IL134078A0 - Controlled release tramadol preparations having a storage-stable release profile and process for the production thereof - Google Patents

Controlled release tramadol preparations having a storage-stable release profile and process for the production thereof

Info

Publication number: IL134078A0
Authority: IL; Israel
Prior art keywords: production; storage; controlled release; stable; release profile
Prior art date: 1999-01-18

Application number

IL13407800A

Other languages

English (en)

Original Assignee

Gruenenthal Chemie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-18

Filing date

2000-01-17

Publication date

2001-04-30

2000-01-17 Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie

2001-04-30 Publication of IL134078A0 publication Critical patent/IL134078A0/xx

Links

TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title 1
238000013270 controlled release Methods 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
229960004380 tramadol Drugs 0.000 title 1
TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL13407800A 1999-01-18 2000-01-17 Controlled release tramadol preparations having a storage-stable release profile and process for the production thereof IL134078A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19901686A DE19901686A1 (de)	1999-01-18	1999-01-18	Retardierte Tramadolzubereitungen mit einem lagerstabilen Freisetzungsprofil und Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
IL134078A0 true IL134078A0 (en)	2001-04-30

Family

ID=7894565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13407800A IL134078A0 (en)	1999-01-18	2000-01-17	Controlled release tramadol preparations having a storage-stable release profile and process for the production thereof

Country Status (23)

Country	Link
US (2)	US6451350B1 (da)
EP (1)	EP1020186B1 (da)
JP (1)	JP2000212075A (da)
KR (1)	KR20000071253A (da)
CN (1)	CN1202814C (da)
AR (1)	AR022253A1 (da)
AT (1)	ATE298563T1 (da)
AU (1)	AU1010500A (da)
CA (1)	CA2295790A1 (da)
CO (1)	CO5150199A1 (da)
DE (2)	DE19901686A1 (da)
DK (1)	DK1020186T3 (da)
ES (1)	ES2245071T3 (da)
HU (1)	HUP0000140A3 (da)
IL (1)	IL134078A0 (da)
NZ (1)	NZ502263A (da)
PE (1)	PE20001454A1 (da)
PL (1)	PL337865A1 (da)
PT (1)	PT1020186E (da)
RU (1)	RU2225198C2 (da)
SI (1)	SI1020186T1 (da)
SK (1)	SK662000A3 (da)
ZA (1)	ZA200000170B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2226886T3 (es) *	1999-08-31	2005-04-01	Grunenthal Gmbh	Forma de administracion de accion retardada que contiene sacarinato de tramadol.
IL146462A (en)	2001-11-13	2015-02-26	Lycored Bio Ltd	Prolonged-release preparations containing as an active compound and analapaxin hydrochloride
US8128957B1 (en)	2002-02-21	2012-03-06	Valeant International (Barbados) Srl	Modified release compositions of at least one form of tramadol
MXPA04008100A (es) *	2002-02-21	2005-06-17	Biovail Lab Int Srl	Formulaciones de liberacion modificada de al menos una forma de tramadol.
US20050182056A9 (en) *	2002-02-21	2005-08-18	Seth Pawan	Modified release formulations of at least one form of tramadol
CN1642532A (zh) *	2002-03-22	2005-07-20	西拉格股份公司	曲马多缓释制剂
MXPA05000128A (es) *	2002-07-05	2005-09-30	Temrel Inc	Composicion de liberacion controlada.
US8487002B2 (en)	2002-10-25	2013-07-16	Paladin Labs Inc.	Controlled-release compositions
TWI319713B (en)	2002-10-25	2010-01-21		Sustained-release tramadol formulations with 24-hour efficacy
US20060172006A1 (en) *	2003-10-10	2006-08-03	Vincent Lenaerts	Sustained-release tramadol formulations with 24-hour clinical efficacy
WO2005097082A1 (en) *	2004-03-31	2005-10-20	Bpsi Holdings, Inc.	Enteric coatings for orally ingestible substrates
NZ565108A (en) *	2005-07-07	2011-10-28	Farnam Co Inc	Sustained release pharmaceutical compositions for highly water soluble drugs
PT1931346E (pt)	2005-09-09	2012-08-14	Angelini Labopharm Llc	Composição de trazodona para administração uma vez por dia
WO2007048219A2 (en)	2005-09-09	2007-05-03	Labopharm Inc.	Sustained drug release composition
MX2008006037A (es) *	2005-11-10	2009-03-03	Circ Pharma Res And Dev Ltd	Drogas para el sistema nervioso central para administracion una-vez-al-dia.
US20070190141A1 (en) *	2006-02-16	2007-08-16	Aaron Dely	Extended release opiate composition
US20070286903A1 (en) *	2006-06-13	2007-12-13	Becicka Brian T	Composition and method for taste masking
CN101095666B (zh) *	2007-08-14	2010-10-06	石药集团欧意药业有限公司	一种盐酸曲马多缓释片剂及其制备方法
SE535628C2 (sv) *	2010-01-29	2012-10-23	Kemira Oyj	Aktiv syrekälla
EP3446713A3 (en) *	2012-05-02	2019-05-15	Capsugel Belgium NV	Aqueous dispersions of controlled release polymers and shells and capsules thereof
CN102920679A (zh) *	2012-11-27	2013-02-13	臧杰	热溶增塑乙基纤维素水分散体缓控释包衣材料制备方法
US20160256399A1 (en)	2013-11-04	2016-09-08	Capsugel Belgium Nv	Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
CN106176683B (zh) *	2016-08-31	2019-04-16	贵州益康制药有限公司	一种盐酸曲马多缓释胶囊及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5273760A (en) *	1991-12-24	1993-12-28	Euroceltigue, S.A.	Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5472712A (en) *	1991-12-24	1995-12-05	Euroceltique, S.A.	Controlled-release formulations coated with aqueous dispersions of ethylcellulose
DE4329794C2 (de) *	1993-09-03	1997-09-18	Gruenenthal Gmbh	Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung
GB9405304D0 (en) *	1994-03-16	1994-04-27	Scherer Ltd R P	Delivery systems for hydrophobic drugs
US6077533A (en) *	1994-05-25	2000-06-20	Purdue Pharma L.P.	Powder-layered oral dosage forms
US5645858A (en) *	1994-10-06	1997-07-08	Ortho Pharmaceutical Corporation	Multilayered controlled release pharmaceutical dosage form
DE19530575A1 (de) *	1995-08-19	1997-02-20	Gruenenthal Gmbh	Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz
DE19630035A1 (de) *	1996-07-25	1998-01-29	Asta Medica Ag	Tramadol Multiple Unit Formulierungen

1999
- 1999-01-18 DE DE19901686A patent/DE19901686A1/de not_active Ceased
- 1999-12-23 SI SI9930825T patent/SI1020186T1/sl unknown
- 1999-12-23 PT PT99125696T patent/PT1020186E/pt unknown
- 1999-12-23 AT AT99125696T patent/ATE298563T1/de active
- 1999-12-23 DK DK99125696T patent/DK1020186T3/da active
- 1999-12-23 EP EP99125696A patent/EP1020186B1/de not_active Expired - Lifetime
- 1999-12-23 DE DE59912219T patent/DE59912219D1/de not_active Expired - Lifetime
- 1999-12-23 ES ES99125696T patent/ES2245071T3/es not_active Expired - Lifetime
2000
- 2000-01-04 PE PE2000000004A patent/PE20001454A1/es not_active Application Discontinuation
- 2000-01-05 AU AU10105/00A patent/AU1010500A/en not_active Abandoned
- 2000-01-11 AR ARP000100110A patent/AR022253A1/es unknown
- 2000-01-11 NZ NZ502263A patent/NZ502263A/en unknown
- 2000-01-14 CA CA002295790A patent/CA2295790A1/en not_active Abandoned
- 2000-01-17 PL PL00337865A patent/PL337865A1/xx not_active Application Discontinuation
- 2000-01-17 JP JP8350A patent/JP2000212075A/ja not_active Withdrawn
- 2000-01-17 HU HU0000140A patent/HUP0000140A3/hu unknown
- 2000-01-17 SK SK66-2000A patent/SK662000A3/sk unknown
- 2000-01-17 CN CNB00104186XA patent/CN1202814C/zh not_active Expired - Fee Related
- 2000-01-17 ZA ZA200000170A patent/ZA200000170B/xx unknown
- 2000-01-17 RU RU2000101021/15A patent/RU2225198C2/ru not_active IP Right Cessation
- 2000-01-17 KR KR1020000002000A patent/KR20000071253A/ko not_active Abandoned
- 2000-01-17 CO CO00002023A patent/CO5150199A1/es unknown
- 2000-01-17 IL IL13407800A patent/IL134078A0/xx unknown
- 2000-01-18 US US09/484,017 patent/US6451350B1/en not_active Expired - Fee Related
2002
- 2002-06-26 US US10/179,389 patent/US20030104061A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HU0000140D0 (en)	2000-03-28
CN1202814C (zh)	2005-05-25
EP1020186A2 (de)	2000-07-19
SK662000A3 (en)	2000-08-14
PE20001454A1 (es)	2000-12-23
CO5150199A1 (es)	2002-04-29
ATE298563T1 (de)	2005-07-15
KR20000071253A (ko)	2000-11-25
EP1020186A3 (de)	2000-09-20
HK1029751A1 (en)	2001-04-12
HUP0000140A3 (en)	2001-03-28
AU1010500A (en)	2000-07-20
CN1270026A (zh)	2000-10-18
ES2245071T3 (es)	2005-12-16
DK1020186T3 (da)	2005-10-17
PT1020186E (pt)	2005-11-30
JP2000212075A (ja)	2000-08-02
NZ502263A (en)	2001-04-27
DE59912219D1 (de)	2005-08-04
US20030104061A1 (en)	2003-06-05
DE19901686A1 (de)	2000-07-20
CA2295790A1 (en)	2000-07-18
US6451350B1 (en)	2002-09-17
ZA200000170B (en)	2000-08-07
EP1020186B1 (de)	2005-06-29
PL337865A1 (en)	2000-07-31
SI1020186T1 (sl)	2005-12-31
RU2225198C2 (ru)	2004-03-10
AR022253A1 (es)	2002-09-04
HUP0000140A2 (hu)	2001-02-28

