IL122098A0 - Vinylpyrrolidinon cephalosplorin derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Vinylpyrrolidinon cephalosplorin derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number: IL122098A0
Authority: IL; Israel
Prior art keywords: lower alkyl; hydrogen; phenyl; hydroxy; optionally substituted
Prior art date: 1996-11-06

Application number

IL12209897A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-06

Filing date

1997-11-04

Publication date

1998-04-05

1997-11-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-04-05 Publication of IL122098A0 publication Critical patent/IL122098A0/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
125000000623 heterocyclic group Chemical group 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
125000001624 naphthyl group Chemical group 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000005504 styryl group Chemical group 0.000 abstract 2
229930186147 Cephalosporin Natural products 0.000 abstract 1
208000035473 Communicable disease Diseases 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
-1 carboxy, amino Chemical group 0.000 abstract 1
125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Separation Using Semi-Permeable Membranes (AREA)

IL12209897A 1996-11-06 1997-11-04 Vinylpyrrolidinon cephalosplorin derivatives their preparation and pharmaceutical compositions containing them IL122098A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96117710		1996-11-06
EP97115996		1997-09-15

Publications (1)

Publication Number	Publication Date
IL122098A0 true IL122098A0 (en)	1998-04-05

Family

ID=26142279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12209897A IL122098A0 (en)	1996-11-06	1997-11-04	Vinylpyrrolidinon cephalosplorin derivatives their preparation and pharmaceutical compositions containing them

Country Status (18)

Country	Link
US (1)	US6294668B1 (da)
EP (1)	EP0841339B1 (da)
JP (1)	JP3065289B2 (da)
KR (1)	KR100273611B1 (da)
CN (1)	CN1081639C (da)
AT (1)	ATE354577T1 (da)
AU (1)	AU727014B2 (da)
CA (1)	CA2220188C (da)
CZ (1)	CZ350197A3 (da)
DE (1)	DE69737382T2 (da)
DK (1)	DK0841339T3 (da)
ES (1)	ES2281090T3 (da)
HU (1)	HUP9701835A3 (da)
IL (1)	IL122098A0 (da)
MA (1)	MA26446A1 (da)
NO (1)	NO975094L (da)
NZ (1)	NZ329106A (da)
SG (1)	SG71055A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150350A (en) *	1997-09-15	2000-11-21	Hoffman-La Roche Inc.	Antimicrobial compositions
ES2190222T3 (es) *	1998-06-15	2003-07-16	Basilea Pharmaceutica Ag	Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem.
US6232306B1 (en)	1998-06-15	2001-05-15	Hoffmann-La Roche Inc.	Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
HUP0102350A2 (hu)	1998-06-22	2001-11-28	F.Hoffmann-La Roche Ag.	Propenil-cefalosporin-származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
AU1654900A (en) *	1998-12-03	2000-06-19	F. Hoffmann-La Roche Ag	Bi-pyrrolidinylvinl (carba) cephalosporins
AU6267100A (en) *	1999-07-07	2001-01-30	F. Hoffmann-La Roche Ag	Vinylpyrrolidinone derivatives with substituted thiazole ring
WO2001060938A1 (fr) *	2000-02-15	2001-08-23	Hitachi Chemical Co., Ltd.	Composition adhesive, procede de production de ladite resine, film adhesif fabrique a partir de ladite resine, substrat pour montage de semi-conducteur et dispositif semi-conducteur
WO2006010978A1 (en) *	2004-06-30	2006-02-02	Wockhardt Limited	Cefdinir polymorphic forms, and imidazole salt
EP2046736B1 (en)	2006-07-27	2019-06-12	Emisphere Technologies, Inc.	Arylsulfanyl compounds and compositions for delivering active agents
CA2732165A1 (en) *	2008-08-04	2010-02-11	Astrazeneca Ab	Therapeutic agents 414
AR076221A1 (es)	2009-04-09	2011-05-26	Astrazeneca Ab	Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
AR076220A1 (es)	2009-04-09	2011-05-26	Astrazeneca Ab	Derivados de pirazol [4,5 - e] pirimidina
EP2435442B1 (de)	2009-05-25	2016-01-13	Sandoz AG	Verfahren zur herstellung von ceftobiprol medocaril
UY35103A (es)	2012-10-29	2014-05-30	Glaxo Group Ltd	Compuestos de cefem 2-sustituidos
CN111471058A (zh) *	2019-01-23	2020-07-31	中国医学科学院药物研究所	用于制备头孢吡普类似物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4255423A (en) *	1977-07-27	1981-03-10	Merck & Co., Inc.	Cephalosporin compounds
FR2457296A1 (fr)	1979-05-23	1980-12-19	Rhone Poulenc Ind	Nouveaux derives de vinyl-3 cephalosporines et leur preparation
IL94946A0 (en)	1989-07-13	1991-06-10	Eisai Co Ltd	3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
KR0174535B1 (ko)	1989-09-04	1999-02-01	알렌 제이 스피글	베타-락탐 함유 화합물 및 그의 제조방법
DE69016719T2 (de)	1989-09-04	1995-06-01	Beecham Group Plc	Cephalosporinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate und Zwischenverbindungen.
GB9019743D0 (en)	1990-09-10	1990-10-24	Beecham Group Plc	Novel compounds
JPH08502513A (ja)	1992-10-23	1996-03-19	藤沢薬品工業株式会社	セフェム化合物、およびそれらの医薬組成物
US5523400A (en)	1993-04-16	1996-06-04	Hoffmann-La Roche Inc.	Cephalosporin antibiotics
ES2185634T3 (es) *	1993-04-16	2003-05-01	Basilea Pharmaceutica Ag	Derivados de cefalosporina.
WO1995009171A1 (en)	1993-09-29	1995-04-06	Meiji Seika Kaisha, Ltd.	Novel cephalosporin derivative
US5559108A (en)	1994-09-02	1996-09-24	Bristol-Myers Squibb Company	Cephalosporin derivatives
US5567698A (en)	1995-02-15	1996-10-22	Bristol-Myers Squibb Company	Pyridinium thiomethyl substituted chepholosporin derivatives
JPH11501017A (ja) *	1995-02-27	1999-01-26	エフ・ホフマン−ラロシュアーゲー	３−ピロリジリデン−２−オン−セファロスポリンの誘導体
JPH08319291A (ja)	1995-05-25	1996-12-03	Meiji Seika Kaisha Ltd	新規セフェム誘導体
AT403161B (de)	1995-07-19	1997-11-25	Biochemie Gmbh	Verfahren zur herstellung von cephemverbindungen
EP0761673A1 (en) *	1995-09-12	1997-03-12	F. Hoffmann-La Roche Ag	Cephalosporin derivatives
US5883247A (en)	1996-06-10	1999-03-16	Hoffmann-La Roche Inc.	Preparation of cephem and isooxacephem derivatives
EP0831093A1 (en)	1996-09-23	1998-03-25	F. Hoffmann-La Roche Ag	1-Carba-(dethia)-Cephalosporin Derivatives

