IL149486A0 - Purine derivatives and pharmaceutical compositions containing the same - Google Patents

Purine derivatives and pharmaceutical compositions containing the same

Info

Publication number: IL149486A0
Authority: IL; Israel
Prior art keywords: same; pharmaceutical compositions; compositions containing; purine derivatives; disorders
Prior art date: 1999-11-12

Application number

IL14948600A

Other languages

English (en)

Original Assignee

Biogen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-12

Filing date

2000-11-13

Publication date

2002-11-10

2000-11-13 Application filed by Biogen Inc filed Critical Biogen Inc

2002-11-10 Publication of IL149486A0 publication Critical patent/IL149486A0/xx

Links

229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
108010060263 Adenosine A1 Receptor Proteins 0.000 abstract 1
102000030814 Adenosine A1 receptor Human genes 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
239000002598 adenosine A1 receptor antagonist Substances 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL14948600A 1999-11-12 2000-11-13 Purine derivatives and pharmaceutical compositions containing the same IL149486A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16528399P	1999-11-12	1999-11-12
PCT/US2000/031100 WO2001034604A2 (en)	1999-11-12	2000-11-13	Adenosine receptor antagonists and methods of making and using the same

Publications (1)

Publication Number	Publication Date
IL149486A0 true IL149486A0 (en)	2002-11-10

Family

ID=22598257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14948600A IL149486A0 (en)	1999-11-12	2000-11-13	Purine derivatives and pharmaceutical compositions containing the same

Country Status (33)

