IL149306A0 - Benzamidine derivatives and pharmaceutical compositions containing the same - Google Patents

Benzamidine derivatives and pharmaceutical compositions containing the same

Info

Publication number: IL149306A0
Authority: IL; Israel
Prior art keywords: group; optionally substituted; hydrogen atom; alkyl group; halogen atom
Prior art date: 1999-10-28

Application number

IL14930600A

Other languages

English (en)

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-28

Filing date

2000-10-25

Publication date

2002-11-10

2000-10-25 Application filed by Sankyo Co filed Critical Sankyo Co

2002-11-10 Publication of IL149306A0 publication Critical patent/IL149306A0/xx

Links

150000003937 benzamidines Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
108010074860 Factor Xa Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
208000015294 blood coagulation disease Diseases 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Manufacture Of Alloys Or Alloy Compounds (AREA)

IL14930600A 1999-10-28 2000-10-25 Benzamidine derivatives and pharmaceutical compositions containing the same IL149306A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP30719299		1999-10-28
PCT/JP2000/007469 WO2001030756A1 (en)	1999-10-28	2000-10-25	Benzamidine derivatives

Publications (1)

Publication Number	Publication Date
IL149306A0 true IL149306A0 (en)	2002-11-10

Family

ID=17966162

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14930600A IL149306A0 (en)	1999-10-28	2000-10-25	Benzamidine derivatives and pharmaceutical compositions containing the same
IL149306A IL149306A (en)	1999-10-28	2002-04-23	History of benzamidine and pharmaceutical preparations containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL149306A IL149306A (en)	1999-10-28	2002-04-23	History of benzamidine and pharmaceutical preparations containing them

Country Status (26)

Country	Link
US (3)	US6555556B1 (cs)
EP (1)	EP1245564B1 (cs)
KR (1)	KR100642953B1 (cs)
CN (2)	CN1293052C (cs)
AT (1)	ATE322479T1 (cs)
AU (1)	AU776193B2 (cs)
BR (1)	BR0015120A (cs)
CA (1)	CA2389156C (cs)
CY (1)	CY1106116T1 (cs)
CZ (1)	CZ20021432A3 (cs)
DE (1)	DE60027204T2 (cs)
DK (1)	DK1245564T3 (cs)
ES (1)	ES2261248T3 (cs)
HK (1)	HK1047431B (cs)
HU (1)	HUP0203161A3 (cs)
IL (2)	IL149306A0 (cs)
MX (1)	MXPA02004218A (cs)
NO (1)	NO323147B1 (cs)
NZ (1)	NZ518581A (cs)
PL (1)	PL354619A1 (cs)
PT (1)	PT1245564E (cs)
RU (1)	RU2222529C2 (cs)
TR (1)	TR200201654T2 (cs)
TW (1)	TWI226886B (cs)
WO (1)	WO2001030756A1 (cs)
ZA (1)	ZA200203278B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60027204T2 (de) *	1999-10-28	2006-11-23	Sankyo Co., Ltd.	Benzamidinderivate
RU2256652C1 (ru) *	2001-04-05	2005-07-20	Санкио Компани, Лимитед	Соединение, фармацевтическая композиция, применение, способ предупреждения или лечения заболеваний
WO2002089803A1 (fr) *	2001-05-07	2002-11-14	Sankyo Company, Limited	Composition d'ionophorese
US7256215B2 (en)	2002-03-15	2007-08-14	Kissei Pharmaceutical Co., Ltd.	Crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative
PT1701722E (pt) *	2004-11-23	2009-12-10	Dong Wha Pharm Co Ltd	Sal do ácido n-hidroxi-4-{5-[4-(5-isopropil-2-metil-1,3-tiazol- 4-il)fenoxi]pentoxi}benzamidina-2-metanossulfónico
CN103159620A (zh) *	2013-03-28	2013-06-19	广西师范大学	一种2-羟基间苯二甲酸的制备方法
US20260001891A1 (en)	2022-11-22	2026-01-01	Keymed Biosciences (Chengdu) Co., Ltd.	Fused ring compound, conjugate thereof and use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57209270A (en) *	1981-06-19	1982-12-22	Chugai Pharmaceut Co Ltd	Proline derivative
ZA928276B (en)	1991-10-31	1993-05-06	Daiichi Seiyaku Co	Aromatic amidine derivates and salts thereof.
US5731324A (en) *	1993-07-22	1998-03-24	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
ZA951617B (en) *	1994-03-04	1997-02-27	Lilly Co Eli	Antithrombotic agents.
NZ296210A (en)	1994-12-02	1998-05-27	Yamanouchi Pharma Co Ltd	Amidinonaphthyl derivatives to inhibit activated blood coagulation factor x
DE4443390A1 (de) *	1994-12-06	1996-06-13	Basf Ag	Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
CA2241904C (en) *	1996-01-02	2004-12-21	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
ES2188979T3 (es) *	1996-09-12	2003-07-01	Schering Ag	Derivados de benzamidina sustituidos con derivados de aminoacidos ciclicos e hidroxiacidos ciclicos, y su uso como anti-coagulantes.
TW542822B (en) *	1997-01-17	2003-07-21	Ajinomoto Kk	Benzamidine derivatives
JP2003522733A (ja) *	1999-02-11	2003-07-29	コアセラピューティクス，インコーポレイティド	Ｘａ因子の阻害剤としてのアルケニルおよびアルキニル化合物
US6350761B1 (en) *	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
DE60027204T2 (de) *	1999-10-28	2006-11-23	Sankyo Co., Ltd.	Benzamidinderivate

2000
- 2000-10-25 DE DE60027204T patent/DE60027204T2/de not_active Expired - Lifetime
- 2000-10-25 DK DK00970070T patent/DK1245564T3/da active
- 2000-10-25 AU AU79574/00A patent/AU776193B2/en not_active Ceased
- 2000-10-25 CN CNB008178003A patent/CN1293052C/zh not_active Expired - Fee Related
- 2000-10-25 MX MXPA02004218A patent/MXPA02004218A/es active IP Right Grant
- 2000-10-25 CN CNA2004100634713A patent/CN1572882A/zh active Pending
- 2000-10-25 HU HU0203161A patent/HUP0203161A3/hu unknown
- 2000-10-25 ES ES00970070T patent/ES2261248T3/es not_active Expired - Lifetime
- 2000-10-25 PT PT00970070T patent/PT1245564E/pt unknown
- 2000-10-25 HK HK02108844.9A patent/HK1047431B/en not_active IP Right Cessation
- 2000-10-25 CZ CZ20021432A patent/CZ20021432A3/cs unknown
- 2000-10-25 RU RU2002111343/04A patent/RU2222529C2/ru not_active IP Right Cessation
- 2000-10-25 CA CA002389156A patent/CA2389156C/en not_active Expired - Fee Related
- 2000-10-25 PL PL00354619A patent/PL354619A1/xx unknown
- 2000-10-25 WO PCT/JP2000/007469 patent/WO2001030756A1/ja not_active Ceased
- 2000-10-25 BR BR0015120-3A patent/BR0015120A/pt not_active Application Discontinuation
- 2000-10-25 AT AT00970070T patent/ATE322479T1/de not_active IP Right Cessation
- 2000-10-25 IL IL14930600A patent/IL149306A0/xx active IP Right Grant
- 2000-10-25 TR TR2002/01654T patent/TR200201654T2/xx unknown
- 2000-10-25 EP EP00970070A patent/EP1245564B1/en not_active Expired - Lifetime
- 2000-10-25 NZ NZ518581A patent/NZ518581A/en unknown
- 2000-10-25 KR KR1020027005382A patent/KR100642953B1/ko not_active Expired - Fee Related
- 2000-10-27 TW TW089122706A patent/TWI226886B/zh not_active IP Right Cessation
2002
- 2002-04-23 IL IL149306A patent/IL149306A/en not_active IP Right Cessation
- 2002-04-24 ZA ZA200203278A patent/ZA200203278B/en unknown
- 2002-04-25 US US10/132,042 patent/US6555556B1/en not_active Expired - Fee Related
- 2002-04-26 NO NO20021990A patent/NO323147B1/no not_active IP Right Cessation
- 2002-11-06 US US10/288,838 patent/US20040010009A1/en not_active Abandoned
2003
- 2003-11-07 US US10/704,355 patent/US20040248981A1/en not_active Abandoned
2006
- 2006-07-04 CY CY20061100927T patent/CY1106116T1/el unknown

