IL141423A - Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof - Google Patents

Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

Info

Publication number: IL141423A
Authority: IL; Israel
Prior art keywords: processes; alendronate sodium; manufacture; pharmaceutical compositions; hydrate forms
Prior art date: 1998-08-27

Application number

IL14142399A

Other languages

English (en)

Other versions

IL141423A0 (en

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-27

Filing date

1999-08-27

Publication date

2005-09-25

1999-08-27 Application filed by Teva Pharma filed Critical Teva Pharma

2002-03-10 Publication of IL141423A0 publication Critical patent/IL141423A0/xx

2005-09-25 Publication of IL141423A publication Critical patent/IL141423A/xx

Links

OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title abstract 4
229960004343 alendronic acid Drugs 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
208000006386 Bone Resorption Diseases 0.000 abstract 1
208000020084 Bone disease Diseases 0.000 abstract 1
230000024279 bone resorption Effects 0.000 abstract 1
238000010348 incorporation Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Orthopedic Medicine & Surgery (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IL14142399A 1998-08-27 1999-08-27 Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof IL141423A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9831398P	1998-08-27	1998-08-27
US12974399P	1999-04-16	1999-04-16
US14446199P	1999-07-19	1999-07-19
PCT/US1999/019838 WO2000012517A1 (en)	1998-08-27	1999-08-27	Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

Publications (2)

Publication Number	Publication Date
IL141423A0 IL141423A0 (en)	2002-03-10
IL141423A true IL141423A (en)	2005-09-25

Family

ID=27378576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14142399A IL141423A (en)	1998-08-27	1999-08-27	Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

Country Status (30)

Country	Link
US (2)	US6281381B1 (lt)
EP (1)	EP1107974B1 (lt)
JP (2)	JP2002523514A (lt)
KR (2)	KR20070034132A (lt)
AT (1)	ATE334993T1 (lt)
AU (1)	AU5698899A (lt)
BG (1)	BG65329B1 (lt)
BR (1)	BR9913472A (lt)
CA (1)	CA2341459A1 (lt)
CZ (1)	CZ2001629A3 (lt)
DE (1)	DE69932620T2 (lt)
DK (1)	DK1107974T3 (lt)
EA (1)	EA002739B1 (lt)
EE (1)	EE04552B1 (lt)
ES (1)	ES2270613T3 (lt)
HR (1)	HRP20010129A2 (lt)
HU (1)	HUP0203078A3 (lt)
IL (1)	IL141423A (lt)
IS (1)	IS5864A (lt)
LT (1)	LT4888B (lt)
LV (1)	LV12720B (lt)
NO (1)	NO20010957L (lt)
NZ (1)	NZ510682A (lt)
PL (1)	PL346347A1 (lt)
PT (1)	PT1107974E (lt)
RO (1)	RO122854B1 (lt)
SI (1)	SI20581B (lt)
SK (1)	SK2482001A3 (lt)
WO (1)	WO2000012517A1 (lt)
YU (1)	YU14701A (lt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2336312T3 (es) *	2001-07-16	2010-04-12	Universite Paris 13	Procedimiento de preparacion de derivados de bisfosfonatos.
GB2383042A (en)	2001-10-18	2003-06-18	Cipla Ltd	Amorphous alendronate sodium
EA006053B1 (ru) *	2001-12-24	2005-08-25	Тева Фармасьютикал Индастриес Лтд.	Твёрдая лекарственная форма, способ её изготовления и устройство
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
ITMI20020146A1 (it) *	2002-01-29	2003-07-29	Lyogen Ltd	Alendronato monosodico amorfo e processo per la sua preparazione
WO2003086415A1 (en) *	2002-04-05	2003-10-23	Merck & Co., Inc.	Method for inhibiting bone resorption with an alendronate and vitamin d formulation
US20080249068A1 (en) *	2002-09-05	2008-10-09	Deluca Hector F	Method of Extending the Dose Range of Vitamin D Compounds
US20050113343A1 (en) *	2003-10-14	2005-05-26	Pliva - Research And Development Ltd.	Solid-state form of alendronate sodium and preparation thereof
US20050181043A1 (en) *	2004-02-12	2005-08-18	Indranil Nandi	Alendronate salt tablet compositions
US20050261250A1 (en) *	2004-05-19	2005-11-24	Merck & Co., Inc.,	Compositions and methods for inhibiting bone resorption
KR20080083068A (ko)	2004-05-24	2008-09-12	더 프록터 앤드 갬블 캄파니	킬레이팅제를 함유하는 비스포스포네이트의 고형의 장용 경구 투여 형태
CZ296937B6 (cs) *	2004-09-02	2006-07-12	Zentiva, A. S	Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové
DE602005016292D1 (de) *	2004-10-29	2009-10-08	Sandoz Ag	Verfahren zur herstellung von glatiramer
US20060134190A1 (en) *	2004-12-16	2006-06-22	Banner Pharmacaps Inc.	Formulations of bisphosphonate drugs with improved bioavailability
CZ297262B6 (cs) *	2004-12-28	2006-10-11	Zentiva, A. S.	Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové
US8003820B2 (en) *	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
AR058168A1 (es) *	2005-11-07	2008-01-23	Merck & Co Inc	Sintesis del alendronato de sodio trihidratado
NZ576347A (en) *	2006-10-27	2011-10-28	Signal Pharm Llc	Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol, compositions thereof, and use therewith
ES2392890T3 (es) *	2006-11-22	2012-12-14	Eisai R&D Management Co., Ltd.	Sal sódica de un compuesto disacarídico, procedimiento para la producción de la misma y uso de la misma
US20090118238A1 (en) *	2007-09-17	2009-05-07	Protia, Llc	Deuterium-enriched alendronate
US20090076144A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched bazedoxifene
US20090170815A1 (en) *	2007-12-28	2009-07-02	Roxane Laboratories Incorporated.	Alendronate oral liquid formulations
JP2013510097A (ja) *	2009-11-03	2013-03-21	リウ、リー	タンシノンｉｉａスルホン酸ナトリウム水和物、並びにその調製方法及び使用
TWI665190B (zh)	2013-11-15	2019-07-11	阿克比治療有限公司	｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3016289A1 (de)	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) *	1982-04-15	1989-01-27	Gentili Ist Spa	Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) *	1984-08-06	1987-01-27	Ciba-Geigy Corporation	Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de)	1984-09-21	1986-04-03	Henkel KGaA, 4000 Düsseldorf	4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) *	1984-10-29	1988-11-16	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici
US4711800A (en) *	1985-06-06	1987-12-08	Divincenzo Maureen	Needlecraft with metallic substrate
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) *	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5159108A (en)	1990-09-18	1992-10-27	Merck & Co., Inc.	Process for preparing an antihypercalcemic agent
US5039819A (en) *	1990-09-18	1991-08-13	Merck & Co., Inc.	Diphosphonate intermediate for preparing an antihypercalcemic agent
WO1996039149A1 (en) *	1995-06-06	1996-12-12	Merck & Co., Inc.	Anhydrous alendronate monosodium salt formulations
AU6148396A (en)	1995-06-06	1996-12-24	Merck & Co., Inc.	Disodium alendronate formulations

