IL135406A0 - Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient - Google Patents

Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient

Info

Publication number: IL135406A0
Authority: IL; Israel
Prior art keywords: group; substituted; groups; protected; unsubstituted alkyl
Prior art date: 1997-10-27

Application number

IL13540698A

Other languages

English (en)

Original Assignee

Toyama Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-27

Filing date

1998-10-27

Publication date

2001-05-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27525611&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL135406(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-10-27 Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd

2001-05-20 Publication of IL135406A0 publication Critical patent/IL135406A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL13540698A 1997-10-27 1998-10-27 Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient IL135406A0 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP31137697		1997-10-27
JP9280798		1998-03-20
JP14058698		1998-05-07
JP24482898		1998-08-31
JP25365698		1998-09-08
PCT/JP1998/004854 WO1999021849A1 (en)	1997-10-27	1998-10-27	Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient

Publications (1)

Publication Number	Publication Date
IL135406A0 true IL135406A0 (en)	2001-05-20

Family

ID=27525611

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13540698A IL135406A0 (en)	1997-10-27	1998-10-27	Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient
IL135406A IL135406A (en)	1997-10-27	2000-03-31	Processes for the production of derivatives of 7 - isoindulinquinoloneacarboxylic acid and intermediates for them, salts of acids 7 - isoindulinquinoloneonacarboxylic hydrates for them, and mixtures containing the same similar active ingredient

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL135406A IL135406A (en)	1997-10-27	2000-03-31	Processes for the production of derivatives of 7 - isoindulinquinoloneacarboxylic acid and intermediates for them, salts of acids 7 - isoindulinquinoloneonacarboxylic hydrates for them, and mixtures containing the same similar active ingredient

Country Status (18)

Country	Link
US (4)	US6337399B1 (de)
EP (1)	EP1031569B1 (de)
KR (2)	KR100565362B1 (de)
CN (3)	CN1195752C (de)
AT (1)	ATE461186T1 (de)
AU (1)	AU750760B2 (de)
CA (3)	CA2568251A1 (de)
CY (1)	CY1110242T1 (de)
DE (1)	DE69841563D1 (de)
DK (1)	DK1031569T3 (de)
ES (1)	ES2341509T3 (de)
HU (1)	HU229995B1 (de)
IL (2)	IL135406A0 (de)
NO (2)	NO318813B1 (de)
NZ (1)	NZ504084A (de)
PT (1)	PT1031569E (de)
TW (2)	TWI242012B (de)
WO (1)	WO1999021849A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1278717B1 (de) *	2000-03-07	2007-06-06	Ranbaxy Laboratories Limited	Eintopfsynthese von 3-cyclopropylamino-2- 2,4-dibromo-3-(difluoromethoxy)benzoyl\|-2-propensäure alkylester als nützliches zwischenprodukt für antibakterielle quinolon-arzneistoffe
DE10111262A1 (de) *	2001-03-09	2002-09-12	Studiengesellschaft Kohle Mbh	Verfahren zur Herstellung von Vinyl- Aryl- und Heteroarylessigsäuren und ihrer Devivate
US6777420B2 (en)	2001-06-15	2004-08-17	Microbiotix, Inc.	Heterocyclic antibacterial compounds
JP2006151808A (ja) *	2002-12-24	2006-06-15	Dai Ichi Seiyaku Co Ltd	抗菌性水性製剤
US20090156577A1 (en) *	2004-09-09	2009-06-18	Benjamin Davis	7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
RU2458051C2 (ru) *	2005-11-24	2012-08-10	ДОМПЕ ФА.Р.МА С.п.А.	(r)-арилалкиламинопроизводные и содержащие их фармацевтические композиции
US7902227B2 (en) *	2007-07-27	2011-03-08	Janssen Pharmaceutica Nv.	C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101298418B (zh) *	2008-06-13	2010-12-15	江苏康鹏农化有限公司	3-氧代-3-(2,4-二卤代-3-二氟甲氧基苯基)丙酸乙酯的制备方法
JP5921826B2 (ja) *	2010-06-30	2016-05-24	富山化学工業株式会社	５−ブロモ−２−（１−置換エチル）安息香酸エステルの新規製造法
CN105017151B (zh)	2011-08-31	2019-04-02	大塚制药株式会社	喹诺酮化合物
WO2013121439A2 (en) *	2012-02-15	2013-08-22	Glenmark Generics Limited	Process for garenoxacin mesylate
CN105837555B (zh) *	2016-03-31	2019-01-25	南京华威医药科技集团有限公司	加雷沙星及其中间体制备方法
CN105801482B (zh) *	2016-04-18	2018-06-22	浙江中欣氟材股份有限公司	一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法
CN105777631B (zh) *	2016-04-18	2018-06-29	浙江中欣氟材股份有限公司	一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法
CN106957255B (zh) *	2017-03-28	2018-01-09	上海馨远医药科技有限公司	一种(R)‑N‑Boc‑5‑溴‑1‑甲基异吲哚啉及其制备方法和应用
CN112028816B (zh) *	2020-09-11	2022-10-14	江阴迈康升华医药科技有限公司	一种取代异吲哚啉的合成方法
CN114105790A (zh) *	2021-12-14	2022-03-01	无锡捷化医药科技有限公司	一种3-氨基-4,5-二溴苯甲酸甲酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5935952A (en) *	1994-08-12	1999-08-10	Toyama Chemical Co., Ltd.	Quinolone- or naphthylidone-carboxylic acid derivates or their salts
DE4431821A1 (de) *	1994-09-07	1996-03-14	Bayer Ag	Verfahren zur Herstellung von N-Arylaminoacrylsäurederivaten und die Verwendung so hergestellter N-Arylaminoacrylsäurederivate zur Herstellung von 4-Chinolon-3-carbonsäurederivaten
ES2188890T3 (es) *	1996-02-09	2003-07-01	Toyama Chemical Co Ltd	Derivados del acido quinoleincarboxilico y sus sales.
JP4252282B2 (ja) *	2001-11-06	2009-04-08	富山化学工業株式会社	２−［（１ｒ）−１−メチル−２−トリチル−２，３−ジヒドロ−１ｈ−５−イソインドリル］−１，３，６，２−ジオキサアザボロカンの非溶媒和物およびその製造法

