IL124894A - Hydrogel Acrylamide Copolymeric seedling for medicinal purposes - Google Patents
Hydrogel Acrylamide Copolymeric seedling for medicinal purposesInfo
- Publication number
- IL124894A IL124894A IL12489497A IL12489497A IL124894A IL 124894 A IL124894 A IL 124894A IL 12489497 A IL12489497 A IL 12489497A IL 12489497 A IL12489497 A IL 12489497A IL 124894 A IL124894 A IL 124894A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogel
- tissue
- polymer
- cells
- polymer hydrogel
- Prior art date
Links
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Neurology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/731,484 US5863551A (en) | 1996-10-16 | 1996-10-16 | Implantable polymer hydrogel for therapeutic uses |
| PCT/CA1997/000766 WO1998016266A1 (en) | 1996-10-16 | 1997-10-15 | Implantable acrylamide copolymer hydrogel for therapeutic uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124894A0 IL124894A0 (en) | 1999-01-26 |
| IL124894A true IL124894A (en) | 2004-06-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12489497A IL124894A (en) | 1996-10-16 | 1997-10-15 | Hydrogel Acrylamide Copolymeric seedling for medicinal purposes |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5863551A (de) |
| EP (1) | EP0929323B1 (de) |
| JP (1) | JP3542810B2 (de) |
| KR (1) | KR100377520B1 (de) |
| CN (1) | CN1211194A (de) |
| AT (1) | ATE284717T1 (de) |
| AU (1) | AU744666B2 (de) |
| BR (1) | BR9706835A (de) |
| CA (1) | CA2240721C (de) |
| CZ (1) | CZ187698A3 (de) |
| DE (1) | DE69731959T2 (de) |
| HU (1) | HUP9902027A3 (de) |
| IL (1) | IL124894A (de) |
| NZ (1) | NZ330664A (de) |
| PL (1) | PL327454A1 (de) |
| RU (1) | RU2198686C2 (de) |
| SK (1) | SK79698A3 (de) |
| WO (1) | WO1998016266A1 (de) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4335316B2 (ja) * | 1996-09-19 | 2009-09-30 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー |
| US8003705B2 (en) * | 1996-09-23 | 2011-08-23 | Incept Llc | Biocompatible hydrogels made with small molecule precursors |
| US20030008396A1 (en) * | 1999-03-17 | 2003-01-09 | Ku David N. | Poly(vinyl alcohol) hydrogel |
| WO1999060938A1 (en) | 1998-05-23 | 1999-12-02 | Focal, Inc. | Method of treatment for premature rupture of membranes in pregnancy (prom) |
| US6165193A (en) | 1998-07-06 | 2000-12-26 | Microvention, Inc. | Vascular embolization with an expansible implant |
| US6464850B1 (en) | 1998-07-31 | 2002-10-15 | Biowhittaker Molecular Applications, Inc. | Method for producing hydrophilic monomers and uses thereof |
| US6117293A (en) * | 1998-07-31 | 2000-09-12 | Biowhittaker Molecular Applications, Inc. | Method for producing hydrophilic monomers and uses thereof |
| US6818018B1 (en) | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| EP1137373A4 (de) * | 1998-12-04 | 2004-05-19 | Chandrashekhar P Pathak | Biokompatible, vernetzte polymere |
| US6511650B1 (en) * | 1999-04-09 | 2003-01-28 | The Regents Of The University Of Michigan | Preparing porous hydrogel products |
| US6264695B1 (en) * | 1999-09-30 | 2001-07-24 | Replication Medical, Inc. | Spinal nucleus implant |
| CA2394077A1 (en) * | 1999-12-16 | 2001-06-21 | Trident Technologies, Llc | System and method for extended delivery of a therapeutic agent with its receptor loading dose |
| US6664305B2 (en) | 2000-06-27 | 2003-12-16 | Bia Separations D.O.O. | Chromatography material and a process of manufacturing that material |
| US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US6638312B2 (en) * | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
| US7204851B2 (en) * | 2000-08-30 | 2007-04-17 | Sdgi Holdings, Inc. | Method and apparatus for delivering an intervertebral disc implant |