Country	Link
US (4)	US6605600B1 (de)
EP (2)	EP1230241B1 (de)
JP (1)	JP2003513976A (de)
KR (1)	KR100845488B1 (de)
CN (1)	CN1187354C (de)
AT (1)	ATE353328T1 (de)
AU (1)	AU784528B2 (de)
BG (1)	BG106693A (de)
BR (1)	BR0015540A (de)
CA (1)	CA2390590C (de)
CY (1)	CY1106560T1 (de)
CZ (1)	CZ20021615A3 (de)
DE (1)	DE60033310T2 (de)
DK (1)	DK1230241T3 (de)
EA (1)	EA010260B1 (de)
EE (1)	EE200200248A (de)
ES (1)	ES2281367T3 (de)
GE (1)	GEP20043267B (de)
HK (1)	HK1049153B (de)
HU (1)	HUP0203371A3 (de)
IL (1)	IL149486A0 (de)
IS (1)	IS6380A (de)
MX (1)	MXPA02004795A (de)
NO (1)	NO20022237L (de)
NZ (2)	NZ519427A (de)
PL (1)	PL198156B1 (de)
PT (1)	PT1230241E (de)
SK (1)	SK6622002A3 (de)
TR (1)	TR200301062T2 (de)
UA (1)	UA77937C2 (de)
WO (1)	WO2001034604A2 (de)
YU (1)	YU33702A (de)
ZA (1)	ZA200203702B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI229674B (en)	1998-12-04	2005-03-21	Astra Pharma Prod	Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
HUP0203371A3 (en) *	1999-11-12	2005-02-28	Biogen Idec Ma Inc Cambridge	Adenosine receptor antagonists and methods of making and using the same
CN100390178C (zh) *	1999-11-12	2008-05-28	拜奥根Idec马萨诸塞公司	作为腺苷受体拮抗剂的多环烷基嘌呤
EP1513848A4 (de) *	2002-06-12	2005-11-09	Biogen Idec Inc	Verfahren zur behandlung von ischämie-reperfusionsverletzungen mit adenosinrezeptorantagonisten
AU2003261206A1 (en) *	2002-07-19	2004-02-09	Aryx Therapeutics	Xanthine derivatives having adenosine a1-receptor antagonist properties
US20040229901A1 (en) *	2003-02-24	2004-11-18	Lauren Otsuki	Method of treatment of disease using an adenosine A1 receptor antagonist
EP1615894A2 (de) *	2003-04-14	2006-01-18	Pfizer Products Inc.	3-azabizyklo(3.2.1)oktanderivate
CA2522971A1 (en)	2003-04-25	2004-11-11	Novacardia, Inc.	Method of improved diuresis in individuals with impaired renal function
US7247639B2 (en) *	2003-06-06	2007-07-24	Endacea, Inc.	A1 adenosine receptor antagonists
CA2644996A1 (en) *	2006-03-02	2007-09-13	Cv Therapeutics, Inc.	A2a adenosine receptor antagonists
CA2648281A1 (en) *	2006-04-06	2007-10-18	Novacardia, Inc.	Co-administration of adenosine a1 receptor antagonists and anticonvulsants
PL2018380T3 (pl)	2006-05-19	2012-05-31	Abbvie Bahamas Ltd	Skondensowane azabicykliczne pochodne alkanowe podstawione bicykloheterocyklem o aktywności wobec OUN
CN101466383A (zh) *	2006-06-16	2009-06-24	美国诺华卡迪亚公司	包含低频率投与aa1ra的肾功能延长改善
WO2008121882A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Improved methods of administration of adenosine a1 receptor antagonists