Also Published As

Publication number	Publication date
US20040010009A1 (en)	2004-01-15
TR200201654T2 (tr)	2002-12-23
DE60027204D1 (en)	2006-05-18
NZ518581A (en)	2004-11-26
ATE322479T1 (de)	2006-04-15
MXPA02004218A (es)	2002-10-17
HK1047431B (en)	2006-07-14
DK1245564T3 (da)	2006-08-14
HUP0203161A3 (en)	2003-12-29
HK1047431A1 (en)	2003-02-21
BR0015120A (pt)	2002-06-25
NO20021990D0 (no)	2002-04-26
US20040248981A1 (en)	2004-12-09
HUP0203161A2 (hu)	2002-12-28
NO323147B1 (no)	2007-01-08
CA2389156C (en)	2009-05-12
CZ20021432A3 (cs)	2002-10-16
KR20020092347A (ko)	2002-12-11
KR100642953B1 (ko)	2006-11-10
RU2222529C2 (ru)	2004-01-27
TWI226886B (en)	2005-01-21
ZA200203278B (en)	2003-08-26
DE60027204T2 (de)	2006-11-23
CY1106116T1 (el)	2011-06-08
EP1245564B1 (en)	2006-04-05
IL149306A (en)	2007-07-04
EP1245564A4 (en)	2003-03-05
AU776193B2 (en)	2004-09-02
PT1245564E (pt)	2006-06-30
CN1572882A (zh)	2005-02-02
ES2261248T3 (es)	2006-11-16
US6555556B1 (en)	2003-04-29
WO2001030756A1 (en)	2001-05-03
AU7957400A (en)	2001-05-08
CN1293052C (zh)	2007-01-03
EP1245564A1 (en)	2002-10-02
CN1413189A (zh)	2003-04-23
NO20021990L (no)	2002-06-25
PL354619A1 (en)	2004-02-09
CA2389156A1 (en)	2001-05-03

Legal Events

Date	Code	Title	Description
2007-12-03	FF	Patent granted
2008-02-10	KB	Patent renewed

Publication	Publication Date	Title
WO2002081448A1 (en)	2002-10-17	Benzamidine derivative
HU9500240D0 (en)	1995-03-28	New prolin-amide derivatives and pharmaceutical compositions containing them as active component
PT1029853E (pt)	2004-05-31	Derivados biciclicos heteroaromaticos uteis como agentes anticancerigenos
WO2001064642A3 (en)	2002-05-02	Benzamides and related inhibitors of factor xa
WO2000071510A3 (en)	2001-08-30	INHIBITORS OF FACTOR Xa
EP0795548A4 (en)	1998-09-02	CHINAZOZINE DERIVATIVES AND THEIR USE
WO1999020606A3 (en)	1999-07-29	Piperidines and piperazines as platelet aggregation inhibitors
DK0976748T3 (da)	2004-03-22	Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
MXPA03008215A (es)	2004-01-29	Inhibidores de integrina alfa v beta 6.
WO2000047554A3 (en)	2001-08-09	INHIBITORS OF FACTOR Xa
NO20015172L (no)	2002-01-23	1-metyl-erytromycin-derivater
NO20052683L (no)	2005-06-03	Nye pyridopyrimidinonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
ES2087038A1 (es)	1996-07-01	Nuevas piperidinas con actividad antagonista del paf.
NO20060147L (no)	2006-03-07	Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
NO20052182L (no)	2005-05-03	Nye forbindelser
GB9502644D0 (en)	1995-03-29	Heterocyclic derivatives
HK1053833A1 (zh)	2003-11-07	取代苯基法呢基转移酶抑制剂
EP1142881A4 (en)	2003-05-07	POLY (ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES
DK0733051T3 (da)	2000-04-03	Bicykliske, heterocykliske forbindelser som neurokinin A-antagonister
NO20060146L (no)	2006-03-07	Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
DE60027204D1 (en)	2006-05-18	Benzamidinderivate
NO20022123L (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
WO2002006280A3 (en)	2003-07-17	INHIBITORS OF FACTOR Xa
EP1130018A4 (en)	2003-01-15	DRUGS FOR DRUG ADDICTION