IL150897A0 - Process for the preparation of acetyl-amidiniophenylalanyl cyclohexylglycyl-pyridinioalaninamides - Google Patents

Process for the preparation of acetyl-amidiniophenylalanyl cyclohexylglycyl-pyridinioalaninamides

Info

Publication number
IL150897A0
IL150897A0 IL15089701A IL15089701A IL150897A0 IL 150897 A0 IL150897 A0 IL 150897A0 IL 15089701 A IL15089701 A IL 15089701A IL 15089701 A IL15089701 A IL 15089701A IL 150897 A0 IL150897 A0 IL 150897A0
Authority
IL
Israel
Prior art keywords
pyridinioalaninamides
amidiniophenylalanyl
cyclohexylglycyl
acetyl
preparation
Prior art date
Application number
IL15089701A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL150897A0 publication Critical patent/IL150897A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL15089701A 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl cyclohexylglycyl-pyridinioalaninamides IL150897A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en) 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (1)

Publication Number Publication Date
IL150897A0 true IL150897A0 (en) 2003-02-12

Family

ID=7628946

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15089701A IL150897A0 (en) 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl cyclohexylglycyl-pyridinioalaninamides
IL150897A IL150897A (en) 2000-01-28 2002-07-24 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridylalanine

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL150897A IL150897A (en) 2000-01-28 2002-07-24 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridylalanine

Country Status (29)

Country Link
US (2) US20010031858A1 (de)
EP (1) EP1254159B9 (de)
JP (1) JP4778181B2 (de)
KR (1) KR100758141B1 (de)
CN (1) CN1176104C (de)
AR (1) AR027246A1 (de)
AT (1) ATE325810T1 (de)
AU (1) AU779722B2 (de)
BR (1) BR0107804A (de)
CA (1) CA2398497C (de)
CZ (1) CZ20022583A3 (de)
DE (1) DE60119491T2 (de)
DK (1) DK1254159T3 (de)
EE (1) EE200200410A (de)
ES (1) ES2262632T3 (de)
HR (1) HRP20020631A2 (de)
HU (1) HUP0301986A2 (de)
IL (2) IL150897A0 (de)
MX (1) MXPA02006762A (de)
NO (1) NO20023577L (de)
NZ (1) NZ520427A (de)
PL (1) PL356801A1 (de)
PT (1) PT1254159E (de)
RU (1) RU2250212C2 (de)
SK (1) SK10842002A3 (de)
TW (1) TWI236481B (de)
WO (1) WO2001055175A2 (de)
YU (1) YU51202A (de)
ZA (1) ZA200205990B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
CN102984945B (zh) * 2010-04-20 2014-08-20 凯瑞斯德生化(苏州)有限公司 一种环烯基在β位取代的丙氨酸的不对称合成方法
US9000192B2 (en) 2010-11-29 2015-04-07 Takasago International Corporation Catalyst for asymmetric hydrogenation and method for manufacturing optically active carbonyl compound using the same
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用
CN115612702A (zh) * 2022-10-09 2023-01-17 深圳市茵诺圣生物科技有限公司 L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4623717A (en) 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4440679A (en) 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
SK47796A3 (en) * 1993-10-15 1997-03-05 Rhone Poulenc Rorer Pharma Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
HUT76346A (en) * 1994-04-26 1997-08-28 Selectide Corp Factor xa inhibitors
UA48993C2 (uk) * 1995-12-20 2002-09-16 Авентіс Фармасьютікалз, Інк СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub>
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
AU779722B2 (en) 2005-02-10
HUP0301986A2 (hu) 2003-09-29
CZ20022583A3 (cs) 2002-10-16
ES2262632T3 (es) 2006-12-01
JP4778181B2 (ja) 2011-09-21
DK1254159T3 (da) 2006-09-11
DE60119491D1 (de) 2006-06-14
EP1254159A2 (de) 2002-11-06
RU2002123046A (ru) 2004-01-10
PT1254159E (pt) 2006-07-31
DE60119491T2 (de) 2006-11-16
CA2398497A1 (en) 2001-08-02
IL150897A (en) 2008-08-07
WO2001055175A3 (en) 2002-02-21
TWI236481B (en) 2005-07-21
AU4051601A (en) 2001-08-07
EP1254159B9 (de) 2006-06-28
NO20023577D0 (no) 2002-07-26
EE200200410A (et) 2003-12-15
AR027246A1 (es) 2003-03-19
US20010031858A1 (en) 2001-10-18
NZ520427A (en) 2004-02-27
RU2250212C2 (ru) 2005-04-20
HRP20020631A2 (en) 2004-12-31
CA2398497C (en) 2011-04-26
WO2001055175A2 (en) 2001-08-02
MXPA02006762A (es) 2002-10-23
NO20023577L (no) 2002-08-28
YU51202A (sh) 2005-11-28
KR20030019306A (ko) 2003-03-06
BR0107804A (pt) 2002-10-22
CN1176104C (zh) 2004-11-17
CN1396928A (zh) 2003-02-12
JP2003523364A (ja) 2003-08-05
PL356801A1 (en) 2004-07-12
US7084250B2 (en) 2006-08-01
HK1051866A1 (en) 2003-08-22
KR100758141B1 (ko) 2007-09-13
ZA200205990B (en) 2003-04-30
ATE325810T1 (de) 2006-06-15
EP1254159B1 (de) 2006-05-10
SK10842002A3 (sk) 2003-04-01
US20040225109A1 (en) 2004-11-11

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Legal Events

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KB Patent renewed