1998
- 1998-10-27 AU AU96486/98A patent/AU750760B2/en not_active Expired
- 1998-10-27 CA CA002568251A patent/CA2568251A1/en not_active Abandoned
- 1998-10-27 ES ES98950405T patent/ES2341509T3/es not_active Expired - Lifetime
- 1998-10-27 DE DE69841563T patent/DE69841563D1/de not_active Expired - Lifetime
- 1998-10-27 NZ NZ504084A patent/NZ504084A/xx not_active IP Right Cessation
- 1998-10-27 KR KR1020007004509A patent/KR100565362B1/ko not_active Expired - Lifetime
- 1998-10-27 EP EP98950405A patent/EP1031569B1/de not_active Expired - Lifetime
- 1998-10-27 CN CNB988106272A patent/CN1195752C/zh not_active Expired - Lifetime
- 1998-10-27 CN CNA031603793A patent/CN1515555A/zh active Pending
- 1998-10-27 WO PCT/JP1998/004854 patent/WO1999021849A1/ja not_active Ceased
- 1998-10-27 TW TW093113303A patent/TWI242012B/zh not_active IP Right Cessation
- 1998-10-27 CA CA002307824A patent/CA2307824C/en not_active Expired - Lifetime
- 1998-10-27 HU HU0101766A patent/HU229995B1/hu unknown
- 1998-10-27 IL IL13540698A patent/IL135406A0/xx active IP Right Grant
- 1998-10-27 CN CNB2004100797208A patent/CN1296369C/zh not_active Expired - Lifetime
- 1998-10-27 US US09/529,407 patent/US6337399B1/en not_active Expired - Lifetime
- 1998-10-27 AT AT98950405T patent/ATE461186T1/de active
- 1998-10-27 DK DK98950405.5T patent/DK1031569T3/da active
- 1998-10-27 TW TW087117800A patent/TW593308B/zh not_active IP Right Cessation
- 1998-10-27 KR KR1020057009280A patent/KR100611869B1/ko not_active Expired - Lifetime
- 1998-10-27 CA CA2593381A patent/CA2593381C/en not_active Expired - Lifetime
- 1998-10-27 PT PT98950405T patent/PT1031569E/pt unknown
2000
- 2000-03-31 IL IL135406A patent/IL135406A/en not_active IP Right Cessation
- 2000-04-26 NO NO20002125A patent/NO318813B1/no not_active IP Right Cessation
2001
- 2001-09-25 US US09/961,364 patent/US6482835B2/en not_active Expired - Lifetime
2002
- 2002-08-01 US US10/209,078 patent/US20050203301A1/en not_active Abandoned
2004
- 2004-05-21 NO NO20042109A patent/NO20042109L/no not_active Application Discontinuation
2007
- 2007-03-27 US US11/691,740 patent/US7371868B2/en not_active Expired - Fee Related
2010
- 2010-06-11 CY CY20101100540T patent/CY1110242T1/el unknown

