IL120317A - Ciprofloxacin-hydrocortisone suspension - Google Patents

Ciprofloxacin-hydrocortisone suspension

Info

Publication number: IL120317A
Authority: IL; Israel
Prior art keywords: amount effective; hydrocortisone; ciprofloxacin; composition; aqueous
Prior art date: 1995-06-06

Application number

IL12031796A

Other languages

English (en)

Other versions

IL120317A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-05

Publication date

2000-08-13

1996-06-05 Application filed by Bayer Ag filed Critical Bayer Ag

1998-06-15 Publication of IL120317A0 publication Critical patent/IL120317A0/xx

2000-08-13 Publication of IL120317A publication Critical patent/IL120317A/xx

Links

229960000890 hydrocortisone Drugs 0.000 title abstract 3
239000000725 suspension Substances 0.000 title abstract 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 4
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
230000000844 anti-bacterial effect Effects 0.000 abstract 2
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229920001213 Polysorbate 20 Polymers 0.000 abstract 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
229960003405 ciprofloxacin Drugs 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
231100001200 nonototoxic Toxicity 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
229950008882 polysorbate Drugs 0.000 abstract 1
229940068977 polysorbate 20 Drugs 0.000 abstract 1
229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Endoscopes (AREA)

IL12031796A 1995-06-06 1996-06-05 Ciprofloxacin-hydrocortisone suspension IL120317A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46504895A	1995-06-06	1995-06-06

Publications (2)

Publication Number	Publication Date
IL120317A0 IL120317A0 (en)	1998-06-15
IL120317A true IL120317A (en)	2000-08-13

Family

ID=23846298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12031796A IL120317A (en)	1995-06-06	1996-06-05	Ciprofloxacin-hydrocortisone suspension

Country Status (16)

Country	Link
US (1)	US5965549A (fr)
EP (1)	EP0782448B1 (fr)
CN (1)	CN1137685C (fr)
AT (1)	ATE214931T1 (fr)
AU (1)	AU708540B2 (fr)
CA (1)	CA2199294C (fr)
DE (1)	DE69620136T2 (fr)
DK (1)	DK0782448T3 (fr)
ES (1)	ES2173287T3 (fr)
IL (1)	IL120317A (fr)
MX (1)	MX9701731A (fr)
NZ (1)	NZ309624A (fr)
PT (1)	PT782448E (fr)
TW (1)	TW464499B (fr)
WO (1)	WO1996039146A1 (fr)
ZA (1)	ZA964653B (fr)

Families Citing this family (37)

