IL109978A - Cyclic ureas derived from alpha omega-diamino acids and their preparation - Google Patents
Cyclic ureas derived from alpha omega-diamino acids and their preparationInfo
- Publication number
- IL109978A IL109978A IL10997894A IL10997894A IL109978A IL 109978 A IL109978 A IL 109978A IL 10997894 A IL10997894 A IL 10997894A IL 10997894 A IL10997894 A IL 10997894A IL 109978 A IL109978 A IL 109978A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- preparation
- omega
- cyclic ureas
- alpha omega
- Prior art date
Links
- -1 Cyclic ureas Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- KZKRPYCBSZIQKN-UHFFFAOYSA-N 2-Imidazolidone-4-carboxylic acid Chemical compound OC(=O)C1CNC(=O)N1 KZKRPYCBSZIQKN-UHFFFAOYSA-N 0.000 abstract 1
- QLEDTTCUFILTKL-UHFFFAOYSA-N 2-oxo-1,3-diazinane-4-carboxylic acid Chemical compound OC(=O)C1CCNC(=O)N1 QLEDTTCUFILTKL-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1836—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from derivatives of carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9300621A BE1007183A3 (fr) | 1993-06-18 | 1993-06-18 | Ureines derivees d'alpha, omega-diaminoacides et procede pour leur preparation. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL109978A0 IL109978A0 (en) | 1994-10-07 |
| IL109978A true IL109978A (en) | 1999-10-28 |
Family
ID=3887112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10997894A IL109978A (en) | 1993-06-18 | 1994-06-10 | Cyclic ureas derived from alpha omega-diamino acids and their preparation |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6060586A (de) |
| EP (2) | EP0922696B1 (de) |
| JP (1) | JP3800248B2 (de) |
| AT (2) | ATE293598T1 (de) |
| AU (1) | AU685794B2 (de) |
| BE (1) | BE1007183A3 (de) |
| CA (1) | CA2125638A1 (de) |
| DE (2) | DE69421849T2 (de) |
| ES (2) | ES2141795T3 (de) |
| HU (1) | HU221844B1 (de) |
| IL (1) | IL109978A (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6160122A (en) * | 1996-06-28 | 2000-12-12 | Abbott Laboratories | Process for the preparation of a disubstituted thiazole |
| US6961921B2 (en) * | 2001-09-06 | 2005-11-01 | Interdigital Technology Corporation | Pipeline architecture for maximum a posteriori (MAP) decoders |
| JPWO2015030106A1 (ja) * | 2013-09-02 | 2017-03-02 | 国立大学法人京都大学 | Ｇｇｔ阻害作用を有する化合物及びｇｇｔファミリー酵素阻害剤 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2288422A (en) * | 1938-11-11 | 1942-06-30 | Gen Aniline & Film Corp | Mixed ureas |
| US2489233A (en) * | 1947-04-26 | 1949-11-22 | Hoffmann La Roche | Imidazolido-tetrahydrofurans |
| US2650921A (en) * | 1948-03-23 | 1953-09-01 | Merck & Co Inc | 2-keto pyrimidines |
| US2773872A (en) * | 1954-04-12 | 1956-12-11 | Merck & Co Inc | Dihydroorotic acid |
| DE1963734A1 (de) * | 1969-12-19 | 1971-06-24 | Bayer Ag | Harnstoffderivate von Acylderivaten des KTI |
| DE2449167C2 (de) * | 1974-10-16 | 1984-05-24 | Grünenthal GmbH, 5190 Stolberg | N-Acyl-L-histidyl-L-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| SE408300B (sv) * | 1974-10-16 | 1979-06-05 | Gruenenthal Chemie | Sett att framstella nya dipeptidderivat |
| JPS56147757A (en) | 1980-04-18 | 1981-11-16 | Ajinomoto Co Inc | Amino acid derivative |
| DE3134933A1 (de) * | 1981-09-03 | 1983-03-31 | Hoechst Ag, 6230 Frankfurt | "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung" |
