IL135705A0 - Using polyamide nuceic acid oligomers to engender a biological response - Google Patents
Using polyamide nuceic acid oligomers to engender a biological responseInfo
- Publication number
- IL135705A0 IL135705A0 IL13570598A IL13570598A IL135705A0 IL 135705 A0 IL135705 A0 IL 135705A0 IL 13570598 A IL13570598 A IL 13570598A IL 13570598 A IL13570598 A IL 13570598A IL 135705 A0 IL135705 A0 IL 135705A0
- Authority
- IL
- Israel
- Prior art keywords
- pna oligomers
- materials
- engender
- biological response
- oligomers
- Prior art date
Links
- 230000008512 biological response Effects 0.000 title abstract 5
- 239000004952 Polyamide Substances 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 229920002647 polyamide Polymers 0.000 title 1
- 238000000034 method Methods 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 5
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000004888 barrier function Effects 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 230000007306 turnover Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/953,269 US6472209B1 (en) | 1997-10-17 | 1997-10-17 | Using polyamide nucleic acid oligomers to engender a biological response |
| US09/016,685 US6743627B1 (en) | 1997-10-17 | 1998-01-30 | Using polyamide nucleic acid oligomers to engender a biological response |
| US16851998A | 1998-10-08 | 1998-10-08 | |
| US09/168,714 US6989270B1 (en) | 1997-10-17 | 1998-10-08 | Using polyamide nucleic acid oligomers to engender a biological response |
| US09/168,791 US6723560B2 (en) | 1998-10-08 | 1998-10-08 | Using polyamide nucleic acid oligomers to engender a biological response |
| PCT/US1998/021888 WO1999020643A1 (en) | 1997-10-17 | 1998-10-16 | Using polyamide nucleic acid oligomers to engender a biological response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL135705A0 true IL135705A0 (en) | 2001-05-20 |
Family
ID=27533701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13570598A IL135705A0 (en) | 1997-10-17 | 1998-10-16 | Using polyamide nuceic acid oligomers to engender a biological response |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6989270B1 (de) |
| EP (1) | EP1042349B1 (de) |
| JP (1) | JP2003523307A (de) |
| AT (1) | ATE405575T1 (de) |
| AU (1) | AU741246B2 (de) |
| BR (1) | BR9814866A (de) |
| CA (1) | CA2306731A1 (de) |
| DE (1) | DE69839921D1 (de) |
| DK (1) | DK1042349T3 (de) |
| ES (1) | ES2312192T3 (de) |
| IL (1) | IL135705A0 (de) |
| WO (1) | WO1999020643A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6723560B2 (en) * | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6806363B1 (en) | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| EP1334114A2 (de) | 2000-10-25 | 2003-08-13 | Mayo Foundation For Medical Education And Research | Transcobalamin-bindende konjugate zur behandlung abnormaler zellulärer proliferation |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2528107B2 (ja) | 1985-03-15 | 1996-08-28 | サマ−トン,ジエ−ムス | ポリヌクレオチド測定試薬と方法 |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5470974A (en) | 1985-03-15 | 1995-11-28 | Neu-Gene Development Group | Uncharged polynucleotide-binding polymers |
| US5783682A (en) | 1990-07-27 | 1998-07-21 | Isis Pharmaceuticals, Inc. | Oligonucleotide mimics having nitrogen-containing linkages |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| WO1995004749A1 (en) | 1993-08-05 | 1995-02-16 | Isis Pharmaceuticals, Inc. | Oligomers for modulating metabolic function |
| AU7523794A (en) | 1993-08-09 | 1995-02-28 | Isis Pharmaceuticals, Inc. | Oligomers for modulating viral processes |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| GB2284209A (en) | 1993-11-25 | 1995-05-31 | Ole Buchardt | Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template |
| US5703067A (en) * | 1995-05-08 | 1997-12-30 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1996035705A1 (en) | 1995-05-10 | 1996-11-14 | Isis Pharmaceuticals, Inc. | Inhibition of transcription factor-mediated transcriptional activation by oligomer strand invasion |
| US6015710A (en) | 1996-04-09 | 2000-01-18 | The University Of Texas System | Modulation of mammalian telomerase by peptide nucleic acids |
| GB9608803D0 (en) | 1996-04-27 | 1996-07-03 | Univ Newcastle | Mitochondrial dna defects |
| NZ501289A (en) | 1997-05-28 | 2001-06-29 | Nielsen Peter E | Conjugated peptide nucleic acids having enhanced cellular uptake |
| AU741546B2 (en) | 1997-07-24 | 2001-12-06 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| US6300318B1 (en) | 1997-09-16 | 2001-10-09 | Peter E. Nielsen | Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor |
| JP2001516562A (ja) | 1997-09-18 | 2001-10-02 | ジーン セラピー システムズ インコーポレーテッド | ペプチド核酸コンジュゲートを用いたdnaの化学修飾 |
| US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6472209B1 (en) * | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
-
1998
- 1998-10-08 US US09/168,714 patent/US6989270B1/en not_active Expired - Fee Related
- 1998-10-16 DE DE69839921T patent/DE69839921D1/de not_active Expired - Fee Related
- 1998-10-16 BR BR9814866-4A patent/BR9814866A/pt not_active IP Right Cessation
- 1998-10-16 ES ES98953610T patent/ES2312192T3/es not_active Expired - Lifetime
- 1998-10-16 AU AU10940/99A patent/AU741246B2/en not_active Ceased
- 1998-10-16 JP JP2000516984A patent/JP2003523307A/ja active Pending
- 1998-10-16 WO PCT/US1998/021888 patent/WO1999020643A1/en not_active Ceased
- 1998-10-16 IL IL13570598A patent/IL135705A0/xx unknown
- 1998-10-16 AT AT98953610T patent/ATE405575T1/de not_active IP Right Cessation
- 1998-10-16 CA CA002306731A patent/CA2306731A1/en not_active Abandoned
- 1998-10-16 DK DK98953610T patent/DK1042349T3/da active
- 1998-10-16 EP EP98953610A patent/EP1042349B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK1042349T3 (da) | 2008-11-10 |
| EP1042349B1 (de) | 2008-08-20 |
| JP2003523307A (ja) | 2003-08-05 |
| ES2312192T3 (es) | 2009-02-16 |
| ATE405575T1 (de) | 2008-09-15 |
| EP1042349A1 (de) | 2000-10-11 |
| AU741246B2 (en) | 2001-11-29 |
| BR9814866A (pt) | 2001-11-20 |
| WO1999020643A1 (en) | 1999-04-29 |
| AU1094099A (en) | 1999-05-10 |
| WO1999020643A9 (en) | 1999-08-05 |
| DE69839921D1 (de) | 2008-10-02 |
| EP1042349A4 (de) | 2004-07-28 |
| CA2306731A1 (en) | 1999-04-29 |
| US6989270B1 (en) | 2006-01-24 |
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