよび方法
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
US8227449B2 (en) * 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
DE60138115D1 (de) 2000-09-12 2009-05-07 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
US7709461B2 (en) * 2000-10-18 2010-05-04 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
JP2002293804A (ja) * 2001-03-28 2002-10-09 Itoham Foods Inc 低分子量ヘパリンの製造法
EP1518120A4 (en) * 2002-03-11 2008-08-13 Momenta Pharmaceuticals Inc ANALYSIS OF SULFATE POLYSACCHARIDES
RU2248801C2 (ru) * 2003-04-21 2005-03-27 ГУ Гематологический научный центр РАМН Способ получения низкомолекулярных гепаринов
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ITMO20040199A1 (it) * 2004-07-29 2004-10-29 Biofer Spa Procedimento per la purificazione da gruppi e n no rsidui di eparine a basso peso molecolare ottentite tramite nitrosazione.
RU2295538C2 (ru) * 2005-03-01 2007-03-20 Гематологический научный центр РАМН Способ получения гепаринов с низкой молекулярной массой
JP2006291028A (ja) * 2005-04-11 2006-10-26 Q P Corp 低分子ヘパリンまたはその塩、ならびにその製造方法
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
CA2974062C (en) * 2010-09-14 2018-07-17 Fuso Pharmaceutical Industries, Ltd. High purity heparin and production method therefor
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN102633905B (zh) * 2011-04-11 2014-10-08 南通天龙畜产品有限公司 一种肝素钠中不被亚硝酸降解且在肝素钠保留时间附近出峰的物质的去除方法
CN104045744B (zh) * 2014-06-26 2016-01-06 常州千红生化制药股份有限公司 达肝素钠的制备方法
CN104098716B (zh) * 2014-07-16 2015-04-22 南京健友生化制药股份有限公司 一种达肝素钠精品的生产方法
US10688249B2 (en) * 2015-06-11 2020-06-23 Virchow Biotech Pvt. Ltd. Multiple dose pharmaceutical compositions containing heparin and/or heparin-like compounds and devices and methods for delivering the same
CN105294885A (zh) * 2015-11-23 2016-02-03 山东大学 一种新来源亚硝酸降解低分子肝素的制备方法
EP3740513B1 (en) * 2018-02-14 2022-06-22 Biological E Limited Improved process for the preparation of dalteparin sodium
RU186728U1 (ru) * 2018-10-19 2019-01-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "МИРЭА - Российский технологический университет" Лабораторное устройство для отмывки порошковых продуктов химических реакций от посторонних примесей
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
CA3144968A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
CN110845641A (zh) * 2019-11-07 2020-02-28 中国药科大学 一种肝素寡糖及其在制备抗血管生成药物中的应用
CN110787489A (zh) * 2019-11-20 2020-02-14 江苏千牧生物科技股份有限公司 一种肝素钠加工使用的分离装置及加工的工艺
CN115304688A (zh) * 2022-08-25 2022-11-08 湖北亿诺瑞生物制药有限公司 一种达肝素钠的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119774A (en) * 1976-03-05 1978-10-10 Ab Kabi Heparin purification method
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4438261A (en) * 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2538404B1 (da) * 1982-12-28 1985-08-23 Anic Spa
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
US5094815A (en) * 1988-05-18 1992-03-10 Cornell Research Foundation, Inc. Photolytic interface for HPLC-chemiluminescence detection of non volatile N-nitroso compounds
US5032679A (en) * 1988-12-15 1991-07-16 Glycomed, Inc. Heparin fragments as inhibitors of smooth muscle cell proliferation
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia

Also Published As

Publication number Publication date
FI107388B (fi) 2001-07-31
TW438812B (en) 2001-06-07
FI942095A0 (fi) 1994-05-06
KR100328095B1 (ko) 2002-06-20
JPH07126302A (ja) 1995-05-16
NZ260460A (en) 1996-02-27
HU9401446D0 (en) 1994-08-29
CA2122930C (en) 2000-10-24
DK0623629T3 (da) 1996-12-23
HUT70553A (en) 1995-10-30
NO306952B1 (no) 2000-01-17
BR9401920A (pt) 1994-11-29
RU2133253C1 (ru) 1999-07-20
DE69400385T2 (de) 1996-12-19
ZA943152B (en) 1995-01-09
CZ113294A3 (en) 1994-12-15
MY110862A (en) 1999-05-31
ES2093494T3 (es) 1996-12-16
CN1096034A (zh) 1994-12-07
FR2704861B1 (fr) 1995-07-28
CN1066155C (zh) 2001-05-23
ATE141618T1 (de) 1996-09-15
FI942095L (fi) 1994-11-08
AU6191294A (en) 1994-11-10
JP3529835B2 (ja) 2004-05-24
AU672291B2 (en) 1996-09-26
NO941686D0 (no) 1994-05-06
EP0623629A1 (fr) 1994-11-09
US5599801A (en) 1997-02-04
CZ287889B6 (cs) 2001-03-14
HK1007432A1 (en) 1999-04-09
DE69400385D1 (de) 1996-09-26
HU221595B (hu) 2002-11-28
EP0623629B1 (fr) 1996-08-21
IL109587A0 (en) 1994-08-26
PL178294B1 (pl) 2000-04-28
RU94015595A (ru) 1996-09-27
GR3021648T3 (en) 1997-02-28
CA2122930A1 (en) 1994-11-08
NO941686L (no) 1994-11-08
FR2704861A1 (fr) 1994-11-10

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