IL111395A - 5-(Arylisoxazole-4-yl)-substituted 2-amino carboxylic acid compounds and pharmaceutical compositions containing them - Google Patents

5-(Arylisoxazole-4-yl)-substituted 2-amino carboxylic acid compounds and pharmaceutical compositions containing them

Info

Publication number: IL111395A
Authority: IL; Israel
Prior art keywords: arylisoxazole; substituted; carboxylic acid; pharmaceutical compositions; compositions containing
Prior art date: 1993-11-01

Application number

IL11139594A

Other languages

English (en)

Other versions

IL111395A0 (en

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-01

Filing date

1994-10-25

Publication date

1999-06-20

1994-10-25 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1994-12-29 Publication of IL111395A0 publication Critical patent/IL111395A0/xx

1999-06-20 Publication of IL111395A publication Critical patent/IL111395A/xx

Links

GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical class NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
KLLLJCACIRKBDT-UHFFFAOYSA-N 2-phenyl-1H-indole Chemical class N1C2=CC=CC=C2C=C1C1=CC=CC=C1 KLLLJCACIRKBDT-UHFFFAOYSA-N 0.000 abstract 1
239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 abstract 1
229960000652 sertindole Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Sewing Machines And Sewing (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Polyurethanes Or Polyureas (AREA)

IL11139594A 1993-11-01 1994-10-25 5-(Arylisoxazole-4-yl)-substituted 2-amino carboxylic acid compounds and pharmaceutical compositions containing them IL111395A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK931234A DK123493D0 (da)	1993-11-01	1993-11-01	Compounds

Publications (2)

Publication Number	Publication Date
IL111395A0 IL111395A0 (en)	1994-12-29
IL111395A true IL111395A (en)	1999-06-20

Family

ID=8102507

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL11139594A IL111395A (en)	1993-11-01	1994-10-25	5-(Arylisoxazole-4-yl)-substituted 2-amino carboxylic acid compounds and pharmaceutical compositions containing them
IL11139494A IL111394A (en)	1993-11-01	1994-10-25	Phenylindole compounds and pharmaceutical compositions containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL11139494A IL111394A (en)	1993-11-01	1994-10-25	Phenylindole compounds and pharmaceutical compositions containing them

Country Status (26)

Country	Link
US (1)	US5703087A (da)
EP (1)	EP0726898B1 (da)
JP (1)	JP3898219B2 (da)
KR (1)	KR100350550B1 (da)
CN (1)	CN1134149A (da)
AT (1)	ATE198199T1 (da)
AU (1)	AU683700B2 (da)
CA (1)	CA2175498C (da)
CZ (1)	CZ291403B6 (da)
DE (1)	DE69426462T2 (da)
DK (2)	DK123493D0 (da)
ES (1)	ES2154303T3 (da)
FI (1)	FI116623B (da)
GR (1)	GR3035462T3 (da)
HU (1)	HUT76063A (da)
IL (2)	IL111395A (da)
LV (1)	LV12805B (da)
NO (1)	NO309038B1 (da)
NZ (1)	NZ275086A (da)
PL (1)	PL176391B1 (da)
PT (1)	PT726898E (da)
RU (1)	RU2156249C2 (da)
SI (1)	SI0726898T1 (da)
SK (1)	SK281761B6 (da)
WO (1)	WO1995012591A1 (da)
ZA (1)	ZA948589B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6489341B1 (en) *	1999-06-02	2002-12-03	Sepracor Inc.	Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
EP1214312B1 (en) *	1999-09-09	2004-04-14	H. Lundbeck A/S	5-aminoalkyl and 5-aminocarbonyl substituted indoles
US20070212412A1 (en) *	2005-09-08	2007-09-13	H. Lundbeck A/S	Stable solid formulation of sertindole
TW200821296A (en) *	2006-06-01	2008-05-16	Lundbeck & Co As H	Use of sertindole for the preventive treatment of suicidal behaviour
PL2509961T3 (pl) *	2009-12-11	2016-09-30		Pochodne imidazolidynodionu
EP2582698B1 (en)	2010-06-16	2016-09-14	Vitae Pharmaceuticals, Inc.	Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
ES2560304T3 (es)	2010-12-06	2016-02-18	Autifony Therapeutics Limited	Derivados de hidantoína útiles como inhibidores de Kv3
EP2718285B1 (en) *	2011-06-07	2016-03-16	Autifony Therapeutics Limited	Hydantoin derivatives as kv3 inhibitors
CN103974944B (zh) *	2011-12-06	2016-11-02	奥蒂福尼疗法有限公司	用作kv3抑制剂的乙内酰脲衍生物
EP2852588B8 (en)	2012-05-22	2018-01-10	Autifony Therapeutics Limited	Hydantoin derivatives as kv3 inhibitors
WO2013175215A1 (en)	2012-05-22	2013-11-28	Autifony Therapeutics Limited	Triazoles as kv3 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE58370B1 (en) *	1985-04-10	1993-09-08	Lundbeck & Co As H	Indole derivatives
GB8908085D0 (en) *	1989-04-11	1989-05-24	Lundbeck & Co As H	New therapeutic use
DK152090D0 (da) *	1990-06-22	1990-06-22	Lundbaek A S H	Piperidylsubstituerede indolderivater

