IL137295A - History of spiropipridine and pharmaceutical preparations containing them - Google Patents

History of spiropipridine and pharmaceutical preparations containing them

Info

Publication number
IL137295A
IL137295A IL13729599A IL13729599A IL137295A IL 137295 A IL137295 A IL 137295A IL 13729599 A IL13729599 A IL 13729599A IL 13729599 A IL13729599 A IL 13729599A IL 137295 A IL137295 A IL 137295A
Authority
IL
Israel
Prior art keywords
sub
ch2ch2
bond
groups
group
Prior art date
Application number
IL13729599A
Other languages
English (en)
Hebrew (he)
Other versions
IL137295A0 (en
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IL137295A0 publication Critical patent/IL137295A0/xx
Publication of IL137295A publication Critical patent/IL137295A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
IL13729599A 1998-01-23 1999-01-22 History of spiropipridine and pharmaceutical preparations containing them IL137295A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1111298 1998-01-23
JP13295998 1998-05-15
PCT/JP1999/000226 WO1999037642A1 (fr) 1998-01-23 1999-01-22 Derives de spiropiperidine

Publications (2)

Publication Number Publication Date
IL137295A0 IL137295A0 (en) 2001-07-24
IL137295A true IL137295A (en) 2005-12-18

Family

ID=26346503

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13729599A IL137295A (en) 1998-01-23 1999-01-22 History of spiropipridine and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US6511975B1 (de)
EP (1) EP1057827B1 (de)
KR (1) KR100629672B1 (de)
CN (1) CN1165533C (de)
AT (1) ATE249455T1 (de)
AU (1) AU741924B2 (de)
BR (1) BR9907173A (de)
CA (1) CA2318361A1 (de)
DE (1) DE69911176T2 (de)
DK (1) DK1057827T3 (de)
ES (1) ES2203061T3 (de)
HU (1) HUP0100939A3 (de)
ID (1) ID25477A (de)
IL (1) IL137295A (de)
MX (1) MXPA00007240A (de)
NO (1) NO317979B1 (de)
NZ (1) NZ505599A (de)
PT (1) PT1057827E (de)
TR (1) TR200002072T2 (de)
WO (1) WO1999037642A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560549B2 (en) * 2004-02-25 2009-07-14 Sankyo Company, Limited Sulfonyloxy derivatives
AU2005214274A1 (en) * 2004-02-25 2005-09-01 Sankyo Company, Limited Indanol derivative
NZ556628A (en) * 2005-03-08 2009-09-25 Janssen Pharmaceutica Nv Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
US8224647B2 (en) 2005-10-03 2012-07-17 Nuance Communications, Inc. Text-to-speech user's voice cooperative server for instant messaging clients
EP3782991A1 (de) 2008-05-14 2021-02-24 The Scripps Research Institute Neue modulatoren von sphingosinphophatrezeptoren
BRPI1014125A2 (pt) 2009-03-17 2016-04-12 Daiichi Sankyo Co Ltd composto, composição farmacêutica, e, uso de um composto.
MX2012005560A (es) * 2009-11-13 2012-10-05 Receptos Inc Moduladores selectivos del receptor de esfingosina 1 fosfato y metodos de sintesis quiral.
ES2665461T3 (es) * 2009-11-13 2018-04-25 Celgene International Ii Sàrl Moduladores del receptor esfingosina 1-fosfato y métodos de síntesis quiral
PH12012500940B1 (en) * 2009-11-13 2018-09-26 Receptos Llc Selective heterocyclic sphingosine 1 phosphate receptor modulators
EP2484674A1 (de) * 2011-02-02 2012-08-08 Rottapharm S.P.A. Spiro-Aminoverbindungen mit NK1-Antagonistenaktivität
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2154569A1 (en) * 1993-01-28 1994-08-04 Jeffrey J. Hale Spiro-substituted azacycles as tachykinin receptor antagonists
RU2135494C1 (ru) 1995-12-01 1999-08-27 Санкио Компани Лимитед Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
JP3192631B2 (ja) * 1997-05-28 2001-07-30 三共株式会社 飽和複素環化合物からなる医薬
CA2290392C (en) 1997-05-30 2006-03-28 Takahide Nishi Salts of optically active sulfoxide derivative

Also Published As

Publication number Publication date
CN1165533C (zh) 2004-09-08
WO1999037642A1 (fr) 1999-07-29
EP1057827A1 (de) 2000-12-06
NO20003630L (no) 2000-09-20
EP1057827B1 (de) 2003-09-10
NZ505599A (en) 2003-06-30
BR9907173A (pt) 2000-10-10
HUP0100939A3 (en) 2002-06-28
ES2203061T3 (es) 2004-04-01
KR20010034280A (ko) 2001-04-25
NO317979B1 (no) 2005-01-17
HK1032780A1 (en) 2001-08-03
EP1057827A4 (de) 2001-11-21
DE69911176D1 (de) 2003-10-16
TR200002072T2 (tr) 2000-12-21
AU741924B2 (en) 2001-12-13
ATE249455T1 (de) 2003-09-15
KR100629672B1 (ko) 2006-09-29
AU2073999A (en) 1999-08-09
CN1294588A (zh) 2001-05-09
HUP0100939A2 (hu) 2002-05-29
IL137295A0 (en) 2001-07-24
DE69911176T2 (de) 2004-06-24
ID25477A (id) 2000-10-05
NO20003630D0 (no) 2000-07-14
PT1057827E (pt) 2003-11-28
US6511975B1 (en) 2003-01-28
CA2318361A1 (en) 1999-07-29
DK1057827T3 (da) 2004-01-26
MXPA00007240A (es) 2002-05-08

Similar Documents

Publication Publication Date Title
EP1057827B1 (de) Spiropiperidin-derivate
WO2001029027A1 (en) 2-alkoxybenzene derivatives
JP2002316987A (ja) ２−アルコキシベンゼン誘導体を含有する医薬
JP2000034288A (ja) スピロピペリジン誘導体
ES2243012T3 (es) Derivados heterociclicos aliciclicos acilados.
RU2184735C2 (ru) Производные спиропиперидина, лекарственное средство, способ профилактики или лечения
HK1032780B (en) Spiropiperidine derivatives
JP3017147B2 (ja) 光学活性スルホキシド誘導体
JP2001031570A (ja) スピロピペリジン誘導体を含有する医薬
CZ20002503A3 (cs) Spiropiperidinové deriváty
JPH11240880A (ja) 脂環式アシル化複素環誘導体
JP2001187790A (ja) ２−アルコキシベンゼン誘導体
JP2000229968A (ja) シクロヘキシルピペリジン誘導体
RU2174122C1 (ru) Ацилированные гетероалициклические производные, лекарственное средство, обладающее селективной антагонистической активностью против nk2-рецепторов, способ профилактики или лечения заболевания
JP2000344670A (ja) 脂環式アシル化複素環誘導体を含有する医薬
JPH10182650A (ja) 光学活性スルホキシド誘導体
JP2000103791A (ja) 医薬合成のための光学活性スルホキシド誘導体
WO2000034274A1 (en) Cyclohexylpiperidine derivatives
MXPA00005587A (en) Alicyclic acylated heterocyclic derivatives
KR100484358B1 (ko) 타키키닌 수용체 길항 작용을 갖는 헤테로시클릭 화합물, 그 의 제법 및 그의 용도
HK1031870B (en) Alicyclic acylated heterocyclic derivatives
CZ20002051A3 (cs) Acylované hetero-alicyklické deriváty
HK1033944A (en) Spiropiperidine derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed