IL131925A0 - Insulin-like growth factor agonist molecules - Google Patents
Insulin-like growth factor agonist moleculesInfo
- Publication number
- IL131925A0 IL131925A0 IL13192598A IL13192598A IL131925A0 IL 131925 A0 IL131925 A0 IL 131925A0 IL 13192598 A IL13192598 A IL 13192598A IL 13192598 A IL13192598 A IL 13192598A IL 131925 A0 IL131925 A0 IL 131925A0
- Authority
- IL
- Israel
- Prior art keywords
- insulin
- growth factor
- agonist molecules
- factor agonist
- molecules
- Prior art date
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 2
- 102000013275 Somatomedins Human genes 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title abstract 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 2
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/825,852 US6121416A (en) | 1997-04-04 | 1997-04-04 | Insulin-like growth factor agonist molecules |
| PCT/US1998/006514 WO1998045427A2 (en) | 1997-04-04 | 1998-03-31 | Insulin-like growth factor agonist peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL131925A0 true IL131925A0 (en) | 2001-03-19 |
Family
ID=25245064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13192598A IL131925A0 (en) | 1997-04-04 | 1998-03-31 | Insulin-like growth factor agonist molecules |
Country Status (13)
| Country | Link |
|---|---|
| US (16) | US6121416A (de) |
| EP (2) | EP0972020B1 (de) |
| JP (1) | JP4562814B2 (de) |
| AT (1) | ATE224951T1 (de) |
| AU (1) | AU732989B2 (de) |
| CA (1) | CA2286264A1 (de) |
| DE (1) | DE69808258T2 (de) |
| DK (1) | DK0972020T3 (de) |
| ES (1) | ES2183344T3 (de) |
| HK (1) | HK1047755A1 (de) |
| IL (1) | IL131925A0 (de) |
| PT (1) | PT972020E (de) |
| WO (1) | WO1998045427A2 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7885697B2 (en) | 2004-07-13 | 2011-02-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| IL143834A0 (en) | 1999-01-06 | 2002-04-21 | Genentech Inc | Insulin-like growth factor (igf) i mutant variants |
| DE60016560T2 (de) | 1999-01-06 | 2005-12-15 | Genentech, Inc., South San Francisco | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
| US20030224017A1 (en) * | 2002-03-06 | 2003-12-04 | Samal Siba K. | Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors |
| CA2389575A1 (en) * | 1999-10-29 | 2001-05-10 | Oregon Health Sciences University | Modulation of neuroendocrine differentiation by protein 25.1 |
| JP2003528149A (ja) | 2000-03-24 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 軟骨性疾患の治療のためのインスリンの使用 |
| DE60133271T2 (de) * | 2000-05-16 | 2009-04-23 | Genentech, Inc., South San Francisco | Behandlung von knorpelerkrankungen |
| FR2810675B1 (fr) * | 2000-06-22 | 2002-09-27 | Pf Medicament | Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes |
| DE60143858D1 (de) * | 2000-11-28 | 2011-02-24 | Premacure Ab | Reduzierung DES RISIKOS FÜR KOMPLIKATIONEN BEI FRÜHGEBURTEN |
| US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| EP1772464B1 (de) | 2001-02-09 | 2009-08-12 | Genentech, Inc. | Verfahren zur Identifizierung von indirekten IGF-1-Agonisten |
| CA2438641A1 (en) | 2001-02-15 | 2002-08-22 | King Pharmaceuticals, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| US6790672B2 (en) * | 2001-02-19 | 2004-09-14 | Board Of Regents The University Of Texas System | Encoded molecular sieve particle-based sensors |
| WO2002072780A2 (en) | 2001-03-14 | 2002-09-19 | Genentech, Inc. | Igf antagonist peptides |
| US6841386B2 (en) | 2001-04-10 | 2005-01-11 | Viacell, Inc. | Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
| US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| WO2003041655A2 (en) * | 2001-11-13 | 2003-05-22 | Loi Tran | Therapeutic agent composition and method of use |
| PL210412B1 (pl) | 2002-05-24 | 2012-01-31 | Schering Corp | Izolowane przeciwciało anty-IGFR lub jego fragment, kompozycja farmaceutyczna, zastosowanie, kwas nukleinowy, zrekombinowany wektor, komórka gospodarza, kompleks, polipeptyd i sposób jego wytwarzania |
| WO2003103608A2 (en) * | 2002-06-11 | 2003-12-18 | The Burnham Institute | Neuroprotective synergy of erythropoietin and insulin-like growth factor |
| US7118877B2 (en) * | 2002-07-08 | 2006-10-10 | Wyeth | Caspase 9 activation and uses therefor |
| US7648957B2 (en) * | 2002-09-04 | 2010-01-19 | Dsm Ip Assets B.V. | Nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction |
| DE60217188T2 (de) * | 2002-09-06 | 2007-10-04 | Telefonaktiebolaget Lm Ericsson (Publ) | Zusammengesetzter leistungsverstärker |
| US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
| US20060128615A1 (en) * | 2002-09-18 | 2006-06-15 | Pierrette Gaudreau | Ghrh analogues |
| EP1560933A4 (de) * | 2002-11-14 | 2007-11-21 | Wyeth Corp | Verfahren und zusammensetzungen zur behandlung neurologischer erkrankungen |
| US7273788B2 (en) * | 2003-05-21 | 2007-09-25 | Micron Technology, Inc. | Ultra-thin semiconductors bonded on glass substrates |
| EP2093570A1 (de) * | 2003-06-06 | 2009-08-26 | Genentech, Inc. | Modulierung der Interaktion zwischen HGF-beta-Kette und c-Met |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| ATE536186T1 (de) | 2003-09-12 | 2011-12-15 | Tercica Inc | Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel |
| CA2541015A1 (en) * | 2003-10-03 | 2005-04-14 | Genentech, Inc. | Igf binding proteins |
| WO2005047512A2 (en) | 2003-11-12 | 2005-05-26 | Shering Corporation | Plasmid system for multigene expression |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| US20050233960A1 (en) | 2003-12-11 | 2005-10-20 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
| CA2560278C (en) * | 2004-03-19 | 2012-11-20 | Matthew Baker | Modified bouganin proteins, cytotoxins and methods and uses thereof |
| WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| MX2007006640A (es) | 2004-12-03 | 2007-06-19 | Schering Corp | Biomarcadores para la preseleccion de pacientes para la terapia con anti-receptor 1 del factor de crecimiento similar a la insulina. |
| AU2006236637B2 (en) * | 2005-04-15 | 2012-09-06 | Merck Sharp & Dohme Corp. | Methods and compositions for treating or preventing cancer |
| WO2006138315A2 (en) * | 2005-06-15 | 2006-12-28 | Schering Corporation | Anti-igf1r antibody formulations |
| US7695928B2 (en) | 2006-04-10 | 2010-04-13 | Genentech, Inc. | Disheveled PDZ modulators |
| WO2008130315A1 (en) | 2007-04-18 | 2008-10-30 | Premacure Ab | Method and product for treatment and/or prevention of complications of prematurity |
| JP2010536880A (ja) | 2007-08-22 | 2010-12-02 | ギリード・コロラド・インコーポレーテッド | 糖尿病の合併症のための療法 |
| US8591455B2 (en) | 2008-02-21 | 2013-11-26 | Dexcom, Inc. | Systems and methods for customizing delivery of sensor data |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US9238080B2 (en) | 2010-05-21 | 2016-01-19 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
| CN103270045A (zh) | 2010-10-20 | 2013-08-28 | 霍夫曼-拉罗奇有限公司 | 用于调控wnt途径的方法和组合物 |
| MX355128B (es) | 2011-10-14 | 2018-04-06 | Genentech Inc | Péptidos inhibidores de bace1 y uso de los mismos para el tratamiento de enfermedades o trastornos neurológicos. |
| EP2766034B1 (de) | 2011-10-14 | 2018-06-13 | F. Hoffmann-La Roche AG | Zymogen-aktivatoren |
| EP3355907B1 (de) | 2015-10-02 | 2021-01-20 | Silver Creek Pharmaceuticals, Inc. | Bispezifische therapeutische proteine zur gewebereparatur |
| IL273174B2 (en) | 2017-09-11 | 2024-12-01 | Shire Human Genetic Therapies | Insulin-like growth factor-1 (igf-1) for use in treating chronic lung diseases |
| BR112020023252A2 (pt) | 2018-05-15 | 2021-02-23 | Lloyd Hung Loi Tran | composição do agente terapêutico e método de uso para tratamento de deficiência cognitiva leve, depressão e distúrbios psicológicos. |
| US20210008172A1 (en) | 2019-07-11 | 2021-01-14 | Opko Biologics Ltd. | Long-acting igf-1 or igf-1 variants and methods of producing same |
| GB201913196D0 (en) | 2019-09-12 | 2019-10-30 | Univ Newcastle | Culture method |
| PT4228676T (pt) | 2020-10-19 | 2025-01-24 | Oak Hill Bio Ltd | Composições adequadas para utilização em recém-nascidos |
| DE102021122096A1 (de) | 2021-08-26 | 2023-03-02 | Forschungsinstitut für Nutztierbiologie | IGF-1, IGFBP-2 und Insulin umfassende Zusammensetzungen und ihre Verwendung |
| WO2023139115A1 (en) | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions and methods for reducing oxidation of igf‐1/igfbp |
| CN117589998B (zh) * | 2023-10-09 | 2025-11-18 | 融智生物科技(青岛)有限公司 | 胰岛素样生长因子i变体的定量检测试剂盒 |
| CN117347626B (zh) * | 2023-12-06 | 2024-03-12 | 安徽惠邦生物工程有限公司 | 人胰岛素样生长因子结合蛋白-1化学发光免疫分析试剂盒及其制备方法 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US3721252A (en) * | 1971-04-01 | 1973-03-20 | Catheter And Instr Corp | Spring guide washer |
| US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| PH23185A (en) | 1983-06-13 | 1989-05-29 | Scheindel Ass Inc | Pressure operated dispensing container |
| WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
| EP0134094B1 (de) | 1983-08-15 | 1987-05-27 | AMP INCORPORATED (a New Jersey corporation) | Elastischer Einpressstift für elektrische Leiterplatten |
| US5077276A (en) * | 1985-08-22 | 1991-12-31 | Gropep Pty Ltd | Growth factor |
| SE8505922D0 (sv) * | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| EP0308500B1 (de) * | 1987-04-06 | 1993-06-16 | Celtrix Pharmaceuticals, Inc. | Menschliche somatomedin-träger-protein-untereinheiten und verfahren zu ihrer herstellung |
| AU607209B2 (en) * | 1987-04-23 | 1991-02-28 | Monsanto Technology Llc | Secretion of insulin-like growth factor-i in e. coli |
| SE8703625D0 (sv) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
| US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
| ATE116335T1 (de) * | 1987-12-24 | 1995-01-15 | Gropep Pty Ltd | Peptid-analoge vom insulinähnlichen wachstums- faktor 1 (igf-1) oder faktor 2 (igf-2). |
| US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
| DE68905203T2 (de) * | 1988-02-05 | 1993-07-22 | Ciba Geigy Ag | Verwendung von igf i zur herstellung eines praeparates fuer die behandlung von nierenkrankheiten. |
| DK131988A (da) * | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
| US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| ATE132164T1 (de) * | 1988-04-12 | 1996-01-15 | Amgen Boulder Inc | Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| GB8826451D0 (en) * | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
| IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
| EP0379338A3 (de) * | 1989-01-17 | 1991-07-24 | Merck & Co. Inc. | Menschlicher insulinähnlicher Wachstumsfaktor und seine Herstellung in Hefe |
| US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
| GB8920381D0 (en) * | 1989-09-08 | 1989-10-25 | Greater Glasgow Health Board | Treatment of insulin-resistant diabetes |
| US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
| US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| US5593844A (en) * | 1990-11-19 | 1997-01-14 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
| US5210017A (en) * | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
| SE9100099D0 (sv) * | 1991-01-11 | 1991-01-11 | Kabi Pharmacia Ab | Use of growth factor |
| US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
| DK1820858T3 (da) * | 1991-03-01 | 2009-11-02 | Dyax Corp | Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf |
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| US5202119A (en) * | 1991-06-28 | 1993-04-13 | Genentech, Inc. | Method of stimulating immune response |
| CA2114251C (en) * | 1991-08-01 | 2007-11-06 | Peter Gluckman | Igf-1 to improve the neural condition |
| US6310040B1 (en) * | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| SE9201573D0 (sv) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | Use of igf-1 |
| HU217543B (hu) * | 1992-06-12 | 2000-02-28 | Albert Einstein College Of Medicine Of Yeshiva University | Eljárás perifériás neuropátia kezelésére és megelőzésére alkalmas gyógyászati készítmények előállítására, valamint inzulinszerű növekedési faktor I-et és kemoterápiás szert tartalmazó gyógyászati készítmények |
| NZ255461A (en) * | 1992-08-20 | 1996-12-20 | Biotechnology & Biolog Science | Specific binding molecules for insulin-like-growth-factor-1 (igf-1), antigens capable of generating them and their use in enhancing igf-1 activity |
| US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
| WO1994016722A1 (en) * | 1993-01-25 | 1994-08-04 | The Beth Israel Hospital Association | Method for modifying, diagnosing, and screening for igf-i sensitive cell barrier properties |
| WO1994016723A2 (en) * | 1993-01-29 | 1994-08-04 | Synergen, Inc. | Wound healing composition |
| US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| AU683121B2 (en) * | 1993-12-23 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| SG55069A1 (en) * | 1993-12-23 | 1998-12-21 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| SE9402370D0 (sv) * | 1994-07-04 | 1994-07-04 | Pharmacia Ab | Use of IGF-I |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| SE9501472D0 (sv) * | 1995-04-21 | 1995-04-21 | Pharmacia Ab | Truncated IGF-I |
| US5622932A (en) * | 1995-05-05 | 1997-04-22 | Eli Lilly And Company | IGF-1 superagonists |
| KR100543190B1 (ko) * | 1995-05-26 | 2006-06-23 | 떼라떼끄놀로지 인코퍼레이티드 | 향상된생물학적효능을갖는키메라성지방체-프로-지알에프유사체 |
| ATE254138T1 (de) * | 1995-06-07 | 2003-11-15 | Ortho Pharma Corp | An den erythropoietin-rezeptor bindende zusammensetzungen und peptide |
| YU34196A (sh) * | 1995-06-07 | 1999-03-04 | Glaxo Group Limited | Peptidi i jedinjenja koja se vezuju za receptor |
| ATE390439T1 (de) * | 1995-06-07 | 2008-04-15 | Glaxo Group Ltd | An einem thrombopoietin rezeptor bindende peptide und zusammensetzungen |
| US5958872A (en) * | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
| EP0854884A1 (de) * | 1996-04-17 | 1998-07-29 | Neurocrine Biosciences, Inc. | Inhibitoren von liganden der insulin-ähnlichen faktor bindenden proteine und methoden für ihre verwendung |
| US6402715B2 (en) | 1996-04-25 | 2002-06-11 | Karl Storz Gmbh & Co. Kg | Surgical instrument system |
| AU7891098A (en) | 1996-12-27 | 1998-07-31 | Daiichi Pharmaceutical Co., Ltd. | Method for elevating the concentration of free insulin-like growth factor |
| US6420518B1 (en) * | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| AU6515499A (en) | 1998-10-16 | 2000-05-08 | Musc Foundation For Research Development | Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof |
-
1997
- 1997-04-04 US US08/825,852 patent/US6121416A/en not_active Expired - Fee Related
-
1998
- 1998-03-31 US US09/052,888 patent/US6251865B1/en not_active Expired - Fee Related
- 1998-03-31 WO PCT/US1998/006514 patent/WO1998045427A2/en not_active Ceased
- 1998-03-31 EP EP98915236A patent/EP0972020B1/de not_active Expired - Lifetime
- 1998-03-31 JP JP54289498A patent/JP4562814B2/ja not_active Expired - Fee Related
- 1998-03-31 PT PT98915236T patent/PT972020E/pt unknown
- 1998-03-31 AT AT98915236T patent/ATE224951T1/de active
- 1998-03-31 ES ES98915236T patent/ES2183344T3/es not_active Expired - Lifetime
- 1998-03-31 IL IL13192598A patent/IL131925A0/xx not_active IP Right Cessation
- 1998-03-31 AU AU69470/98A patent/AU732989B2/en not_active Ceased
- 1998-03-31 DK DK98915236T patent/DK0972020T3/da active
- 1998-03-31 DE DE69808258T patent/DE69808258T2/de not_active Expired - Lifetime
- 1998-03-31 CA CA002286264A patent/CA2286264A1/en not_active Abandoned
- 1998-03-31 EP EP02014880A patent/EP1251137A3/de not_active Withdrawn
-
2000
- 2000-11-28 US US09/724,127 patent/US6635619B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,157 patent/US6693079B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,065 patent/US6716586B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,062 patent/US6713451B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,114 patent/US6680298B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,095 patent/US6693078B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,481 patent/US6949349B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,890 patent/US6608031B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,873 patent/US6677305B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,547 patent/US6632794B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/723,931 patent/US6645775B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,912 patent/US6689751B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,901 patent/US6620789B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,913 patent/US6683053B1/en not_active Expired - Fee Related
-
2002
- 2002-12-30 HK HK02109420.9A patent/HK1047755A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6713451B1 (en) | 2004-03-30 |
| US6121416A (en) | 2000-09-19 |
| PT972020E (pt) | 2003-02-28 |
| DE69808258T2 (de) | 2003-09-18 |
| JP2002510194A (ja) | 2002-04-02 |
| WO1998045427A2 (en) | 1998-10-15 |
| US6683053B1 (en) | 2004-01-27 |
| EP1251137A2 (de) | 2002-10-23 |
| DE69808258D1 (de) | 2002-10-31 |
| US6693078B1 (en) | 2004-02-17 |
| US6632794B1 (en) | 2003-10-14 |
| US6251865B1 (en) | 2001-06-26 |
| EP1251137A3 (de) | 2003-04-16 |
| US6949349B1 (en) | 2005-09-27 |
| JP4562814B2 (ja) | 2010-10-13 |
| US6677305B1 (en) | 2004-01-13 |
| AU6947098A (en) | 1998-10-30 |
| ES2183344T3 (es) | 2003-03-16 |
| EP0972020A1 (de) | 2000-01-19 |
| US6645775B1 (en) | 2003-11-11 |
| DK0972020T3 (da) | 2003-02-03 |
| US6620789B1 (en) | 2003-09-16 |
| US6680298B1 (en) | 2004-01-20 |
| CA2286264A1 (en) | 1998-10-15 |
| WO1998045427A3 (en) | 1999-01-07 |
| US6716586B1 (en) | 2004-04-06 |
| US6689751B1 (en) | 2004-02-10 |
| ATE224951T1 (de) | 2002-10-15 |
| US6608031B1 (en) | 2003-08-19 |
| US6693079B1 (en) | 2004-02-17 |
| AU732989B2 (en) | 2001-05-03 |
| HK1047755A1 (en) | 2003-03-07 |
| EP0972020B1 (de) | 2002-09-25 |
| US6635619B1 (en) | 2003-10-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL131925A0 (en) | Insulin-like growth factor agonist molecules | |
| CANALIS | Effect of growth factors on bone cell replication and differentiation | |
| HUP0003173A3 (en) | Use of glp-1 or analogs for preparing pharmaceutical compositions useful in treatment of myocardial infarction | |
| IL95118A0 (en) | Polypeptide derivatives,their preparation and pharmaceutical compositions containing them | |
| MX9707487A (es) | Uso de composiciones que comprenden compuestos efectivos biologicamente estabilizados. | |
| BG103297A (en) | Aralkyl and aralkyliden heterocyclic lactams and imides | |
| IL113812A (en) | Copolymer-1 pharmaceutical compositions containing it and its use | |
| PL338438A1 (en) | Cosmetic composition containing siloxane-based polyamides as thickening agents | |
| EE200100649A (et) | A-beeta peptiidi kompositsioonid ja meetodid nende valmistamiseks | |
| WO2000002916A3 (en) | PEPTIDE COMPOSITIONS MIMICKING TGF-β ACTIVITY | |
| MY104992A (en) | Composition inducing a binding. | |
| DE69838730D1 (de) | Zusammensetzung zur zahnbeschichtung | |
| AU2001263215A1 (en) | Method for treating cartilage disorders | |
| AU6207290A (en) | Gum composition containing protein macrocolloids | |
| PT877803E (pt) | Receptor da proteina ob e composicoes e metodos afins | |
| WO2000042031A3 (en) | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents | |
| EP0992584A3 (de) | Gereinigte Säugetier FLT3 Liganden und deren Agonisten und Antagonisten | |
| HU9300192D0 (en) | Polypeptide compounds promoting growth hormone emission | |
| BG103872A (en) | Glycoconjugates of 20(s)-camptotecin | |
| WO2002034916A3 (en) | Novel mutant igbp-3 molecules that do not bind to igfs, but retain their ability to functionally bind igfbp-3 receptor | |
| FI972170A0 (fi) | Peptidejä, jotka kykenevät sitoutumaan GAP-proteiinin SH3-domeeniin, näitä peptidejä koodittavia nukleotidisekvenssejä, niiden valmistus ja käyttö | |
| IL129359A0 (en) | Bi-aromatic compounds bound by a heteroethynylene radical and pharmaceutical and cosmetic compositions containing same | |
| EE05182B1 (et) | Asendatud homopiperidlbensimidasooli analoog, meetod selle valmistamiseks ning seda sisaldav farmatseutiline kompositsioon | |
| HUP9904547A3 (en) | Benzoxazole derivative with an affinity to binding sites of amino acid receptors and pharmaceutical compositions containing the same | |
| EP0588177A3 (en) | An interferon-alpha/beta binding protein, its preparation and pharmaceutical compositions containing it |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |