IL148678A0 - Dna sequencing method - Google Patents

Dna sequencing method

Info

Publication number
IL148678A0
IL148678A0 IL14867800A IL14867800A IL148678A0 IL 148678 A0 IL148678 A0 IL 148678A0 IL 14867800 A IL14867800 A IL 14867800A IL 14867800 A IL14867800 A IL 14867800A IL 148678 A0 IL148678 A0 IL 148678A0
Authority
IL
Israel
Prior art keywords
dna sequencing
sequencing method
polynucleotide
enzyme
detection
Prior art date
Application number
IL14867800A
Other languages
English (en)
Original Assignee
Medical Biosystems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Biosystems Ltd filed Critical Medical Biosystems Ltd
Publication of IL148678A0 publication Critical patent/IL148678A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
IL14867800A 1999-10-06 2000-10-06 Dna sequencing method IL148678A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9923644.0A GB9923644D0 (en) 1999-10-06 1999-10-06 DNA sequencing
PCT/GB2000/003860 WO2001025480A2 (fr) 1999-10-06 2000-10-06 Procede de sequençage de l'adn

Publications (1)

Publication Number Publication Date
IL148678A0 true IL148678A0 (en) 2002-09-12

Family

ID=10862234

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14867800A IL148678A0 (en) 1999-10-06 2000-10-06 Dna sequencing method
IL148678A IL148678A (en) 1999-10-06 2002-03-13 A method for sequencing DNA sequences

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148678A IL148678A (en) 1999-10-06 2002-03-13 A method for sequencing DNA sequences

Country Status (20)

Country Link
US (4) US20050214849A1 (fr)
EP (1) EP1226271B1 (fr)
JP (2) JP5030249B2 (fr)
KR (1) KR100809171B1 (fr)
CN (1) CN1159457C (fr)
AT (1) ATE388242T1 (fr)
AU (1) AU769102B2 (fr)
BR (1) BR0014468A (fr)
CA (1) CA2386115C (fr)
DE (1) DE60038244T2 (fr)
DK (1) DK1226271T3 (fr)
EA (1) EA006702B1 (fr)
ES (1) ES2302497T3 (fr)
GB (1) GB9923644D0 (fr)
IL (2) IL148678A0 (fr)
IS (1) IS6333A (fr)
MX (1) MXPA02003534A (fr)
NZ (1) NZ517775A (fr)
PT (1) PT1226271E (fr)
WO (1) WO2001025480A2 (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001511358A (ja) * 1997-07-28 2001-08-14 メディカル・バイオシステムズ・リミテッド 核酸配列の解析
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9907812D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Sequencing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
EP1681356B1 (fr) 1999-05-19 2011-10-19 Cornell Research Foundation, Inc. Procédé de séquenage d'acides nucléiques
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
GB9923644D0 (en) 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
ATE377093T1 (de) 2000-07-07 2007-11-15 Visigen Biotechnologies Inc Sequenzbestimmung in echtzeit
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
SE0201655D0 (sv) * 2002-05-31 2002-05-31 Amersham Biosciences Ab A method of electrophoresis
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
CA2513899C (fr) 2003-01-29 2013-03-26 454 Corporation Procede d'amplification et de sequencage d'acides nucleiques
CA2532220A1 (fr) * 2003-07-15 2005-01-27 Daniel Henry Densham Mesure d'une reaction d'amplification de polynucleotide
GB0317343D0 (en) * 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005080605A2 (fr) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Procedes et kits pour analyser des sequences de polynucleotides
US7635562B2 (en) 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
CA2579150C (fr) 2004-09-17 2014-11-25 Pacific Biosciences Of California, Inc. Appareil et procede d'analyse de molecules
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
CA2648149A1 (fr) * 2006-03-31 2007-11-01 Solexa, Inc. Systemes et procedes pour analyse de sequencage par synthese
GB0721340D0 (en) * 2007-10-30 2007-12-12 Isis Innovation Polymerase-based single-molecule DNA sequencing
EP4230747A3 (fr) 2008-03-28 2023-11-15 Pacific Biosciences Of California, Inc. Compositions et procédés de séquençage d'acide nucléique
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US20110294116A1 (en) * 2008-12-11 2011-12-01 The Regents of the Unicersity of California Methods and systems for direct sequencing of single dna molecules
US8911972B2 (en) 2009-12-16 2014-12-16 Pacific Biosciences Of California, Inc. Sequencing methods using enzyme conformation
WO2011159942A1 (fr) 2010-06-18 2011-12-22 Illumina, Inc. Sondes conformationnelles et procédés de séquençage d'acides nucléiques
GB2503604B (en) 2011-03-21 2020-04-22 Biodesy Llc Classification of kinase inhibitors using second harmonic optical techniques
DE102013202721A1 (de) * 2013-02-20 2014-08-21 Siemens Aktiengesellschaft Sequenziervorrichtung zum Sequenzieren mindestens eines Nukleinsäureeinzelstrangs und Verfahren zum Sequenzieren mindestens eines Nukleinsäureeinzelstrangs
GB201306444D0 (en) * 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
CN113913505A (zh) 2014-07-15 2022-01-11 亿明达股份有限公司 生物化学激活的电子装置
WO2016106286A1 (fr) 2014-12-23 2016-06-30 Biodesy, Inc. Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire
US10077470B2 (en) 2015-07-21 2018-09-18 Omniome, Inc. Nucleic acid sequencing methods and systems
EP3449012B1 (fr) 2016-04-29 2020-12-23 Omniome, Inc. Procédé de séquençage faisant appel à la déstabilisation d'un complexe ternaire pour identifier des nucléotides apparentés
US10428378B2 (en) 2016-08-15 2019-10-01 Omniome, Inc. Sequencing method for rapid identification and processing of cognate nucleotide pairs
EP3497236B1 (fr) 2016-08-15 2021-11-03 Omniome, Inc. Procédé de séquençage d'acides nucléiques
EP3562962B1 (fr) 2016-12-30 2022-01-05 Omniome, Inc. Procédé et système utilisant des polymérases pouvant être distinguées pour détecter des complexes ternaires et identifier des nucléotides parents
WO2018136487A1 (fr) 2017-01-20 2018-07-26 Omniome, Inc. Procédé de détection de nucléotides apparentés dans un flux de travaux de séquençage d'acides nucléiques
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
WO2019055867A1 (fr) * 2017-09-15 2019-03-21 Illumina, Inc. Système de détection de séquence
EP3697932A1 (fr) 2017-10-19 2020-08-26 Omniome, Inc. Réduction du bruit de fond et stabilisation de complexes simultanées dans des flux de travaux de dosage par liaison
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
US10344328B2 (en) 2017-11-17 2019-07-09 Ultima Genomics, Inc. Methods for biological sample processing and analysis
US12239980B2 (en) 2018-12-07 2025-03-04 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US10512911B1 (en) * 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US10900078B2 (en) 2019-03-14 2021-01-26 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method
CN116287109A (zh) * 2022-09-29 2023-06-23 清华大学 一种测量单分子rna力谱的方法及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
GB8910880D0 (en) * 1989-05-11 1989-06-28 Amersham Int Plc Sequencing method
WO1991006678A1 (fr) 1989-10-26 1991-05-16 Sri International Sequençage d'adn
US5583026A (en) * 1994-08-31 1996-12-10 Cornell Research Foundation, Inc. Process for reconstituting the polymerase III* and other subassemblies of E. coli DNA polymerase III holoenzyme from peptide subunits
GB9208733D0 (en) 1992-04-22 1992-06-10 Medical Res Council Dna sequencing method
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
CA2158642A1 (fr) 1993-03-19 1994-09-29 Hubert Koster Sequencage de l'adn par spectrometrie de masse, via la degradation de l'exonuclease
WO1995006138A1 (fr) * 1993-08-25 1995-03-02 The Regents Of The University Of California Procede microscopique pour la detection de micro-mouvements
US5747247A (en) * 1994-07-25 1998-05-05 The Regents Of The University Of California Spectroscopic helicase assay
US5801042A (en) * 1994-08-18 1998-09-01 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
WO1998035012A2 (fr) * 1997-02-12 1998-08-13 Chan Eugene Y Procedes et produits permettant d'analyser des polymeres
CA2282418A1 (fr) * 1997-03-05 1998-09-11 Scriptgen Pharmaceuticals, Inc. Selection par anisotropie a fluorescence pour identifier des composes presentant une affinite avec des acides nucleiques
US6159687A (en) * 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
JP2001511358A (ja) 1997-07-28 2001-08-14 メディカル・バイオシステムズ・リミテッド 核酸配列の解析
US7875440B2 (en) * 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US6210896B1 (en) * 1998-08-13 2001-04-03 Us Genomics Molecular motors
WO2000009757A1 (fr) 1998-08-13 2000-02-24 U.S. Genomics, Inc. Polymeres caracterises optiquement
WO2000053805A1 (fr) * 1999-03-10 2000-09-14 Asm Scientific, Inc. Procede de sequençage direct d'acides nucleiques
GB9907812D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Sequencing
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6335420B1 (en) 1999-11-22 2002-01-01 Ibc Advanced Technologies, Inc. Polyamide ligand-containing polymeric resins and methods of using the same for removing, separating and/or concentrating desired metal ions from solutions
GB9923644D0 (en) * 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
US6908736B1 (en) * 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
GB0112238D0 (en) 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB0317343D0 (en) 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
GB0413082D0 (en) 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US20100301398A1 (en) * 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) * 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8574835B2 (en) * 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) * 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions

Also Published As

Publication number Publication date
ES2302497T3 (es) 2008-07-16
US7939264B1 (en) 2011-05-10
WO2001025480A3 (fr) 2002-05-16
AU7546700A (en) 2001-05-10
CN1391615A (zh) 2003-01-15
IL148678A (en) 2008-12-29
US20110177520A1 (en) 2011-07-21
JP2003511043A (ja) 2003-03-25
IS6333A (is) 2002-04-05
KR100809171B1 (ko) 2008-02-29
PT1226271E (pt) 2008-05-23
EA200200428A1 (ru) 2002-10-31
ATE388242T1 (de) 2008-03-15
KR20020059444A (ko) 2002-07-12
BR0014468A (pt) 2002-08-20
DK1226271T3 (da) 2008-07-07
WO2001025480A2 (fr) 2001-04-12
CA2386115C (fr) 2010-06-15
EA006702B1 (ru) 2006-02-24
CN1159457C (zh) 2004-07-28
AU769102B2 (en) 2004-01-15
JP5030249B2 (ja) 2012-09-19
DE60038244D1 (de) 2008-04-17
CA2386115A1 (fr) 2001-04-12
EP1226271B1 (fr) 2008-03-05
MXPA02003534A (es) 2004-09-10
DE60038244T2 (de) 2009-04-23
GB9923644D0 (en) 1999-12-08
US20050214849A1 (en) 2005-09-29
NZ517775A (en) 2004-01-30
HK1045857A1 (en) 2002-12-13
US20120214164A1 (en) 2012-08-23
EP1226271A2 (fr) 2002-07-31
JP2012196201A (ja) 2012-10-18

Similar Documents

Publication Publication Date Title
GB9923644D0 (en) DNA sequencing
IL158743A0 (en) Polynucleotide sequencing method
TW200720441A (en) New labelling strategies for the sensitive detection of analytes
DE602004018776D1 (de) Verfahren zum nachweis von alkyliertem cytosin in dna
WO2001029261A3 (fr) Procede d"etablissement de profils d"expression de genes d"un jeu ordonne de micro-echantillons haute densite
MXPA02001307A (es) Deteccion de micro-organismos.
WO2000060114A3 (fr) Sequencage de polynucleotide par helicase
WO2004022785A3 (fr) Outil d'identification pour zones d'hydrocarbures
IL132966A0 (en) Method and system for detecting oligonucleotides in a sample
WO2004057016A3 (fr) Methodes de capture, de detection et de quantification d'hybrides d'arn/adn et rnase h modifiee utile dans lesdites methodes
WO2005031004A3 (fr) Procede de detection specifique rapide de micro-organismes nocifs pour les boissons
DE60130970D1 (de) Reagenziensatz zur detektion von mikroorganismen, vorrichtung zur quantifizierungvon mikroorganismen und verfahren zur quantifizierung von mikroorganismen
WO2002103043A3 (fr) Procede pour la mise en evidence rapide specifique de bacteries a effet nefaste sur la biere
WO2004000995A3 (fr) Procedes, sondes et molecules accessoires permettant de detecter des polymorphismes nucleotidiques uniques
DE50106653D1 (de) In situ-hybridisierungs-anordnung zum spezifischen nachweis von mikroorganismen
WO2004009843A3 (fr) Detection de micro-organismes
ES2189459T3 (es) Deteccion de resistencias a antibioticos en microorganismos.
ATE440964T1 (de) Verfahren zur detektion von polynukleotidkinase und deren verwendung als markierung
WO2001007649A3 (fr) Procede de detection de micro-organismes
WO2001062953A3 (fr) Procede electrochimique de detection d'acides nucleiques
WO2004104550A3 (fr) Detection rapide et specifique enterobacter sakazakii
AU2001226785A1 (en) Method, kit and dna probes for detecting a fungal species in clinical material
MXPA05009253A (es) Metodo para la deteccion de microorganismos en un proceso de electrodeposicion.
GB0223655D0 (en) Method of diagnosis
AU2002328823A1 (en) Detection of microbiological contaminants in samples of non-living material