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US6395746B1 (en) *	1998-09-30	2002-05-28	Alcon Manufacturing, Ltd.	Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
AR020661A1 (es) *	1998-09-30	2002-05-22	Alcon Lab Inc	Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6716830B2 (en)	1998-09-30	2004-04-06	Alcon, Inc.	Ophthalmic antibiotic compositions containing moxifloxacin
AU6275999A (en) *	1998-09-30	2000-04-17	Alcon Laboratories, Inc.	Antibiotic compositions for treatment of the eye, ear and nose
US6509327B1 (en)	1998-09-30	2003-01-21	Alcon Manufacturing, Ltd.	Compositions and methods for treating otic, ophthalmic and nasal infections
US6500360B2 (en) *	1999-06-18	2002-12-31	Bernard Bendiner	Sorbic acid and/or its derivatives, such as potassium sorbate, as a preventative for rust, corrosion and scale on metal surfaces
US7064132B2 (en) *	1999-11-28	2006-06-20	Scientific Development And Research, Inc.	Composition and method for treatment of otitis external
US6156294A (en)	1999-11-28	2000-12-05	Scientific Development And Research, Inc.	Composition and method for treatment of otitis media
ES2160090B1 (es) *	2000-03-16	2002-07-01	Vita Invest Sa	Composiciones acuosas de ciprofloxacino, contenidas en envases monodosis y su utilizacion.
CA2412575C (fr) *	2000-07-26	2009-12-29	Onkar N. Singh	Procede ameliore de fabrication de compositions contenant de la ciprofloxacine et de l'hydrocortisone
HUP0303696A3 (en)	2000-09-25	2005-05-30	Bayer Healthcare Llc Tarrytown	Otic microbial combinations for treatment of animals with ruptured tympanic membrane
US20030139382A1 (en)	2001-09-21	2003-07-24	Alcon, Inc.	Method of treating middle ear infections
US7718189B2 (en)	2002-10-29	2010-05-18	Transave, Inc.	Sustained release of antiinfectives
US20040101506A1 (en) *	2002-11-25	2004-05-27	Fust Charles A.	Composition for the prevention and treatment of inflammation of the ear
US7842791B2 (en)	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
ES2270361T3 (es) *	2003-03-20	2007-04-01	Pharmacia Corporation	Formulacion dispersable de un agente antiinflamatorio.
US20050009931A1 (en) *	2003-03-20	2005-01-13	Britten Nancy Jean	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20040214753A1 (en) *	2003-03-20	2004-10-28	Britten Nancy Jean	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) *	2003-03-20	2005-01-06	Britten Nancy Jean	Dispersible formulation of an anti-inflammatory agent
AU2004258746A1 (en) *	2003-07-31	2005-02-03	Pharmacia & Upjohn Company Llc	Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
JP2007500691A (ja) *	2003-07-31	2007-01-18	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	抗炎症剤の分散性製剤
EP1699431B1 (fr)	2003-12-12	2015-08-19	Otic Pharma Ltd.	Compositions pour le traitement de troubles auriculaires et procedes d'utilisation de ces compositions
US8940321B2 (en)	2003-12-12	2015-01-27	Otic Pharma Ltd.	Compositions for treatment of ear disorders and methods of use thereof
US20060019987A1 (en) *	2004-07-23	2006-01-26	Fust Charles A	Methods and compositions for inhibiting, destroying, and/or inactivating viruses
ES2798263T3 (es)	2005-12-08	2020-12-10	Insmed Inc	Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
WO2008137717A1 (fr)	2007-05-04	2008-11-13	Transave, Inc.	Compositions de médicaments multicationiques pour réduire des interactions avec des biomolécules polyanioniques et leurs procédés et utilisations
US9119783B2 (en)	2007-05-07	2015-09-01	Insmed Incorporated	Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en)	2007-05-07	2015-08-25	Insmed Incorporated	Methods of treating pulmonary disorders with liposomal amikacin formulations
UA111147C2 (uk) *	2009-11-11	2016-04-11	Байєр Б.В.	Способи та композиції для лікування або профілактики зовнішнього отиту
DK2366408T3 (da)	2010-03-01	2012-10-22	Salvat Lab Sa	Vandige, klare opløsninger af fluocinolonacetonid til behandling af inflammation i øret
HU227743B1 (en) *	2011-07-22	2012-02-28	Debreceni Egyetem	Eardrop composition and process for producing this
BR112014013564A2 (pt) *	2011-12-09	2017-06-13	Lupin Ltd	composição farmacêutica tópica destinada à aplicação ao olho, ouvido ou nariz
CA2891487A1 (fr)	2012-11-29	2014-06-05	Insmed Incorporated	Formulations de vancomycine stabilisees
MX384843B (es)	2014-05-15	2025-03-14	Insmed Inc	Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
US9393243B1 (en)	2015-07-14	2016-07-19	Nilesh Parikh	Topical Ciprofloxacin compositions
EP3773505B1 (fr)	2018-03-30	2026-04-29	Insmed Incorporated	Procédés pour la fabrication continue de produits médicamenteux liposomaux
EP3787602A4 (fr)	2018-05-02	2022-03-23	Insmed Incorporated	Procédés de fabrication de formulations de médicament liposomal

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4025620A (en) *	1975-10-22	1977-05-24	Leo Pharmaceutical Products Ltd., A/S	Treatment of canine otitis and composition therefor
US4670444B1 (en) *	1980-09-03	1999-02-09	Bayer Ag	and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
ATE34720T1 (de) *	1983-03-31	1988-06-15	Payne Packaging Ltd	Streifen.
DE3537761A1 (de) *	1985-10-24	1987-04-30	Bayer Ag	Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE3704907A1 (de) *	1987-02-17	1988-08-25	Bayer Ag	Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
DE3902079A1 (de) *	1988-04-15	1989-10-26	Bayer Ag	I.m. injektionsformen von gyrase-inhibitoren
US5061729A (en) *	1988-06-08	1991-10-29	Biogal Gyogyszergyar	Pharmaceutical composition and process for preparing the same
US5271939A (en) *	1988-10-03	1993-12-21	Alcon Laboratories, Inc.	Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation
US5260073A (en) *	1990-05-21	1993-11-09	Norwich Eaton Pharmaceuticals, Inc.	Use of phenylpropanolamine as a mucus secretogogue in the upper airways
WO1994010976A1 (fr) *	1992-11-16	1994-05-26	Ciba Vision Ag, Hettlingen	Systeme d'administration de medicaments ophtalmiques a base de borate/alcool polyvinylique
US5422116A (en) *	1994-02-18	1995-06-06	Ciba-Geigy Corporation	Liquid ophthalmic sustained release delivery system
ES2088742B1 (es) *	1994-06-29	1997-03-16	Salvat Lab Sa	Composicion antibiotica de aplicacion otica.

1996
- 1996-06-05 WO PCT/US1996/008864 patent/WO1996039146A1/fr not_active Ceased
- 1996-06-05 DE DE69620136T patent/DE69620136T2/de not_active Expired - Lifetime
- 1996-06-05 MX MX9701731A patent/MX9701731A/es unknown
- 1996-06-05 IL IL12031796A patent/IL120317A/xx not_active IP Right Cessation
- 1996-06-05 CA CA002199294A patent/CA2199294C/fr not_active Expired - Lifetime
- 1996-06-05 PT PT96917172T patent/PT782448E/pt unknown
- 1996-06-05 ZA ZA964653A patent/ZA964653B/xx unknown
- 1996-06-05 ES ES96917172T patent/ES2173287T3/es not_active Expired - Lifetime
- 1996-06-05 DK DK96917172T patent/DK0782448T3/da active
- 1996-06-05 NZ NZ309624A patent/NZ309624A/en not_active IP Right Cessation
- 1996-06-05 AU AU59840/96A patent/AU708540B2/en not_active Expired
- 1996-06-05 EP EP96917172A patent/EP0782448B1/fr not_active Expired - Lifetime
- 1996-06-05 AT AT96917172T patent/ATE214931T1/de active
- 1996-06-05 CN CNB96190870XA patent/CN1137685C/zh not_active Expired - Lifetime
- 1996-06-06 TW TW085106748A patent/TW464499B/zh not_active IP Right Cessation
1997
- 1997-02-18 US US08/801,891 patent/US5965549A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT782448E (pt)	2002-07-31
AU5984096A (en)	1996-12-24
WO1996039146A1 (fr)	1996-12-12
US5965549A (en)	1999-10-12
DE69620136D1 (de)	2002-05-02
EP0782448A4 (fr)	1998-05-20
MX9701731A (es)	1997-10-31
ATE214931T1 (de)	2002-04-15
AU708540B2 (en)	1999-08-05
CN1137685C (zh)	2004-02-11
CN1160999A (zh)	1997-10-01
EP0782448B1 (fr)	2002-03-27
ES2173287T3 (es)	2002-10-16
CA2199294C (fr)	2000-09-19
TW464499B (en)	2001-11-21
DE69620136T2 (de)	2002-08-01
EP0782448A1 (fr)	1997-07-09
HK1002552A1 (en)	1998-09-04
IL120317A0 (en)	1998-06-15
CA2199294A1 (fr)	1996-12-12
NZ309624A (en)	1999-04-29
ZA964653B (en)	1996-12-12
DK0782448T3 (da)	2002-07-08

Legal Events

Date	Code	Title
2000-12-06	FF	Patent granted
2001-06-14	KB	Patent renewed
2002-07-25	KB	Patent renewed
2010-11-30	KB	Patent renewed
2014-06-30	KB	Patent renewed
2016-12-29	EXP	Patent expired

Publication	Publication Date	Title
IL120317A0 (en)	1998-06-15	Otic antibacterial compositions
CA2289717A1 (fr)	1998-11-12	Nouveau traitement de la constipation
WO1996028148A3 (fr)	1996-11-14	Emploi d'un anti-inflammatoire non steroidien r dans une composition protectrice pour le traitement du cancer colorectal
RU94041223A (ru)	1996-10-20	Средство для лечения мотонейроновых заболеваний
EP1086702A3 (fr)	2001-04-04	Toxines de botulinum pour le traitement des cephalées de la migraine
FI980822A7 (fi)	1998-04-09	Farmaseuttinen koostumus vaikuttavan aineen iho- tai limakalvopintaan tai iho- tai limakalvopinnan läpi
CA2031880A1 (fr)	1991-06-22	Agent anti-inflammatoire combine
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
CA2321560A1 (fr)	1999-09-16	Traitement de la retinopathie diabetique ou des inflammations oculaires au moyen d'un inhibiteur des tyrosine-kinases tel que la genisteine
WO2001030802A3 (fr)	2002-02-14	Traitements therapeutiques pour des deficiences en cellules sanguines
CA2107669A1 (fr)	1993-08-08	Preparation pour le traitement des lesions et des hemorroides
PT902789E (pt)	2002-07-31	Derivados de androsteno
MY111260A (en)	1999-10-30	Pharmaceutical composition for the treatment of nicotine dependence
AU2002231889A1 (en)	2002-08-06	Halogenated composition, method for preparing same and uses thereof
AU1865100A (en)	2000-07-31	Hyaluronate lyase used for promoting penetration in topical agents
KR950016760A (ko)	1995-07-20	치질 치료제
RU94045866A (ru)	1996-10-20	Применение бисфенилалкилпиперазинов для лечения расстройств, вызванных злоупотреблением веществами, способ лечения
CA2156481A1 (fr)	1994-09-01	Compositions antagonistes du recepteur 5-ht2, utiles pour le traitement des troubles veineux
HUP9902415A2 (hu)	1999-11-29	Azonnal felszabaduló szilárd beadási formák és eljárás azok előállítására
EP0799618A3 (fr)	1997-11-12	Utilisation d'antagonistes de l'adrénorécepteur alpha 1 dans la fabrication d'unmédicament pur la prévention et au traitment du cancer
EP0906108A4 (fr)	2000-12-06	Procede de traitement de l'insuffisance cardiaque par des antagonistes de l'endotheline
WO1999065475A3 (fr)	2000-04-06	Combinaison de phentolamine et apomorphine pour le traitement concernant les fonctions et les dysfonctionnements sexuels
FR2754824B1 (fr)	1999-03-05	Nouvelle composition contenant du chitosan
PT1140001E (pt)	2005-09-30	Composicao para tratamento de queimaduras
WO1998014193A1 (fr)	1998-04-09	Utilisation d'un antagoniste de la substance p dans la fabrication d'un medicament pour traiter les douleurs oculaires