IL136425A - Transformed hydrolyzed thiazolidinedione, its preparation process and pharmaceutical preparations containing it - Google Patents

Transformed hydrolyzed thiazolidinedione, its preparation process and pharmaceutical preparations containing it

Info

Publication number: IL136425A
Authority: IL; Israel
Prior art keywords: hydrate; hydrate according; provides; diabetes mellitus; prophylaxis
Prior art date: 1997-12-16

Application number

IL13642598A

Other languages

English (en)

Hebrew (he)

Other versions

IL136425A0 (en

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-16

Filing date

1998-12-14

Publication date

2004-08-31

1998-12-14 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1998-12-14 Priority to IL16084798A priority Critical patent/IL160847A0/xx

2001-06-14 Publication of IL136425A0 publication Critical patent/IL136425A0/xx

2004-08-31 Publication of IL136425A publication Critical patent/IL136425A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL13642598A 1997-12-16 1998-12-14 Transformed hydrolyzed thiazolidinedione, its preparation process and pharmaceutical preparations containing it IL136425A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL16084798A IL160847A0 (en)	1997-12-16	1998-12-14	A hydrate of substituted thiazolidinedione derivative, process for its preparation and pharmaceutical composition comprising the same

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9726563.1A GB9726563D0 (en)	1997-12-16	1997-12-16	Novel pharmaceutical
PCT/EP1998/008153 WO1999031093A1 (fr)	1997-12-16	1998-12-14	Derive substitue de la thiazolidinedione son procede de preparation et ses emplois en pharmacie

Publications (2)

Publication Number	Publication Date
IL136425A0 IL136425A0 (en)	2001-06-14
IL136425A true IL136425A (en)	2004-08-31

Family

ID=10823691

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13642598A IL136425A (en)	1997-12-16	1998-12-14	Transformed hydrolyzed thiazolidinedione, its preparation process and pharmaceutical preparations containing it
IL16084798A IL160847A0 (en)	1997-12-16	1998-12-14	A hydrate of substituted thiazolidinedione derivative, process for its preparation and pharmaceutical composition comprising the same

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL16084798A IL160847A0 (en)	1997-12-16	1998-12-14	A hydrate of substituted thiazolidinedione derivative, process for its preparation and pharmaceutical composition comprising the same

Country Status (37)