WO2008121893A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20090228097A1 (en) *	2008-03-07	2009-09-10	Abbott Cardiovascular Systems Inc.	A1 Adenosine Receptor Antagonist-Coated Implantable Medical Device
CN114790164B (zh)	2021-08-13	2022-12-27	苏州璞正医药有限公司	一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3155664A (en) *	1959-11-13	1964-11-03	Endo Lab	Derivatives of theophylline
DE8817122U1 (de)	1988-12-22	1993-02-04	Boehringer Ingelheim Kg, 55218 Ingelheim	Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
US5290782A (en)	1989-09-01	1994-03-01	Kyowa Hakko Kogyo Co., Ltd.	Xanthine derivatives
JPH06102662B2 (ja) *	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
DE69033614T2 (de)	1989-10-20	2001-04-19	Kyowa Hakko Kogyo K.K., Tokio/Tokyo	Kondensierte Purinderivate
DE4019892A1 (de) *	1990-06-22	1992-01-02	Boehringer Ingelheim Kg	Neue xanthinderivate
CA2061544A1 (en)	1991-02-25	1992-08-26	Fumio Suzuki	Xanthine compounds
ATE180482T1 (de)	1991-11-08	1999-06-15	Kyowa Hakko Kogyo Kk	Xanthinderivate zur behandlung der demenz
US5336769A (en)	1992-02-17	1994-08-09	Kyowa Hakko Kogyo Co., Ltd.	Xanthine derivatives
US5342841A (en)	1992-03-12	1994-08-30	Kyowa Hakko Kogyo Co., Ltd.	Xanthine derivatives
TW252044B (de)	1992-08-10	1995-07-21	Boehringer Ingelheim Kg
WO1994016702A1 (fr)	1993-01-26	1994-08-04	Kyowa Hakko Kogyo Co., Ltd.	Medicament contre l'elimination irreguliere des matieres fecales
JP3729874B2 (ja) *	1993-04-07	2005-12-21	協和醗酵工業株式会社	キサンチン誘導体
US5395836A (en)	1993-04-07	1995-03-07	Kyowa Hakko Kogyo Co., Ltd.	8-tricycloalkyl xanthine derivatives
US5446046A (en) *	1993-10-28	1995-08-29	University Of Florida Research Foundation	A1 adenosine receptor agonists and antagonists as diuretics
WO1998057644A1 (en)	1997-06-16	1998-12-23	Kyowa Hakko Kogyo Co., Ltd.	Preventive and remedy for drug-induced nephropathy
WO1998057645A1 (en)	1997-06-16	1998-12-23	Kyowa Hakko Kogyo Co., Ltd.	Hepatic edema remedy
DE19816857A1 (de) *	1998-04-16	1999-10-21	Boehringer Ingelheim Pharma	Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0955301A3 (de) *	1998-04-27	2001-04-18	Pfizer Products Inc.	7-Aza-bicyclo[2.2.1]-heptan Derivate, deren Herstellung und Verwendung aufgrund ihrer Affinität für neuronale nikotinische Acetylcholin Rezeptoren
EP1092435B1 (de)	1998-07-02	2007-04-04	Kyowa Hakko Kogyo Co., Ltd.	Antidiabetische medikamente
CN100390178C (zh) *	1999-11-12	2008-05-28	拜奥根Idec马萨诸塞公司	作为腺苷受体拮抗剂的多环烷基嘌呤
HUP0203371A3 (en) *	1999-11-12	2005-02-28	Biogen Idec Ma Inc Cambridge	Adenosine receptor antagonists and methods of making and using the same

