IL122215A - Dolastatin derivatives as antineoplastics and their preparation - Google Patents

Dolastatin derivatives as antineoplastics and their preparation

Info

Publication number: IL122215A
Authority: IL; Israel
Prior art keywords: antineoplastics; preparation; dolastatin derivatives; dolastatin; derivatives
Prior art date: 1995-06-07

Application number

IL12221596A

Other languages

English (en)

Other versions

IL122215A0 (en

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-03

Publication date

2001-08-26

1996-06-03 Application filed by Basf Ag filed Critical Basf Ag

1998-04-05 Publication of IL122215A0 publication Critical patent/IL122215A0/xx

2001-08-26 Publication of IL122215A publication Critical patent/IL122215A/xx

Links

230000000118 anti-neoplastic effect Effects 0.000 title 1
229940034982 antineoplastic agent Drugs 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical class CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IL12221596A 1995-06-07 1996-06-03 Dolastatin derivatives as antineoplastics and their preparation IL122215A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/472,453 US5831002A (en)	1992-05-20	1995-06-07	Antitumor peptides
PCT/EP1996/002392 WO1996040751A1 (en)	1995-06-07	1996-06-03	Novel dolastatin derivatives, their preparation and use

Publications (2)

Publication Number	Publication Date
IL122215A0 IL122215A0 (en)	1998-04-05
IL122215A true IL122215A (en)	2001-08-26

Family

ID=23875567

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL12221696A IL122216A (en)	1995-06-07	1996-06-03	Dolastatin derivatives as antineoplastics and their preparation
IL12221596A IL122215A (en)	1995-06-07	1996-06-03	Dolastatin derivatives as antineoplastics and their preparation

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL12221696A IL122216A (en)	1995-06-07	1996-06-03	Dolastatin derivatives as antineoplastics and their preparation

Country Status (33)

Country	Link
US (1)	US5831002A (cs)
EP (2)	EP0871656B1 (cs)
JP (2)	JP3957751B2 (cs)
KR (2)	KR100437985B1 (cs)
CN (2)	CN1182153C (cs)
AR (2)	AR003427A1 (cs)
AT (2)	ATE223431T1 (cs)
AU (2)	AU725170B2 (cs)
BG (2)	BG102125A (cs)
BR (2)	BR9609424A (cs)
CA (2)	CA2219818C (cs)
CO (2)	CO4700527A1 (cs)
CZ (2)	CZ293683B6 (cs)
DE (2)	DE69623992T2 (cs)
DK (2)	DK0871656T3 (cs)
ES (2)	ES2188759T3 (cs)
HR (2)	HRP960257A2 (cs)
HU (2)	HU228071B1 (cs)
IL (2)	IL122216A (cs)
MX (2)	MX9709146A (cs)
MY (2)	MY119042A (cs)
NO (2)	NO317670B1 (cs)
NZ (2)	NZ310443A (cs)
PL (2)	PL185763B1 (cs)
PT (2)	PT832104E (cs)
RO (2)	RO118953B1 (cs)
SI (2)	SI0832104T1 (cs)
SK (1)	SK282466B6 (cs)
TR (2)	TR199701545T1 (cs)
TW (2)	TW508357B (cs)
UA (2)	UA46775C2 (cs)
WO (2)	WO1996040752A1 (cs)
ZA (2)	ZA964711B (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
US20010009901A1 (en) *	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
