BR0016553A - 2-(1h-indol-3-il)-2-oxo-acetamidas com atividades antitumor - Google Patents

2-(1h-indol-3-il)-2-oxo-acetamidas com atividades antitumor

Info

Publication number
BR0016553A
BR0016553A BR0016553-0A BR0016553A BR0016553A BR 0016553 A BR0016553 A BR 0016553A BR 0016553 A BR0016553 A BR 0016553A BR 0016553 A BR0016553 A BR 0016553A
Authority
BR
Brazil
Prior art keywords
acetamides
oxo
indol
antitumor activities
antitumor
Prior art date
Application number
BR0016553-0A
Other languages
English (en)
Inventor
Ernesto Menta
Nicoletts Pescalli
Original Assignee
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma Spa filed Critical Novuspharma Spa
Publication of BR0016553A publication Critical patent/BR0016553A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"2-(1H-INDOL-3-IL)-2-OXO-ACETAMIDAS COM ATIVIDADE ANTITUMOR". 2-(1 H-Indoi-3-il)-2-oxo-acetamidas tendo atividade antitumor, em particular contra tumores sólidos, mais precisamente tumores de cólon e de pulmão, da seguinte fórmula (I) em que Y é um átomo de oxigênio ou de enxofre e X, R~ 1~, R~ 2~, R~ 3~, R~ 4~ e R~ 5~ são como definidos na reivindicação 1.
BR0016553-0A 1999-12-23 2000-12-21 2-(1h-indol-3-il)-2-oxo-acetamidas com atividades antitumor BR0016553A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI002693A IT1315267B1 (it) 1999-12-23 1999-12-23 Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en) 1999-12-23 2000-12-21 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (1)

Publication Number Publication Date
BR0016553A true BR0016553A (pt) 2002-09-17

Family

ID=11384182

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016553-0A BR0016553A (pt) 1999-12-23 2000-12-21 2-(1h-indol-3-il)-2-oxo-acetamidas com atividades antitumor

Country Status (24)

Country Link
US (1) US6753342B2 (pt)
EP (1) EP1244652B1 (pt)
JP (1) JP2003519140A (pt)
KR (1) KR100795533B1 (pt)
CN (1) CN1250542C (pt)
AT (1) ATE302772T1 (pt)
AU (1) AU776332B2 (pt)
BR (1) BR0016553A (pt)
CA (1) CA2395205A1 (pt)
CZ (1) CZ20022170A3 (pt)
DE (1) DE60022227T2 (pt)
EA (1) EA004925B1 (pt)
ES (1) ES2246918T3 (pt)
HU (1) HUP0203524A3 (pt)
IL (2) IL150329A0 (pt)
IT (1) IT1315267B1 (pt)
MX (1) MXPA02006217A (pt)
NO (1) NO323312B1 (pt)
NZ (1) NZ519689A (pt)
PL (1) PL356541A1 (pt)
SK (1) SK285682B6 (pt)
TR (1) TR200201613T2 (pt)
WO (1) WO2001047916A1 (pt)
ZA (1) ZA200204964B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200003130T2 (tr) 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
IT1318641B1 (it) * 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP2386551A1 (en) * 2002-07-09 2011-11-16 Fasgen Inc. Novel compounds, pharmaceutical compositions containing same, and methods of use for same
US7749999B2 (en) 2003-09-11 2010-07-06 Itherx Pharmaceuticals, Inc. Alpha-ketoamides and derivatives thereof
CA2558545C (en) 2004-03-11 2012-10-16 Actelion Pharmaceuticals Ltd Indol-1-yl-acetic acid derivatives
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP2674428B1 (en) 2006-04-07 2016-04-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8884020B2 (en) * 2006-08-07 2014-11-11 Ironwood Pharmaceuticals, Inc. Indole compounds
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX353408B (es) 2010-04-22 2018-01-11 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2012135027A2 (en) * 2011-03-25 2012-10-04 The Research Foundation Of State University Of New York Thiolactone antibiotics
AR092857A1 (es) 2012-07-16 2015-05-06 Vertex Pharma Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas
RU2744460C2 (ru) 2014-04-15 2021-03-09 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
CN115785079B (zh) * 2022-11-28 2024-02-13 沈阳药科大学 4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123147A (en) * 1995-08-02 2004-02-19 Univ Newcastle Ventures Ltd Benzamide imidazole - 4 carboxamide and their use
CO4970714A1 (es) * 1997-09-05 2000-11-07 Boehringer Mannheim Gmbh Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler

Also Published As

Publication number Publication date
CZ20022170A3 (cs) 2002-09-11
DE60022227T2 (de) 2006-06-22
MXPA02006217A (es) 2004-02-26
DE60022227D1 (de) 2005-09-29
HUP0203524A3 (en) 2008-01-28
US20030158153A1 (en) 2003-08-21
ATE302772T1 (de) 2005-09-15
EP1244652B1 (en) 2005-08-24
NO323312B1 (no) 2007-03-12
SK285682B6 (sk) 2007-06-07
IT1315267B1 (it) 2003-02-03
NO20022976L (no) 2002-06-20
AU2170401A (en) 2001-07-09
EA004925B1 (ru) 2004-10-28
EP1244652A1 (en) 2002-10-02
AU776332B2 (en) 2004-09-02
ZA200204964B (en) 2004-01-29
HUP0203524A2 (hu) 2003-03-28
JP2003519140A (ja) 2003-06-17
NO20022976D0 (no) 2002-06-20
ITMI992693A1 (it) 2001-06-23
CA2395205A1 (en) 2001-07-05
SK8962002A3 (en) 2002-11-06
TR200201613T2 (tr) 2002-10-21
KR100795533B1 (ko) 2008-01-16
IL150329A (en) 2006-07-05
CN1250542C (zh) 2006-04-12
WO2001047916A1 (en) 2001-07-05
US6753342B2 (en) 2004-06-22
EA200200558A1 (ru) 2002-12-26
CN1413205A (zh) 2003-04-23
KR20020063247A (ko) 2002-08-01
NZ519689A (en) 2004-02-27
ITMI992693A0 (it) 1999-12-23
PL356541A1 (en) 2004-06-28
ES2246918T3 (es) 2006-03-01
IL150329A0 (en) 2002-12-01

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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