ATE244711T1 - Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten - Google Patents

Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten

Info

Publication number
ATE244711T1
ATE244711T1 AT98932069T AT98932069T ATE244711T1 AT E244711 T1 ATE244711 T1 AT E244711T1 AT 98932069 T AT98932069 T AT 98932069T AT 98932069 T AT98932069 T AT 98932069T AT E244711 T1 ATE244711 T1 AT E244711T1
Authority
AT
Austria
Prior art keywords
quinoline
receptor antagonists
carboxamide derivatives
carboxamide
derivatives
Prior art date
Application number
AT98932069T
Other languages
English (en)
Inventor
Giuseppe Arnaldo Mari Giardina
Zambeletti Via
Mario Grugni
Davide Graziani
Luca Francesco Raveglia
Zambeletti
Original Assignee
Glaxosmithkline Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en
Priority claimed from IT002354 external-priority patent/IT1295358B1/it
Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it
Application filed by Glaxosmithkline Spa filed Critical Glaxosmithkline Spa
Application granted granted Critical
Publication of ATE244711T1 publication Critical patent/ATE244711T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98932069T 1997-05-23 1998-05-18 Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten ATE244711T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710750.2A GB9710750D0 (en) 1997-05-23 1997-05-23 Novel compounds
IT002354 IT1295358B1 (it) 1997-10-17 1997-10-17 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it) 1997-12-16 1997-12-16 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE244711T1 true ATE244711T1 (de) 2003-07-15

Family

ID=27268859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98932069T ATE244711T1 (de) 1997-05-23 1998-05-18 Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten

Country Status (26)

Country Link
EP (1) EP0983262B1 (de)
JP (1) JP2002500645A (de)
CN (1) CN1264378A (de)
AP (1) AP9901695A0 (de)
AR (1) AR012732A1 (de)
AT (1) ATE244711T1 (de)
AU (1) AU8209898A (de)
BG (1) BG104009A (de)
BR (1) BR9809652A (de)
CA (1) CA2291111A1 (de)
CO (1) CO4950515A1 (de)
DE (1) DE69816290T2 (de)
DZ (1) DZ2498A1 (de)
EA (1) EA199901062A1 (de)
ES (1) ES2201509T3 (de)
HU (1) HUP0002300A3 (de)
ID (1) ID22876A (de)
IL (1) IL133036A0 (de)
MA (1) MA26501A1 (de)
NO (1) NO995711L (de)
OA (1) OA11515A (de)
PE (1) PE75199A1 (de)
PL (1) PL336942A1 (de)
SK (1) SK159299A3 (de)
TR (1) TR199902883T2 (de)
WO (1) WO1998052942A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202007017299U1 (de) * 2007-12-12 2009-04-23 Drebo Werkzeugfabrik Gmbh Bohrer

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
JP2002530377A (ja) * 1998-11-20 2002-09-17 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキシアミド誘導体
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
WO2000064877A1 (en) * 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
WO2002013825A1 (en) * 2000-08-11 2002-02-21 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
EP1334089A1 (de) * 2000-11-13 2003-08-13 GlaxoSmithKline S.p.A. Chinolinderivate als nk-3- und nk-2-antagonisten
WO2002044165A1 (en) * 2000-11-28 2002-06-06 Glaxosmithkline Spa Quinoline derivatives as nk-3 antagonists
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
US6540733B2 (en) 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
EP1385839B1 (de) * 2001-04-11 2006-02-22 GlaxoSmithKline S.p.A. 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
GB0425075D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
CA2611060A1 (en) * 2005-06-03 2006-12-07 R. Thomas Simpson Quinoline derivatives as nk3 antagonists
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69531458T2 (de) * 1994-05-27 2004-08-05 Glaxosmithkline S.P.A. Chinolinderivate als tachykinin nk3 rezeptor antagonisten
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202007017299U1 (de) * 2007-12-12 2009-04-23 Drebo Werkzeugfabrik Gmbh Bohrer

Also Published As

Publication number Publication date
EP0983262A1 (de) 2000-03-08
HUP0002300A3 (en) 2002-01-28
BR9809652A (pt) 2001-09-11
TR199902883T2 (xx) 2000-05-22
IL133036A0 (en) 2001-03-19
EA199901062A1 (ru) 2000-08-28
CA2291111A1 (en) 1998-11-26
DE69816290D1 (de) 2003-08-14
AP9901695A0 (en) 1999-12-31
HUP0002300A2 (hu) 2001-06-28
ES2201509T3 (es) 2004-03-16
CO4950515A1 (es) 2000-09-01
SK159299A3 (en) 2000-06-12
OA11515A (en) 2004-02-04
JP2002500645A (ja) 2002-01-08
MA26501A1 (fr) 2004-12-20
AR012732A1 (es) 2000-11-08
EP0983262B1 (de) 2003-07-09
NO995711L (no) 2000-01-19
ID22876A (id) 1999-12-16
NO995711D0 (no) 1999-11-22
AU8209898A (en) 1998-12-11
PE75199A1 (es) 1999-10-22
PL336942A1 (en) 2000-07-17
CN1264378A (zh) 2000-08-23
DE69816290T2 (de) 2004-05-27
DZ2498A1 (fr) 2003-01-25
BG104009A (en) 2000-07-31
WO1998052942A1 (en) 1998-11-26

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