| EP1563808B1 (de) | 2000-08-30 | 2008-04-02 | Warsaw Orthopedic, Inc. | Bandscheibenimplantate |
| US7503936B2 (en) * | 2000-08-30 | 2009-03-17 | Warsaw Orthopedic, Inc. | Methods for forming and retaining intervertebral disc implants |
| US20020026244A1 (en) * | 2000-08-30 | 2002-02-28 | Trieu Hai H. | Intervertebral disc nucleus implants and methods |
| US6620196B1 (en) | 2000-08-30 | 2003-09-16 | Sdgi Holdings, Inc. | Intervertebral disc nucleus implants and methods |
| US6878384B2 (en) | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
| KR100444944B1 (ko) * | 2001-05-24 | 2004-08-18 | 선바이오(주) | 생체 접착제용 폴리에틸렌글리콜 수화젤 |
| US20030032961A1 (en) * | 2001-07-16 | 2003-02-13 | Pelo Mark Joseph | Devices from naturally occurring biologically derived materials |
| US7201917B2 (en) | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
| JP4197157B2 (ja) * | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | 軟骨修復再生装置および方法 |
| US8025896B2 (en) * | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
| AU2002316694B2 (en) | 2001-07-16 | 2007-09-06 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
| JP4302515B2 (ja) * | 2001-07-16 | 2009-07-29 | デピュイ・プロダクツ・インコーポレイテッド | 単体型外科装置および方法 |
| US8092529B2 (en) * | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
| US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
| MXPA04002967A (es) * | 2001-09-28 | 2004-07-15 | Biopharma Dev Ltd | Hidrogel biocompatible polifuncional y metodo para la produccion del mismo. |
| US20040047843A1 (en) * | 2002-02-12 | 2004-03-11 | Uab Research Foundation | Method for spinal cord reconnection |
| US20030229333A1 (en) * | 2002-02-22 | 2003-12-11 | Control Delivery Systems, Inc. | Methods for treating otic disorders |
| EP1482994A1 (de) * | 2002-03-11 | 2004-12-08 | First Water Limited | Saugfähige hydrogele |
| KR100675459B1 (ko) * | 2002-04-10 | 2007-01-26 | 오브스체스트보 에스 오그라니체노이 오트베트스트벤노스츄 (비타겔) | 다관능 생체적합 친수성 젤 및 그 제조방법 |
| JP2005530768A (ja) * | 2002-05-09 | 2005-10-13 | メディジーンズ | 血漿または血清を含有した創傷治療用医薬組成物 |
| US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
| AU2003254677A1 (en) * | 2002-08-09 | 2004-02-25 | Ottawa Health Research Institute | Innervated artificial tissues and uses thereof |
| US7569222B2 (en) * | 2002-11-18 | 2009-08-04 | Woerly Stephane | Hydrogel membrane composition and use thereof |
| AU2003303206A1 (en) * | 2002-12-18 | 2004-07-14 | The Regents Of The University Of California | Biocompatible hydrogel bone-like composites |
| WO2004071336A2 (en) * | 2003-02-06 | 2004-08-26 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Hydrophilic fibrous capsule resistant prosthetic device |
| US7785769B2 (en) * | 2003-07-25 | 2010-08-31 | The United States of America as reprsented by the Secretary of the Navy | Immobilization of oligonucleotides and proteins in sugar-containing hydrogels |
| EP1729678A4 (de) * | 2004-02-06 | 2011-08-10 | Georgia Tech Res Inst | Lasttragende biokompatible vorrichtung |
| WO2005077013A2 (en) | 2004-02-06 | 2005-08-25 | Georgia Tech Research Corporation | Surface directed cellular attachment |
| US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US7569233B2 (en) * | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US20050278025A1 (en) * | 2004-06-10 | 2005-12-15 | Salumedica Llc | Meniscus prosthesis |
| US7303074B2 (en) * | 2004-09-22 | 2007-12-04 | Dombrowski Trudy M | Foldable organizer device |
| US20070142326A1 (en) * | 2004-09-30 | 2007-06-21 | Youe-Kong Shue | Treatment of a condition in a mammal with administration of aminosugar and uses thereof |
| US20060089719A1 (en) * | 2004-10-21 | 2006-04-27 | Trieu Hai H | In situ formation of intervertebral disc implants |
| US7313829B1 (en) * | 2004-10-29 | 2008-01-01 | Payload Systems, Inc. | Sealing device for body suit and sealing method using hydrogels |
| US7513866B2 (en) * | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
| RU2290939C2 (ru) * | 2004-12-14 | 2007-01-10 | Государственное образовательное учреждение высшего профессионального образования Новосибирская государственная медицинская академия Министерства здравоохранения Российской Федерации | Средство для лечения повреждений спинного и головного мозга |
| US7354627B2 (en) * | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
| US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
| BRPI0615391A2 (pt) * | 2005-08-26 | 2011-05-17 | Synthes Gmbh | prótese para substituir ou suplementar um núcleo pulposo de um disco intervertebral |
| US8383415B2 (en) * | 2005-10-13 | 2013-02-26 | Dso National Laboratories | Hydrogel composition to enhance fluorescence |
| WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| DE602007008692D1 (de) * | 2006-03-03 | 2010-10-07 | Akzo Nobel Nv | Verfahren zur modifizierung biologisch abbaubarer polymere |
| US8377091B2 (en) | 2006-06-15 | 2013-02-19 | Microvention, Inc. | Embolization device constructed from expansile polymer |
| US8066750B2 (en) | 2006-10-06 | 2011-11-29 | Warsaw Orthopedic, Inc | Port structures for non-rigid bone plates |
| US7871440B2 (en) * | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
| EP2149581A4 (de) * | 2007-04-20 | 2010-04-14 | Uchrezhdenie Rossiiskoi Akadem | Monomer und zusammensetzung zur herstellung eines niederprozentigen hydrogels und/oder eines hydrogels mit einem geringen quervernetzungsgehalt, hydrogel und darauf basierender biochip |
| WO2008130068A1 (en) * | 2007-04-23 | 2008-10-30 | Modern Cell & Tissue Technologies Inc. | Method for preparing a porous polymer scaffold using dry ice |
| US8067028B2 (en) * | 2007-08-13 | 2011-11-29 | Confluent Surgical Inc. | Drug delivery device |
| CN101903051B (zh) | 2007-12-21 | 2013-07-31 | 微温森公司 | 用于生物医药用途的水凝胶细丝 |
| CA2715460C (en) | 2008-02-13 | 2020-02-18 | President And Fellows Of Harvard College | Continuous cell programming devices |
| WO2009108760A2 (en) | 2008-02-26 | 2009-09-03 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
| US8586086B2 (en) | 2008-05-29 | 2013-11-19 | Politecnico Di Milano | Hydrogel capable of containing and conveying cells |
| US20120009242A1 (en) * | 2008-11-03 | 2012-01-12 | University Of Maryland, College Park | Blood coagulation inducing polymer hydrogel |
| FR2942408B1 (fr) | 2009-02-24 | 2012-01-27 | Stephane Woerly | Hydrogel heterogene hybride et son utilisation therapeutique |
| BRPI1014645B1 (pt) | 2009-04-30 | 2020-07-07 | Technip France | método e sistema para compartilhar linhas de amarração |
| US10639396B2 (en) | 2015-06-11 | 2020-05-05 | Microvention, Inc. | Polymers |
| FR2945293B1 (fr) * | 2009-05-11 | 2011-06-17 | Teoxane | Procede de preparation d'un gel reticule. |
| CN102791183B (zh) | 2009-10-26 | 2015-07-08 | 微排放器公司 | 由可膨胀的聚合物构成的栓塞装置 |
| HRP20200310T1 (hr) | 2010-10-06 | 2020-08-21 | President And Fellows Of Harvard College | Hidrogelovi koji stvaraju pore pogodni za injekcije, namijenjeni staničnim terapijama na bazi materijala |
| US9095558B2 (en) | 2010-10-08 | 2015-08-04 | Board Of Regents, The University Of Texas System | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
| US8946194B2 (en) | 2010-10-08 | 2015-02-03 | Board Of Regents, University Of Texas System | One-step processing of hydrogels for mechanically robust and chemically desired features |
| EP2629780A4 (de) | 2010-10-20 | 2014-10-01 | 206 Ortho Inc | Implantierbares polymer für knochen- und gefässläsionen |
| US11484627B2 (en) | 2010-10-20 | 2022-11-01 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US10525169B2 (en) | 2010-10-20 | 2020-01-07 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11207109B2 (en) | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US10525168B2 (en) | 2010-10-20 | 2020-01-07 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11058796B2 (en) | 2010-10-20 | 2021-07-13 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
| ES2685327T3 (es) * | 2011-04-28 | 2018-10-08 | President And Fellows Of Harvard College | Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| CA3048443C (en) | 2011-05-26 | 2021-01-05 | Cartiva, Inc. | Tapered joint implant and related tools |
| US9486512B2 (en) | 2011-06-03 | 2016-11-08 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
| RU2521194C2 (ru) * | 2011-11-16 | 2014-06-27 | Общество с ограниченной ответственностью предприятие "Репер" | Матрица для клеточной трансплантологии |
| EP2819620A4 (de) | 2012-02-29 | 2015-11-04 | 206 Ortho Inc | Verfahren und vorrichtung zur behandlung von knochenbrüchen unter verwendung von zusammengesetzten implantaten |
| CN102600067B (zh) * | 2012-04-10 | 2013-08-21 | 武汉大学 | 含氨基葡萄糖单元的糖肽水凝胶的制备方法及其在制备术后疤痕抑制剂上的应用 |
| ES2773895T3 (es) | 2012-04-16 | 2020-07-15 | Harvard College | Composiciones de sílice mesoporosa para modular las respuestas inmunitarias |
| DE102012019984A1 (de) * | 2012-10-11 | 2014-04-17 | Leibniz-Institut für Oberflächenmodifizierung e.V. | Verfahren zur Herstellung von porösen Gelen mit inkorporierten katalytisch oder biologisch aktiven Materialien sowie damit hergestellte Gele und deren Verwendung |
| BR112015013774A2 (pt) | 2012-12-11 | 2017-07-11 | Univ Texas | membrana de hidrogel para prevenção de adesão |
| US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
| EP3795635A1 (de) | 2013-05-23 | 2021-03-24 | 206 ORTHO, Inc. | Vorrichtung zur behandlung von knochenbrüchen und/oder zur stärkung und/oder vermehrung von knochen einschliesslich der bereitstellung und verwendung zusammengesetzter implantate |
| JP6599361B2 (ja) | 2014-04-29 | 2019-10-30 | マイクロベンション インコーポレイテッド | 活性剤を含むポリマー |
| CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
| WO2015200905A2 (en) | 2014-06-28 | 2015-12-30 | Oligasis, Llc | Dual pdgf/vegf antagonists |
| US9947242B2 (en) * | 2014-07-22 | 2018-04-17 | Synaptive Medical (Barbados) Inc. | Method for producing anatomical phantoms with constituents having variable densities |
| US10150884B2 (en) * | 2014-08-14 | 2018-12-11 | The Secant Group, Llc | Composition, methods and devices useful for manufacturing of implantable articles |
| WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| EP3277219B1 (de) | 2015-03-31 | 2020-07-29 | Cartiva, Inc. | Hydrogelimplantate mit porösen materialien |
| EP3892241A1 (de) | 2015-03-31 | 2021-10-13 | Cartiva, Inc. | Bohrer für karpometakarpalimplantat |
| US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
| CA2981074C (en) | 2015-04-14 | 2023-03-28 | Cartiva, Inc. | Tooling for creating tapered opening in tissue and related methods |
| RU2594427C1 (ru) * | 2015-06-10 | 2016-08-20 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | Композиция для формирования макропористого носителя, используемого при трехмерном культивировании клеток животных или человека, и способ получения указанного носителя |
| IL290457B2 (en) | 2015-12-30 | 2025-02-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
| DE102016000458A1 (de) * | 2016-01-12 | 2017-07-27 | Friedrich-Schiller-Universität Jena | Poröse Glycopolymer-funktionalisierte Cryogele und deren Verwendung |
| WO2017136837A1 (en) | 2016-02-06 | 2017-08-10 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| AU2017295704B2 (en) | 2016-07-13 | 2023-07-13 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| CN110418651A (zh) | 2016-08-02 | 2019-11-05 | 哈佛学院院长等 | 用于调节免疫应答的生物材料 |
| US11980700B2 (en) | 2017-03-08 | 2024-05-14 | Alafair Biosciences, Inc. | Hydrogel medium for the storage and preservation of tissue |
| CN107096065B (zh) * | 2017-04-05 | 2019-11-15 | 浙江大学 | 含多聚唾液酸复合纳米纤维膜及制备方法和应用 |
| CN108187137A (zh) * | 2018-02-27 | 2018-06-22 | 崔友军 | 一种可生物降解神经修复支架的制备方法 |
| CA3092588A1 (en) | 2018-03-02 | 2019-09-06 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| PL241064B1 (pl) | 2018-10-01 | 2022-08-01 | Dolniak Blazej | Sposób wytwarzania lepko-sprężystego żelu uzupełniającego maź stawową i lepko-sprężysty żel uzupełniający maź stawową |
| JP2022514568A (ja) | 2018-12-17 | 2022-02-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫系のモジュレーションのための生物工学的スキャフォールドおよびその使用 |
| JP2022549270A (ja) | 2019-09-23 | 2022-11-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | バイオマテリアルベースの無抗原ワクチンおよびその使用 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| EP4084802A4 (de) * | 2020-01-03 | 2024-03-13 | Repertoire Immune Medicines, Inc. | Zusammensetzungen von hydrogelen und verfahren zur verwendung davon |
| FR3108260B1 (fr) * | 2020-03-17 | 2024-01-05 | Neurobiomat | Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ |
| CN113599566B (zh) * | 2021-08-30 | 2022-10-25 | 重庆市沙坪坝区中智医谷研究院 | 一种疏水性高分子止血修复材料、其制备方法及应用 |
| CN113729654B (zh) * | 2021-09-14 | 2023-03-28 | 华中科技大学 | 术后皮瓣与重建肢体血流状态检测表皮贴附式传感系统 |
| DE102023131358A1 (de) * | 2023-11-09 | 2025-05-15 | INM - Leibniz-Institut für Neue Materialien gemeinnützige Gesellschaft mit beschränkter Haftung | Selbst-schmierende Kontaktlinsen |
| CN120757703B (zh) * | 2025-09-09 | 2025-12-02 | 天津大学 | 一种基于两性离子聚合物的水凝胶睾丸假体及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8418772D0 (en) * | 1984-07-24 | 1984-08-30 | Geistlich Soehne Ag | Chemical substances |
| GB8422950D0 (en) * | 1984-09-11 | 1984-10-17 | Warne K J | Hydrogel |
| US4902295A (en) * | 1985-08-26 | 1990-02-20 | Hana Biologics, Inc. | Transplantable artificial tissue |
| US5266325A (en) * | 1990-09-28 | 1993-11-30 | Hydro Med Science Division Of National Patent Development Corp. | Preparation of homogeneous hydrogel copolymers |
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- 1996-10-16 US US08/731,484 patent/US5863551A/en not_active Expired - Lifetime
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- 1997-10-15 RU RU98113303/14A patent/RU2198686C2/ru not_active IP Right Cessation
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- 1997-10-15 EP EP97944663A patent/EP0929323B1/de not_active Expired - Lifetime
- 1997-10-15 SK SK796-98A patent/SK79698A3/sk unknown
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| ATE284717T1 (de) | 2005-01-15 |
| DE69731959D1 (de) | 2005-01-20 |
| NZ330664A (en) | 1999-10-28 |
| EP0929323B1 (de) | 2004-12-15 |
| SK79698A3 (en) | 1999-01-11 |
| HUP9902027A3 (en) | 2001-04-28 |
| AU744666B2 (en) | 2002-02-28 |
| IL124894A0 (en) | 1999-01-26 |
| CA2240721A1 (en) | 1998-04-23 |
| CA2240721C (en) | 2007-01-09 |
| WO1998016266A1 (en) | 1998-04-23 |
| KR19990072185A (ko) | 1999-09-27 |
| JP2000503884A (ja) | 2000-04-04 |
| HUP9902027A2 (hu) | 1999-10-28 |
| RU2198686C2 (ru) | 2003-02-20 |
| DE69731959T2 (de) | 2006-04-13 |
| PL327454A1 (en) | 1998-12-07 |
| JP3542810B2 (ja) | 2004-07-14 |
| CZ187698A3 (cs) | 1998-11-11 |
| CN1211194A (zh) | 1999-03-17 |
| KR100377520B1 (ko) | 2003-06-09 |
| AU4612697A (en) | 1998-05-11 |
| US5863551A (en) | 1999-01-26 |
| BR9706835A (pt) | 1999-12-28 |
| EP0929323A1 (de) | 1999-07-21 |
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