1993
- 1993-11-01 DK DK931234A patent/DK123493D0/da not_active Application Discontinuation
1994
- 1994-10-25 IL IL11139594A patent/IL111395A/xx not_active IP Right Cessation
- 1994-10-25 IL IL11139494A patent/IL111394A/en not_active IP Right Cessation
- 1994-10-28 SI SI9430356T patent/SI0726898T1/xx unknown
- 1994-10-28 US US08/635,905 patent/US5703087A/en not_active Expired - Fee Related
- 1994-10-28 ES ES94931520T patent/ES2154303T3/es not_active Expired - Lifetime
- 1994-10-28 DE DE69426462T patent/DE69426462T2/de not_active Expired - Fee Related
- 1994-10-28 PL PL94314181A patent/PL176391B1/pl not_active IP Right Cessation
- 1994-10-28 EP EP94931520A patent/EP0726898B1/en not_active Expired - Lifetime
- 1994-10-28 KR KR1019960702237A patent/KR100350550B1/ko not_active Expired - Fee Related
- 1994-10-28 NZ NZ275086A patent/NZ275086A/en not_active IP Right Cessation
- 1994-10-28 RU RU96110902/04A patent/RU2156249C2/ru not_active IP Right Cessation
- 1994-10-28 WO PCT/DK1994/000407 patent/WO1995012591A1/en not_active Ceased
- 1994-10-28 AT AT94931520T patent/ATE198199T1/de not_active IP Right Cessation
- 1994-10-28 HU HU9601144A patent/HUT76063A/hu not_active Application Discontinuation
- 1994-10-28 CN CN94193987A patent/CN1134149A/zh active Pending
- 1994-10-28 AU AU80577/94A patent/AU683700B2/en not_active Ceased
- 1994-10-28 JP JP51296895A patent/JP3898219B2/ja not_active Expired - Fee Related
- 1994-10-28 SK SK534-96A patent/SK281761B6/sk not_active IP Right Cessation
- 1994-10-28 PT PT94931520T patent/PT726898E/pt unknown
- 1994-10-28 CA CA002175498A patent/CA2175498C/en not_active Expired - Fee Related
- 1994-10-28 DK DK94931520T patent/DK0726898T3/da active
- 1994-10-28 CZ CZ19961248A patent/CZ291403B6/cs not_active IP Right Cessation
- 1994-11-01 ZA ZA948589A patent/ZA948589B/xx unknown
1996
- 1996-04-30 NO NO961746A patent/NO309038B1/no not_active IP Right Cessation
- 1996-04-30 FI FI961844A patent/FI116623B/fi active IP Right Grant
2001
- 2001-02-22 GR GR20010400296T patent/GR3035462T3/el not_active IP Right Cessation
- 2001-12-20 LV LV010178A patent/LV12805B/xx unknown

Also Published As

Publication number	Publication date
EP0726898B1 (en)	2000-12-20
KR960705814A (ko)	1996-11-08
PL314181A1 (en)	1996-08-19
CZ124896A3 (en)	1996-09-11
KR100350550B1 (ko)	2002-12-12
IL111394A0 (en)	1994-12-29
CA2175498A1 (en)	1995-05-11
SK53496A3 (en)	1996-11-06
FI116623B (fi)	2006-01-13
FI961844L (fi)	1996-04-30
NO309038B1 (no)	2000-12-04
RU2156249C2 (ru)	2000-09-20
ES2154303T3 (es)	2001-04-01
US5703087A (en)	1997-12-30
SI0726898T1 (en)	2001-04-30
PT726898E (pt)	2001-05-31
FI961844A0 (fi)	1996-04-30
PL176391B1 (pl)	1999-05-31
EP0726898A1 (en)	1996-08-21
ATE198199T1 (de)	2001-01-15
NO961746D0 (no)	1996-04-30
NO961746L (no)	1996-06-28
DE69426462D1 (de)	2001-01-25
CZ291403B6 (cs)	2003-03-12
CA2175498C (en)	2005-07-26
NZ275086A (en)	1997-10-24
WO1995012591A1 (en)	1995-05-11
IL111394A (en)	1998-08-16
LV12805B (lv)	2002-05-20
HU9601144D0 (en)	1996-07-29
JPH09506083A (ja)	1997-06-17
DE69426462T2 (de)	2001-04-26
DK0726898T3 (da)	2001-04-30
DK123493D0 (da)	1993-11-01
AU8057794A (en)	1995-05-23
HUT76063A (en)	1997-06-30
IL111395A0 (en)	1994-12-29
ZA948589B (en)	1995-06-26
GR3035462T3 (en)	2001-05-31
SK281761B6 (sk)	2001-07-10
AU683700B2 (en)	1997-11-20
LV12805A (en)	2002-03-20
CN1134149A (zh)	1996-10-23
HK1013817A1 (en)	1999-09-10
JP3898219B2 (ja)	2007-03-28

Legal Events

Date	Code	Title
1999-10-28	FF	Patent granted
2000-06-29	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
NO963439L (no)	1996-08-16	Sammensetninger inneholdende mikronisert vebivolol
IL111395A0 (en)	1994-12-29	(5-arylisoxazol-4-yl) -substituted 2-amino carboxylic acid compounds
NO941784D0 (no)	1994-05-11	Acykliske etylendiaminderivater som substans P reseptor-antagonister
FI943499A0 (fi)	1994-07-25	Happokorvikkeita sisältäviä tetrahydro-1H-bentsatsepinoneja
HU9402466D0 (en)	1994-10-28	Indole derivatives as steroid-5-alpha-reductase inhibitors
DE69626514D1 (de)	2003-04-10	Mono-und disulfosubstituierte anthrachinone und deren verwendung zur behandlung von knochenmatrixerkrankungen
PL313037A1 (en)	1996-05-27	Phenoxphenylocyclopententenylohydroxyureas
IL108288A0 (en)	1994-04-12	Pyrrolidine derivatives, their preparation and medicaments containing them
GR3033333T3 (en)	2000-09-29	Carbamoyl carboxylic acid amides
DE69416873D1 (en)	1999-04-08	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
ATE170527T1 (de)	1998-09-15	Phosphonobernsteinsäurederivate und ihre verwendung als arzneimittel