| DE3522938A1 (de) * | 1985-06-27 | 1987-01-08 | Bayer Ag | Leistungsfoerdernde mittel |
| US5032577A (en) * | 1986-12-31 | 1991-07-16 | Abbott Laboratories | Peptidylaminodiols |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US4980384A (en) | 1988-09-05 | 1990-12-25 | Shin-Etsu Chemical Co., Ltd. | Foamable silicone rubber composition and method for curing the same |
| US5151497A (en) * | 1989-02-21 | 1992-09-29 | Japan Tobacco Inc. | Histidyl peptide derivatives |
| DE3918057C1 (de) * | 1989-06-02 | 1990-05-03 | Degussa Ag, 6000 Frankfurt, De | |
| WO1991000081A2 (en) * | 1989-06-21 | 1991-01-10 | The Catholic University Of America | Anti-malarial composition and method of use |
| US5312831A (en) * | 1993-05-12 | 1994-05-17 | American Cyanamid Company | Urethanes and ureas that induce cytokine production |
-
1993
- 1993-06-18 BE BE9300621A patent/BE1007183A3/fr not_active IP Right Cessation
-
1994
- 1994-06-09 DE DE69421849T patent/DE69421849T2/de not_active Expired - Fee Related
- 1994-06-09 AT AT99103523T patent/ATE293598T1/de not_active IP Right Cessation
- 1994-06-09 ES ES94201643T patent/ES2141795T3/es not_active Expired - Lifetime
- 1994-06-09 ES ES99103523T patent/ES2242315T3/es not_active Expired - Lifetime
- 1994-06-09 AT AT94201643T patent/ATE187162T1/de not_active IP Right Cessation
- 1994-06-09 DE DE69434344T patent/DE69434344T2/de not_active Expired - Fee Related
- 1994-06-09 EP EP99103523A patent/EP0922696B1/de not_active Expired - Lifetime
- 1994-06-09 EP EP94201643A patent/EP0629612B1/de not_active Expired - Lifetime
- 1994-06-10 CA CA002125638A patent/CA2125638A1/fr not_active Abandoned
- 1994-06-10 IL IL10997894A patent/IL109978A/xx not_active IP Right Cessation
- 1994-06-17 HU HU9401821A patent/HU221844B1/hu not_active IP Right Cessation
- 1994-06-17 AU AU64781/94A patent/AU685794B2/en not_active Ceased
- 1994-06-20 JP JP13711794A patent/JP3800248B2/ja not_active Expired - Fee Related
-
1997
- 1997-06-17 US US08/985,658 patent/US6060586A/en not_active Expired - Fee Related
-
2000
- 2000-02-11 US US09/502,561 patent/US6310178B1/en not_active Expired - Fee Related
-
2001
- 2001-09-04 US US09/944,209 patent/US7030214B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7030214B2 (en) | 2006-04-18 |
| EP0922696A3 (de) | 2003-01-22 |
| ATE293598T1 (de) | 2005-05-15 |
| EP0922696A2 (de) | 1999-06-16 |
| BE1007183A3 (fr) | 1995-04-18 |
| DE69434344D1 (de) | 2005-05-25 |
| JPH0748356A (ja) | 1995-02-21 |
| DE69434344T2 (de) | 2006-01-19 |
| JP3800248B2 (ja) | 2006-07-26 |
| ATE187162T1 (de) | 1999-12-15 |
| US6310178B1 (en) | 2001-10-30 |
| CA2125638A1 (fr) | 1994-12-19 |
| HUT71414A (en) | 1995-11-28 |
| EP0629612A1 (de) | 1994-12-21 |
| AU685794B2 (en) | 1998-01-29 |
| DE69421849T2 (de) | 2000-06-29 |
| ES2141795T3 (es) | 2000-04-01 |
| EP0922696B1 (de) | 2005-04-20 |
| ES2242315T3 (es) | 2005-11-01 |
| US20020058784A1 (en) | 2002-05-16 |
| DE69421849D1 (de) | 2000-01-05 |
| IL109978A0 (en) | 1994-10-07 |
| HU9401821D0 (en) | 1994-09-28 |
| EP0629612B1 (de) | 1999-12-01 |
| US6060586A (en) | 2000-05-09 |
| AU6478194A (en) | 1994-12-22 |
| HU221844B1 (hu) | 2003-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |