IL117496A - Nitrogen dioxide donors and / or substrates and nitrogen dioxide inhibitors for cervical dilation regulation - Google Patents

Nitrogen dioxide donors and / or substrates and nitrogen dioxide inhibitors for cervical dilation regulation

Info

Publication number: IL117496A
Authority: IL; Israel
Prior art keywords: nitric oxide; induction; cervical; use according; diene
Prior art date: 1995-03-14

Application number

IL11749696A

Other languages

English (en)

Hebrew (he)

Other versions

IL117496A0 (en

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-14

Filing date

1996-03-14

Publication date

2002-12-01

1996-03-14 Application filed by Schering Ag filed Critical Schering Ag

1997-03-18 Publication of IL117496A0 publication Critical patent/IL117496A0/xx

2002-12-01 Publication of IL117496A publication Critical patent/IL117496A/en

Links

MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical class O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 44
239000002840 nitric oxide donor Substances 0.000 title claims abstract description 18
229940123134 Nitric oxide inhibitor Drugs 0.000 title claims abstract description 17
239000000758 substrate Substances 0.000 title claims abstract description 17
230000001105 regulatory effect Effects 0.000 title claims abstract description 6
238000004519 manufacturing process Methods 0.000 claims abstract description 24
239000003814 drug Substances 0.000 claims abstract description 12
230000005070 ripening Effects 0.000 claims description 34
KCWZGJVSDFYRIX-YFKPBYRVSA-N N(gamma)-nitro-L-arginine methyl ester Chemical compound COC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O KCWZGJVSDFYRIX-YFKPBYRVSA-N 0.000 claims description 24
230000006698 induction Effects 0.000 claims description 21
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 14
230000035935 pregnancy Effects 0.000 claims description 14
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
230000000708 anti-progestin effect Effects 0.000 claims description 10
239000003418 antiprogestin Substances 0.000 claims description 10
150000003180 prostaglandins Chemical class 0.000 claims description 8
IEXUMDBQLIVNHZ-YOUGDJEHSA-N (8s,11r,13r,14s,17s)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(O)CCCO)[C@@]2(C)C1 IEXUMDBQLIVNHZ-YOUGDJEHSA-N 0.000 claims description 6
229950011093 onapristone Drugs 0.000 claims description 6
102000004127 Cytokines Human genes 0.000 claims description 5
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ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 5
229930064664 L-arginine Natural products 0.000 claims description 5
235000014852 L-arginine Nutrition 0.000 claims description 5
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 5
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HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 claims description 3
125000001841 imino group Chemical group [H]N=* 0.000 claims description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
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NCGICGYLBXGBGN-UHFFFAOYSA-N 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride Chemical compound Cl.[N-]1OC(=N)C=[N+]1N1CCOCC1 NCGICGYLBXGBGN-UHFFFAOYSA-N 0.000 claims description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 2
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MRAUNPAHJZDYCK-BYPYZUCNSA-N L-nitroarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O MRAUNPAHJZDYCK-BYPYZUCNSA-N 0.000 claims description 2
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
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DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
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239000000003 vaginal tablet Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000006442 vascular tone Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Materials For Medical Uses (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)

IL11749696A 1995-03-14 1996-03-14 Nitrogen dioxide donors and / or substrates and nitrogen dioxide inhibitors for cervical dilation regulation IL117496A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95250059		1995-03-14

Publications (2)

Publication Number	Publication Date
IL117496A0 IL117496A0 (en)	1997-03-18
IL117496A true IL117496A (en)	2002-12-01

Family

ID=8221039

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11749696A IL117496A (en)	1995-03-14	1996-03-14	Nitrogen dioxide donors and / or substrates and nitrogen dioxide inhibitors for cervical dilation regulation

Country Status (26)

