NO20023577L - Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider - Google Patents

Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider

Info

Publication number: NO20023577L
Authority: NO; Norway
Prior art keywords: pyridinioalanine; amidinophenylalanyl; cyclohexylglycyl; amides; acetyl
Prior art date: 2000-01-28

Application number

NO20023577A

Other languages

English (en)

Norwegian (no)

Other versions

NO20023577D0 (no

Inventor

Gerhard Breipohl

Wolfgang Holla

Heiner Jendralla

Gerhard Beck

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-28

Filing date

2002-07-26

Publication date

2002-08-28

2002-07-26 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2002-07-26 Publication of NO20023577D0 publication Critical patent/NO20023577D0/no

2002-08-28 Publication of NO20023577L publication Critical patent/NO20023577L/no

Links

RIFFXNRHBJPOGV-RDPSFJRHSA-O (2S)-2-[acetyl(carbamimidoyl)amino]-N-[2-[[(2S)-1-amino-1-oxopropan-2-yl]-pyridin-1-ium-1-ylamino]-2-oxoethyl]-N-cyclohexyl-3-phenylpropanamide Chemical class C(C)(=O)N([C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)N([C@@H](C)C(=O)N)[N+]1=CC=CC=C1)C1CCCCC1)C(N)=N RIFFXNRHBJPOGV-RDPSFJRHSA-O 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Public Health (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO20023577A 2000-01-28 2002-07-26 Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider NO20023577L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10003586		2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en)	2000-01-28	2001-01-18	Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (2)

Publication Number	Publication Date
NO20023577D0 NO20023577D0 (no)	2002-07-26
NO20023577L true NO20023577L (no)	2002-08-28

Family

ID=7628946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20023577A NO20023577L (no)	2000-01-28	2002-07-26	Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider

Country Status (29)

Country	Link
US (2)	US20010031858A1 (de)
EP (1)	EP1254159B9 (de)
JP (1)	JP4778181B2 (de)
KR (1)	KR100758141B1 (de)
CN (1)	CN1176104C (de)
AR (1)	AR027246A1 (de)
AT (1)	ATE325810T1 (de)
AU (1)	AU779722B2 (de)
BR (1)	BR0107804A (de)
CA (1)	CA2398497C (de)
CZ (1)	CZ20022583A3 (de)
DE (1)	DE60119491T2 (de)
DK (1)	DK1254159T3 (de)
EE (1)	EE200200410A (de)
ES (1)	ES2262632T3 (de)
HR (1)	HRP20020631A2 (de)
HU (1)	HUP0301986A2 (de)
IL (2)	IL150897A0 (de)
MX (1)	MXPA02006762A (de)
NO (1)	NO20023577L (de)
NZ (1)	NZ520427A (de)
PL (1)	PL356801A1 (de)
PT (1)	PT1254159E (de)
RU (1)	RU2250212C2 (de)
SK (1)	SK10842002A3 (de)
TW (1)	TWI236481B (de)
WO (1)	WO2001055175A2 (de)
YU (1)	YU51202A (de)
ZA (1)	ZA200205990B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH695999A5 (de)	2002-02-28	2006-11-15	Wilex Ag	Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) *	2005-12-07	2007-06-14	Technische Universität München	Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) *	2010-01-27	2012-08-22	宁波武盛化学有限公司	制备n-乙酰基-dl-环己基甘氨酸的方法
CN102984945B (zh) *	2010-04-20	2014-08-20	凯瑞斯德生化(苏州)有限公司	一种环烯基在β位取代的丙氨酸的不对称合成方法
US9000192B2 (en)	2010-11-29	2015-04-07	Takasago International Corporation	Catalyst for asymmetric hydrogenation and method for manufacturing optically active carbonyl compound using the same
CN115068469B (zh) *	2022-07-08	2024-02-27	深圳市小分子新药创新中心有限公司	Tigit抑制剂及其应用
CN115612702A (zh) *	2022-10-09	2023-01-17	深圳市茵诺圣生物科技有限公司	L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2916711A1 (de)	1979-04-25	1980-11-06	Behringwerke Ag	Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4623717A (en)	1980-03-05	1986-11-18	Miles Laboratories, Inc.	Pasteurized therapeutically active protein compositions
US4440679A (en)	1980-03-05	1984-04-03	Cutter Laboratories, Inc.	Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
SK47796A3 (en) *	1993-10-15	1997-03-05	Rhone Poulenc Rorer Pharma	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5849510A (en)	1994-04-26	1998-12-15	Selectide Corporation	Factor Xa inhibitors
HUT76346A (en) *	1994-04-26	1997-08-28	Selectide Corp	Factor xa inhibitors
UA48993C2 (uk) *	1995-12-20	2002-09-16	Авентіс Фармасьютікалз, Інк	СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub>
DE19856443A1 (de)	1998-12-08	2000-06-21	Centeon Pharma Gmbh	Stabilisiertes Antithrombin III-Präparat

2001
- 2001-01-18 PT PT01911497T patent/PT1254159E/pt unknown
- 2001-01-18 AR ARP010100225A patent/AR027246A1/es unknown
- 2001-01-18 RU RU2002123046/04A patent/RU2250212C2/ru not_active IP Right Cessation
- 2001-01-18 EE EEP200200410A patent/EE200200410A/xx unknown
- 2001-01-18 AU AU40516/01A patent/AU779722B2/en not_active Ceased
- 2001-01-18 PL PL01356801A patent/PL356801A1/xx unknown
- 2001-01-18 EP EP01911497A patent/EP1254159B9/de not_active Expired - Lifetime
- 2001-01-18 KR KR1020027009583A patent/KR100758141B1/ko not_active Expired - Fee Related
- 2001-01-18 CZ CZ20022583A patent/CZ20022583A3/cs unknown
- 2001-01-18 YU YU51202A patent/YU51202A/sh unknown
- 2001-01-18 SK SK1084-2002A patent/SK10842002A3/sk unknown
- 2001-01-18 JP JP2001561027A patent/JP4778181B2/ja not_active Expired - Fee Related
- 2001-01-18 HR HRP20020631 patent/HRP20020631A2/hr not_active Application Discontinuation
- 2001-01-18 DK DK01911497T patent/DK1254159T3/da active
- 2001-01-18 ES ES01911497T patent/ES2262632T3/es not_active Expired - Lifetime
- 2001-01-18 AT AT01911497T patent/ATE325810T1/de active
- 2001-01-18 HU HU0301986A patent/HUP0301986A2/hu unknown
- 2001-01-18 MX MXPA02006762A patent/MXPA02006762A/es active IP Right Grant
- 2001-01-18 CN CNB018041523A patent/CN1176104C/zh not_active Expired - Fee Related
- 2001-01-18 CA CA2398497A patent/CA2398497C/en not_active Expired - Fee Related
- 2001-01-18 NZ NZ520427A patent/NZ520427A/en unknown
- 2001-01-18 WO PCT/EP2001/000523 patent/WO2001055175A2/en not_active Ceased
- 2001-01-18 IL IL15089701A patent/IL150897A0/xx active IP Right Grant
- 2001-01-18 BR BR0107804-6A patent/BR0107804A/pt not_active Application Discontinuation
- 2001-01-18 DE DE60119491T patent/DE60119491T2/de not_active Expired - Lifetime
- 2001-01-26 US US09/769,487 patent/US20010031858A1/en not_active Abandoned
- 2001-03-07 TW TW090101207A patent/TWI236481B/zh not_active IP Right Cessation
2002
- 2002-07-24 IL IL150897A patent/IL150897A/en not_active IP Right Cessation
- 2002-07-26 ZA ZA200205990A patent/ZA200205990B/en unknown
- 2002-07-26 NO NO20023577A patent/NO20023577L/no unknown
2004
- 2004-06-17 US US10/869,076 patent/US7084250B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU779722B2 (en)	2005-02-10
HUP0301986A2 (hu)	2003-09-29
CZ20022583A3 (cs)	2002-10-16
ES2262632T3 (es)	2006-12-01
JP4778181B2 (ja)	2011-09-21
DK1254159T3 (da)	2006-09-11
DE60119491D1 (de)	2006-06-14
EP1254159A2 (de)	2002-11-06
RU2002123046A (ru)	2004-01-10
PT1254159E (pt)	2006-07-31
DE60119491T2 (de)	2006-11-16
CA2398497A1 (en)	2001-08-02
IL150897A (en)	2008-08-07
WO2001055175A3 (en)	2002-02-21
TWI236481B (en)	2005-07-21
AU4051601A (en)	2001-08-07
EP1254159B9 (de)	2006-06-28
NO20023577D0 (no)	2002-07-26
EE200200410A (et)	2003-12-15
AR027246A1 (es)	2003-03-19
US20010031858A1 (en)	2001-10-18
NZ520427A (en)	2004-02-27
RU2250212C2 (ru)	2005-04-20
HRP20020631A2 (en)	2004-12-31
CA2398497C (en)	2011-04-26
WO2001055175A2 (en)	2001-08-02
MXPA02006762A (es)	2002-10-23
YU51202A (sh)	2005-11-28
KR20030019306A (ko)	2003-03-06
BR0107804A (pt)	2002-10-22
CN1176104C (zh)	2004-11-17
CN1396928A (zh)	2003-02-12
JP2003523364A (ja)	2003-08-05
IL150897A0 (en)	2003-02-12
PL356801A1 (en)	2004-07-12
US7084250B2 (en)	2006-08-01
HK1051866A1 (en)	2003-08-22
KR100758141B1 (ko)	2007-09-13
ZA200205990B (en)	2003-04-30
ATE325810T1 (de)	2006-06-15
EP1254159B1 (de)	2006-05-10
SK10842002A3 (sk)	2003-04-01
US20040225109A1 (en)	2004-11-11

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