IL150953A0 - A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer - Google Patents

A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer

Info

Publication number: IL150953A0
Authority: IL; Israel
Prior art keywords: camptothecin; cancer; treatment; pyrimidine derivative; composition
Prior art date: 2000-02-28

Application number

IL15095301A

Other languages

English (en)

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-28

Filing date

2001-02-26

Publication date

2003-02-12

2001-02-26 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2003-02-12 Publication of IL150953A0 publication Critical patent/IL150953A0/xx

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 4
150000003230 pyrimidines Chemical class 0.000 title abstract 3
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title abstract 2
229940127093 camptothecin Drugs 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 title abstract 2
GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 abstract 1
GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 abstract 1
229960004117 capecitabine Drugs 0.000 abstract 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical group C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL15095301A 2000-02-28 2001-02-26 A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer IL150953A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US18537800P	2000-02-28	2000-02-28
US20893800P	2000-06-05	2000-06-05
PCT/EP2001/002723 WO2001062235A2 (en)	2000-02-28	2001-02-26	A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer

Publications (1)

Publication Number	Publication Date
IL150953A0 true IL150953A0 (en)	2003-02-12

Family

ID=26881090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15095301A IL150953A0 (en)	2000-02-28	2001-02-26	A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer

Country Status (28)

Country	Link
US (3)	US6503889B2 (no)
EP (1)	EP1278518B1 (no)
JP (1)	JP2003523980A (no)
KR (1)	KR100717916B1 (no)
CN (1)	CN1424912A (no)
AT (1)	ATE344670T1 (no)
AU (1)	AU785467B2 (no)
BR (1)	BR0108728A (no)
CA (1)	CA2401191C (no)
CY (1)	CY1105803T1 (no)
CZ (1)	CZ298259B6 (no)
DE (1)	DE60124387T2 (no)
DK (1)	DK1278518T3 (no)
EA (1)	EA005619B1 (no)
EE (1)	EE200200471A (no)
ES (1)	ES2273841T3 (no)
HR (1)	HRP20020658A2 (no)
HU (1)	HUP0300848A3 (no)
IL (1)	IL150953A0 (no)
MX (1)	MXPA02008355A (no)
NO (1)	NO324772B1 (no)
NZ (1)	NZ520593A (no)
PL (1)	PL363110A1 (no)
PT (1)	PT1278518E (no)
SK (1)	SK12242002A3 (no)
TW (1)	TWI239841B (no)
WO (1)	WO2001062235A2 (no)
YU (1)	YU64602A (no)

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GB9808052D0 (en)	1998-04-17	1998-06-17	Secr Defence	Implants for administering substances and methods of producing implants
US20080113025A1 (en) *	1998-11-02	2008-05-15	Elan Pharma International Limited	Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20030092608A1 (en) *	2001-08-21	2003-05-15	Takayuki Kawaguchi	Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
US7026301B2 (en) *	2002-10-17	2006-04-11	New York University	Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
ITMI20030317A1 (it) *	2003-02-21	2004-08-22	Pharmacia Italia Spa	Terapia combinata comprendente un derivato dell'indolopirrolocarbazolo ed un altro agente antitumorale.
US20050153885A1 (en) *	2003-10-08	2005-07-14	Yun Anthony J.	Treatment of conditions through modulation of the autonomic nervous system
HRP20080598T3 (en) *	2003-11-13	2009-01-31	Pharma Mar	Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
TWI351284B (en)	2004-04-09	2011-11-01	Chugai Pharmaceutical Co Ltd	Novel water-soluble prodrugs
MXPA06013902A (es) *	2004-05-28	2007-01-26	Pfizer Prod Inc	Procedimiento para tratar el crecimiento de celulas anormal.
EP1761281A1 (en) *	2004-06-04	2007-03-14	Pfizer Products Incorporated	Method for treating abnormal cell growth
CA2569139A1 (en) *	2004-06-04	2005-12-22	Smithkline Beecham (Cork) Limited	Lapatinib with letrozole for use in a treatment of breast cancer
US8569277B2 (en)	2004-08-11	2013-10-29	Palo Alto Investors	Methods of treating a subject for a condition
GB2442615A (en) *	2005-04-12	2008-04-09	Elan Pharma Int Ltd	Modified release compositions comprising a fluorocytidine derivative for the treatment of cancer
EA016838B1 (ru) *	2005-06-07	2012-07-30	Йельский Университет	Способы лечения рака и других заболеваний или патологических состояний с применением клевудина (lfmau) и телбивудина (ldt)
TW200744603A (en) *	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
WO2010129545A2 (en)	2009-05-04	2010-11-11	Psivida Us, Inc.	Porous silicon drug-eluting particles
SI2835053T1 (sl) *	2010-03-12	2016-09-30	Genzyme Corporation	Kombinirana terapija za zdravljenje raka dojke
EP2635255B1 (en)	2010-11-01	2019-08-21	EyePoint Pharmaceuticals US, Inc.	Bioerodible silicon-based devices for delivery of therapeutic agents
EP2968571A4 (en)	2013-03-15	2016-09-07	Psivida Inc	BIODEGRADABLE SILICONE BASED COMPOSITIONS FOR THE DELIVERY OF THERAPEUTIC AGENTS
WO2025247281A1 (zh) *	2024-05-28	2025-12-04	上海靶康联耀生物医药科技有限公司	一种药物组合物

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JPS57116074A (en)	1981-01-09	1982-07-19	Yakult Honsha Co Ltd	Novel camptothecin derivative and its preparation
JPS57116015A (en)	1981-01-09	1982-07-19	Yakult Honsha Co Ltd	Antitumor agent
US4399276A (en)	1981-01-09	1983-08-16	Kabushiki Kaisha Yakult Honsha	7-Substituted camptothecin derivatives
US4473692A (en)	1981-09-04	1984-09-25	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
JPS58154582A (ja)	1982-03-10	1983-09-14	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体およびその製造法
JPS595188A (ja)	1982-06-30	1984-01-12	Yakult Honsha Co Ltd	１０−ヒドロキシカンプトテシンの製造法
JPS5951289A (ja)	1982-09-17	1984-03-24	Yakult Honsha Co Ltd	新規な９−置換−カンプトテシン誘導体
JPS6019790A (ja)	1983-07-14	1985-01-31	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
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JPH0615547B2 (ja)	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
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US5552154A (en) *	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
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AU671491B2 (en) *	1992-12-18	1996-08-29	F. Hoffmann-La Roche Ag	N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
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GB9510716D0 (en)	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
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US5670500A (en)	1995-05-31	1997-09-23	Smithkline Beecham Corporation	Water soluble camptothecin analogs
DE69623961T2 (de)	1995-06-21	2003-05-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.), Paris	Camptothecinanaloge, verfahren zur ihrer herstellung, ihre verwendungals arzneimittel und diese enthaltende pharmazeutische zusammenfassungen
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2001
- 2001-02-26 CA CA002401191A patent/CA2401191C/en not_active Expired - Fee Related
- 2001-02-26 HR HRP20020658 patent/HRP20020658A2/hr not_active Application Discontinuation
- 2001-02-26 BR BR0108728-2A patent/BR0108728A/pt not_active Application Discontinuation
- 2001-02-26 KR KR1020027011248A patent/KR100717916B1/ko not_active Expired - Fee Related
- 2001-02-26 CZ CZ20022892A patent/CZ298259B6/cs not_active IP Right Cessation
- 2001-02-26 NZ NZ520593A patent/NZ520593A/en unknown
- 2001-02-26 EP EP01933683A patent/EP1278518B1/en not_active Expired - Lifetime
- 2001-02-26 PL PL01363110A patent/PL363110A1/xx not_active Application Discontinuation
- 2001-02-26 PT PT01933683T patent/PT1278518E/pt unknown
- 2001-02-26 DK DK01933683T patent/DK1278518T3/da active
- 2001-02-26 JP JP2001561302A patent/JP2003523980A/ja not_active Withdrawn
- 2001-02-26 HU HU0300848A patent/HUP0300848A3/hu unknown
- 2001-02-26 MX MXPA02008355A patent/MXPA02008355A/es active IP Right Grant
- 2001-02-26 DE DE60124387T patent/DE60124387T2/de not_active Expired - Fee Related
- 2001-02-26 EA EA200200922A patent/EA005619B1/ru unknown
- 2001-02-26 IL IL15095301A patent/IL150953A0/xx unknown
- 2001-02-26 SK SK1224-2002A patent/SK12242002A3/sk unknown
- 2001-02-26 ES ES01933683T patent/ES2273841T3/es not_active Expired - Lifetime
- 2001-02-26 CN CN01805704A patent/CN1424912A/zh active Pending
- 2001-02-26 YU YU64602A patent/YU64602A/sh unknown
- 2001-02-26 AU AU60111/01A patent/AU785467B2/en not_active Ceased
- 2001-02-26 AT AT01933683T patent/ATE344670T1/de not_active IP Right Cessation
- 2001-02-26 EE EEP200200471A patent/EE200200471A/xx unknown
- 2001-02-26 WO PCT/EP2001/002723 patent/WO2001062235A2/en not_active Ceased
- 2001-02-27 US US09/793,520 patent/US6503889B2/en not_active Expired - Fee Related
- 2001-02-27 TW TW090104504A patent/TWI239841B/zh not_active IP Right Cessation
2002
- 2002-01-02 US US10/032,489 patent/US6664242B2/en not_active Expired - Fee Related
- 2002-08-27 NO NO20024076A patent/NO324772B1/no unknown
- 2002-09-18 US US10/245,500 patent/US20030096789A1/en not_active Abandoned
2006
- 2006-11-24 CY CY20061101699T patent/CY1105803T1/el unknown