Publication	Publication Date	Title
IL134078A0 (en)	2001-04-30	Controlled release tramadol preparations having a storage-stable release profile and process for the production thereof
HUP0203875A3 (en)	2005-01-28	Microcapsule and process for production thereof
HUP0001949A3 (en)	2002-05-28	Refastenable packing and process for manufacturing refastenable packing
ZA200000911B (en)	2000-09-13	A catalyst material and a process for its preparation.
AU2944700A (en)	2000-10-04	Quickly disintegrating tablets and process for producing the same
AU5889701A (en)	2001-12-17	Novel oxazolidinone derivatives and a process for the preparation thereof
ZA985489B (en)	1999-01-20	Propylene terpolymers and a process for the production thereof
SG87108A1 (en)	2002-03-19	Monofilament and process for producing the same
AU7466900A (en)	2001-04-17	A process for the preparation of h-tyr-d-ala-phe(f)-phe-nh2
HUP0004037A3 (en)	2002-03-28	Novel dihydronaphthalene compounds and process for producing the same
IL153505A0 (en)	2003-07-06	Dds compound and process for the preparation thereof
AU9095898A (en)	1999-10-25	Humidity-controlling functional material and process for the production thereof
ZA987952B (en)	1999-03-02	Process for the manufacturing of a molding
AU2002327085A1 (en)	2003-05-29	Sustained release micropellets and process for producing the same
AU5537500A (en)	2001-01-31	Dry pigment granulate and a method for the manufacture thereof
AU7968500A (en)	2001-04-30	A recombinant urushi lacquer and a process for preparing the same
IL139023A0 (en)	2001-11-25	Process for the preparation of 2,3,5-trimethyl-p- benzoquinone
HUP0204145A3 (en)	2005-05-30	Process for preparing a quinolylacrylonitrile derivative and its intermediate and the novel intermediate
HUP0102124A3 (en)	2002-12-28	Process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof
HUP0104213A3 (en)	2003-10-28	Vancoresmycin, a process for its production and its use as a pharmaceutical
HUP0002751A3 (en)	2002-01-28	Novel grignard-reagents and process for producing thereof
AU3193200A (en)	2000-10-09	Tablets and process for producing the same
PL345192A1 (en)	2001-12-03	Mumbaistatin, a process for its production and its use as a pharmaceutical
EP1088584A4 (en)	2004-05-12	METHOD FOR PRODUCING MICROCAPSULES AND MICROCAPSULES THEREFORE RECEIVED
HUP9900761A3 (en)	2000-06-28	A process for the preparation of 4-(desdimethyl-amino)-tetracyclines