IL150329A0 - 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity - Google Patents

2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Info

Publication number: IL150329A0
Authority: IL; Israel
Prior art keywords: acetamides; indol; oxo; antitumor activity; colon
Prior art date: 1999-12-23

Application number

IL15032900A

Other languages

English (en)

Original Assignee

Novuspharma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2000-12-21

Publication date

2002-12-01

2000-12-21 Application filed by Novuspharma Spa filed Critical Novuspharma Spa

2002-12-01 Publication of IL150329A0 publication Critical patent/IL150329A0/xx

Links

AWMLDBKLOPNOAR-UHFFFAOYSA-N 2-(1h-indol-3-yl)-2-oxoacetamide Chemical class C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
208000037841 lung tumor Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

IL15032900A 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity IL150329A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI002693A IT1315267B1 (it)	1999-12-23	1999-12-23	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en)	1999-12-23	2000-12-21	2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (1)

Publication Number	Publication Date
IL150329A0 true IL150329A0 (en)	2002-12-01

Family

ID=11384182

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15032900A IL150329A0 (en)	1999-12-23	2000-12-21	2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity
IL150329A IL150329A (en)	1999-12-23	2002-06-19	H1) - 2 - Indole – 3 – Eyal) - 2 - Oxo - acetamides with antisertic activity

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL150329A IL150329A (en)	1999-12-23	2002-06-19	H1) - 2 - Indole – 3 – Eyal) - 2 - Oxo - acetamides with antisertic activity

Country Status (24)

Country	Link
US (1)	US6753342B2 (de)
EP (1)	EP1244652B1 (de)
JP (1)	JP2003519140A (de)
KR (1)	KR100795533B1 (de)
CN (1)	CN1250542C (de)
AT (1)	ATE302772T1 (de)
AU (1)	AU776332B2 (de)
BR (1)	BR0016553A (de)
CA (1)	CA2395205A1 (de)
CZ (1)	CZ20022170A3 (de)
DE (1)	DE60022227T2 (de)
EA (1)	EA004925B1 (de)
ES (1)	ES2246918T3 (de)
HU (1)	HUP0203524A3 (de)
IL (2)	IL150329A0 (de)
IT (1)	IT1315267B1 (de)
MX (1)	MXPA02006217A (de)
NO (1)	NO323312B1 (de)
NZ (1)	NZ519689A (de)
PL (1)	PL356541A1 (de)
SK (1)	SK285682B6 (de)
TR (1)	TR200201613T2 (de)
WO (1)	WO2001047916A1 (de)
ZA (1)	ZA200204964B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1076657T3 (da)	1998-04-28	2004-11-08	Elbion Ag	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
IT1318641B1 (it)	2000-07-25	2003-08-27	Novuspharma Spa	Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de)	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
US7649012B2 (en) *	2002-07-09	2010-01-19	Fasgen, Inc.	Compounds, pharmaceutical compositions containing same, and methods of use for same
SG146624A1 (en)	2003-09-11	2008-10-30	Kemia Inc	Cytokine inhibitors
RU2376286C2 (ru) *	2004-03-11	2009-12-20	Актелион Фармасьютиклз Лтд	Производные индол-1-илуксусной кислоты
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
JP5420395B2 (ja)	2006-04-07	2014-02-19	バーテックスファーマシューティカルズインコーポレイテッド	Ａｔｐ結合カセット輸送体の調節剤
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
WO2008019357A2 (en) *	2006-08-07	2008-02-14	Ironwood Pharmaceuticals, Inc.	Indole compounds
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2569678C2 (ru)	2010-04-22	2015-11-27	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения циклоалкилкарбоксамидо-индольных соединений
AR084433A1 (es)	2010-12-22	2013-05-15	Ironwood Pharmaceuticals Inc	Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2012135027A2 (en) *	2011-03-25	2012-10-04	The Research Foundation Of State University Of New York	Thiolactone antibiotics
AU2013290444B2 (en)	2012-07-16	2018-04-26	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
PL3925607T5 (pl)	2014-04-15	2026-06-01	Vertex Pharmaceuticals Incorporated	Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN115785079B (zh) *	2022-11-28	2024-02-13	沈阳药科大学	4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0841924T3 (da) *	1995-08-02	2003-02-10	Univ Newcastle Ventures Ltd	Benzimidazolforbindelser
CO4970714A1 (es) *	1997-09-05	2000-11-07	Boehringer Mannheim Gmbh	Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) *	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DK1076657T3 (da) *	1998-04-28	2004-11-08	Elbion Ag	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

1999
- 1999-12-23 IT IT1999MI002693A patent/IT1315267B1/it active
2000
- 2000-12-21 WO PCT/EP2000/013068 patent/WO2001047916A1/en not_active Ceased
- 2000-12-21 TR TR2002/01613T patent/TR200201613T2/xx unknown
- 2000-12-21 CN CNB00817492XA patent/CN1250542C/zh not_active Expired - Fee Related
- 2000-12-21 AU AU21704/01A patent/AU776332B2/en not_active Ceased
- 2000-12-21 MX MXPA02006217A patent/MXPA02006217A/es active IP Right Grant
- 2000-12-21 KR KR1020027007960A patent/KR100795533B1/ko not_active Expired - Fee Related
- 2000-12-21 DE DE60022227T patent/DE60022227T2/de not_active Expired - Fee Related
- 2000-12-21 AT AT00985225T patent/ATE302772T1/de not_active IP Right Cessation
- 2000-12-21 SK SK896-2002A patent/SK285682B6/sk not_active IP Right Cessation
- 2000-12-21 BR BR0016553-0A patent/BR0016553A/pt not_active Application Discontinuation
- 2000-12-21 CZ CZ20022170A patent/CZ20022170A3/cs unknown
- 2000-12-21 HU HU0203524A patent/HUP0203524A3/hu unknown
- 2000-12-21 IL IL15032900A patent/IL150329A0/xx active IP Right Grant
- 2000-12-21 US US10/149,406 patent/US6753342B2/en not_active Expired - Fee Related
- 2000-12-21 JP JP2001549386A patent/JP2003519140A/ja active Pending
- 2000-12-21 PL PL00356541A patent/PL356541A1/xx not_active IP Right Cessation
- 2000-12-21 NZ NZ519689A patent/NZ519689A/en unknown
- 2000-12-21 ES ES00985225T patent/ES2246918T3/es not_active Expired - Lifetime
- 2000-12-21 CA CA002395205A patent/CA2395205A1/en not_active Abandoned
- 2000-12-21 EP EP00985225A patent/EP1244652B1/de not_active Expired - Lifetime
- 2000-12-21 EA EA200200558A patent/EA004925B1/ru not_active IP Right Cessation
2002
- 2002-06-19 IL IL150329A patent/IL150329A/en not_active IP Right Cessation
- 2002-06-20 ZA ZA200204964A patent/ZA200204964B/en unknown
- 2002-06-20 NO NO20022976A patent/NO323312B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
TR200201613T2 (tr)	2002-10-21
MXPA02006217A (es)	2004-02-26
EP1244652B1 (de)	2005-08-24
NO20022976D0 (no)	2002-06-20
IL150329A (en)	2006-07-05
WO2001047916A1 (en)	2001-07-05
CZ20022170A3 (cs)	2002-09-11
US20030158153A1 (en)	2003-08-21
CA2395205A1 (en)	2001-07-05
ES2246918T3 (es)	2006-03-01
CN1413205A (zh)	2003-04-23
ATE302772T1 (de)	2005-09-15
IT1315267B1 (it)	2003-02-03
DE60022227D1 (de)	2005-09-29
HUP0203524A3 (en)	2008-01-28
DE60022227T2 (de)	2006-06-22
SK285682B6 (sk)	2007-06-07
EA200200558A1 (ru)	2002-12-26
KR100795533B1 (ko)	2008-01-16
NO20022976L (no)	2002-06-20
EA004925B1 (ru)	2004-10-28
EP1244652A1 (de)	2002-10-02
ZA200204964B (en)	2004-01-29
BR0016553A (pt)	2002-09-17
HUP0203524A2 (hu)	2003-03-28
JP2003519140A (ja)	2003-06-17
ITMI992693A0 (it)	1999-12-23
PL356541A1 (en)	2004-06-28
ITMI992693A1 (it)	2001-06-23
SK8962002A3 (en)	2002-11-06
CN1250542C (zh)	2006-04-12
AU2170401A (en)	2001-07-09
NO323312B1 (no)	2007-03-12
US6753342B2 (en)	2004-06-22
AU776332B2 (en)	2004-09-02
KR20020063247A (ko)	2002-08-01
NZ519689A (en)	2004-02-27

Legal Events

Date	Code	Title
2006-12-27	FF	Patent granted
2007-02-12	KB	Patent renewed
2007-05-21	KB	Patent renewed

Publication	Publication Date	Title
PL356541A1 (en)	2004-06-28	2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity
DE69918422D1 (de)	2004-08-05	Phthalazinone pde iii/iv hemmer
DE60015927D1 (en)	2004-12-23	Phenylharnstoff und phenylthioharnstoffderivate
TR199901653T2 (xx)	1999-10-21	Fitalazinonlar.
YU19499A (sh)	2001-09-28	Benzonaftiridini kao bronhijalni terapeutici
MXPA02010088A (es)	2004-08-19	Derivados de ecteinascidina antitumorales.
PL338339A1 (en)	2000-10-23	Novel derivatives of tetrazole
MXPA05007296A (es)	2005-09-30	Compuestos de (2-carboxamido)(3-amino)tiofeno.
PL341239A1 (en)	2001-03-26	Dihydrobenzofuranes
YU1302A (sh)	2005-03-15	Derivati aminotiazola i njihova primena kao liganada crf receptora
SI1086096T1 (en)	2003-12-31	Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
DE60005689D1 (de)	2003-11-06	Neue aminobenzophenone
SE9903290D0 (sv)	1999-09-15	Novel compounds
SI1377574T1 (de)	2005-08-31
BG106937A (en)	2003-04-30	Novel indole derivatives
GB9907055D0 (en)	1999-05-19	Antibacterial agents
ZA983231B (en)	1999-10-18	Substituted benzyloxyimino compounds.
BG105247A (en)	2001-11-30	N-substituted azabicycloheptane derivatives, production and use thereof
ES2159489A1 (es)	2001-10-01	Nuevos derivados de imidazol con actividad antiinflamatoria.
ATE243698T1 (de)	2003-07-15	1,2-dihydro-1-oxo-pyrazino(1,2-)indolederivate
ES2166710A1 (es)	2003-12-01	Nuevos compuestos heterociclicos con actividad antiinflamatoria.
PL373989A1 (en)	2005-09-19	Novel benzonaphthyridines
BG105329A (en)	2001-12-29	N-substituted azabicycloheptane derivatives, production and use thereof
MX9706968A (es)	1997-11-29	Compuesto de tiocarbamoilo.
AP2001002047A0 (en)	2001-03-31	Isoquinoliness as urokinase inhibitors.