ATE461186T1 - Salz eines 7-isoindolinchinoloncarbonsäure- derivats, sein monohydrat und zusammensetzungen die diese als wirksamen bestandteil enthalten - Google Patents

Salz eines 7-isoindolinchinoloncarbonsäure- derivats, sein monohydrat und zusammensetzungen die diese als wirksamen bestandteil enthalten

Info

Publication number: ATE461186T1
Authority: AT; Austria
Prior art keywords: group; substituted; groups; protected; unsubstituted alkyl
Prior art date: 1997-10-27

Application number

AT98950405T

Other languages

English (en)

Inventor

Minoru Yamada

Shoichi Hamamoto

Kazuya Hayashi

Kazuko Takaoka

Hiroko Matsukura

Minako Yotsuji

Kenji Yonezawa

Katsuji Ojima

Tamotsu Takamatsu

Kyoko Taya

Hirohiko Yamamoto

Taro Kiyoto

Hironori Kotsubo

Original Assignee

Toyama Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-27

Filing date

1998-10-27

Publication date

2010-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27525611&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE461186(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-10-27 Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461186T1 publication Critical patent/ATE461186T1/de

Links

239000004480 active ingredient Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
150000004682 monohydrates Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000004414 alkyl thio group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000001118 alkylidene group Chemical group 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT98950405T 1997-10-27 1998-10-27 Salz eines 7-isoindolinchinoloncarbonsäure- derivats, sein monohydrat und zusammensetzungen die diese als wirksamen bestandteil enthalten ATE461186T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP31137697		1997-10-27
JP9280798		1998-03-20
JP14058698		1998-05-07
JP24482898		1998-08-31
JP25365698		1998-09-08
PCT/JP1998/004854 WO1999021849A1 (en)	1997-10-27	1998-10-27	Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient

Publications (1)

Publication Number	Publication Date
ATE461186T1 true ATE461186T1 (de)	2010-04-15

Family

ID=27525611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98950405T ATE461186T1 (de)	1997-10-27	1998-10-27	Salz eines 7-isoindolinchinoloncarbonsäure- derivats, sein monohydrat und zusammensetzungen die diese als wirksamen bestandteil enthalten

Country Status (18)

Country	Link
US (4)	US6337399B1 (de)
EP (1)	EP1031569B1 (de)
KR (2)	KR100611869B1 (de)
CN (3)	CN1515555A (de)
AT (1)	ATE461186T1 (de)
AU (1)	AU750760B2 (de)
CA (3)	CA2307824C (de)
CY (1)	CY1110242T1 (de)
DE (1)	DE69841563D1 (de)
DK (1)	DK1031569T3 (de)
ES (1)	ES2341509T3 (de)
HU (1)	HU229995B1 (de)
IL (2)	IL135406A0 (de)
NO (2)	NO318813B1 (de)
NZ (1)	NZ504084A (de)
PT (1)	PT1031569E (de)
TW (2)	TW593308B (de)
WO (1)	WO1999021849A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3590801A (en) *	2000-03-07	2001-09-17	Ranbaxy Laboratories Limited	One-pot synthesis of alkyl 3-cyclopropylamino-2-(2,4-dibromo-3-(difluoromethoxy)benzoyl -2-propenoate as a useful intermediate for antibacterial quinolone medicaments
DE10111262A1 (de) *	2001-03-09	2002-09-12	Studiengesellschaft Kohle Mbh	Verfahren zur Herstellung von Vinyl- Aryl- und Heteroarylessigsäuren und ihrer Devivate
US6777420B2 (en)	2001-06-15	2004-08-17	Microbiotix, Inc.	Heterocyclic antibacterial compounds
JP2006151808A (ja) *	2002-12-24	2006-06-15	Dai Ichi Seiyaku Co Ltd	抗菌性水性製剤
US20090156577A1 (en) *	2004-09-09	2009-06-18	Benjamin Davis	7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
HRP20161260T1 (hr) *	2005-11-24	2016-11-18	Dompé Farmaceutici S.P.A.	Derivati (r)-arilkilamina i farmaceutski pripravci koji ih sadrže
US7902227B2 (en) *	2007-07-27	2011-03-08	Janssen Pharmaceutica Nv.	C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101298418B (zh) *	2008-06-13	2010-12-15	江苏康鹏农化有限公司	3-氧代-3-(2,4-二卤代-3-二氟甲氧基苯基)丙酸乙酯的制备方法
JP5921826B2 (ja) *	2010-06-30	2016-05-24	富山化学工業株式会社	５−ブロモ−２−（１−置換エチル）安息香酸エステルの新規製造法
KR101560073B1 (ko)	2011-08-31	2015-10-13	오쓰까 세이야꾸 가부시키가이샤	퀴놀론 화합물
WO2013121439A2 (en) *	2012-02-15	2013-08-22	Glenmark Generics Limited	Process for garenoxacin mesylate
CN105837555B (zh) *	2016-03-31	2019-01-25	南京华威医药科技集团有限公司	加雷沙星及其中间体制备方法
CN105777631B (zh) *	2016-04-18	2018-06-29	浙江中欣氟材股份有限公司	一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法
CN105801482B (zh) *	2016-04-18	2018-06-22	浙江中欣氟材股份有限公司	一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法
CN106957255B (zh) *	2017-03-28	2018-01-09	上海馨远医药科技有限公司	一种(R)‑N‑Boc‑5‑溴‑1‑甲基异吲哚啉及其制备方法和应用
CN112028816B (zh) *	2020-09-11	2022-10-14	江阴迈康升华医药科技有限公司	一种取代异吲哚啉的合成方法
CN114105790A (zh) *	2021-12-14	2022-03-01	无锡捷化医药科技有限公司	一种3-氨基-4,5-二溴苯甲酸甲酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2196271C (en) *	1994-08-12	2007-01-09	Toyama Chemical Co., Ltd.	Quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
DE4431821A1 (de) *	1994-09-07	1996-03-14	Bayer Ag	Verfahren zur Herstellung von N-Arylaminoacrylsäurederivaten und die Verwendung so hergestellter N-Arylaminoacrylsäurederivate zur Herstellung von 4-Chinolon-3-carbonsäurederivaten
IL124944A (en) *	1996-02-09	2003-06-24	Toyama Chemical Co Ltd	Quinolonecarboxylic acid derivatives or their salts and pharmaceutical compositions containing them
JP4252282B2 (ja) *	2001-11-06	2009-04-08	富山化学工業株式会社	２−［（１ｒ）−１−メチル−２−トリチル−２，３−ジヒドロ−１ｈ−５−イソインドリル］−１，３，６，２−ジオキサアザボロカンの非溶媒和物およびその製造法

1998
- 1998-10-27 TW TW087117800A patent/TW593308B/zh not_active IP Right Cessation
- 1998-10-27 EP EP98950405A patent/EP1031569B1/de not_active Expired - Lifetime
- 1998-10-27 DE DE69841563T patent/DE69841563D1/de not_active Expired - Lifetime
- 1998-10-27 KR KR1020057009280A patent/KR100611869B1/ko not_active Expired - Lifetime
- 1998-10-27 NZ NZ504084A patent/NZ504084A/xx not_active IP Right Cessation
- 1998-10-27 PT PT98950405T patent/PT1031569E/pt unknown
- 1998-10-27 KR KR1020007004509A patent/KR100565362B1/ko not_active Expired - Lifetime
- 1998-10-27 CA CA002307824A patent/CA2307824C/en not_active Expired - Lifetime
- 1998-10-27 TW TW093113303A patent/TWI242012B/zh not_active IP Right Cessation
- 1998-10-27 DK DK98950405.5T patent/DK1031569T3/da active
- 1998-10-27 AT AT98950405T patent/ATE461186T1/de active
- 1998-10-27 CN CNA031603793A patent/CN1515555A/zh active Pending
- 1998-10-27 CA CA2593381A patent/CA2593381C/en not_active Expired - Lifetime
- 1998-10-27 CN CNB988106272A patent/CN1195752C/zh not_active Expired - Lifetime
- 1998-10-27 ES ES98950405T patent/ES2341509T3/es not_active Expired - Lifetime
- 1998-10-27 IL IL13540698A patent/IL135406A0/xx active IP Right Grant
- 1998-10-27 AU AU96486/98A patent/AU750760B2/en not_active Expired
- 1998-10-27 HU HU0101766A patent/HU229995B1/hu unknown
- 1998-10-27 WO PCT/JP1998/004854 patent/WO1999021849A1/ja not_active Ceased
- 1998-10-27 US US09/529,407 patent/US6337399B1/en not_active Expired - Lifetime
- 1998-10-27 CN CNB2004100797208A patent/CN1296369C/zh not_active Expired - Lifetime
- 1998-10-27 CA CA002568251A patent/CA2568251A1/en not_active Abandoned
2000
- 2000-03-31 IL IL135406A patent/IL135406A/en not_active IP Right Cessation
- 2000-04-26 NO NO20002125A patent/NO318813B1/no not_active IP Right Cessation
2001
- 2001-09-25 US US09/961,364 patent/US6482835B2/en not_active Expired - Lifetime
2002
- 2002-08-01 US US10/209,078 patent/US20050203301A1/en not_active Abandoned
2004
- 2004-05-21 NO NO20042109A patent/NO20042109L/no not_active Application Discontinuation
2007
- 2007-03-27 US US11/691,740 patent/US7371868B2/en not_active Expired - Fee Related
2010
- 2010-06-11 CY CY20101100540T patent/CY1110242T1/el unknown