Country	Link
US (4)	US20020133016A1 (fr)
EP (1)	EP1042321A1 (fr)
JP (1)	JP2002508371A (fr)
KR (1)	KR100549141B1 (fr)
CN (3)	CN1285831A (fr)
AP (1)	AP1363A (fr)
AR (2)	AR017211A1 (fr)
AU (2)	AU2272299A (fr)
BG (1)	BG64850B1 (fr)
BR (1)	BR9813598A (fr)
CA (1)	CA2314967A1 (fr)
CO (1)	CO4990943A1 (fr)
CZ (1)	CZ300081B6 (fr)
DZ (1)	DZ2679A1 (fr)
EA (1)	EA002833B1 (fr)
EG (1)	EG22250A (fr)
GB (1)	GB9726563D0 (fr)
HR (1)	HRP20000404A2 (fr)
HU (1)	HUP0102292A3 (fr)
ID (1)	ID24714A (fr)
IL (2)	IL136425A (fr)
MA (1)	MA26581A1 (fr)
MY (1)	MY128573A (fr)
NO (1)	NO317255B1 (fr)
NZ (1)	NZ504703A (fr)
OA (1)	OA11900A (fr)
PE (1)	PE20000125A1 (fr)
PL (1)	PL341213A1 (fr)
RS (1)	RS50080B (fr)
SA (1)	SA99200200B1 (fr)
SK (1)	SK286422B6 (fr)
TR (2)	TR200001793T2 (fr)
TW (1)	TW487709B (fr)
UA (1)	UA66821C2 (fr)
UY (2)	UY25309A1 (fr)
WO (1)	WO1999031093A1 (fr)
ZA (1)	ZA9811504B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE39384E1 (en)	1993-09-01	2006-11-07	Smithkline Beecham P.L.C.	Substituted thiazolidinedione derivatives
US20020137940A1 (en)	1997-12-16	2002-09-26	Smithkline Beecham P.L.C.	5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726568D0 (en)	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
US6664278B2 (en)	1997-12-16	2003-12-16	Smithkline Beecham P.L.C.	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9909041D0 (en) *	1999-04-20	1999-06-16	Smithkline Beecham Plc	Novel pharmaceutical
US20040248945A1 (en)	1999-04-23	2004-12-09	Smithkline Beecham P.L.C.	Thiazolidinedione derivative and its use as antidiabetic
HK1045152A1 (zh) *	1999-04-23	2002-11-15	Smithkline Beecham Plc	噻唑烷二酮衍生物及其用作抗糖尿病藥的應用
PL351684A1 (en) *	1999-04-23	2003-06-02	Smithkline Beecham Plc	Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt
AU765498B2 (en) *	1999-04-23	2003-09-18	Smithkline Beecham Plc	Novel pharmaceutical
GB0014005D0 (en) *	2000-06-08	2000-08-02	Smithkline Beecham Plc	Novel pharmaceutical
GB0021784D0 (en) *	2000-09-05	2000-10-18	Smithkline Beecham Plc	Novel pharmaceutical
GB0021978D0 (en) *	2000-09-07	2000-10-25	Smithkline Beecham Plc	Novel pharmaceutical
AU2002350965A1 (en) *	2001-12-13	2003-06-23	Smithkline Beecham Plc	Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
KR100450700B1 (ko) *	2002-03-22	2004-10-01	주식회사종근당	티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물
EP1468997A3 (fr) *	2003-04-18	2004-11-03	CHEMI S.p.A.	Formes polymorphes de maléate de rosiglitatone
GB2405403A (en) *	2003-08-29	2005-03-02	Cipla Ltd	Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
EP1841414A1 (fr) *	2003-12-31	2007-10-10	Alpharma, Inc.	Preparations de rosiglitazone et de metformine
WO2005065654A2 (fr) *	2003-12-31	2005-07-21	Alpharma, Inc.	Preparations de rosiglitazone
ITMI20041537A1 (it) *	2004-07-28	2004-10-28	Chemi Spa	Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) *	2005-05-24	2007-09-26	Zentiva, A. S.	Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
US7435741B2 (en) *	2006-05-09	2008-10-14	Teva Pharmaceutical Industries, Ltd.	2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
EP2184055A1 (fr)	2008-11-07	2010-05-12	LEK Pharmaceuticals d.d.	Procédé de préparation de formes galéniques solides de maléate de rosiglitazone

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288095B1 (en) *	1987-09-04	2001-09-11	Beecham Group P.L.C.	Compounds
ATE186724T1 (de) *	1987-09-04	1999-12-15	Beecham Group Plc	Substituierte thiazolidindionderivate
GB8820389D0 (en) *	1988-08-26	1988-09-28	Beecham Group Plc	Novel compounds
GB9124513D0 (en) *	1991-11-19	1992-01-08	Smithkline Beecham Plc	Novel process
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
US5741803A (en) *	1992-09-05	1998-04-21	Smithkline Beecham Plc	Substituted thiazolidinedionle derivatives
JPH09512249A (ja) *	1994-02-10	1997-12-09	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	腎臓疾患を治療するためのインスリンセンシタイザーの使用
DE4404198A1 (de)	1994-02-10	1995-08-17	Henkel Kgaa	2-Fluor-6-nitroaniline
US20020137940A1 (en)	1997-12-16	2002-09-26	Smithkline Beecham P.L.C.	5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6664278B2 (en)	1997-12-16	2003-12-16	Smithkline Beecham P.L.C.	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
MXPA03002580A (es)	2000-09-26	2003-10-15	Cord Janet I	Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion.

