IL151429A0 - Il-8 receptor antagonists - Google Patents

Il-8 receptor antagonists

Info

Publication number
IL151429A0
IL151429A0 IL15142901A IL15142901A IL151429A0 IL 151429 A0 IL151429 A0 IL 151429A0 IL 15142901 A IL15142901 A IL 15142901A IL 15142901 A IL15142901 A IL 15142901A IL 151429 A0 IL151429 A0 IL 151429A0
Authority
IL
Israel
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Application number
IL15142901A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IL151429A0 publication Critical patent/IL151429A0/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
IL15142901A 2000-03-01 2001-03-01 Il-8 receptor antagonists IL151429A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18618300P 2000-03-01 2000-03-01
PCT/US2001/006564 WO2001064208A1 (fr) 2000-03-01 2001-03-01 Antagonistes du recepteur de l'interleukine-8 (il-8)

Publications (1)

Publication Number Publication Date
IL151429A0 true IL151429A0 (en) 2003-04-10

Family

ID=22683958

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15142901A IL151429A0 (en) 2000-03-01 2001-03-01 Il-8 receptor antagonists

Country Status (28)

Country Link
EP (1) EP1261328B1 (fr)
JP (1) JP2003525242A (fr)
KR (1) KR20020080460A (fr)
CN (1) CN1416339A (fr)
AP (1) AP2002002605A0 (fr)
AR (1) AR033803A1 (fr)
AT (1) ATE299698T1 (fr)
AU (1) AU2001239970A1 (fr)
BG (1) BG107014A (fr)
BR (1) BR0108866A (fr)
CA (1) CA2401659A1 (fr)
CZ (1) CZ20022932A3 (fr)
DE (1) DE60112051T2 (fr)
DZ (1) DZ3309A1 (fr)
EA (1) EA200200933A1 (fr)
ES (1) ES2245976T3 (fr)
HU (1) HUP0300599A3 (fr)
IL (1) IL151429A0 (fr)
MA (1) MA25657A1 (fr)
MX (1) MXPA02008589A (fr)
NO (1) NO20024133L (fr)
OA (1) OA12184A (fr)
PE (1) PE20011190A1 (fr)
PL (1) PL358540A1 (fr)
SK (1) SK12352002A3 (fr)
UY (1) UY26601A1 (fr)
WO (1) WO2001064208A1 (fr)
ZA (1) ZA200206988B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1454204A (zh) * 2000-05-30 2003-11-05 史密丝克莱恩比彻姆公司 Il－8受体拮抗剂
JP2004520412A (ja) * 2001-01-16 2004-07-08 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
WO2002076926A1 (fr) * 2001-02-02 2002-10-03 Schering Corporation Composes de cyclobutene-1,2-diones 3,4-di-substitues en tant qu'antagonistes du recepteur de chimiokines cxc
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
CN1289471C (zh) * 2001-04-16 2006-12-13 先灵公司 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
JP2005505595A (ja) 2001-10-12 2005-02-24 シェーリング　コーポレイション Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
WO2003080053A1 (fr) * 2002-03-18 2003-10-02 Schering Corporation Traitements combines pour maladies induites par la chimiokine
PE20040570A1 (es) * 2002-10-09 2004-08-30 Pharmacopeia Drug Discovery Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina
ES2308299T3 (es) * 2003-12-19 2008-12-01 Schering Corp Tiadiazoles como ligandos de receptores de cxc-y cc-quimioquinas.
TW200530231A (en) * 2003-12-22 2005-09-16 Schering Corp Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
EP1912971A2 (fr) 2005-06-29 2008-04-23 Shering Corporation Oxadiazoles di-substitutees utilisees en tant que ligands des recepteurs des chimiokines cxc
MX2008000367A (es) 2005-06-29 2008-03-07 Schering Corp Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos de receptor de quimiocina en la que dos cisternas son separadas por un solo aminoacido.
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
EP3737366B1 (fr) 2018-01-08 2026-02-25 ChemoCentryx, Inc. Méthodes de traitement du psoriasis pustuleux généralisé avec un antagoniste de ccr6 ou cxcr2
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists

Also Published As

Publication number Publication date
EP1261328A4 (fr) 2003-05-28
OA12184A (en) 2006-05-09
CZ20022932A3 (cs) 2003-05-14
DE60112051T2 (de) 2006-04-27
WO2001064208A1 (fr) 2001-09-07
NO20024133L (no) 2002-10-31
ES2245976T3 (es) 2006-02-01
CA2401659A1 (fr) 2001-09-07
UY26601A1 (es) 2001-08-27
AR033803A1 (es) 2004-01-07
HUP0300599A2 (hu) 2003-07-28
HUP0300599A3 (en) 2003-09-29
MXPA02008589A (es) 2003-02-24
PE20011190A1 (es) 2002-01-06
PL358540A1 (en) 2004-08-09
CN1416339A (zh) 2003-05-07
MA25657A1 (fr) 2002-12-31
BR0108866A (pt) 2004-02-25
EA200200933A1 (ru) 2003-02-27
JP2003525242A (ja) 2003-08-26
DZ3309A1 (en) 2001-09-07
KR20020080460A (ko) 2002-10-23
BG107014A (bg) 2003-05-30
EP1261328B1 (fr) 2005-07-20
ATE299698T1 (de) 2005-08-15
AU2001239970A1 (en) 2001-09-12
DE60112051D1 (de) 2005-08-25
EP1261328A1 (fr) 2002-12-04
SK12352002A3 (sk) 2003-02-04
NO20024133D0 (no) 2002-08-30
AP2002002605A0 (en) 2002-09-30
ZA200206988B (en) 2003-10-16

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