IL133036A0 - Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists - Google Patents

Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Info

Publication number: IL133036A0
Authority: IL; Israel
Prior art keywords: quinoline; receptor antagonists; carboxamide derivatives; carboxamide; derivatives
Prior art date: 1997-05-23

Application number

IL13303698A

Other languages

English (en)

Original Assignee

Smithkline Beecham Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1998-05-18

Publication date

2001-03-19

1997-05-23 Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en

1997-10-17 Priority claimed from IT002354 external-priority patent/IT1295358B1/it

1997-12-16 Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it

1998-05-18 Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa

2001-03-19 Publication of IL133036A0 publication Critical patent/IL133036A0/xx

Links

108010040722 Neurokinin-2 Receptors Proteins 0.000 title 1
108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
102100029409 Neuromedin-K receptor Human genes 0.000 title 1
102100037342 Substance-K receptor Human genes 0.000 title 1
LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL13303698A 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists IL133036A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9710750.2A GB9710750D0 (en)	1997-05-23	1997-05-23	Novel compounds
IT002354 IT1295358B1 (it)	1997-10-17	1997-10-17	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it)	1997-12-16	1997-12-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (en)	1997-05-23	1998-05-18	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Publications (1)

Publication Number	Publication Date
IL133036A0 true IL133036A0 (en)	2001-03-19

Family

ID=27268859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13303698A IL133036A0 (en)	1997-05-23	1998-05-18	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Country Status (26)

Country	Link
EP (1)	EP0983262B1 (de)
JP (1)	JP2002500645A (de)
CN (1)	CN1264378A (de)
AP (1)	AP9901695A0 (de)
AR (1)	AR012732A1 (de)
AT (1)	ATE244711T1 (de)
AU (1)	AU8209898A (de)
BG (1)	BG104009A (de)
BR (1)	BR9809652A (de)
CA (1)	CA2291111A1 (de)
CO (1)	CO4950515A1 (de)
DE (1)	DE69816290T2 (de)
DZ (1)	DZ2498A1 (de)
EA (1)	EA199901062A1 (de)
ES (1)	ES2201509T3 (de)
HU (1)	HUP0002300A3 (de)
ID (1)	ID22876A (de)
IL (1)	IL133036A0 (de)
MA (1)	MA26501A1 (de)
NO (1)	NO995711L (de)
OA (1)	OA11515A (de)
PE (1)	PE75199A1 (de)
PL (1)	PL336942A1 (de)
SK (1)	SK159299A3 (de)
TR (1)	TR199902883T2 (de)
WO (1)	WO1998052942A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6780875B2 (en) *	1998-11-20	2004-08-24	Smithkline Beecham S.P.A.	Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
GB9825554D0 (en)	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
JP2002530377A (ja) *	1998-11-20	2002-09-17	スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ	Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキシアミド誘導体
AU4038000A (en)	1999-03-29	2000-10-16	Neurogen Corporation	4-substituted quinoline derivatives as gaba receptor ligands
WO2000064877A1 (en)	1999-04-26	2000-11-02	Neurogen Corporation	2-aminoquinolinecarboxamides: neurokinin receptor ligands
WO2002013825A1 (en) *	2000-08-11	2002-02-21	Smithkline Beecham P.L.C.	Novel pharmaceutical use of quinnoline derivatives
EP1334089A1 (de) *	2000-11-13	2003-08-13	GlaxoSmithKline S.p.A.	Chinolinderivate als nk-3- und nk-2-antagonisten
AU2002226356A1 (en) *	2000-11-28	2002-06-11	Glaxosmithkline S.P.A.	Quinoline derivatives as nk-3 antagonists
GB0028964D0 (en) *	2000-11-28	2001-01-10	Smithkline Beecham Spa	Novel compounds
US6540733B2 (en)	2000-12-29	2003-04-01	Corazon Technologies, Inc.	Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
GB0109122D0 (en) *	2001-04-11	2001-05-30	Smithkline Beecham Spa	Novel compounds
DE60209362T2 (de) *	2001-04-11	2006-10-26	Glaxosmithkline S.P.A.	3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
GB0425077D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425075D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425076D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
MX2007014831A (es) *	2005-06-03	2008-02-15	Astrazeneca Ab	Derivados de quinolina como antagonistas de neurocinina-3.
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
AR057130A1 (es)	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) *	2007-12-12	2009-04-23	Drebo Werkzeugfabrik Gmbh	Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK282721B6 (sk) *	1994-05-27	2002-11-06	Smithkline Beecham S.P.A.	Nepeptidové NK3 antagonistické látky, spôsob ich výroby, farmaceutické prostriedky s ich obsahom a ich použitie
AR004735A1 (es) *	1995-11-24	1999-03-10	Smithkline Beecham Spa	Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

1998
- 1998-05-18 EP EP98932069A patent/EP0983262B1/de not_active Expired - Lifetime
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/en not_active Ceased
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 CA CA002291111A patent/CA2291111A1/en not_active Abandoned
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/xx active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown

Also Published As

Publication number	Publication date
TR199902883T2 (xx)	2000-05-22
DE69816290D1 (de)	2003-08-14
CA2291111A1 (en)	1998-11-26
AU8209898A (en)	1998-12-11
CN1264378A (zh)	2000-08-23
MA26501A1 (fr)	2004-12-20
OA11515A (en)	2004-02-04
WO1998052942A1 (en)	1998-11-26
ES2201509T3 (es)	2004-03-16
JP2002500645A (ja)	2002-01-08
CO4950515A1 (es)	2000-09-01
NO995711D0 (no)	1999-11-22
AR012732A1 (es)	2000-11-08
BG104009A (en)	2000-07-31
DZ2498A1 (fr)	2003-01-25
EA199901062A1 (ru)	2000-08-28
HUP0002300A3 (en)	2002-01-28
ID22876A (id)	1999-12-16
BR9809652A (pt)	2001-09-11
SK159299A3 (en)	2000-06-12
HUP0002300A2 (hu)	2001-06-28
PE75199A1 (es)	1999-10-22
EP0983262B1 (de)	2003-07-09
DE69816290T2 (de)	2004-05-27
PL336942A1 (en)	2000-07-17
ATE244711T1 (de)	2003-07-15
EP0983262A1 (de)	2000-03-08
AP9901695A0 (en)	1999-12-31
NO995711L (no)	2000-01-19

Publication	Publication Date	Title
IL143137A0 (en)	2002-04-21	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
IL133036A0 (en)	2001-03-19	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
IL124418A0 (en)	1998-12-06	Quinoline-4-carboxamide derivatives their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists
HU9603262D0 (en)	1997-01-28	Quinoline derivatives as tachykinin nk3 receptor antagonists
CY2505B1 (en)	2005-12-23	Quinoline derivatives as nk3 antagonists
PL350184A1 (en)	2002-11-18	Indole derivatives and their use as mcp-1 antagonists
AP9901459A0 (en)	1999-03-31	Tetrahydroquinoline derivatives as eaa antagonists
IL132571A0 (en)	2001-03-19	Ergoline derivatives and ther use as somatostatin receptor antagonists
AU2002215043A1 (en)	2002-05-21	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
EP1248607A4 (de)	2004-10-06	Urotensin-ii rezeptorantagonisten
GB9521696D0 (en)	1996-01-03	Combination of LTD4 receptor antagonists with glucocorticosteriods
IL140062A0 (en)	2002-02-10	Tetrahydroquinoline derivatives as glycine antagonists
IL127304A0 (en)	1999-09-22	Indoline derivatives useful as 5-ht-2c receptor antagonists
AU2002220702A1 (en)	2002-05-21	Quinoline derivatives as nk-3 and nk-2 antagonists
PL330796A1 (en)	1999-06-07	Derivatives of indolin useful as antagonists of 5-ht-2c receptor
IL142362A0 (en)	2002-03-10	Ureidopiperidine derivatives as selective human nk3 receptor antagonists
HK1028236A (en)	2001-02-09	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
AU2002310838A1 (en)	2002-10-28	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
AU2002308138A1 (en)	2002-10-28	3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
HU9603342D0 (en)	1997-01-28	Quinoline derivatives as leukotriene antagonists
SI0940391T1 (en)	2004-12-31	Quinoline derivatives as tachykinin NK3 receptor antagonists
SI1003504T1 (en)	2003-12-31	Indole derivatives and their use as mcp-1 antagonists
SI1086093T1 (sl)	2005-12-31	Derivati tetrahidrokinolina kot antagonisti glicina
SI1214312T1 (en)	2004-10-31	5-aminoalkyl and 5-aminocarbonyl substituted indoles
HK1030601A (en)	2001-05-11	Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists