IL112700A0 - Indole derivatives useful for treating estrogen-related neoplasms and disorders - Google Patents
Indole derivatives useful for treating estrogen-related neoplasms and disordersInfo
- Publication number
- IL112700A0 IL112700A0 IL11270095A IL11270095A IL112700A0 IL 112700 A0 IL112700 A0 IL 112700A0 IL 11270095 A IL11270095 A IL 11270095A IL 11270095 A IL11270095 A IL 11270095A IL 112700 A0 IL112700 A0 IL 112700A0
- Authority
- IL
- Israel
- Prior art keywords
- indole derivatives
- derivatives useful
- disorders
- neoplasms
- treating estrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20005794A | 1994-02-22 | 1994-02-22 | |
| US36204694A | 1994-12-22 | 1994-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL112700A0 true IL112700A0 (en) | 1995-05-26 |
Family
ID=26895427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11270095A IL112700A0 (en) | 1994-02-22 | 1995-02-20 | Indole derivatives useful for treating estrogen-related neoplasms and disorders |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5877202A (fr) |
| EP (1) | EP0746544B1 (fr) |
| JP (1) | JP3536258B2 (fr) |
| KR (1) | KR100362864B1 (fr) |
| CN (1) | CN1141627A (fr) |
| AT (1) | ATE170839T1 (fr) |
| AU (1) | AU680740B2 (fr) |
| CA (1) | CA2183731C (fr) |
| DE (1) | DE69504637T2 (fr) |
| DK (1) | DK0746544T3 (fr) |
| ES (1) | ES2122555T3 (fr) |
| FI (1) | FI963272L (fr) |
| HU (1) | HUT76133A (fr) |
| IL (1) | IL112700A0 (fr) |
| NO (1) | NO963483L (fr) |
| NZ (1) | NZ281431A (fr) |
| WO (1) | WO1995022524A1 (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880137A (en) * | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| AU6015098A (en) * | 1997-02-24 | 1998-09-09 | Cornell Research Foundation Inc. | Method of screening agents as candidates for drugs or sources of drugs |
| US6150395A (en) * | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
| US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| WO1999059969A1 (fr) * | 1998-05-15 | 1999-11-25 | American Home Products Corporation | Compositions comprenant des composes a base de 2-phenyl-indole et de formulations d'oestrogenes |
| US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
| CA2382683A1 (fr) * | 1999-09-13 | 2001-03-22 | American Home Products Corporation | Conjugues glucopyranosides de 2-(4-hydroxy-phenyl)-1-{4-(2-amin-1-yl-ethoxy)-benzyl|-1h-indol-5-ols |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| WO2001058869A2 (fr) * | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Modulateurs de recepteurs aux cannabinoides, leurs procedes de preparation et utilisations de modulateurs de recepteurs aux cannabinoides pour le traitement de maladies respiratoires et non respiratoires |
| US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| AU2002211828A1 (en) * | 2000-10-02 | 2002-04-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US20030130199A1 (en) * | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| FR2842526B1 (fr) | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments |
| WO2004087051A2 (fr) * | 2003-03-27 | 2004-10-14 | Merck & Co., Inc. | Compositions ophtalmiques pour traiter une hypertension oculaire |
| CA2562783A1 (fr) | 2004-04-26 | 2005-12-01 | Vanderbilt University | Derives d'acides indoleacetique et indenacetique comme agents therapeutiques a toxicite gastrointestinale reduite |
| US8765488B2 (en) | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
| JP5460054B2 (ja) * | 2005-11-23 | 2014-04-02 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 腫瘍形成性ｒａｓ特異的細胞障害性化合物およびその使用法 |
| CA2777782C (fr) | 2009-10-15 | 2016-06-28 | Children's Medical Center Corporation | Inhibiteurs de sepiapterine reductase pour le traitement de la douleur |
| BR112013004868B1 (pt) | 2010-08-30 | 2021-06-22 | Arzeda Corp. | Método para produzir ácido 2,4-dihidroxipentanoico e método para produzir um material polimérico ou produto contendo polímero |
| WO2013059245A1 (fr) | 2011-10-17 | 2013-04-25 | Vanderbilt University | Analogues de l'indométacine destinés au traitement du cancer de la prostate résistant à la castration |
| ES2802251T3 (es) | 2012-01-06 | 2021-01-18 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| JP5997288B2 (ja) * | 2012-03-05 | 2016-09-28 | 大連理工大学 | ナフタレンを基本骨格とする二光子蛍光プローブ、その製造方法及びその利用方法 |
| TWI747873B (zh) | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| US10815247B2 (en) * | 2016-12-28 | 2020-10-27 | Promega Corporation | Functionalized NANOLUC inhibitors |
| CA3217559A1 (fr) * | 2021-05-05 | 2022-11-10 | Kamaluddin Abdur-Rashid | Procedes et precurseurs de tryptamine catalytiques |
| CN116410120A (zh) * | 2023-04-19 | 2023-07-11 | 四川农业大学 | 一种2-苯基吲哚酰胺类抗肿瘤化合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH483421A (de) * | 1964-12-31 | 1969-12-31 | Merck & Co Inc | Verfahren zur Herstellung von 2-Phenyl-indolyl-Säuren |
| ES2067635T3 (es) * | 1989-12-04 | 1995-04-01 | Searle & Co | Derivados heterociclicos de beta-aminoacidos acilaminodiolicos. |
| JPH05504968A (ja) * | 1990-03-07 | 1993-07-29 | ローン―プーラン・ロレ・ソシエテ・アノニム | グリシンアミド誘導体、その製造及びそれを含む医薬品 |
| US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| EP0639567A1 (fr) * | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Derive d'indole |
| JPH0835029A (ja) * | 1994-07-19 | 1996-02-06 | Toyota Motor Corp | 高強度高延性鋳造アルミニウム合金およびその製造方法 |
-
1995
- 1995-01-31 NZ NZ281431A patent/NZ281431A/en unknown
- 1995-01-31 WO PCT/US1995/001372 patent/WO1995022524A1/fr not_active Ceased
- 1995-01-31 DE DE69504637T patent/DE69504637T2/de not_active Expired - Lifetime
- 1995-01-31 EP EP95910164A patent/EP0746544B1/fr not_active Expired - Lifetime
- 1995-01-31 KR KR1019960704579A patent/KR100362864B1/ko not_active Expired - Fee Related
- 1995-01-31 CN CN95191750A patent/CN1141627A/zh active Pending
- 1995-01-31 FI FI963272A patent/FI963272L/fi unknown
- 1995-01-31 HU HU9602299A patent/HUT76133A/hu unknown
- 1995-01-31 ES ES95910164T patent/ES2122555T3/es not_active Expired - Lifetime
- 1995-01-31 CA CA002183731A patent/CA2183731C/fr not_active Expired - Lifetime
- 1995-01-31 AT AT95910164T patent/ATE170839T1/de not_active IP Right Cessation
- 1995-01-31 DK DK95910164T patent/DK0746544T3/da active
- 1995-01-31 AU AU18373/95A patent/AU680740B2/en not_active Ceased
- 1995-01-31 JP JP52182295A patent/JP3536258B2/ja not_active Expired - Lifetime
- 1995-02-20 IL IL11270095A patent/IL112700A0/xx unknown
-
1996
- 1996-01-31 US US08/594,505 patent/US5877202A/en not_active Expired - Lifetime
- 1996-08-21 NO NO963483A patent/NO963483L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2183731C (fr) | 2000-03-21 |
| JP3536258B2 (ja) | 2004-06-07 |
| ES2122555T3 (es) | 1998-12-16 |
| DE69504637T2 (de) | 1999-05-06 |
| ATE170839T1 (de) | 1998-09-15 |
| DE69504637D1 (de) | 1998-10-15 |
| WO1995022524A1 (fr) | 1995-08-24 |
| KR100362864B1 (ko) | 2003-04-16 |
| AU1837395A (en) | 1995-09-04 |
| NO963483D0 (no) | 1996-08-21 |
| NZ281431A (en) | 1997-09-22 |
| DK0746544T3 (da) | 1999-06-07 |
| FI963272A0 (fi) | 1996-08-21 |
| JPH09509169A (ja) | 1997-09-16 |
| US5877202A (en) | 1999-03-02 |
| FI963272A7 (fi) | 1996-08-21 |
| EP0746544B1 (fr) | 1998-09-09 |
| CN1141627A (zh) | 1997-01-29 |
| AU680740B2 (en) | 1997-08-07 |
| HUT76133A (en) | 1997-06-30 |
| EP0746544A1 (fr) | 1996-12-11 |
| CA2183731A1 (fr) | 1995-08-24 |
| NO963483L (no) | 1996-10-22 |
| FI963272L (fi) | 1996-08-21 |
| HU9602299D0 (en) | 1996-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of name of proprietor(s) |
Owner name: AVENTIS INC. Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC. |