IL141184A0 - Amide derivatives which are useful as cytokine inhibitors - Google Patents

Amide derivatives which are useful as cytokine inhibitors

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Publication number
IL141184A0
IL141184A0 IL14118499A IL14118499A IL141184A0 IL 141184 A0 IL141184 A0 IL 141184A0 IL 14118499 A IL14118499 A IL 14118499A IL 14118499 A IL14118499 A IL 14118499A IL 141184 A0 IL141184 A0 IL 141184A0
Authority
IL
Israel
Prior art keywords
alkoxy
alkyl
halogeno
heterocyclyl
heteroaryl
Prior art date
Application number
IL14118499A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL141184A0 publication Critical patent/IL141184A0/xx

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14118499A 1998-08-04 1999-07-29 Amide derivatives which are useful as cytokine inhibitors IL141184A0 (en)

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Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US7772432B2 (en) * 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
DK1017378T3 (da) 1997-09-23 2003-03-17 Astrazeneca Ab Amidderivater til behandling af sygdomme medieret af cytokiner
PL195600B1 (pl) 1998-05-15 2007-10-31 Astrazeneca Ab Pochodne benzamidowe, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku do leczenia stanów medycznych powstających za pośrednictwem cytokin
SK286247B6 (sk) 1998-05-15 2008-06-06 Astrazeneca Ab Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
WO2000007991A1 (fr) 1998-08-04 2000-02-17 Astrazeneca Ab Derives d'amides utiles comme inhibiteurs de la production de cytokines
CA2341370A1 (fr) 1998-08-20 2000-03-02 Smithkline Beecham Corporation Nouveaux composes de triazole substitues
ATE254105T1 (de) 1998-09-25 2003-11-15 Astrazeneca Ab Benzamid-derivate und ihre verwendung als cytokine inhibitoren
DE69914357T2 (de) 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
AU761453B2 (en) 1999-03-17 2003-06-05 Astrazeneca Ab Amide derivatives
JP2002539187A (ja) 1999-03-17 2002-11-19 アストラゼネカ アクチボラグ アミド誘導体
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
EP1233950B1 (fr) 1999-11-23 2005-10-05 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-ones comme inhibiteurs de csbp/p38 kinase
ATE281439T1 (de) 1999-11-23 2004-11-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
JP2003514900A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
US6943161B2 (en) 1999-12-28 2005-09-13 Pharmacopela Drug Discovery, Inc. Pyrimidine and triazine kinase inhibitors
WO2001064642A2 (fr) * 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides et inhibiteurs connexes du facteur xa
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
DE60130771T2 (de) 2000-07-27 2008-07-17 Eli Lilly And Co., Indianapolis Substituierte heterocyclische amide
EP1310488A4 (fr) * 2000-08-09 2005-08-10 Mitsubishi Pharma Corp Composes amide bicycliques condenses et utilisations medicales associees
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
ATE375980T1 (de) 2002-02-12 2007-11-15 Smithkline Beecham Corp Nicotinamide und deren verwendung als p38 inhibitoren
ES2278170T3 (es) 2002-07-09 2007-08-01 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias.
GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
GB0308186D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308185D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308201D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
FR2854158B1 (fr) * 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
EP2385041B1 (fr) 2003-05-01 2013-09-18 Bristol-Myers Squibb Company Composés de pyrazole-amines utilés en tant qu'inhibiteurs de kinase
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
GB0329572D0 (en) * 2003-12-20 2004-01-28 Astrazeneca Ab Amide derivatives
BR122015015718B1 (pt) 2004-01-28 2016-05-10 Mitsui Chemicals Inc derivados de amida
GB0402143D0 (en) * 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US20080051416A1 (en) * 2004-10-05 2008-02-28 Smithkline Beecham Corporation Novel Compounds
DE102005023834A1 (de) 2004-11-20 2006-05-24 Bayer Healthcare Ag Substituierte[(Phenylethanoyl)amino]benzamide
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
GB0512429D0 (en) * 2005-06-17 2005-07-27 Smithkline Beecham Corp Novel compound
MX295245B (es) 2005-06-21 2012-01-26 Mitsui Chemicals Inc Derivado de amida e insecticida que contiene el mismo.
JP4580836B2 (ja) * 2005-07-25 2010-11-17 三井化学アグロ株式会社 殺虫殺菌組成物
CA2616749C (fr) * 2005-07-27 2012-01-03 Mitsui Chemicals, Inc. Composition antiparasitaire
US7754717B2 (en) * 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
US20070213378A1 (en) * 2006-03-10 2007-09-13 Lymphosign Inc. Compounds for modulating cell proliferation, compositions and methods related thereto
WO2008031534A1 (fr) 2006-09-11 2008-03-20 Syngenta Participations Ag Composés insecticides
EP2083816A2 (fr) 2006-10-27 2009-08-05 Brystol-Myers Squibb Company Composés d'amide hétérocyclique utiles comme inhibiteurs de kinase
CN101595092B (zh) 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
US8012955B2 (en) * 2006-12-28 2011-09-06 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
TW200904421A (en) 2007-05-03 2009-02-01 Astellas Pharma Inc New compounds
EP1992344A1 (fr) 2007-05-18 2008-11-19 Institut Curie P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
EP2184273A1 (fr) 2008-11-05 2010-05-12 Bayer CropScience AG Composés substitués par l'halogène comme pesticides
