IL111083A0 - Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same - Google Patents

Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same

Info

Publication number: IL111083A0
Authority: IL; Israel
Prior art keywords: alkyl; branched; straight; same; compositions containing
Prior art date: 1993-09-30

Application number

IL11108394A

Other languages

English (en)

Original Assignee

Bracco Int Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-30

Filing date

1994-09-29

Publication date

1994-11-28

1994-09-29 Application filed by Bracco Int Bv filed Critical Bracco Int Bv

1994-11-28 Publication of IL111083A0 publication Critical patent/IL111083A0/xx

Links

239000000203 mixture Substances 0.000 title abstract 2
150000002678 macrocyclic compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052688 Gadolinium Inorganic materials 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
LGAILEFNHXWAJP-BMEPFDOTSA-N macrocycle Chemical group N([C@H]1[C@@H](C)CC)C(=O)C(N=2)=CSC=2CNC(=O)C(=C(O2)C)N=C2[C@H]([C@@H](C)CC)NC(=O)C2=CSC1=N2 LGAILEFNHXWAJP-BMEPFDOTSA-N 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Soft Magnetic Materials (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL11108394A 1993-09-30 1994-09-29 Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same IL111083A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/129,870 US5358704A (en)	1993-09-30	1993-09-30	Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Publications (1)

Publication Number	Publication Date
IL111083A0 true IL111083A0 (en)	1994-11-28

Family

ID=22441998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11108394A IL111083A0 (en)	1993-09-30	1994-09-29	Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same

Country Status (14)

Country	Link
US (1)	US5358704A (cs)
EP (2)	EP0670832B1 (cs)
JP (1)	JP3949714B2 (cs)
KR (1)	KR960702447A (cs)
CN (1)	CN1115180A (cs)
AT (2)	ATE288422T1 (cs)
AU (1)	AU7623494A (cs)
CA (1)	CA2150452A1 (cs)
CZ (1)	CZ136995A3 (cs)
DE (2)	DE69430730T2 (cs)
HK (1)	HK1046131A1 (cs)
IL (1)	IL111083A0 (cs)
NO (1)	NO300131B1 (cs)
WO (1)	WO1995009161A1 (cs)