Country	Link
US (1)	US6333350B1 (cs)
EP (1)	EP0814785B1 (cs)
JP (1)	JP4579349B2 (cs)
KR (2)	KR100434239B1 (cs)
CN (1)	CN1151781C (cs)
AT (1)	ATE377417T1 (cs)
AU (1)	AU713172B2 (cs)
CA (1)	CA2214779A1 (cs)
CZ (1)	CZ292395B6 (cs)
DE (1)	DE69637313T2 (cs)
ES (1)	ES2297838T3 (cs)
HU (1)	HUP9800826A3 (cs)
ID (1)	ID20742A (cs)
IL (1)	IL117496A (cs)
IS (1)	IS4555A (cs)
MX (1)	MX9707007A (cs)
MY (1)	MY116500A (cs)
NO (1)	NO318598B1 (cs)
NZ (1)	NZ305169A (cs)
PL (1)	PL183461B1 (cs)
RU (1)	RU2199346C2 (cs)
SK (1)	SK124197A3 (cs)
TW (1)	TW421594B (cs)
UA (1)	UA57703C2 (cs)
WO (1)	WO1996028145A1 (cs)
ZA (1)	ZA962089B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1151781C (zh)	1995-03-14	2004-06-02	舍林股份公司	一氧化氮的供体或者一氧化氮的抑制剂调节子宫颈扩张和伸展的用途
WO1997031631A1 (en) *	1996-02-27	1997-09-04	Rpms Technology Limited	Cox-2 selective inhibitors for managing labour and uterine contractions
US6232434B1 (en)	1996-08-02	2001-05-15	Duke University Medical Center	Polymers for delivering nitric oxide in vivo
DE19809845A1 (de) *	1998-03-03	1999-09-09	Jenapharm Gmbh	S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
ITMI20002117A1 (it) *	2000-09-29	2002-03-29	Ibsa Inst Biochimique Sa	Uso di sodio nitroprussiato in ostetricia e ginecologia
US20050113409A1 (en) *	2003-09-03	2005-05-26	Pharmacia Corporation	Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith
RU2267133C2 (ru) *	2004-03-04	2005-12-27	Государственное учреждение "Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова" Минздрава России	Способ диагностики угрозы преждевременных родов
WO2006089561A1 (en) *	2005-02-23	2006-08-31	Abbas Abdelsalam Ghazi	Pharmaceutical compositions containing organic acids useful for softening and ripening uterine cervix.
US8828981B2 (en)	2007-02-06	2014-09-09	George Creasy	Progesterone for the treatment or prevention of spontaneous preterm birth
CN102283827A (zh) *	2008-10-16	2011-12-21	四川维信医药科技有限责任公司	单硝酸异山梨酯的新用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993007114A1 (en) *	1991-09-24	1993-04-15	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5508045A (en)	1992-10-09	1996-04-16	The Regents Of The University Of California	Method and agents for control and management of labor during pregnancy
US5895783A (en) *	1993-07-16	1999-04-20	Schering Aktiengesellschaft	Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
FI962109A7 (fi) *	1993-11-16	1996-07-15	Schering Ag	Kohdun supistumishäiriöiden hoito typpioksidisyntaasin substraatilla j a/tai luovuttajalla tai typpioksidi-inhibiittorilla
US5550369A (en)	1994-02-28	1996-08-27	Electro-Pro, Inc.	Triangulation position detection method and apparatus
CN1151781C (zh)	1995-03-14	2004-06-02	舍林股份公司	一氧化氮的供体或者一氧化氮的抑制剂调节子宫颈扩张和伸展的用途

1996
- 1996-03-14 CN CNB961934336A patent/CN1151781C/zh not_active Expired - Fee Related
- 1996-03-14 CZ CZ19972851A patent/CZ292395B6/cs not_active IP Right Cessation
- 1996-03-14 KR KR10-2003-7009932A patent/KR100434239B1/ko not_active Expired - Fee Related
- 1996-03-14 NZ NZ305169A patent/NZ305169A/en unknown
- 1996-03-14 JP JP52783596A patent/JP4579349B2/ja not_active Expired - Fee Related
- 1996-03-14 DE DE69637313T patent/DE69637313T2/de not_active Expired - Lifetime
- 1996-03-14 ES ES96909707T patent/ES2297838T3/es not_active Expired - Lifetime
- 1996-03-14 ID IDP960631A patent/ID20742A/id unknown
- 1996-03-14 KR KR1019970706469A patent/KR100434238B1/ko not_active Expired - Fee Related
- 1996-03-14 IL IL11749696A patent/IL117496A/en not_active IP Right Cessation
- 1996-03-14 AU AU53117/96A patent/AU713172B2/en not_active Ceased
- 1996-03-14 SK SK1241-97A patent/SK124197A3/sk unknown
- 1996-03-14 RU RU97117084/14A patent/RU2199346C2/ru not_active IP Right Cessation
- 1996-03-14 CA CA002214779A patent/CA2214779A1/en not_active Abandoned
- 1996-03-14 WO PCT/US1996/003540 patent/WO1996028145A1/en not_active Ceased
- 1996-03-14 HU HU9800826A patent/HUP9800826A3/hu unknown
- 1996-03-14 PL PL96322252A patent/PL183461B1/pl not_active IP Right Cessation
- 1996-03-14 MY MYPI96000945A patent/MY116500A/en unknown
- 1996-03-14 ZA ZA962089A patent/ZA962089B/xx unknown
- 1996-03-14 AT AT96909707T patent/ATE377417T1/de not_active IP Right Cessation
- 1996-03-14 UA UA97105013A patent/UA57703C2/uk unknown
- 1996-03-14 EP EP96909707A patent/EP0814785B1/en not_active Expired - Lifetime
- 1996-06-27 TW TW085107778A patent/TW421594B/zh not_active IP Right Cessation
1997
- 1997-09-05 IS IS4555A patent/IS4555A/is unknown
- 1997-09-12 NO NO19974204A patent/NO318598B1/no unknown
- 1997-09-12 MX MX9707007A patent/MX9707007A/es not_active IP Right Cessation
1999
- 1999-01-25 US US09/236,085 patent/US6333350B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ305169A (en)	1999-10-28
IS4555A (is)	1997-09-05
CZ292395B6 (cs)	2003-09-17
CA2214779A1 (en)	1996-09-19
KR100434239B1 (ko)	2004-06-09
JP4579349B2 (ja)	2010-11-10
KR100434238B1 (ko)	2004-07-16
NO974204D0 (no)	1997-09-12
EP0814785B1 (en)	2007-11-07
AU713172B2 (en)	1999-11-25
ES2297838T3 (es)	2008-05-01
JPH11502200A (ja)	1999-02-23
AU5311796A (en)	1996-10-02
CZ285197A3 (cs)	1998-03-18
RU2199346C2 (ru)	2003-02-27
UA57703C2 (uk)	2003-07-15
HUP9800826A3 (en)	1998-08-28
PL183461B1 (pl)	2002-06-28
NO318598B1 (no)	2005-04-18
SK124197A3 (en)	1998-06-03
WO1996028145A1 (en)	1996-09-19
KR20040004515A (ko)	2004-01-13
US6333350B1 (en)	2001-12-25
EP0814785A1 (en)	1998-01-07
ZA962089B (en)	1997-08-27
PL322252A1 (en)	1998-01-19
DE69637313T2 (de)	2008-09-04
KR19980703060A (ko)	1998-09-05
HUP9800826A1 (hu)	1998-07-28
IL117496A0 (en)	1997-03-18
MY116500A (en)	2004-02-28
TW421594B (en)	2001-02-11
DE69637313D1 (de)	2007-12-20
MX9707007A (es)	1998-06-30
CN1182366A (zh)	1998-05-20
ATE377417T1 (de)	2007-11-15
CN1151781C (zh)	2004-06-02
ID20742A (id)	1999-02-25
NO974204L (no)	1997-11-13

