IL133395A - Water-soluble chlorhexidine formulations - Google Patents

Water-soluble chlorhexidine formulations

Info

Publication number: IL133395A
Authority: IL; Israel
Prior art keywords: acid; chlorhexidine; lactone; water; solutions
Prior art date: 1998-12-11

Application number

IL13339599A

Other languages

English (en)

Other versions

IL133395A0 (en

Original Assignee

Degussa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-11

Filing date

1999-12-09

Publication date

2004-06-20

1999-12-09 Application filed by Degussa filed Critical Degussa

2001-04-30 Publication of IL133395A0 publication Critical patent/IL133395A0/xx

2004-06-20 Publication of IL133395A publication Critical patent/IL133395A/en

Links

GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title claims abstract description 53
239000000203 mixture Substances 0.000 title claims abstract description 26
238000009472 formulation Methods 0.000 title claims abstract description 17
229960003260 chlorhexidine Drugs 0.000 title claims abstract description 16
239000002253 acid Substances 0.000 claims abstract description 26
150000002596 lactones Chemical class 0.000 claims abstract description 14
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 11
150000007513 acids Chemical class 0.000 claims abstract description 8
239000000126 substance Substances 0.000 claims abstract description 7
UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims abstract description 5
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims abstract description 5
IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 claims abstract description 5
AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 claims abstract description 5
229940099563 lactobionic acid Drugs 0.000 claims abstract description 5
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 4
PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims abstract description 4
235000012208 gluconic acid Nutrition 0.000 claims abstract description 4
239000000174 gluconic acid Substances 0.000 claims abstract description 4
235000012209 glucono delta-lactone Nutrition 0.000 claims abstract description 4
229960003681 gluconolactone Drugs 0.000 claims abstract description 4
229950006191 gluconic acid Drugs 0.000 claims abstract 2
239000000243 solution Substances 0.000 description 23
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
150000003839 salts Chemical class 0.000 description 12
QSNSCYSYFYORTR-UHFFFAOYSA-N 4-chloroaniline Chemical compound NC1=CC=C(Cl)C=C1 QSNSCYSYFYORTR-UHFFFAOYSA-N 0.000 description 10
239000007864 aqueous solution Substances 0.000 description 7
239000000645 desinfectant Substances 0.000 description 7
RGHNJXZEOKUKBD-KKQCNMDGSA-N D-gulonic acid Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-KKQCNMDGSA-N 0.000 description 6
RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 6
150000001450 anions Chemical class 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000012266 salt solution Substances 0.000 description 4
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
238000003860 storage Methods 0.000 description 3
RGHNJXZEOKUKBD-QMKXCQHVSA-N (2r,3r,4s,5s)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-QMKXCQHVSA-N 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
HVBSAKJJOYLTQU-UHFFFAOYSA-N 4-aminobenzenesulfonic acid Chemical compound NC1=CC=C(S(O)(=O)=O)C=C1 HVBSAKJJOYLTQU-UHFFFAOYSA-N 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
RGHNJXZEOKUKBD-MGCNEYSASA-N D-galactonic acid Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-MGCNEYSASA-N 0.000 description 2
OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 2
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 2
230000007774 longterm Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
239000002245 particle Substances 0.000 description 2
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
239000000725 suspension Substances 0.000 description 2
WTXGYGWMPUGBAL-SQOUGZDYSA-N (3r,4s,5r,6r)-3,4,5,6-tetrahydroxyoxepan-2-one Chemical compound O[C@@H]1COC(=O)[C@H](O)[C@@H](O)[C@@H]1O WTXGYGWMPUGBAL-SQOUGZDYSA-N 0.000 description 1
VIVCRCODGMFTFY-DVKNGEFBSA-N (3r,4s,5s)-3,4-dihydroxy-5-[(1r,2r)-1,2,3-trihydroxypropyl]oxolan-2-one Chemical compound OC[C@@H](O)[C@@H](O)[C@@H]1OC(=O)[C@H](O)[C@@H]1O VIVCRCODGMFTFY-DVKNGEFBSA-N 0.000 description 1
SXZYCXMUPBBULW-KLVWXMOXSA-N (3r,4s,5s)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-one Chemical compound OC[C@H](O)[C@@H]1OC(=O)[C@H](O)[C@@H]1O SXZYCXMUPBBULW-KLVWXMOXSA-N 0.000 description 1
AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 1
WACQLQIAUWURGA-UHFFFAOYSA-N 3-hydroxy-2,2-bis(hydroxymethyl)propanoic acid Chemical compound OCC(CO)(CO)C(O)=O WACQLQIAUWURGA-UHFFFAOYSA-N 0.000 description 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 description 1
BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
SXZYCXMUPBBULW-LECHCGJUSA-N D-(-)-Gulono-gamma-lactone Chemical compound OC[C@@H](O)[C@@H]1OC(=O)[C@H](O)[C@@H]1O SXZYCXMUPBBULW-LECHCGJUSA-N 0.000 description 1
SXZYCXMUPBBULW-AIHAYLRMSA-N D-galactono-1,4-lactone Chemical compound OC[C@@H](O)[C@@H]1OC(=O)[C@H](O)[C@H]1O SXZYCXMUPBBULW-AIHAYLRMSA-N 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
108010077895 Sarcosine Proteins 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
239000000654 additive Substances 0.000 description 1
AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229940072107 ascorbate Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 1
229960000830 captopril Drugs 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960003333 chlorhexidine gluconate Drugs 0.000 description 1
YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
230000000249 desinfective effect Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
229910000041 hydrogen chloride Inorganic materials 0.000 description 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
229940116298 l- malic acid Drugs 0.000 description 1
229940099584 lactobionate Drugs 0.000 description 1
JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
235000019136 lipoic acid Nutrition 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
238000000034 method Methods 0.000 description 1
238000003801 milling Methods 0.000 description 1
RHFUXPCCELGMFC-UHFFFAOYSA-N n-(6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-n-phenylmethoxyacetamide Chemical compound OC1C(C)(C)OC2=CC=C(C#N)C=C2C1N(C(=O)C)OCC1=CC=CC=C1 RHFUXPCCELGMFC-UHFFFAOYSA-N 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
UNYNVICDCJHOPO-UHFFFAOYSA-N quabalactone III Natural products CC1OC(=O)C(O)=C1C UNYNVICDCJHOPO-UHFFFAOYSA-N 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
229950000244 sulfanilic acid Drugs 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229960001367 tartaric acid Drugs 0.000 description 1
229960002663 thioctic acid Drugs 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000723 toxicological property Toxicity 0.000 description 1
238000002061 vacuum sublimation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