1997
- 1997-10-29 EP EP97118780A patent/EP0841339B1/en not_active Expired - Lifetime
- 1997-10-29 ES ES97118780T patent/ES2281090T3/es not_active Expired - Lifetime
- 1997-10-29 AT AT97118780T patent/ATE354577T1/de active
- 1997-10-29 DK DK97118780T patent/DK0841339T3/da active
- 1997-10-29 DE DE69737382T patent/DE69737382T2/de not_active Expired - Lifetime
- 1997-11-03 MA MA24852A patent/MA26446A1/fr unknown
- 1997-11-04 IL IL12209897A patent/IL122098A0/xx unknown
- 1997-11-04 CA CA002220188A patent/CA2220188C/en not_active Expired - Fee Related
- 1997-11-04 NZ NZ329106A patent/NZ329106A/xx unknown
- 1997-11-05 HU HU9701835A patent/HUP9701835A3/hu unknown
- 1997-11-05 CN CN97122431A patent/CN1081639C/zh not_active Expired - Fee Related
- 1997-11-05 SG SG1997003954A patent/SG71055A1/en unknown
- 1997-11-05 KR KR1019970058137A patent/KR100273611B1/ko not_active Expired - Fee Related
- 1997-11-05 AU AU44356/97A patent/AU727014B2/en not_active Ceased
- 1997-11-05 US US08/964,640 patent/US6294668B1/en not_active Expired - Fee Related
- 1997-11-05 NO NO975094A patent/NO975094L/no not_active Application Discontinuation
- 1997-11-05 CZ CZ973501A patent/CZ350197A3/cs unknown
- 1997-11-06 JP JP9304115A patent/JP3065289B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3065289B2 (ja)	2000-07-17
CZ350197A3 (cs)	1998-05-13
DK0841339T3 (da)	2007-07-02
CA2220188C (en)	2008-04-08
CN1081639C (zh)	2002-03-27
HUP9701835A3 (en)	2001-04-28
NZ329106A (en)	1998-12-23
KR19980042094A (ko)	1998-08-17
SG71055A1 (en)	2000-03-21
HU9701835D0 (en)	1997-12-29
DE69737382T2 (de)	2007-10-31
DE69737382D1 (de)	2007-04-05
ES2281090T3 (es)	2007-09-16
HUP9701835A2 (hu)	1999-05-28
US6294668B1 (en)	2001-09-25
NO975094L (no)	1998-05-07
CA2220188A1 (en)	1998-05-06
AU4435697A (en)	1998-05-14
NO975094D0 (no)	1997-11-05
MA26446A1 (fr)	2004-12-20
EP0841339A1 (en)	1998-05-13
KR100273611B1 (ko)	2000-12-15
AU727014B2 (en)	2000-11-30
CN1181382A (zh)	1998-05-13
ATE354577T1 (de)	2007-03-15
EP0841339B1 (en)	2007-02-21
JPH10139783A (ja)	1998-05-26

Publication	Publication Date	Title
IL122098A0 (en)	1998-04-05	Vinylpyrrolidinon cephalosplorin derivatives their preparation and pharmaceutical compositions containing them
NO912805D0 (no)	1991-07-17	Fremgangsmaate for fremstilling av pyrazolopyridin-forbindelser.
IL109321A0 (en)	1994-07-31	Cephalosporin derivatives, their manufacture and pharmaceutical compositions containing them
NO882608D0 (no)	1988-06-14	Fremgangsmaate for fremstilling av terapeutisk aktive pyrazolopyrideirer.
RU94012924A (ru)	1995-12-20	Производные цефалоспорина
DK96786D0 (da)	1986-03-03	Aminosyrederivater
AU1060592A (en)	1992-08-06	N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3,2,1)octanes, intermediates and a process for the preparation thereof and their use as medicaments
MX9708525A (es)	1998-05-31	Derivados de vinilpirrolidinon-cefalosporina.
PL304334A1 (en)	1995-01-23	Pharmaceutical composition of gastric protective action, including antiulceric one and method of treating diseases of gastrointestinal tract