Legal Events

Date	Code	Title
2003-05-29	FF	Patent granted
2003-06-24	FF	Patent granted
2003-07-31	KB	Patent renewed
2006-12-07	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US6028106A (en)	2000-02-22	Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents
US5470847A (en)	1995-11-28	Ovulation control by regulating nitric oxide levels with arginine derivatives
US8247450B2 (en)	2012-08-21	Linoleic acid active agents for enhancing probability of becoming pregnant
JPH10506899A (ja)	1998-07-07	子癇前症を含むアテローム硬化性血管疾病の予防および治療、および高血圧症の治療、ならびにホルモン代替治療のためのプロスタシクリンとエストロゲンまたはプロゲスチンとの組合せ物
AU4243396A (en)	1996-11-29	Endothelin antagonists and endothelin synthase inhibitors fo r the prevention and treatment of uterine contractility diso rders, preeclampsia, atherosclerotic vascular disease, hyper tension and for hormone replacement therapy
JPH09500122A (ja)	1997-01-07	子癇前症及び早期分娩の治療のためのプロゲステロン剤と一酸化窒素シンターゼ基質及び／又はドナーとの組合せ
BG62953B1 (bg)	2000-12-29	Метод за подобряване на имплантацията след ин витро оплождане
EP0814785B1 (en)	2007-11-07	Use of nitric oxide donors or nitric oxide inhibitors for regulating cervical dilatation and extensibility
JP2001525803A (ja)	2001-12-11	勃起機能不全治療用の薬剤の調製のためのミソプロストール及び／又はミソプロストール酸の用途
WO1996028145A9 (en)	1996-12-05	Use of nitric oxide donors or nitric oxide inhibitors for regulating cervical dilatation and extensibility
US5512557A (en)	1996-04-30	Coronary heart disease treated with 17βoestradiol
Waltman et al.	1973	The effect of anti-inflammatory drugs on parturition parameters in the rat
US5962413A (en)	1999-10-05	Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor
PL178174B1 (pl)	2000-03-31	Kompozycje farmaceutyczne do hamowania kurczliwości macicy lub stymulowania kurczliwości macicy
Fuchs	1980	Prevention of premature birth
Zuckerman et al.	1979	Prostaglandins and their inhibitors in premature labour
Åkerlund et al.	1983	Vasopressin effects on isolated non‐pregnant myometrium and uterine arteries and their inhibition by deamino‐ethyl‐lysine‐vasopressin and deamino‐ethyl‐oxytocin
Waltman et al.	1974	The effect of analgesic drugs on the instillation/abortion time of hypertonic saline induced mid-trimester abortion
Calder	1994	Therapies for Starting and Stopping Labour
a CAAASAAAA	1998	8OO