IL112700A0 - Indole derivatives useful for treating estrogen-related neoplasms and disorders - Google Patents
Indole derivatives useful for treating estrogen-related neoplasms and disordersInfo
- Publication number
- IL112700A0 IL112700A0 IL11270095A IL11270095A IL112700A0 IL 112700 A0 IL112700 A0 IL 112700A0 IL 11270095 A IL11270095 A IL 11270095A IL 11270095 A IL11270095 A IL 11270095A IL 112700 A0 IL112700 A0 IL 112700A0
- Authority
- IL
- Israel
- Prior art keywords
- indole derivatives
- derivatives useful
- disorders
- neoplasms
- treating estrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20005794A | 1994-02-22 | 1994-02-22 | |
| US36204694A | 1994-12-22 | 1994-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL112700A0 true IL112700A0 (en) | 1995-05-26 |
Family
ID=26895427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11270095A IL112700A0 (en) | 1994-02-22 | 1995-02-20 | Indole derivatives useful for treating estrogen-related neoplasms and disorders |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5877202A (de) |
| EP (1) | EP0746544B1 (de) |
| JP (1) | JP3536258B2 (de) |
| KR (1) | KR100362864B1 (de) |
| CN (1) | CN1141627A (de) |
| AT (1) | ATE170839T1 (de) |
| AU (1) | AU680740B2 (de) |
| CA (1) | CA2183731C (de) |
| DE (1) | DE69504637T2 (de) |
| DK (1) | DK0746544T3 (de) |
| ES (1) | ES2122555T3 (de) |
| FI (1) | FI963272A0 (de) |
| HU (1) | HUT76133A (de) |
| IL (1) | IL112700A0 (de) |
| NO (1) | NO963483L (de) |
| NZ (1) | NZ281431A (de) |
| WO (1) | WO1995022524A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880137A (en) * | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
| US6150395A (en) | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
| US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
| CA2331318A1 (en) * | 1998-05-15 | 1999-11-25 | James Harrison Pickar | Compositions comprising 2-phenyl-indole compounds and estrogen formulations |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
| EP1212335B1 (de) * | 1999-09-13 | 2006-01-18 | Wyeth | Glucopyranosid-konjugate von 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-olen |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| AU2001234958A1 (en) * | 2000-02-11 | 2001-08-20 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| CA2424222A1 (en) * | 2000-10-02 | 2002-04-11 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US20030130199A1 (en) * | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| FR2842526B1 (fr) | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments |
| CA2519899A1 (en) * | 2003-03-27 | 2004-10-14 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| JP2007534702A (ja) | 2004-04-26 | 2007-11-29 | バンダービルト・ユニバーシティ | 胃腸毒性の低い治療薬としてのインドール酢酸、及びインデン酢酸誘導体 |
| US8765488B2 (en) | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
| CN101360422B (zh) * | 2005-11-23 | 2013-10-23 | 得克萨斯大学体系董事会 | 致癌Ras特异性细胞毒化合物及其使用方法 |
| WO2011047156A1 (en) | 2009-10-15 | 2011-04-21 | Hercules Technology Management Co V, Inc. | Sepiapterin reductase inhibitors for the treatment of pain |
| CN107098807B (zh) | 2010-08-30 | 2020-07-10 | 阿泽达公司 | 用于生产乙酰丙酸、乙酰丙酸酯、戊内酯、以及其衍生物的发酵路径 |
| US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| PL2800738T3 (pl) * | 2012-01-06 | 2020-10-19 | Novartis Ag | Związki heterocykliczne i sposoby ich stosowania |
