IL150329A0 - 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity - Google Patents

2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Info

Publication number
IL150329A0
IL150329A0 IL15032900A IL15032900A IL150329A0 IL 150329 A0 IL150329 A0 IL 150329A0 IL 15032900 A IL15032900 A IL 15032900A IL 15032900 A IL15032900 A IL 15032900A IL 150329 A0 IL150329 A0 IL 150329A0
Authority
IL
Israel
Prior art keywords
acetamides
indol
oxo
antitumor activity
colon
Prior art date
Application number
IL15032900A
Other languages
English (en)
Original Assignee
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma Spa filed Critical Novuspharma Spa
Publication of IL150329A0 publication Critical patent/IL150329A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15032900A 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity IL150329A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI002693A IT1315267B1 (it) 1999-12-23 1999-12-23 Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en) 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (1)

Publication Number Publication Date
IL150329A0 true IL150329A0 (en) 2002-12-01

Family

ID=11384182

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15032900A IL150329A0 (en) 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity
IL150329A IL150329A (en) 1999-12-23 2002-06-19 H1) - 2 - Indole – 3 – Eyal) - 2 - Oxo - acetamides with antisertic activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL150329A IL150329A (en) 1999-12-23 2002-06-19 H1) - 2 - Indole – 3 – Eyal) - 2 - Oxo - acetamides with antisertic activity

Country Status (24)

Country Link
US (1) US6753342B2 (de)
EP (1) EP1244652B1 (de)
JP (1) JP2003519140A (de)
KR (1) KR100795533B1 (de)
CN (1) CN1250542C (de)
AT (1) ATE302772T1 (de)
AU (1) AU776332B2 (de)
BR (1) BR0016553A (de)
CA (1) CA2395205A1 (de)
CZ (1) CZ20022170A3 (de)
DE (1) DE60022227T2 (de)
EA (1) EA004925B1 (de)
ES (1) ES2246918T3 (de)
HU (1) HUP0203524A3 (de)
IL (2) IL150329A0 (de)
IT (1) IT1315267B1 (de)
MX (1) MXPA02006217A (de)
NO (1) NO323312B1 (de)
NZ (1) NZ519689A (de)
PL (1) PL356541A1 (de)
SK (1) SK285682B6 (de)
TR (1) TR200201613T2 (de)
WO (1) WO2001047916A1 (de)
ZA (1) ZA200204964B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL198983B1 (pl) 1998-04-28 2008-08-29 Elbion Ag Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania
IT1318641B1 (it) * 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EA013371B1 (ru) * 2002-07-09 2010-04-30 Фасджен, Ллс. Новые соединения, содержащие их фармацевтические композиции и способы их применения
WO2005023761A2 (en) 2003-09-11 2005-03-17 Kemia, Inc. Cytokine inhibitors
JP4861976B2 (ja) * 2004-03-11 2012-01-25 アクテリオン ファーマシューティカルズ リミテッド インドール−１−イル酢酸誘導体
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
NZ571803A (en) 2006-04-07 2011-12-22 Vertex Pharma Amide indole derivatives as modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
SG176477A1 (en) * 2006-08-07 2011-12-29 Ironwood Pharmaceuticals Inc Indole compounds
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2608474T3 (es) 2010-04-22 2017-04-11 Vertex Pharmaceuticals Incorporated Proceso de producción de compuestos indol cycloalkylcarboxamido
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2012135027A2 (en) * 2011-03-25 2012-10-04 The Research Foundation Of State University Of New York Thiolactone antibiotics
WO2014014841A1 (en) 2012-07-16 2014-01-23 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
ES2885181T3 (es) 2014-04-15 2021-12-13 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
CN115785079B (zh) * 2022-11-28 2024-02-13 沈阳药科大学 4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0841924B1 (de) * 1995-08-02 2002-10-02 Newcastle University Ventures Limited Benzimidazol verbindungen
CO4970714A1 (es) 1997-09-05 2000-11-07 Boehringer Mannheim Gmbh Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
PL198983B1 (pl) * 1998-04-28 2008-08-29 Elbion Ag Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania

Also Published As

Publication number Publication date
TR200201613T2 (tr) 2002-10-21
IT1315267B1 (it) 2003-02-03
NO323312B1 (no) 2007-03-12
BR0016553A (pt) 2002-09-17
KR20020063247A (ko) 2002-08-01
ITMI992693A0 (it) 1999-12-23
EP1244652B1 (de) 2005-08-24
US20030158153A1 (en) 2003-08-21
ITMI992693A1 (it) 2001-06-23
JP2003519140A (ja) 2003-06-17
EP1244652A1 (de) 2002-10-02
AU2170401A (en) 2001-07-09
NO20022976L (no) 2002-06-20
SK285682B6 (sk) 2007-06-07
CA2395205A1 (en) 2001-07-05
MXPA02006217A (es) 2004-02-26
US6753342B2 (en) 2004-06-22
ZA200204964B (en) 2004-01-29
CN1250542C (zh) 2006-04-12
ATE302772T1 (de) 2005-09-15
DE60022227T2 (de) 2006-06-22
DE60022227D1 (de) 2005-09-29
WO2001047916A1 (en) 2001-07-05
IL150329A (en) 2006-07-05
HUP0203524A3 (en) 2008-01-28
NZ519689A (en) 2004-02-27
CZ20022170A3 (cs) 2002-09-11
HUP0203524A2 (hu) 2003-03-28
PL356541A1 (en) 2004-06-28
EA200200558A1 (ru) 2002-12-26
CN1413205A (zh) 2003-04-23
EA004925B1 (ru) 2004-10-28
SK8962002A3 (en) 2002-11-06
ES2246918T3 (es) 2006-03-01
KR100795533B1 (ko) 2008-01-16
AU776332B2 (en) 2004-09-02
NO20022976D0 (no) 2002-06-20

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Legal Events

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