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DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4318369C1 (de) *	1993-05-28	1995-02-09	Schering Ag	Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
JPH0797340A (ja) *	1993-06-03	1995-04-11	Terumo Corp	Ｍｒｉ造影剤組成物
IT1269839B (it) *	1994-05-26	1997-04-15	Bracco Spa	Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
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US5980862A (en) *	1995-06-02	1999-11-09	Research Corporation Technologies	Magnetic resonance imaging agents for the detection of physiological agents
EP0846003A1 (en) *	1995-08-17	1998-06-10	Monsanto Company	Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5900228A (en)	1996-07-31	1999-05-04	California Institute Of Technology	Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
DE19744004C1 (de) *	1997-09-26	1999-07-22	Schering Ag	Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) *	1997-09-26	2002-12-17	Schering Aktiengesellschaft	Lipophilic metal complexes for necrosis and infarction imaging
US6713046B1 (en)	1997-10-27	2004-03-30	Research Corporation Technologies	Magnetic resonance imaging agents for the delivery of therapeutic agents
EP1032430A2 (en)	1997-11-17	2000-09-06	Research Corporation Technologies, Inc.	Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it)	1997-12-30	1999-08-03	Bracco Spa	Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) *	1998-05-16	2000-07-25	Bracco Research Usa Inc.	Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) *	1998-08-28	2000-05-02	Desreux; Jean F.	Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
AU2001276956A1 (en)	2000-07-17	2002-01-30	California Institute Of Technology	Macrocyclic mri contrast agents
AU2002211517A1 (en)	2000-10-04	2002-04-15	California Institute Of Technology	Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) *	2001-04-20	2003-01-02	Meade Thomas J.	Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
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US20040038303A1 (en) *	2002-04-08	2004-02-26	Unger Gretchen M.	Biologic modulations with nanoparticles
CA2495442C (en) *	2002-09-06	2013-12-10	Martin W. Brechbiel	Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
EP1587547A2 (en) *	2003-01-22	2005-10-26	The General Hospital Corporation	Amyloid-binding, metal-chelating agents
US7012140B1 (en) *	2003-07-14	2006-03-14	Board Of Regents, The University Of Texas System	Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060088475A1 (en) *	2004-05-10	2006-04-27	Northwestern University	Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
AU2005253962A1 (en)	2004-06-09	2005-12-29	Kereos, Inc.	Lipophilic derivatives of chelate monoamides
CA2591942A1 (en)	2005-01-13	2006-07-20	Cinvention Ag	Composite materials containing carbon nanoparticles
JP2009511727A (ja) *	2005-10-18	2009-03-19	シンベンションアーゲー	熱硬化粒子及びその製造方法
US20090317335A1 (en) *	2006-04-20	2009-12-24	Wenbin Lin	Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
US20080241061A1 (en) *	2006-11-21	2008-10-02	Lanza Gregory M	Methods of imaging employing chelating agents
CN100459932C (zh) *	2007-01-15	2009-02-11	北京大学人民医院	一种mri分子影像探针及其制备方法
CN101646402A (zh) *	2007-01-19	2010-02-10	金文申有限公司	用粉末模塑法制成的多孔、不可降解植入物
CA2677699A1 (en) *	2007-02-28	2008-09-04	Cinvention Ag	High surface cultivation system
WO2008104599A1 (en) *	2007-02-28	2008-09-04	Cinvention Ag	High surface cultivation system bag
EP2072060A1 (en)	2007-12-18	2009-06-24	Institut Curie	Methods and compositions for the preparation and use of toxin conjugates.
US20100029909A1 (en) *	2008-05-23	2010-02-04	Northwestern University	Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en)	2008-05-23	2013-11-12	Northwestern University	Compositions and methods comprising magnetic resonance contrast agents
CA2726050A1 (en)	2008-05-30	2009-12-10	Siemens Medical Solutions Usa, Inc.	Achievement of high therapeutic index through molecular imaging guided targeted drug treatment
EP2416806B8 (en)	2009-04-10	2017-03-15	INSERM (Institut National de la Santé et de la Recherche Médicale)	Fucoidans as ligands for the diagnosis of degenerative pathologies
EP2646058A1 (en)	2010-12-03	2013-10-09	INSERM (Institut National de la Santé et de la Recherche Médicale)	Agents for the molecular imaging of serine-protease in human pathologies
EP2658869B1 (en)	2010-12-30	2019-06-12	INSERM (Institut National de la Santé et de la Recherche Médicale)	Antigen binding formats for use in therapeutic treatments or diagnostic assays
EP2836597A1 (en)	2012-04-11	2015-02-18	Institut National de la Santé et de la Recherche Médicale (INSERM)	Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (en)	2012-11-15	2014-05-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for the preparation of immunoconjugates and uses thereof
CN111700877A (zh)	2014-09-03	2020-09-25	吉倪塞思公司	治疗性纳米粒子和相关的组合物、方法和系统
HRP20200922T1 (hr)	2016-09-27	2020-09-18	Bayer Pharma Aktiengesellschaft	Postupak za proizvodnju kristalnog oblika modifikacije a kalkobutrola
WO2018204872A2 (en)	2017-05-05	2018-11-08	Fusion Pharmaceuticals Inc.	Igf-1r monoclonal antibodies and uses thereof
MA48861A (fr)	2017-05-05	2020-04-01	Fusion Pharmaceuticals Inc	Améliorations pharmacocinétiques de chélates bifonctionnels et leurs utilisations
US10093741B1 (en)	2017-05-05	2018-10-09	Fusion Pharmaceuticals Inc.	IGF-1R monoclonal antibodies and uses thereof
US11607462B2 (en)	2017-05-16	2023-03-21	Northwestern University	Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

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DE3267697D1 (en) *	1981-08-24	1986-01-09	Asahi Chemical Ind	Tetraazaannulene cobalt complex compounds and method for preparation thereof
EP0108181B1 (de) *	1982-11-03	1987-04-29	Ciba-Geigy Ag	Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenkobalt(III)jodid
DE3562917D1 (en) *	1984-04-18	1988-06-30	Ciba Geigy Ag	Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
US4880008A (en) *	1985-05-08	1989-11-14	The General Hospital Corporation	Vivo enhancement of NMR relaxivity
US4899755A (en) *	1985-05-08	1990-02-13	The General Hospital Corporation	Hepatobiliary NMR contrast agents
GB8603537D0 (en) *	1986-02-13	1986-03-19	Parker D	Conjugate compound
DE3625417C2 (de) *	1986-07-28	1998-10-08	Schering Ag	Tetraazacyclododecan-Derivate
DE4001655A1 (de) *	1990-01-18	1991-07-25	Schering Ag	6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP3131219B2 (ja) *	1990-01-19	2001-01-31	ニユコメド・イメージング・アクシエセルカペト	キレート化合物

1993
- 1993-09-30 US US08/129,870 patent/US5358704A/en not_active Expired - Lifetime
1994
- 1994-09-29 JP JP51019495A patent/JP3949714B2/ja not_active Expired - Fee Related
- 1994-09-29 CN CN94190738A patent/CN1115180A/zh active Pending
- 1994-09-29 EP EP94926365A patent/EP0670832B1/en not_active Expired - Lifetime
- 1994-09-29 CZ CZ951369A patent/CZ136995A3/cs unknown
- 1994-09-29 EP EP01127327A patent/EP1184377B1/en not_active Expired - Lifetime
- 1994-09-29 IL IL11108394A patent/IL111083A0/xx unknown
- 1994-09-29 CA CA002150452A patent/CA2150452A1/en not_active Abandoned
- 1994-09-29 AU AU76234/94A patent/AU7623494A/en not_active Abandoned
- 1994-09-29 AT AT01127327T patent/ATE288422T1/de not_active IP Right Cessation
- 1994-09-29 DE DE69430730T patent/DE69430730T2/de not_active Expired - Fee Related
- 1994-09-29 WO PCT/IB1994/000298 patent/WO1995009161A1/en not_active Ceased
- 1994-09-29 KR KR1019950702155A patent/KR960702447A/ko not_active Withdrawn
- 1994-09-29 DE DE69434260T patent/DE69434260T2/de not_active Expired - Fee Related
- 1994-09-29 AT AT94926365T patent/ATE218554T1/de not_active IP Right Cessation
1995
- 1995-05-29 NO NO952111A patent/NO300131B1/no unknown
2002
- 2002-09-06 HK HK02106580.1A patent/HK1046131A1/en unknown

Also Published As

Publication number	Publication date
EP0670832A1 (en)	1995-09-13
WO1995009161A1 (en)	1995-04-06
EP0670832B1 (en)	2002-06-05
ATE288422T1 (de)	2005-02-15
EP1184377A1 (en)	2002-03-06
AU7623494A (en)	1995-04-18
ATE218554T1 (de)	2002-06-15
NO952111D0 (no)	1995-05-29
DE69434260D1 (de)	2005-03-10
DE69430730D1 (de)	2002-07-11
HK1046131A1 (en)	2002-12-27
JPH08503967A (ja)	1996-04-30
EP1184377B1 (en)	2005-02-02
CA2150452A1 (en)	1995-04-06
CZ136995A3 (en)	1995-12-13
JP3949714B2 (ja)	2007-07-25
NO952111L (no)	1995-05-29
DE69430730T2 (de)	2003-02-06
CN1115180A (zh)	1996-01-17
DE69434260T2 (de)	2006-01-19
NO300131B1 (no)	1997-04-14
KR960702447A (ko)	1996-04-27
US5358704A (en)	1994-10-25

Publication	Publication Date	Title
IL111083A0 (en)	1994-11-28	Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same
GR3029603T3 (en)	1999-06-30	Cytotoxic stilbene derivatives and pharmaceutical composition containing them.
DE69024826D1 (de)	1996-02-29	Aza-Macrozyklen und Verfahren zu deren Herstellung
IE883844L (en)	1989-06-24	Macrocyclic chelating agents and chelates thereof
IL106164A0 (en)	1993-10-20	Polyazamacrocyclic compounds and their complexes with metal ions
IL114785A0 (en)	1995-11-27	Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
TW337985B (en)	1998-08-11	"N-(B-branched alkyl)-1, 2-benzisothiolin, 3ones, their preparation and their use as industrial biocides"
WO1998006400A3 (en)	1998-03-26	Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells
NZ230128A (en)	1990-10-26	Dibenzooxepine-pyridinium and -pyrrolo derivatives and pharmaceutical compositions
IL111725A0 (en)	1995-01-24	3'-aziridino-anthracycline derivatives, their preparation and pharmaceutical compositions containing them
IL102409A0 (en)	1993-01-14	Mono and bis alkylamino-anthracyclines,their preparation and pharmaceutical compositions containing them
ES8303393A1 (es)	1983-02-01	Un procedimiento para preparar derivados del acido ascorbico.
NZ236143A (en)	1993-08-26	1-heterocyclyl-2,4,6-triiodo-1,3-dicarboamide benzene derivatives and radiodiagnostic compositions
YU80689A (en)	1991-02-28	Hetero-tetracyclical lactame derivatives
ES8206537A1 (es)	1982-08-16	Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina
IL92010A (en)	1993-06-10	Pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0000275A2 (hu)	2000-06-28	Fenantridiniumszármazékok, valamint ezeket a vegyületeket tartalmazó gyógyászati készítmények
IE820238L (en)	1982-08-04	Carbapenem derivatives
GB8515212D0 (en)	1985-07-17	Thiazolidine derivatives
PT84760A (en)	1987-05-01	Heterocyclic compounds
IL76936A (en)	1989-01-31	3-amino-2,3-dihydro-1-benzoxepine compounds,their preparation and pharmaceutical compositions containing them
ES2018407A6 (es)	1991-04-01	Procedimiento para la obtencion de 1-ariloxi-3-nitroamino-2-propanoles.
MX9605046A (es)	1998-02-28	Derivados de adenosina.