1997
- 1997-12-16 GB GBGB9726563.1A patent/GB9726563D0/en not_active Ceased
1998
- 1998-12-14 SK SK918-2000A patent/SK286422B6/sk not_active IP Right Cessation
- 1998-12-14 OA OA00000177A patent/OA11900A/en unknown
- 1998-12-14 RS YUP-364/00A patent/RS50080B/sr unknown
- 1998-12-14 BR BR9813598-8A patent/BR9813598A/pt not_active Application Discontinuation
- 1998-12-14 EA EA200000656A patent/EA002833B1/ru not_active IP Right Cessation
- 1998-12-14 CN CN98812091A patent/CN1285831A/zh active Pending
- 1998-12-14 CZ CZ20002206A patent/CZ300081B6/cs not_active IP Right Cessation
- 1998-12-14 UA UA2000063483A patent/UA66821C2/uk unknown
- 1998-12-14 IL IL13642598A patent/IL136425A/en unknown
- 1998-12-14 PL PL98341213A patent/PL341213A1/xx not_active Application Discontinuation
- 1998-12-14 AP APAP/P/2000/001829A patent/AP1363A/en active
- 1998-12-14 ID IDW20001128A patent/ID24714A/id unknown
- 1998-12-14 WO PCT/EP1998/008153 patent/WO1999031093A1/fr not_active Ceased
- 1998-12-14 HR HR20000404A patent/HRP20000404A2/hr not_active Application Discontinuation
- 1998-12-14 CN CNA2008100919932A patent/CN101318957A/zh active Pending
- 1998-12-14 MA MA25391A patent/MA26581A1/fr unknown
- 1998-12-14 TR TR2000/01793T patent/TR200001793T2/xx unknown
- 1998-12-14 IL IL16084798A patent/IL160847A0/xx unknown
- 1998-12-14 NZ NZ504703A patent/NZ504703A/xx unknown
- 1998-12-14 JP JP2000539017A patent/JP2002508371A/ja not_active Withdrawn
- 1998-12-14 HU HU0102292A patent/HUP0102292A3/hu unknown
- 1998-12-14 AU AU22722/99A patent/AU2272299A/en not_active Abandoned
- 1998-12-14 KR KR1020007006514A patent/KR100549141B1/ko not_active Expired - Fee Related
- 1998-12-14 CA CA002314967A patent/CA2314967A1/fr not_active Abandoned
- 1998-12-14 CN CNA2008100919928A patent/CN101318956A/zh active Pending
- 1998-12-14 EP EP98966320A patent/EP1042321A1/fr not_active Withdrawn
- 1998-12-15 AR ARP980106364A patent/AR017211A1/es unknown
- 1998-12-15 UY UY25309A patent/UY25309A1/es not_active IP Right Cessation
- 1998-12-15 UY UY25306A patent/UY25306A1/es unknown
- 1998-12-15 MY MYPI98005673A patent/MY128573A/en unknown
- 1998-12-15 DZ DZ980289A patent/DZ2679A1/fr active
- 1998-12-15 AR ARP980106368A patent/AR016161A1/es not_active Application Discontinuation
- 1998-12-15 EG EG155398A patent/EG22250A/xx active
- 1998-12-15 ZA ZA9811504A patent/ZA9811504B/xx unknown
- 1998-12-16 TW TW087121120A patent/TW487709B/zh not_active IP Right Cessation
- 1998-12-16 CO CO98074832A patent/CO4990943A1/es unknown
- 1998-12-16 PE PE1998001231A patent/PE20000125A1/es not_active Application Discontinuation
- 1998-12-16 TR TR1998/02624A patent/TR199802624A2/xx unknown
1999
- 1999-05-31 SA SA99200200A patent/SA99200200B1/ar unknown
2000
- 2000-06-15 NO NO20003070A patent/NO317255B1/no not_active IP Right Cessation
- 2000-07-13 BG BG104606A patent/BG64850B1/bg unknown
2002
- 2002-02-08 US US10/071,339 patent/US20020133016A1/en not_active Abandoned
- 2002-03-20 AU AU27538/02A patent/AU770818B2/en not_active Ceased
2003
- 2003-01-30 US US10/354,365 patent/US20030139604A1/en not_active Abandoned