1999
- 1999-08-27 IL IL14142399A patent/IL141423A/xx not_active IP Right Cessation
- 1999-08-27 KR KR1020077004456A patent/KR20070034132A/ko not_active Ceased
- 1999-08-27 CA CA002341459A patent/CA2341459A1/en not_active Abandoned
- 1999-08-27 JP JP2000567539A patent/JP2002523514A/ja not_active Withdrawn
- 1999-08-27 NZ NZ510682A patent/NZ510682A/en not_active IP Right Cessation
- 1999-08-27 KR KR1020017002535A patent/KR20010079701A/ko not_active Ceased
- 1999-08-27 AT AT99944004T patent/ATE334993T1/de not_active IP Right Cessation
- 1999-08-27 HR HR20010129A patent/HRP20010129A2/hr not_active Application Discontinuation
- 1999-08-27 EA EA200100184A patent/EA002739B1/ru not_active IP Right Cessation
- 1999-08-27 AU AU56988/99A patent/AU5698899A/en not_active Abandoned
- 1999-08-27 SK SK248-2001A patent/SK2482001A3/sk unknown
- 1999-08-27 ES ES99944004T patent/ES2270613T3/es not_active Expired - Lifetime
- 1999-08-27 RO ROA200100219A patent/RO122854B1/ro unknown
- 1999-08-27 EE EEP200100126A patent/EE04552B1/xx not_active IP Right Cessation
- 1999-08-27 US US09/384,145 patent/US6281381B1/en not_active Expired - Fee Related
- 1999-08-27 CZ CZ2001629A patent/CZ2001629A3/cs unknown
- 1999-08-27 PT PT99944004T patent/PT1107974E/pt unknown
- 1999-08-27 PL PL99346347A patent/PL346347A1/xx not_active Application Discontinuation
- 1999-08-27 YU YU14701A patent/YU14701A/sh unknown
- 1999-08-27 DE DE69932620T patent/DE69932620T2/de not_active Expired - Fee Related
- 1999-08-27 WO PCT/US1999/019838 patent/WO2000012517A1/en not_active Ceased
- 1999-08-27 EP EP99944004A patent/EP1107974B1/en not_active Expired - Lifetime
- 1999-08-27 BR BR9913472-1A patent/BR9913472A/pt not_active Application Discontinuation
- 1999-08-27 DK DK99944004T patent/DK1107974T3/da active
- 1999-08-27 SI SI9920070A patent/SI20581B/sl not_active IP Right Cessation
- 1999-08-27 HU HU0203078A patent/HUP0203078A3/hu unknown
2001
- 2001-02-26 LT LT2001016A patent/LT4888B/lt not_active IP Right Cessation
- 2001-02-26 IS IS5864A patent/IS5864A/is unknown
- 2001-02-26 BG BG105292A patent/BG65329B1/bg unknown
- 2001-02-26 NO NO20010957A patent/NO20010957L/no not_active Application Discontinuation
- 2001-04-05 LV LVP-01-26A patent/LV12720B/en unknown
- 2001-07-03 US US09/898,756 patent/US6696601B2/en not_active Expired - Fee Related
2009
- 2009-02-18 JP JP2009035788A patent/JP2009143955A/ja active Pending

Also Published As

Publication number	Publication date
SK2482001A3 (en)	2002-01-07
NZ510682A (en)	2003-09-26
NO20010957L (no)	2001-04-26
WO2000012517A1 (en)	2000-03-09
CA2341459A1 (en)	2000-03-09
BG105292A (en)	2001-12-29
DK1107974T3 (da)	2006-10-30
JP2002523514A (ja)	2002-07-30
JP2009143955A (ja)	2009-07-02
BG65329B1 (bg)	2008-02-29
US6696601B2 (en)	2004-02-24
KR20070034132A (ko)	2007-03-27
NO20010957D0 (no)	2001-02-26
WO2000012517A9 (en)	2000-07-13
LV12720A (lv)	2001-09-20
HUP0203078A2 (hu)	2003-01-28
EP1107974A1 (en)	2001-06-20
EP1107974A4 (en)	2001-09-26
LT2001016A (lt)	2001-10-25
CZ2001629A3 (cs)	2001-08-15
DE69932620D1 (de)	2006-09-14
EA200100184A1 (ru)	2001-10-22
EA002739B1 (ru)	2002-08-29
YU14701A (sh)	2003-01-31
LT4888B (lt)	2002-02-25
ATE334993T1 (de)	2006-08-15
IL141423A0 (en)	2002-03-10
US20030065214A1 (en)	2003-04-03
HRP20010129A2 (en)	2005-04-30
IS5864A (is)	2001-02-26
AU5698899A (en)	2000-03-21
SI20581A (sl)	2001-12-31
PT1107974E (pt)	2006-10-31
ES2270613T3 (es)	2007-04-01
RO122854B1 (ro)	2010-03-30
EP1107974B1 (en)	2006-08-02
PL346347A1 (en)	2002-02-11
KR20010079701A (ko)	2001-08-22
EE200100126A (et)	2002-06-17
BR9913472A (pt)	2002-03-05
HUP0203078A3 (en)	2005-01-28
DE69932620T2 (de)	2006-12-14
EE04552B1 (et)	2005-10-17
US6281381B1 (en)	2001-08-28
LV12720B (en)	2002-02-20
SI20581B (sl)	2008-06-30

Legal Events

Date	Code	Title	Description
2006-09-05	KB	Patent renewed
2010-10-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL141423A0 (en)	2002-03-10	Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
DE60038038D1 (en)	2008-03-27	Phosphonatverbindungen
ZA200210092B (en)	2003-12-12	alpha crystalline form of perindopril tert-butylamine salt.
NZ272610A (en)	1997-08-22	The manufacture of dispersible tablets containing fluoxetine by direct compression
PL339548A1 (en)	2000-12-18	Implant for uniting two fragments of fractured bone
MXPA02012904A (es)	2003-09-22	Nueva forma cristalina y de sal de ter-butilamina de perindopril, metodo de preparacion y composiciones farmaceuticas que contienen las mismas.
CA2337991A1 (en)	2000-01-27	Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents
AP2000001947A0 (en)	2000-12-31	Novel crystalline forms of an antiviral benzidazole compound.
HU0102813D0 (en)	2001-09-28	New betha crystalline form of perindopril tert-butylamine salt, process for its preparation and pharmaceutical compositions containing it
HUP0401141A3 (en)	2011-07-28	Crystalline forms of fluvastatin sodium, process for their preparation and pharmaceutical compositions containing them
AU2001276420A1 (en)	2002-01-31	Novel gamma crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same.
PT1051159E (pt)	2002-09-30	Composicoes farmaceuticas solidas contendo miltefosina para administracao oral no tratamento de leishmaniose
CA2431515A1 (en)	2002-08-01	Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
UA66932C2 (en)	2004-06-15	Complex of eletriptan and sulphobutylether-beta-cyclodextrin, pharmaceutical composition, method for their manufacture and method for treating migraine
EP1702924A3 (en)	2007-07-18	Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
HK1034715A (en)	2001-11-02	Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ZA200101451B (en)	2002-02-21	Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof.
HUP9801781A3 (en)	2000-08-28	Process for producing indolil-methane compounds and pharmaceutical compositions for inhibiting transcriptase (rt) enzyme comprising the same compounds
MY118194A (en)	2004-09-30	Pharmaceutical compositions for use in inhibiting bone resorption
BG104673A (en)	2001-05-31	Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis
HU0102815D0 (en)	2001-09-28	New alpha crystalline form of perindopril tert-butylamine salt, process for its preparation and pharmaceutical compositions containing it