TW474946B (en) *	1995-12-15	2002-02-01	Basf Ag	Novel compounds, the preparation and use thereof
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) *	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) *	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
CA2360740A1 (en)	1999-03-02	2000-09-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7018642B2 (en)	2001-04-27	2006-03-28	The Procter & Gamble Company	Compounds, compositions, and methods for controlling biofilms
AU2002359792A1 (en) *	2001-12-18	2003-06-30	Proteologics, Inc.	Methods and compositions for the inhibition of viral release
WO2003072754A2 (en) *	2002-02-27	2003-09-04	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
WO2006013552A2 (en)	2004-08-02	2006-02-09	Ramot At Tel Aviv University Ltd.	Articles of peptide nanostructures and method of forming the same
WO2006122408A1 (en)	2005-05-18	2006-11-23	Aegera Therapeutics Inc.	Bir domain binding compounds
AU2006283677A1 (en) *	2005-08-19	2007-03-01	Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Topical formulations of histone deacetylase inhibitors and methods of using the same
US10004828B2 (en) *	2005-10-11	2018-06-26	Romat at Tel-Aviv University Ltd.	Self-assembled Fmoc-ff hydrogels
BRPI0711591A2 (pt)	2006-05-16	2011-11-16	Aegera Therapeutics, Inc.	composto de ligação de domìnio bir da iap
JP5452223B2 (ja) *	2006-07-24	2014-03-26	テトラロジックファーマシューティカルズコーポレーション	Ｉａｐ阻害剤
EP2146719B1 (en)	2007-04-12	2013-08-14	ScinoPharm Taiwan, Ltd.	Process for making galantamine
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en)	2009-07-02	2012-10-09	Tetralogic Pharmaceuticals Corp.	2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
NZ602368A (en)	2010-02-12	2014-10-31	Pharmascience Inc	Iap bir domain binding compounds
KR20140003521A (ko)	2010-12-30	2014-01-09	이난타 파마슈티칼스, 인코포레이티드	페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
CN103534256B (zh)	2010-12-30	2016-08-10	益安药业	大环丙型肝炎丝氨酸蛋白酶抑制剂
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
KR20200128601A (ko) *	2011-05-27	2020-11-13	암브룩스, 인코포레이티드	비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
WO2015103490A1 (en)	2014-01-03	2015-07-09	Abbvie, Inc.	Solid antiviral dosage forms
CA3230737A1 (en)	2021-09-03	2023-03-09	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4879278A (en) *	1989-05-16	1989-11-07	Arizona Board Of Regents	Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DK0934950T3 (da) *	1991-08-09	2002-07-29	Teikoku Hormone Mfg Co Ltd	Tetrapeptidderivat
UA45304C2 (uk) *	1992-05-20	2002-04-15	Басф Аг	Похідні пептиду або їх солі, фармацевтична композиція
US5530097A (en) *	1994-08-01	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory peptide amides
US5504191A (en) *	1994-08-01	1996-04-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide methyl esters

1995
- 1995-06-07 US US08/472,453 patent/US5831002A/en not_active Expired - Lifetime
1996
- 1996-06-03 AT AT96918660T patent/ATE223431T1/de active
- 1996-06-03 PT PT96918660T patent/PT832104E/pt unknown
- 1996-06-03 IL IL12221696A patent/IL122216A/en not_active IP Right Cessation
- 1996-06-03 DE DE69623992T patent/DE69623992T2/de not_active Expired - Lifetime
- 1996-06-03 WO PCT/EP1996/002393 patent/WO1996040752A1/en not_active Ceased
- 1996-06-03 UA UA98010069A patent/UA46775C2/uk unknown
- 1996-06-03 DK DK96918661T patent/DK0871656T3/da active
- 1996-06-03 IL IL12221596A patent/IL122215A/xx not_active IP Right Cessation
- 1996-06-03 EP EP96918661A patent/EP0871656B1/en not_active Expired - Lifetime
- 1996-06-03 NZ NZ310443A patent/NZ310443A/en not_active IP Right Cessation
- 1996-06-03 PL PL96323726A patent/PL185763B1/pl unknown
- 1996-06-03 MX MX9709146A patent/MX9709146A/es unknown
- 1996-06-03 HU HU9801910A patent/HU228071B1/hu not_active IP Right Cessation
- 1996-06-03 ES ES96918661T patent/ES2188759T3/es not_active Expired - Lifetime
- 1996-06-03 AU AU61242/96A patent/AU725170B2/en not_active Ceased
- 1996-06-03 MX MX9709147A patent/MX9709147A/es unknown
- 1996-06-03 KR KR1019970709063A patent/KR100437985B1/ko not_active Expired - Fee Related
- 1996-06-03 KR KR1019970709064A patent/KR100437986B1/ko not_active Expired - Fee Related
- 1996-06-03 CN CNB961944684A patent/CN1182153C/zh not_active Expired - Fee Related
- 1996-06-03 UA UA98010070A patent/UA46776C2/uk unknown
- 1996-06-03 MY MYPI96002155A patent/MY119042A/en unknown
- 1996-06-03 NZ NZ310444A patent/NZ310444A/xx not_active IP Right Cessation
- 1996-06-03 TR TR97/01545T patent/TR199701545T1/xx unknown
- 1996-06-03 DK DK96918660T patent/DK0832104T3/da active
- 1996-06-03 CA CA002219818A patent/CA2219818C/en not_active Expired - Fee Related
- 1996-06-03 EP EP96918660A patent/EP0832104B1/en not_active Expired - Lifetime
- 1996-06-03 WO PCT/EP1996/002392 patent/WO1996040751A1/en not_active Ceased
- 1996-06-03 TR TR97/01544T patent/TR199701544T1/xx unknown
- 1996-06-03 CA CA002219819A patent/CA2219819C/en not_active Expired - Fee Related
- 1996-06-03 ES ES96918660T patent/ES2186783T3/es not_active Expired - Lifetime
- 1996-06-03 AU AU61241/96A patent/AU725164B2/en not_active Ceased
- 1996-06-03 CZ CZ19973765A patent/CZ293683B6/cs not_active IP Right Cessation
- 1996-06-03 BR BR9609424-9A patent/BR9609424A/pt not_active Application Discontinuation
- 1996-06-03 CN CNB961944676A patent/CN1182154C/zh not_active Expired - Fee Related
- 1996-06-03 RO RO97-02264A patent/RO118953B1/ro unknown
- 1996-06-03 SK SK1653-97A patent/SK282466B6/sk not_active IP Right Cessation
- 1996-06-03 PL PL96323723A patent/PL185762B1/pl unknown
- 1996-06-03 DE DE69623472T patent/DE69623472T2/de not_active Expired - Lifetime
- 1996-06-03 AT AT96918661T patent/ATE224910T1/de active
- 1996-06-03 SI SI9630539T patent/SI0832104T1/xx unknown
- 1996-06-03 CZ CZ19973763A patent/CZ293682B6/cs not_active IP Right Cessation
- 1996-06-03 JP JP50013197A patent/JP3957751B2/ja not_active Expired - Fee Related
- 1996-06-03 RO RO97-02254A patent/RO119783B1/ro unknown
- 1996-06-03 PT PT96918661T patent/PT871656E/pt unknown
- 1996-06-03 BR BR9609423A patent/BR9609423A/pt not_active Application Discontinuation
- 1996-06-03 SI SI9630550T patent/SI0871656T1/xx unknown
- 1996-06-03 JP JP50013297A patent/JP4221062B2/ja not_active Expired - Fee Related
- 1996-06-03 HU HU9801817A patent/HU228073B1/hu not_active IP Right Cessation
- 1996-06-04 MY MYPI96002170A patent/MY124487A/en unknown
- 1996-06-06 ZA ZA9604711A patent/ZA964711B/xx unknown
- 1996-06-06 HR HR08/472,453A patent/HRP960257A2/hr not_active Application Discontinuation
- 1996-06-06 HR HR08/472,453A patent/HRP960277A2/hr not_active Application Discontinuation
- 1996-06-06 AR ARP960102981A patent/AR003427A1/es active IP Right Grant
- 1996-06-06 AR ARP960102980A patent/AR003136A1/es active IP Right Grant
- 1996-06-06 ZA ZA9604710A patent/ZA964710B/xx unknown
- 1996-06-07 TW TW085106866A patent/TW508357B/zh not_active IP Right Cessation
- 1996-06-07 CO CO96029751A patent/CO4700527A1/es unknown
- 1996-06-07 CO CO96029749A patent/CO4700526A1/es unknown
- 1996-10-02 TW TW085106867A patent/TW424096B/zh not_active IP Right Cessation
1997
- 1997-12-05 NO NO19975711A patent/NO317670B1/no not_active IP Right Cessation
- 1997-12-05 NO NO19975710A patent/NO318384B1/no not_active IP Right Cessation
- 1997-12-18 BG BG102125A patent/BG102125A/xx unknown
- 1997-12-29 BG BG102152A patent/BG102152A/xx unknown

Also Published As

Publication number	Publication date
JP4221062B2 (ja)	2009-02-12
DE69623472T2 (de)	2003-08-21
BG102125A (en)	1998-09-30
CN1187198A (zh)	1998-07-08
DK0832104T3 (da)	2003-01-06
NO318384B1 (no)	2005-03-14
PL185762B1 (pl)	2003-07-31
DK0871656T3 (da)	2003-01-27
SK165397A3 (en)	1998-10-07
SK282466B6 (sk)	2002-02-05
ZA964711B (en)	1997-12-08
JPH11504653A (ja)	1999-04-27
UA46775C2 (uk)	2002-06-17
KR19990022583A (ko)	1999-03-25
JPH11504652A (ja)	1999-04-27
AU6124196A (en)	1996-12-30
CA2219818C (en)	2008-05-20
CA2219818A1 (en)	1996-12-19
CA2219819C (en)	2008-05-20
AU6124296A (en)	1996-12-30
DE69623472D1 (de)	2002-10-10
ATE224910T1 (de)	2002-10-15
AU725164B2 (en)	2000-10-05
BG102152A (en)	1998-09-30
MX9709147A (es)	1998-03-31
CN1182153C (zh)	2004-12-29
EP0832104B1 (en)	2002-09-04
KR100437985B1 (ko)	2004-09-18
IL122215A0 (en)	1998-04-05
MX9709146A (es)	1998-03-31
HRP960257A2 (en)	1998-02-28
DE69623992T2 (de)	2003-05-22
ES2188759T3 (es)	2003-07-01
BR9609424A (pt)	2000-03-28
CO4700527A1 (es)	1998-12-29
AU725170B2 (en)	2000-10-05
SI0871656T1 (en)	2003-08-31
RO118953B1 (ro)	2004-01-30
US5831002A (en)	1998-11-03
ES2186783T3 (es)	2003-05-16
CZ293682B6 (cs)	2004-07-14
EP0871656A1 (en)	1998-10-21
EP0871656B1 (en)	2002-09-25
CZ376597A3 (cs)	1998-06-17
TR199701544T1 (xx)	1998-03-21
KR19990022582A (ko)	1999-03-25
HUP9801817A3 (en)	1999-06-28
PT832104E (pt)	2002-12-31
SI0832104T1 (en)	2003-08-31
HU228073B1 (hu)	2012-09-28
NO975711D0 (no)	1997-12-05
NO975710D0 (no)	1997-12-05
HU228071B1 (hu)	2012-09-28
HUP9801817A2 (hu)	1998-11-30
CN1182154C (zh)	2004-12-29
PL323723A1 (en)	1998-04-14
NO317670B1 (no)	2004-11-29
AR003136A1 (es)	1998-07-08
UA46776C2 (uk)	2002-06-17
BR9609423A (pt)	1999-06-29
CZ376397A3 (cs)	1998-06-17
IL122216A0 (en)	1998-04-05
PL185763B1 (pl)	2003-07-31
NO975710L (no)	1998-02-02
KR100437986B1 (ko)	2004-09-18
PL323726A1 (en)	1998-04-14
MY119042A (en)	2005-03-31
TW424096B (en)	2001-03-01
PT871656E (pt)	2002-12-31
EP0832104A1 (en)	1998-04-01
CA2219819A1 (en)	1996-12-19
ZA964710B (en)	1997-12-08
NO975711L (no)	1998-01-30
CO4700526A1 (es)	1998-12-29
CZ293683B6 (cs)	2004-07-14
CN1187199A (zh)	1998-07-08
IL122216A (en)	2002-02-10
NZ310443A (en)	1999-10-28
WO1996040751A1 (en)	1996-12-19
ATE223431T1 (de)	2002-09-15
AR003427A1 (es)	1998-08-05
MY124487A (en)	2006-06-30
TR199701545T1 (xx)	1998-04-21
HRP960277A2 (en)	1997-10-31
HUP9801910A3 (en)	1999-06-28
RO119783B1 (ro)	2005-03-30
DE69623992D1 (de)	2002-10-31
NZ310444A (en)	1999-11-29
HUP9801910A2 (hu)	1999-01-28
WO1996040752A1 (en)	1996-12-19
JP3957751B2 (ja)	2007-08-15
TW508357B (en)	2002-11-01

Legal Events

Date	Code	Title
2002-02-10	KB	Patent renewed
2002-07-25	KB	Patent renewed
2003-09-17	HP	Change in proprietorship
2006-08-01	KB	Patent renewed
2010-11-30	KB	Patent renewed
2014-06-30	KB	Patent renewed
2016-12-29	EXP	Patent expired

Publication	Publication Date	Title
IL116851A0 (en)	1996-07-23	3-arylidene-2-oxindole derivatives their preparation and use
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