Also Published As

Publication number	Publication date
ATE461186T1 (de)	2010-04-15
AU750760B2 (en)	2002-07-25
NO20002125L (no)	2000-06-07
EP1031569A4 (de)	2003-04-23
KR20050055796A (ko)	2005-06-13
EP1031569B1 (de)	2010-03-17
KR100565362B1 (ko)	2006-03-30
HU229995B1 (en)	2015-04-28
EP1031569A1 (de)	2000-08-30
CY1110242T1 (el)	2015-01-14
KR100611869B1 (ko)	2006-08-11
US7371868B2 (en)	2008-05-13
DK1031569T3 (da)	2010-05-10
WO1999021849A1 (en)	1999-05-06
HK1030779A1 (en)	2001-05-18
US20050203301A1 (en)	2005-09-15
NO20042109L (no)	2000-06-07
US20070225506A1 (en)	2007-09-27
CN1616455A (zh)	2005-05-18
ES2341509T3 (es)	2010-06-21
AU9648698A (en)	1999-05-17
TW200420557A (en)	2004-10-16
HUP0101766A3 (en)	2002-10-28
NO318813B1 (no)	2005-05-09
CA2593381A1 (en)	1999-05-06
CN1278257A (zh)	2000-12-27
HUP0101766A2 (hu)	2001-12-28
CN1195752C (zh)	2005-04-06
KR20010031474A (ko)	2001-04-16
NZ504084A (en)	2003-02-28
US20020049328A1 (en)	2002-04-25
US6337399B1 (en)	2002-01-08
CA2593381C (en)	2010-05-25
CA2307824C (en)	2008-02-19
US6482835B2 (en)	2002-11-19
DE69841563D1 (de)	2010-04-29
TW593308B (en)	2004-06-21
CN1296369C (zh)	2007-01-24
NO20002125D0 (no)	2000-04-26
CN1515555A (zh)	2004-07-28
CA2568251A1 (en)	1999-05-06
IL135406A (en)	2006-10-05
CA2307824A1 (en)	1999-05-06
TWI242012B (en)	2005-10-21
PT1031569E (pt)	2010-05-10

Legal Events

Date	Code	Title	Description
2007-05-21	FF	Patent granted
2007-07-24	KB	Patent renewed

Publication	Publication Date	Title
IL135406A0 (en)	2001-05-20	Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient
IL114875A (en)	1999-12-22	Quinolone or naphthylidone-carboxylic acid derivatives or their salts and pharmaceutical compositions containing them
PT976748E (pt)	2004-03-31	Derivados de pirrolidina com actividade inibidora de fosfolipase a2
HUT58720A (en)	1992-03-30	Process for producing n-/aryl-oxy-alkyl/-hetroaryl-piperidine- and heteroaryl-piperazine derivatives and pharmaceutical compositions containing them
ES2063300T3 (es)	1995-01-01	Derivado de acido aminobencensulfonico.
IL136100A0 (en)	2001-05-20	Biphenylamidine derivatives, prodrugs thereof and pharmaceutical compositions containing the same
DE60016384D1 (de)	2005-01-05	Chondrogonese promotoren und indolin-2-on derivate
DK0806413T3 (da)	2002-01-28	2-substituerede viatmin D3-derivater
AU1018497A (en)	1997-07-24	Quinolinone derivative and anti-allergic agent with said quinolinone derivative as the active ingredient
HUT60491A (en)	1992-09-28	Process for producing substituted n-benzylindole derivatives having leukotriene antagonist effect and pharmaceutical compositions comprising such compounds
AU1589695A (en)	1995-08-21	Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
KR970702244A (ko)	1997-05-13	페넴 유도체 및 이를 함유하는 항균제(penem derivatives and antimicrobial agent containing the same)
AU3648093A (en)	1993-10-05	Pyrrolidine derivatives useful as 5-HT3-antagonists
ZA200002151B (en)	2000-11-07	1-AZA-2-alkyl-6-aryl-cycloalkane compounds, a process for their preparation and pharmaceutical compositions containing them.
EP0798304A4 (de)	1999-02-10	Medikamente gegen trhombocytopenie
AU1735397A (en)	1997-09-16	Pyridonecarboxylic acid derivatives and intermediates for the synthesis thereo
PL342826A1 (en)	2001-07-02	Derivatives of cycloalkenes, their production and application
ATE242211T1 (de)	2003-06-15	Verfahren zur synthese von 4-substituierten azetidinon-derivaten