| WO2013131235A1 (zh) * | 2012-03-05 | 2013-09-12 | 大连理工大学 | 一类以萘为母体的双光子荧光探针、其制备方法及应用 |
| TWI747873B (zh) | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| WO2018125992A1 (en) * | 2016-12-28 | 2018-07-05 | Promega Corporation | Functionalized nanoluc inhibitors |
| JP2024516279A (ja) * | 2021-05-05 | 2024-04-12 | カレ ケミカル テクノロジーズ インコーポレイテッド | 触媒トリプタミンプロセスおよび前駆体 |
| CN116410120A (zh) * | 2023-04-19 | 2023-07-11 | 四川农业大学 | 一种2-苯基吲哚酰胺类抗肿瘤化合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1482845A (fr) * | 1964-12-31 | 1967-06-02 | Merck & Co Inc | Composés de l'indol |
| ATE118207T1 (de) * | 1989-12-04 | 1995-02-15 | Searle & Co | Heterozyklische acylaminodiol-beta-aminosäure- derivate. |
| WO1991013874A1 (fr) * | 1990-03-07 | 1991-09-19 | Rhone-Poulenc Rorer S.A. | Derives de glycinamide, leur preparation et les medicaments les contenant |
| US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| US5496844A (en) * | 1992-05-08 | 1996-03-05 | Otsuka Pharmaceutical Factory, Inc. | Indole derivatives |
| JPH0835029A (ja) * | 1994-07-19 | 1996-02-06 | Toyota Motor Corp | 高強度高延性鋳造アルミニウム合金およびその製造方法 |
-
1995
- 1995-01-31 EP EP95910164A patent/EP0746544B1/de not_active Expired - Lifetime
- 1995-01-31 HU HU9602299A patent/HUT76133A/hu unknown
- 1995-01-31 DE DE69504637T patent/DE69504637T2/de not_active Expired - Lifetime
- 1995-01-31 FI FI963272A patent/FI963272A0/fi unknown
- 1995-01-31 CN CN95191750A patent/CN1141627A/zh active Pending
- 1995-01-31 AT AT95910164T patent/ATE170839T1/de not_active IP Right Cessation
- 1995-01-31 DK DK95910164T patent/DK0746544T3/da active
- 1995-01-31 JP JP52182295A patent/JP3536258B2/ja not_active Expired - Lifetime
- 1995-01-31 ES ES95910164T patent/ES2122555T3/es not_active Expired - Lifetime
- 1995-01-31 KR KR1019960704579A patent/KR100362864B1/ko not_active Expired - Fee Related
- 1995-01-31 WO PCT/US1995/001372 patent/WO1995022524A1/en not_active Ceased
- 1995-01-31 NZ NZ281431A patent/NZ281431A/en unknown
- 1995-01-31 CA CA002183731A patent/CA2183731C/en not_active Expired - Lifetime
- 1995-01-31 AU AU18373/95A patent/AU680740B2/en not_active Ceased
- 1995-02-20 IL IL11270095A patent/IL112700A0/xx unknown
-
1996
- 1996-01-31 US US08/594,505 patent/US5877202A/en not_active Expired - Lifetime
- 1996-08-21 NO NO963483A patent/NO963483L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI963272A7 (fi) | 1996-08-21 |
| JP3536258B2 (ja) | 2004-06-07 |
| DE69504637T2 (de) | 1999-05-06 |
| KR100362864B1 (ko) | 2003-04-16 |
| JPH09509169A (ja) | 1997-09-16 |
| DK0746544T3 (da) | 1999-06-07 |
| DE69504637D1 (de) | 1998-10-15 |
| CA2183731A1 (en) | 1995-08-24 |
| NZ281431A (en) | 1997-09-22 |
| ATE170839T1 (de) | 1998-09-15 |
| US5877202A (en) | 1999-03-02 |
| HU9602299D0 (en) | 1996-10-28 |
| EP0746544B1 (de) | 1998-09-09 |
| AU680740B2 (en) | 1997-08-07 |
| NO963483L (no) | 1996-10-22 |
| WO1995022524A1 (en) | 1995-08-24 |
| CA2183731C (en) | 2000-03-21 |
| FI963272L (fi) | 1996-08-21 |
| HUT76133A (en) | 1997-06-30 |
| FI963272A0 (fi) | 1996-08-21 |
| ES2122555T3 (es) | 1998-12-16 |
| EP0746544A1 (de) | 1996-12-11 |
| NO963483D0 (no) | 1996-08-21 |
| CN1141627A (zh) | 1997-01-29 |
| AU1837395A (en) | 1995-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of name of proprietor(s) |
Owner name: AVENTIS INC. Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC. |