IL130083A0 - 3-Pyridyl enantiomers and their use as analgesics - Google Patents

3-Pyridyl enantiomers and their use as analgesics

Info

Publication number
IL130083A0
IL130083A0 IL13008397A IL13008397A IL130083A0 IL 130083 A0 IL130083 A0 IL 130083A0 IL 13008397 A IL13008397 A IL 13008397A IL 13008397 A IL13008397 A IL 13008397A IL 130083 A0 IL130083 A0 IL 130083A0
Authority
IL
Israel
Prior art keywords
analgesics
enantiomers
pyridyl
formula
compounds
Prior art date
Application number
IL13008397A
Other languages
English (en)
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IL130083A0 publication Critical patent/IL130083A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL13008397A 1996-12-10 1997-12-10 3-Pyridyl enantiomers and their use as analgesics IL130083A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76327896A 1996-12-10 1996-12-10
US3232196P 1996-12-10 1996-12-10
PCT/US1997/022811 WO1998025920A1 (en) 1996-12-10 1997-12-10 3-pyridyl enantiomers and their use as analgesics

Publications (1)

Publication Number Publication Date
IL130083A0 true IL130083A0 (en) 2000-02-29

Family

ID=26708255

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13008397A IL130083A0 (en) 1996-12-10 1997-12-10 3-Pyridyl enantiomers and their use as analgesics

Country Status (21)

Country Link
EP (1) EP0950057B1 (de)
JP (2) JP4272261B2 (de)
KR (2) KR100422995B1 (de)
CN (1) CN1125064C (de)
AT (1) ATE227717T1 (de)
AU (1) AU733881B2 (de)
BG (1) BG64196B1 (de)
BR (1) BR9714677A (de)
CA (2) CA2698384C (de)
DE (1) DE69717148T2 (de)
DK (1) DK0950057T3 (de)
ES (1) ES2189003T3 (de)
HU (1) HUP0001110A3 (de)
IL (1) IL130083A0 (de)
NO (1) NO992705L (de)
NZ (1) NZ335810A (de)
PL (1) PL333920A1 (de)
PT (1) PT950057E (de)
SK (1) SK75999A3 (de)
TR (1) TR199901904T2 (de)
WO (1) WO1998025920A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1068186A2 (de) 1998-04-02 2001-01-17 Targacept, Inc. 3-pyridylalkoxyamine oder aryloxyalkylamine derivate als cholinergische agonisten
US6054451A (en) * 1998-04-21 2000-04-25 Algos Pharmaceutical Corporation Analgesic composition and method for alleviating pain
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US20010031771A1 (en) 1999-05-24 2001-10-18 Gary Maurice Dull Pharmaceutical compositions and methods for use
US6103911A (en) * 1999-06-15 2000-08-15 Abbott Laboratories Process for reduction of (2R)-4-oxoazetidinone-2-carboxylic acid
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2003097043A1 (en) * 2002-05-15 2003-11-27 Abbott Laboratories Treatment of neuropathic pain
EP1741709A1 (de) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl substituierte Amide mit gesättigtem Linker, und deren Verwendung als Pharmaka
WO2007065820A1 (en) 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity
TW200800020A (en) * 2006-01-26 2008-01-01 Basf Ag Methods to use 3-pyridyl derivatives as pesticides
US20100234349A1 (en) 2006-09-04 2010-09-16 Olsen Gunnar M Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
DE102007058504A1 (de) 2007-12-05 2009-07-09 Acino Ag Transdermales therapeutisches System mit einem Gehalt an einem Modulator für nikotinische Acetylcholinrezeptoren (nAChR)
KR20110091501A (ko) 2008-10-14 2011-08-11 싸이코제닉스 아이엔씨. 니코틴성 아세틸콜린 수용체 리간드 및 이들의 용도
US8474529B2 (en) * 2009-04-09 2013-07-02 Regency Technologies Llc Control of concentric tubing direction
AR075988A1 (es) * 2009-04-09 2011-05-11 Lilly Co Eli Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico
WO2013002365A1 (ja) 2011-06-30 2013-01-03 東レ株式会社 止痒剤
EP2983666B1 (de) * 2013-03-27 2019-10-09 Georgetown University 2-halo-5-alkynyl-pyridyl-nikotinliganden
EP3634528B1 (de) 2017-06-07 2023-06-07 Shifamed Holdings, LLC Intravaskuläre fluidbewegungsvorrichtungen, systeme und verwendungsverfahren
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
EP3746149B1 (de) 2018-02-01 2025-08-06 Shifamed Holdings, LLC Intravaskuläre blutpumpen
WO2020028537A1 (en) 2018-07-31 2020-02-06 Shifamed Holdings, Llc Intravascaular blood pumps and methods of use
WO2020073047A1 (en) 2018-10-05 2020-04-09 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
WO2021011473A1 (en) 2019-07-12 2021-01-21 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US12465748B2 (en) 2019-08-07 2025-11-11 Supira Medical, Inc. Catheter blood pumps and collapsible pump housings
EP4501393A3 (de) 2019-09-25 2025-04-09 Shifamed Holdings, LLC Katheterblutpumpen und zusammenklappbare pumpengehäuse
WO2021062260A1 (en) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
EP4072650A4 (de) 2019-12-11 2024-01-10 Shifamed Holdings, LLC Absteigende aorten- und hohlvenenblutpumpen
EP4077947A4 (de) 2019-12-19 2024-01-10 Shifamed Holdings, LLC Intravaskuläre blutpumpen, motoren und fluidsteuerung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8301702D0 (en) * 1983-01-21 1983-02-23 Shell Int Research Azetidine compounds
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
IL118279A (en) * 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Also Published As

Publication number Publication date
BG103556A (en) 2000-06-30
DK0950057T3 (da) 2003-03-10
KR20040004476A (ko) 2004-01-13
CN1125064C (zh) 2003-10-22
DE69717148T2 (de) 2003-10-02
HUP0001110A3 (en) 2002-04-29
SK75999A3 (en) 2000-05-16
NO992705L (no) 1999-08-03
BG64196B1 (bg) 2004-04-30
PL333920A1 (en) 2000-01-31
AU733881B2 (en) 2001-05-31
CA2273917C (en) 2010-05-25
JP5364872B2 (ja) 2013-12-11
JP2009143924A (ja) 2009-07-02
NZ335810A (en) 2001-03-30
HUP0001110A2 (hu) 2001-04-28
KR20000069399A (ko) 2000-11-25
DE69717148D1 (de) 2002-12-19
EP0950057A1 (de) 1999-10-20
JP4272261B2 (ja) 2009-06-03
CA2698384C (en) 2012-05-01
CA2698384A1 (en) 1998-06-18
CA2273917A1 (en) 1998-06-18
WO1998025920A1 (en) 1998-06-18
AU5601098A (en) 1998-07-03
CN1245496A (zh) 2000-02-23
EP0950057B1 (de) 2002-11-13
BR9714677A (pt) 2000-10-03
PT950057E (pt) 2003-04-30
ATE227717T1 (de) 2002-11-15
KR100422995B1 (ko) 2004-03-12
KR100472154B1 (ko) 2005-02-21
ES2189003T3 (es) 2003-07-01
JP2001504857A (ja) 2001-04-10
NO992705D0 (no) 1999-06-03
TR199901904T2 (xx) 1999-10-21

Similar Documents

Publication Publication Date Title
PL333920A1 (en) 3-pyridyl enantiomers and their application as pain-relieving agents
NO961478L (no) Levobupivacaine anvendelig for kontroll av kronisk smerte
MY119375A (en) Treatment of tinnitus using neuroprotective agents
PT998287E (pt) Utilizacao de levobupivacaina
AU2160492A (en) Treatment of human diseases involving dysregulation or dysfunction of the nervous system
UA41355C2 (uk) Засіб для лікування нейро-сніду
PL342099A1 (en) Therapeutic agents
GR3025568T3 (en) Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia.
WO2000071520A3 (en) Aryl substituted alkylamines capable of activating nicotinic cholinergic receptors
CA2289017A1 (en) The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer
CA2091134A1 (en) Therapeutic agent for threatened abortion
AU1656997A (en) Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of cancer
IL131478A0 (en) Methods for treatment of scar tissue
IL118833A0 (en) The use of sertraline to treat post myocardial infarction patients
AU4937499A (en) Use of succinic acid or salts thereof and method of treating insulin resistance
MY113406A (en) Methods of inhibiting physiological conditions associated with an excess of bradykinin
EE04951B1 (et) R-(+)-alfa-(2,3-dimetoksfenl)-1-[2-(4-fluorofenl)etl]-4-piperidiinmetanooli kasutamine uneh„irete raviks
MX9701528A (es) Derivados de 1, 1, 2,- trifenilbut-1-eno para tratar la enfermedad de alzheimer.
UA33498A (uk) Спосіб лікування терапевтично резистентних форм шизофренії