IL13339599A 1998-12-11 1999-12-09 Water-soluble chlorhexidine formulations IL133395A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19857151A DE19857151A1 (de)	1998-12-11	1998-12-11	Chlorhexidin-Formulierungen, neue Chlorhexidinsalze, sie enthaltende Lösungen und deren Verwendung

Publications (2)

Publication Number	Publication Date
IL133395A0 IL133395A0 (en)	2001-04-30
IL133395A true IL133395A (en)	2004-06-20

Family

ID=7890710

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13339599A IL133395A (en)	1998-12-11	1999-12-09	Water-soluble chlorhexidine formulations

Country Status (12)

Country	Link
US (1)	US6500466B2 (pl)
EP (1)	EP1018337B1 (pl)
JP (1)	JP2000178189A (pl)
AU (1)	AU751521B2 (pl)
BR (1)	BR9905832A (pl)
CA (1)	CA2292226C (pl)
DE (2)	DE19857151A1 (pl)
DK (1)	DK1018337T3 (pl)
ES (1)	ES2192014T3 (pl)
IL (1)	IL133395A (pl)
PL (1)	PL200514B1 (pl)
ZA (1)	ZA997575B (pl)

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Publication number	Priority date	Publication date	Assignee	Title
DE10052322A1 (de) *	2000-10-21	2002-05-02	Degussa	Wasserlösliche chlorhexidinhaltige Zusammensetzungen und deren Verwendung
GB0211576D0 (en) *	2002-05-21	2002-06-26	Cheetham J K	A novel formula for modification of chemical compounds on flavour solubility and stability
US7074459B2 (en) *	2003-05-23	2006-07-11	Stockel Richard F	Method for preserving wood
US20050114266A1 (en) *	2003-11-26	2005-05-26	Lingan Satkunanathan	System and method for managing licenses using interactive wizards
KR101146059B1 (ko) *	2006-07-31	2012-05-14	가부시끼가이샤 도시바	비휘발성 메모리 시스템 및 비휘발성 메모리 시스템을 위한데이터 판독/기입 방법
US10314935B2 (en)	2009-01-07	2019-06-11	Entrotech Life Sciences, Inc.	Chlorhexidine-containing antimicrobial laminates
WO2011061272A2 (en) *	2009-11-18	2011-05-26	Medichem S.A.	A di(4-chloro-phenyldiguanido) derivative which is free of potential genotoxicity and a process for reducing the residual amount of p-chloroaniline in said di(4-chloro-phenyldiguanido) derivative
PL2665363T3 (pl) *	2011-01-21	2020-07-27	Avery Dennison Corporation	Klej zawierający glukonian chlorheksydyny
WO2012158483A2 (en)	2011-05-16	2012-11-22	Avery Dennison Corporation	Adhesive containing microparticles
CN105567115B (zh)	2013-02-07	2018-09-07	艾利丹尼森公司	具有改进性质的抗微生物粘合剂
EP2968014B1 (en)	2013-03-15	2019-04-24	Avery Dennison Corporation	Transparent cover dressing application system and inclusion of label strip
US11039615B2 (en)	2014-04-18	2021-06-22	Entrotech Life Sciences, Inc.	Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby
JP6338435B2 (ja) *	2014-04-25	2018-06-06	日本ゼトック株式会社	皮膚外用剤
EP3151813B1 (en)	2014-06-05	2020-12-09	Avery Dennison Corporation	Articles with active agent concentrated at the substrate contacting surface and related methods
RU2696259C2 (ru) *	2017-10-23	2019-08-01	Общество С Ограниченной Ответственностью "Сан Системз"	Солюбилизация хлоргексидина основания, антисептическая и дезинфицирующая композиции
DE102019000321A1 (de)	2019-01-14	2020-07-16	Beuth Hochschule Für Technik Berlin	Orale Polymerzusammensetzung mit verzögerter Freisetzung
DE102019000322A1 (de)	2019-01-14	2020-07-16	Beuth Hochschule Für Technik Berlin	Polymerzusammensetzung mit antiseptischen Eigenschaften und Verfahren zur Herstellung
US20240197938A1 (en) *	2021-01-04	2024-06-20	Harcros Chemicals, Inc.	Antimicrobial compounds based on glucoheptonic acids and their salts
CN114391550B (zh)	2022-01-06	2022-11-22	江南大学	一种水溶性氯己定类抗菌剂及其制备方法和应用

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JPS5726612A (en) *	1980-07-24	1982-02-12	Lion Corp	Preparation of oral composition
GB8427499D0 (en) *	1984-10-31	1984-12-05	Stafford Miller Ltd	Oral hygiene products
JPS61130210A (ja) *	1984-11-28	1986-06-18	Sunstar Inc	クロルヘキシジンを安定に配合したパスタ
FR2579979B1 (pl) *	1985-04-05	1987-06-26	Pf Cosmetique
US6051609A (en) *	1997-09-09	2000-04-18	Tristrata Technology, Inc.	Additives enhancing the effect of therapeutic agents
US5389677B1 (en) *	1986-12-23	1997-07-15	Tristrata Inc	Method of treating wrinkles using glycalic acid
SE465905B (sv) *	1989-03-15	1991-11-18	Gunnar Roella	Tandvaardsmedel som innehaaller ett acetat- eller glukonatsalt av en antimikrobiell bisbiguanid
JP3305108B2 (ja) *	1994-03-30	2002-07-22	サンスター株式会社	歯磨組成物
JPH09301858A (ja) *	1996-05-13	1997-11-25	Senju Pharmaceut Co Ltd	グルコン酸クロルヘキシジン安定化水性薬剤
FR2752731B1 (fr) *	1996-08-28	2001-04-27	Pioch Michel	Composition utile notamment en chirurgie dentaire
US5877212A (en) *	1997-04-16	1999-03-02	Yu; Ruey J.	Molecular complex and control-release of alpha hydroxyacids

1998
- 1998-12-11 DE DE19857151A patent/DE19857151A1/de not_active Withdrawn
1999
- 1999-11-25 DK DK99123468T patent/DK1018337T3/da active
- 1999-11-25 DE DE59904218T patent/DE59904218D1/de not_active Expired - Lifetime
- 1999-11-25 EP EP99123468A patent/EP1018337B1/de not_active Expired - Lifetime
- 1999-11-25 ES ES99123468T patent/ES2192014T3/es not_active Expired - Lifetime
- 1999-12-09 ZA ZA9907575A patent/ZA997575B/xx unknown
- 1999-12-09 IL IL13339599A patent/IL133395A/en not_active IP Right Cessation
- 1999-12-10 JP JP11352069A patent/JP2000178189A/ja not_active Ceased
- 1999-12-10 PL PL337107A patent/PL200514B1/pl unknown
- 1999-12-10 CA CA002292226A patent/CA2292226C/en not_active Expired - Fee Related
- 1999-12-10 AU AU64454/99A patent/AU751521B2/en not_active Ceased
- 1999-12-13 US US09/458,717 patent/US6500466B2/en not_active Expired - Lifetime
- 1999-12-13 BR BR9905832-4A patent/BR9905832A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2292226A1 (en)	2000-06-11
EP1018337A2 (de)	2000-07-12
EP1018337A3 (de)	2001-01-03
ES2192014T3 (es)	2003-09-16
IL133395A0 (en)	2001-04-30
US20020018814A1 (en)	2002-02-14
PL337107A1 (en)	2000-06-19
AU6445499A (en)	2000-06-15
PL200514B1 (pl)	2009-01-30
CA2292226C (en)	2009-02-10
DK1018337T3 (da)	2003-05-05
DE59904218D1 (de)	2003-03-13
DE19857151A1 (de)	2000-06-15
BR9905832A (pt)	2000-08-29
EP1018337B1 (de)	2003-02-05
ZA997575B (en)	2000-06-12
AU751521B2 (en)	2002-08-22
JP2000178189A (ja)	2000-06-27
US6500466B2 (en)	2002-12-31

Legal Events

Date	Code	Title
2004-11-24	FF	Patent granted
2006-02-21	KB	Patent renewed
2018-07-31	MM9K	Patent not in force due to non-payment of renewal fees

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