Also Published As

Publication number	Publication date
IL135406A0 (en)	2001-05-20
US7371868B2 (en)	2008-05-13
CN1296369C (zh)	2007-01-24
HUP0101766A2 (hu)	2001-12-28
TW593308B (en)	2004-06-21
EP1031569B1 (de)	2010-03-17
IL135406A (en)	2006-10-05
HK1030779A1 (en)	2001-05-18
KR100611869B1 (ko)	2006-08-11
CA2307824C (en)	2008-02-19
US20020049328A1 (en)	2002-04-25
KR20010031474A (ko)	2001-04-16
TW200420557A (en)	2004-10-16
HU229995B1 (en)	2015-04-28
PT1031569E (pt)	2010-05-10
EP1031569A1 (de)	2000-08-30
WO1999021849A1 (en)	1999-05-06
NO20002125D0 (no)	2000-04-26
CY1110242T1 (el)	2015-01-14
ES2341509T3 (es)	2010-06-21
NO318813B1 (no)	2005-05-09
CN1515555A (zh)	2004-07-28
CN1616455A (zh)	2005-05-18
DE69841563D1 (de)	2010-04-29
NZ504084A (en)	2003-02-28
TWI242012B (en)	2005-10-21
EP1031569A4 (de)	2003-04-23
CN1278257A (zh)	2000-12-27
CA2307824A1 (en)	1999-05-06
AU9648698A (en)	1999-05-17
US6337399B1 (en)	2002-01-08
CN1195752C (zh)	2005-04-06
AU750760B2 (en)	2002-07-25
KR20050055796A (ko)	2005-06-13
HUP0101766A3 (en)	2002-10-28
DK1031569T3 (da)	2010-05-10
US20050203301A1 (en)	2005-09-15
CA2593381C (en)	2010-05-25
KR100565362B1 (ko)	2006-03-30
US6482835B2 (en)	2002-11-19
US20070225506A1 (en)	2007-09-27
NO20042109L (no)	2000-06-07
NO20002125L (no)	2000-06-07
CA2568251A1 (en)	1999-05-06
CA2593381A1 (en)	1999-05-06

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2010-09-15

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Publication	Publication Date	Title
ATE461186T1 (de)	2010-04-15	Salz eines 7-isoindolinchinoloncarbonsäure- derivats, sein monohydrat und zusammensetzungen die diese als wirksamen bestandteil enthalten
IL114875A (en)	1999-12-22	Quinolone or naphthylidone-carboxylic acid derivatives or their salts and pharmaceutical compositions containing them
ATE226574T1 (de)	2002-11-15	4,6-diarylpyrimidin-derivate und deren salze
DE69820248D1 (de)	2004-01-15	Pyrrolidin-derivate die eine phospholipase-a2-hemmende wirkung haben
HUT62582A (en)	1993-05-28	Process for producing pyrimidine nucleoside derivatives and pharmaceutical compositions comprising same as active ingredient
KR960022486A (ko)	1996-07-18	신규 티아졸리딘-4-온 유도체
DE69623497D1 (de)	2002-10-10	1-methylcarbapenem-derivate
DE69512208D1 (de)	1999-10-21	Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren
DK0806413T3 (da)	2002-01-28	2-substituerede viatmin D3-derivater
DE69702775D1 (de)	2000-09-21	Chinolinonderivate und diese enthaltende antiallergische Zusammensetzungen
ATE218562T1 (de)	2002-06-15	Substituierte aminochinazolinon (thion) derivate und deren sälze, deren zwischenprodukten und pestkontrollemittel und deren verwendungsmittel
HUT60491A (en)	1992-09-28	Process for producing substituted n-benzylindole derivatives having leukotriene antagonist effect and pharmaceutical compositions comprising such compounds
HUT62890A (en)	1993-06-28	Process for producing benzothiazole derivatives and pharmaceutical compositions comprising such compounds
KR970705540A (ko)	1997-10-09	구아니디노메틸 사이클로헥산 카복실산 에스테르 유도체(Guanidinomethyl cyclohexane carboxylic ester derivative)
NO20002315L (no)	2000-11-06	Nye 1-aza-2-alkyl-6-aryl-cykloalkanforbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem
FI944207A0 (fi)	1994-09-12	Cyclohexane derivatives
PL342826A1 (en)	2001-07-02	Derivatives of cycloalkenes, their production and application