2000
- 2000-11-13 HU HU0203371A patent/HUP0203371A3/hu unknown
- 2000-11-13 KR KR1020027006022A patent/KR100845488B1/ko not_active Expired - Fee Related
- 2000-11-13 DE DE60033310T patent/DE60033310T2/de not_active Expired - Lifetime
- 2000-11-13 NZ NZ519427A patent/NZ519427A/en not_active IP Right Cessation
- 2000-11-13 EA EA200200562A patent/EA010260B1/ru not_active IP Right Cessation
- 2000-11-13 AU AU20421/01A patent/AU784528B2/en not_active Ceased
- 2000-11-13 AT AT00983698T patent/ATE353328T1/de active
- 2000-11-13 HK HK02109300.4A patent/HK1049153B/en not_active IP Right Cessation
- 2000-11-13 CN CNB008161984A patent/CN1187354C/zh not_active Expired - Fee Related
- 2000-11-13 UA UA2002064854A patent/UA77937C2/uk unknown
- 2000-11-13 PT PT00983698T patent/PT1230241E/pt unknown
- 2000-11-13 TR TR2003/01062T patent/TR200301062T2/xx unknown
- 2000-11-13 GE GEAP20006495A patent/GEP20043267B/en unknown
- 2000-11-13 MX MXPA02004795A patent/MXPA02004795A/es active IP Right Grant
- 2000-11-13 JP JP2001536551A patent/JP2003513976A/ja active Pending
- 2000-11-13 CZ CZ20021615A patent/CZ20021615A3/cs unknown
- 2000-11-13 WO PCT/US2000/031100 patent/WO2001034604A2/en not_active Ceased
- 2000-11-13 CA CA2390590A patent/CA2390590C/en not_active Expired - Fee Related
- 2000-11-13 EP EP00983698A patent/EP1230241B1/de not_active Expired - Lifetime
- 2000-11-13 PL PL356044A patent/PL198156B1/pl not_active IP Right Cessation
- 2000-11-13 ES ES00983698T patent/ES2281367T3/es not_active Expired - Lifetime
- 2000-11-13 BR BR0015540-3A patent/BR0015540A/pt not_active Application Discontinuation
- 2000-11-13 SK SK662-2002A patent/SK6622002A3/sk unknown
- 2000-11-13 IL IL14948600A patent/IL149486A0/xx unknown
- 2000-11-13 DK DK00983698T patent/DK1230241T3/da active
- 2000-11-13 EE EEP200200248A patent/EE200200248A/xx unknown
- 2000-11-13 YU YU33702A patent/YU33702A/sh unknown
- 2000-11-13 EP EP06026675A patent/EP1775297A3/de not_active Withdrawn
- 2000-11-13 US US09/711,554 patent/US6605600B1/en not_active Expired - Fee Related
2002
- 2002-05-09 ZA ZA200203702A patent/ZA200203702B/xx unknown
- 2002-05-10 IS IS6380A patent/IS6380A/is unknown
- 2002-05-10 NO NO20022237A patent/NO20022237L/no not_active Application Discontinuation
- 2002-05-13 BG BG106693A patent/BG106693A/bg unknown
2003
- 2003-06-12 US US10/461,534 patent/US20030225038A1/en not_active Abandoned
- 2003-09-01 NZ NZ527918A patent/NZ527918A/en not_active IP Right Cessation
2005
- 2005-05-13 US US11/128,550 patent/US20050222179A1/en not_active Abandoned
2007
- 2007-05-04 CY CY20071100590T patent/CY1106560T1/el unknown
- 2007-07-27 US US11/829,269 patent/US20080004293A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA02004795A (es)	2005-07-01
EE200200248A (et)	2003-06-16
SK6622002A3 (en)	2003-02-04
UA77937C2 (en)	2007-02-15
YU33702A (sh)	2005-03-15
NZ527918A (en)	2005-05-27
WO2001034604A3 (en)	2002-01-10
CN1399636A (zh)	2003-02-26
AU2042101A (en)	2001-06-06
US6605600B1 (en)	2003-08-12
DE60033310D1 (de)	2007-03-22
HK1049153B (en)	2007-09-28
PT1230241E (pt)	2007-05-31
PL356044A1 (en)	2004-06-14
CY1106560T1 (el)	2012-01-25
JP2003513976A (ja)	2003-04-15
NO20022237L (no)	2002-07-12
HUP0203371A2 (hu)	2003-02-28
BR0015540A (pt)	2002-07-23
CN1187354C (zh)	2005-02-02
NZ519427A (en)	2003-08-29
CA2390590A1 (en)	2001-05-17
CA2390590C (en)	2010-03-16
DE60033310T2 (de)	2007-11-22
EP1775297A2 (de)	2007-04-18
KR20020049043A (ko)	2002-06-24
WO2001034604A2 (en)	2001-05-17
NO20022237D0 (no)	2002-05-10
TR200301062T2 (tr)	2003-09-22
KR100845488B1 (ko)	2008-07-10
EP1775297A3 (de)	2008-12-03
HK1049153A1 (en)	2003-05-02
ZA200203702B (en)	2003-10-29
DK1230241T3 (da)	2007-06-04
HUP0203371A3 (en)	2005-02-28
AU784528B2 (en)	2006-04-27
PL198156B1 (pl)	2008-05-30
EA010260B1 (ru)	2008-06-30
EA200200562A1 (ru)	2002-10-31
GEP20043267B (en)	2004-06-25
US20080004293A1 (en)	2008-01-03
CZ20021615A3 (cs)	2002-08-14
IS6380A (is)	2002-05-10
US20050222179A1 (en)	2005-10-06
EP1230241A2 (de)	2002-08-14
BG106693A (bg)	2003-01-31
ES2281367T3 (es)	2007-10-01
US20030225038A1 (en)	2003-12-04
ATE353328T1 (de)	2007-02-15
EP1230241B1 (de)	2007-02-07

Publication	Publication Date	Title
IL149487A0 (en)	2002-11-10	Polycycloalkylpurine derivatives and pharmaceutical compositions containing the same
IL149486A0 (en)	2002-11-10	Purine derivatives and pharmaceutical compositions containing the same
WO1999002502A3 (en)	1999-06-03	Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
IL127244A (en)	2005-11-20	Substituted amines, methods of their preparation and pharmaceutical compositions containing them
CA2415966A1 (en)	2002-01-24	Tetrahydro-heterocycloazepinyl pyrimidine derivatives
UA27748C2 (uk)	2000-10-16	Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція
HUT61022A (en)	1992-11-30	Process for producing 8-substituted purine derivatives functioning as selective adenosine receptor, as well as pharmaceutical compositions comprising same as active ingredient
WO2003048164A3 (en)	2003-10-16	Adenosine a2a receptor antagonists
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