Also Published As

Publication number	Publication date
ES2273841T3 (es)	2007-05-16
US6503889B2 (en)	2003-01-07
PT1278518E (pt)	2007-01-31
CA2401191C (en)	2006-05-02
NO324772B1 (no)	2007-12-10
EP1278518A2 (en)	2003-01-29
HUP0300848A3 (en)	2005-03-29
SK12242002A3 (sk)	2003-02-04
US20020091132A1 (en)	2002-07-11
ATE344670T1 (de)	2006-11-15
HRP20020658A2 (en)	2004-12-31
US20020068743A1 (en)	2002-06-06
YU64602A (sh)	2005-06-10
CZ20022892A3 (cs)	2002-11-13
NZ520593A (en)	2004-10-29
EA200200922A1 (ru)	2003-04-24
US20030096789A1 (en)	2003-05-22
JP2003523980A (ja)	2003-08-12
PL363110A1 (en)	2004-11-15
KR100717916B1 (ko)	2007-05-11
HUP0300848A2 (hu)	2003-08-28
EP1278518B1 (en)	2006-11-08
WO2001062235A2 (en)	2001-08-30
AU6011101A (en)	2001-09-03
NO20024076L (no)	2002-08-27
WO2001062235A3 (en)	2002-11-14
EE200200471A (et)	2003-12-15
DK1278518T3 (da)	2007-01-15
US6664242B2 (en)	2003-12-16
TWI239841B (en)	2005-09-21
CZ298259B6 (cs)	2007-08-08
EA005619B1 (ru)	2005-04-28
NO20024076D0 (no)	2002-08-27
AU785467B2 (en)	2007-07-26
CA2401191A1 (en)	2001-08-30
KR20020082856A (ko)	2002-10-31
BR0108728A (pt)	2003-12-30
DE60124387D1 (de)	2006-12-21
CN1424912A (zh)	2003-06-18
MXPA02008355A (es)	2002-12-13
DE60124387T2 (de)	2007-10-11
CY1105803T1 (el)	2011-02-02

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