IL150406A0 - Dipeptide nitrile cathepsin k inhibitors - Google Patents

Dipeptide nitrile cathepsin k inhibitors

Info

Publication number
IL150406A0
IL150406A0 IL15040601A IL15040601A IL150406A0 IL 150406 A0 IL150406 A0 IL 150406A0 IL 15040601 A IL15040601 A IL 15040601A IL 15040601 A IL15040601 A IL 15040601A IL 150406 A0 IL150406 A0 IL 150406A0
Authority
IL
Israel
Prior art keywords
inhibitors
dipeptide nitrile
nitrile cathepsin
cathepsin
dipeptide
Prior art date
Application number
IL15040601A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL150406A0 publication Critical patent/IL150406A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15040601A 2000-02-10 2001-02-08 Dipeptide nitrile cathepsin k inhibitors IL150406A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0003111.2A GB0003111D0 (en) 2000-02-10 2000-02-10 Organic compounds
PCT/EP2001/001359 WO2001058886A1 (fr) 2000-02-10 2001-02-08 Inhibiteurs de cathepsine nitrile dipeptide k

Publications (1)

Publication Number Publication Date
IL150406A0 true IL150406A0 (en) 2002-12-01

Family

ID=9885359

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15040601A IL150406A0 (en) 2000-02-10 2001-02-08 Dipeptide nitrile cathepsin k inhibitors

Country Status (30)

Country Link
US (4) US6642239B2 (fr)
EP (1) EP1254124B1 (fr)
JP (1) JP3942895B2 (fr)
KR (1) KR100544553B1 (fr)
CN (2) CN1636980A (fr)
AR (1) AR029466A1 (fr)
AT (1) ATE402930T1 (fr)
AU (1) AU764334B2 (fr)
BR (1) BR0108118A (fr)
CA (1) CA2396158C (fr)
CO (1) CO5261578A1 (fr)
CZ (1) CZ20022721A3 (fr)
DE (1) DE60135087D1 (fr)
ES (1) ES2310177T3 (fr)
GB (1) GB0003111D0 (fr)
HU (1) HUP0300148A3 (fr)
IL (1) IL150406A0 (fr)
MX (1) MXPA02007768A (fr)
MY (1) MY122826A (fr)
NO (1) NO20023780L (fr)
NZ (1) NZ519940A (fr)
PE (1) PE20020220A1 (fr)
PL (1) PL200119B1 (fr)
PT (1) PT1254124E (fr)
RU (2) RU2265601C2 (fr)
SK (1) SK11462002A3 (fr)
TR (1) TR200201752T2 (fr)
TW (1) TWI258473B (fr)
WO (1) WO2001058886A1 (fr)
ZA (1) ZA200206218B (fr)

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GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
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MXPA04004450A (es) 2001-11-14 2004-08-11 Aventis Pharma Inc Nuevos compuestos y composiciones como inhibidores de catepsina s.
CN100430052C (zh) * 2002-03-05 2008-11-05 默克弗罗斯特加拿大有限公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
WO2004052921A1 (fr) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Derives de cyanomethyle en tant qu'inhibiteurs de la protease a cysteine
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CA2532948A1 (fr) * 2003-07-21 2005-02-17 Novartis Ag Combinaisons d'un inhibiteur de cathepsine k et d'un bisphophonate utilisees dans le traitement des metastases osseuses, de la croissance des tumeurs et de la perte osseuse induite par une tumeur
CA2545723A1 (fr) * 2003-11-19 2005-06-02 Novartis Ag Utilisation d'inhibiteurs de cathepsine k dans des maladies de la perte osseuse severe
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GB0614044D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614053D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
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BRPI0702541A2 (pt) 2007-06-21 2009-02-10 Petroleo Brasileiro Sa processo de craqueamento catalÍtico para produÇço de diesel a partir de sementes de oleaginosas
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WO2009076490A1 (fr) * 2007-12-12 2009-06-18 Velcura Therapeutics, Inc. Utilisation d'antagonistes de la cathepsine l dans le traitement de maladie des os
EP2240491B1 (fr) 2008-01-09 2015-07-15 Amura Therapeutics Limited DÉRIVÉS DE TÉTRAHYDROFURO(2,3-b)PYRROL-3-ONE COMME INHIBITEURS DE CYSTÉINE PROTÉINASES
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US9593138B2 (en) 2012-10-05 2017-03-14 Wayne State University Nitrile-containing enzyme inhibitors and ruthenium complexes thereof
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WO2014199644A1 (fr) 2013-06-14 2014-12-18 生化学工業株式会社 DÉRIVÉ α-OXOACYL AMINO-CAPROLACTAM

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JP2001139320A (ja) * 1999-11-05 2001-05-22 Asahi Glass Co Ltd 球状シリカゲルの製造方法
ES2270898T3 (es) * 1999-12-24 2007-04-16 F. Hoffmann-La Roche Ag Derivados de nitrilo como inhibidores de catepsina k.
DE60132975T2 (de) * 2000-01-06 2009-02-26 Merck Frosst Canada Inc., Kirkland Neue substanzen und verbindungen als protease-inhibitoren
GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
US20050267129A1 (en) 2005-12-01
CN1183122C (zh) 2005-01-05
HK1050197A1 (en) 2003-06-13
NZ519940A (en) 2004-02-27
RU2293732C2 (ru) 2007-02-20
CN1636980A (zh) 2005-07-13
ES2310177T3 (es) 2009-01-01
US20010016207A1 (en) 2001-08-23
US6642239B2 (en) 2003-11-04
RU2265601C2 (ru) 2005-12-10
KR100544553B1 (ko) 2006-01-24
TR200201752T2 (tr) 2002-10-21
KR20020072310A (ko) 2002-09-14
BR0108118A (pt) 2003-02-25
ZA200206218B (en) 2003-08-05
US20070191392A1 (en) 2007-08-16
PT1254124E (pt) 2008-11-03
RU2002123350A (ru) 2004-01-10
WO2001058886A1 (fr) 2001-08-16
NO20023780D0 (no) 2002-08-09
US20030203919A1 (en) 2003-10-30
CO5261578A1 (es) 2003-03-31
SK11462002A3 (sk) 2003-01-09
CZ20022721A3 (cs) 2002-11-13
PE20020220A1 (es) 2002-03-25
ATE402930T1 (de) 2008-08-15
DE60135087D1 (de) 2008-09-11
AR029466A1 (es) 2003-07-02
JP3942895B2 (ja) 2007-07-11
CA2396158C (fr) 2010-02-02
JP2003522764A (ja) 2003-07-29
HUP0300148A2 (en) 2003-05-28
AU764334B2 (en) 2003-08-14
RU2005108133A (ru) 2006-09-10
PL357901A1 (en) 2004-07-26
TWI258473B (en) 2006-07-21
NO20023780L (no) 2002-08-09
MXPA02007768A (es) 2002-10-11
HUP0300148A3 (en) 2005-04-28
EP1254124A1 (fr) 2002-11-06
EP1254124B1 (fr) 2008-07-30
AU4642601A (en) 2001-08-20
MY122826A (en) 2006-05-31
GB0003111D0 (en) 2000-03-29
CA2396158A1 (fr) 2001-08-16
PL200119B1 (pl) 2008-12-31
CN1398260A (zh) 2003-02-19

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