EP2253617A1 (fr) 2009-05-20 2010-11-24 Bayer CropScience AG Composés halogénés comme pesticides
CN103502221B (zh) 2011-03-18 2016-03-30 拜耳知识产权有限责任公司 N-(3-氨甲酰基苯基)-1h-吡唑-5-甲酰胺衍生物及其用于防治动物害虫的用途
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
PL2953942T3 (pl) 2013-02-06 2018-03-30 Bayer Cropscience Aktiengesellschaft Podstawione halogenem pochodne pirazolu jako środki do zwalczania szkodników
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
AR098311A1 (es) 2013-11-05 2016-05-26 Bayer Cropscience Ag Compuestos para el control de artrópodos
CA2932353A1 (fr) * 2013-12-13 2015-06-18 Steven P. Treon Procede pour traiter un lymphome lymphoplasmocytaire
EP3079683A4 (fr) 2013-12-13 2017-12-20 Dana-Farber Cancer Institute, Inc. Procédé pour traiter un lymphome lymphoplasmocytaire
MX2016008653A (es) 2014-01-03 2016-09-26 Bayer Animal Health Gmbh Nuevas pirazolil-heteroarilamidas como agentes plaguicidas.
AR101401A1 (es) 2014-08-08 2016-12-14 Bayer Cropscience Ag Derivados de bipirazol, sustituidos con halógeno
EP3715346B1 (fr) 2014-10-22 2024-01-03 Dana-Farber Cancer Institute, Inc. Composés contenant des groupes thiazolyle pour le traitement de maladies prolifératives
WO2016174049A1 (fr) 2015-04-30 2016-11-03 Bayer Animal Health Gmbh Combinaisons anti-parasitaires comprenant des composés à substitution halogène
BR112018002867B1 (pt) 2015-08-13 2022-07-26 Bayer Cropscience Aktiengesellschaft Derivados de pirrol, diazol, triazol ou tetrazol, indicados para o controle de artrópodes
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
WO2018177995A1 (fr) 2017-03-31 2018-10-04 Bayer Cropscience Aktiengesellschaft Carboxamides tricycliques pour lutter contre les anthropodes
WO2018177993A1 (fr) 2017-03-31 2018-10-04 Bayer Cropscience Aktiengesellschaft Pyrazoles pour lutter contre les arthropodes
CN118416236A (zh) 2018-01-31 2024-08-02 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
IL276398B2 (en) 2018-01-31 2026-03-01 Deciphera Pharmaceuticals Llc Combination therapy for mastocytosis
WO2020185812A1 (fr) 2019-03-11 2020-09-17 Teva Pharmaceuticals International Gmbh Formes à l'état solide de riprétinib
TWI878335B (zh) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
EP4013412B1 (fr) 2019-08-12 2026-01-28 Deciphera Pharmaceuticals, LLC Ripretinib pour le traitement de tumeurs stromales gastro-intestinales
MX2022008103A (es) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
EP4084779B1 (fr) 2019-12-30 2024-10-09 Deciphera Pharmaceuticals, LLC Compositions de 1-(4-bromo-5-(1-éthyl-7-(méthylamino)-2-oxo-1,2-dihydro -1,6-naphthyridine-3-yl)-2-fluorophényl)-3-phényluree
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1903899A (en) * 1933-04-18 Cabboxylic acid abylides oe the benzene sebies and process oe making
US1909960A (en) 1929-08-06 1933-05-23 Du Pont Intermediate for azo dyes
NL129433C (fr) * 1963-09-21
DE2812252A1 (de) 1978-03-21 1979-10-04 Bayer Ag 1,2,4-triazol-blockierte polyisocyanate als vernetzer fuer lackbindemittel
US4749729A (en) 1984-06-21 1988-06-07 American Cyanamid Company Epoxy resin compositions curable above 160 F. and below 250 F.
JPH0753835B2 (ja) * 1985-05-20 1995-06-07 大日本インキ化学工業株式会社 アゾレ−キ顔料の製造法
GB9413975D0 (en) * 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
JPH04177350A (ja) * 1990-11-13 1992-06-24 Fuji Photo Film Co Ltd 感光材料
AU2552492A (en) 1991-08-23 1993-03-16 United States of America as represented by The Secretary Department of Health and Human Services, The Raf protein kinase therapeutics
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
AU6526896A (en) * 1995-07-22 1997-02-18 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
WO1997005878A1 (fr) 1995-08-10 1997-02-20 Merck & Co., Inc. Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation
EP0849256B1 (fr) * 1995-08-22 2005-06-08 Japan Tobacco Inc. Composes amide et leur utilisation
JPH09124571A (ja) * 1995-11-01 1997-05-13 Japan Tobacco Inc アミド化合物及びその用途
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
JP2001506230A (ja) 1996-08-09 2001-05-15 スミスクライン・ビーチャム・コーポレイション 新規ピペラジン含有化合物
GB9623833D0 (en) 1996-11-16 1997-01-08 Zeneca Ltd Chemical compound
DK1017378T3 (da) * 1997-09-23 2003-03-17 Astrazeneca Ab Amidderivater til behandling af sygdomme medieret af cytokiner
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9809347D0 (en) 1998-05-05 1998-07-01 Reckitt & Colmann Prod Ltd Compositions
SK286247B6 (sk) 1998-05-15 2008-06-06 Astrazeneca Ab Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi
PL195600B1 (pl) 1998-05-15 2007-10-31 Astrazeneca Ab Pochodne benzamidowe, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku do leczenia stanów medycznych powstających za pośrednictwem cytokin
WO2000007991A1 (fr) 1998-08-04 2000-02-17 Astrazeneca Ab Derives d'amides utiles comme inhibiteurs de la production de cytokines
ATE254105T1 (de) 1998-09-25 2003-11-15 Astrazeneca Ab Benzamid-derivate und ihre verwendung als cytokine inhibitoren
ATE232205T1 (de) 1998-10-01 2003-02-15 Astrazeneca Ab Chinolin- und chinazolin derivate und ihre verwendung als inhibitoren von krankheiten, bei denen cytokine beteiligt wird
AU761453B2 (en) 1999-03-17 2003-06-05 Astrazeneca Ab Amide derivatives
JP2002539187A (ja) 1999-03-17 2002-11-19 アストラゼネカ アクチボラグ アミド誘導体
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives

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NO321017B1 (no) 2006-02-27
ATE221047T1 (de) 2002-08-15
ES2178895T3 (es) 2003-01-01
CA2337770C (fr) 2009-01-20
IL141184A (en) 2009-11-18
HUP0103366A3 (en) 2002-12-28
AU5179199A (en) 2000-02-28
EP1102743B1 (fr) 2002-07-24
DK1102743T3 (da) 2002-09-30
HK1037608A1 (en) 2002-02-15
BRPI9912726B8 (pt) 2021-07-06
SK286446B6 (sk) 2008-10-07
BRPI9912726A (pt) 2001-05-02
CN1330631A (zh) 2002-01-09
HUP0103366A2 (hu) 2002-01-28
JP2002522414A (ja) 2002-07-23
WO2000007980A1 (fr) 2000-02-17
RU2220951C2 (ru) 2004-01-10
CN1243724C (zh) 2006-03-01
CZ301971B6 (cs) 2010-08-18
CA2337770A1 (fr) 2000-02-17
HU230343B1 (hu) 2016-02-29
PL195722B1 (pl) 2007-10-31
DE69902277D1 (de) 2002-08-29
KR20010099608A (ko) 2001-11-09
PL345809A1 (en) 2002-01-02
CZ2001384A3 (cs) 2001-07-11
SK1722001A3 (en) 2001-08-06
PT1102743E (pt) 2002-12-31
NO20010533L (no) 2001-03-30
GB9816837D0 (en) 1998-09-30
AU756292B2 (en) 2003-01-09
KR100628285B1 (ko) 2006-09-27
US6821965B1 (en) 2004-11-23
JP4502509B2 (ja) 2010-07-14
NO20010533D0 (no) 2001-01-31
EP1102743A1 (fr) 2001-05-30
DE69902277T2 (de) 2003-06-18
NZ509162A (en) 2004-01-30
ZA200100617B (en) 2002-01-22

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