2005
- 2005-08-17 US US11/205,426 patent/US20050288513A1/en not_active Abandoned
2006
- 2006-09-28 US US11/536,313 patent/US7368574B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ504703A (en)	2002-12-20
UY25306A1 (es)	2000-12-29
UY25309A1 (es)	1999-07-19
BG64850B1 (bg)	2006-06-30
YU36400A (sh)	2003-12-31
JP2002508371A (ja)	2002-03-19
BR9813598A (pt)	2000-10-10
AP1363A (en)	2005-01-21
AU2753802A (en)	2002-05-16
AU770818B2 (en)	2004-03-04
NO317255B1 (no)	2004-09-27
HRP20000404A2 (en)	2000-12-31
WO1999031093A1 (fr)	1999-06-24
GB9726563D0 (en)	1998-02-11
SK9182000A3 (en)	2000-12-11
CN101318956A (zh)	2008-12-10
AP2000001829A0 (en)	2000-06-30
KR100549141B1 (ko)	2006-02-03
SK286422B6 (sk)	2008-09-05
CZ20002206A3 (cs)	2000-12-13
PE20000125A1 (es)	2000-03-03
CN101318957A (zh)	2008-12-10
CA2314967A1 (fr)	1999-06-24
US20070037859A1 (en)	2007-02-15
OA11900A (en)	2006-04-10
EA002833B1 (ru)	2002-10-31
CN1285831A (zh)	2001-02-28
AR017211A1 (es)	2001-08-22
TW487709B (en)	2002-05-21
CZ300081B6 (cs)	2009-01-28
BG104606A (en)	2001-02-28
ZA9811504B (en)	2000-06-15
US20050288513A1 (en)	2005-12-29
HUP0102292A2 (hu)	2002-05-29
US20020133016A1 (en)	2002-09-19
SA99200200B1 (ar)	2006-11-11
HUP0102292A3 (en)	2003-12-29
RS50080B (sr)	2009-01-22
TR200001793T2 (tr)	2000-10-23
UA66821C2 (uk)	2004-06-15
US20030139604A1 (en)	2003-07-24
EA200000656A1 (ru)	2000-12-25
AU2272299A (en)	1999-07-05
PL341213A1 (en)	2001-03-26
EP1042321A1 (fr)	2000-10-11
IL136425A0 (en)	2001-06-14
TR199802624A3 (tr)	1999-10-21
US7368574B2 (en)	2008-05-06
MA26581A1 (fr)	2004-12-20
EG22250A (en)	2002-11-30
ID24714A (id)	2000-08-03
NO20003070L (no)	2000-06-15
AR016161A1 (es)	2001-06-20
CO4990943A1 (es)	2000-12-26
NO20003070D0 (no)	2000-06-15
TR199802624A2 (xx)	1999-10-21
IL160847A0 (en)	2004-08-31
KR20010033140A (ko)	2001-04-25
DZ2679A1 (fr)	2003-03-29
MY128573A (en)	2007-02-28

Publication	Publication Date	Title
AU770818B2 (en)	2004-03-04	Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use
US20070203200A1 (en)	2007-08-30	5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt, hydrate as pharmaceutical
EP1173434B1 (fr)	2003-08-20	Derive du thiazolindione et son utilisation comme antidiabetique
EP1661895A1 (fr)	2006-05-31	Produit pharmaceutique constitue par un hydrate, sel de l'acide maleique, de 5-[ 4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione
US7045633B2 (en)	2006-05-16	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US6664278B2 (en)	2003-12-16	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US7358366B2 (en)	2008-04-15	Thiazolidinedione derivative and its use as antidiabetic
AU774613B2 (en)	2004-07-01	Hydrate of 5-(4-(2- (N-methyl-N- (2-pyridil)amino) ethoxy)benzyl) thiazolidine-2,4-dione maleic acid salt
AU770817B2 (en)	2004-03-04	5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,dione,maleic acid salt, hydrate as pharmaceutical
HK1092138A (en)	2007-02-02	5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
ZA200108722B (en)	2002-09-11	Thiazolidinedione derivative and its use as antidiabetic.
HK1110326A (en)	2008-07-11	Novel pharmaceutical