IL157543A0 - Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors - Google Patents

Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors

Info

Publication number
IL157543A0
IL157543A0 IL15754302A IL15754302A IL157543A0 IL 157543 A0 IL157543 A0 IL 157543A0 IL 15754302 A IL15754302 A IL 15754302A IL 15754302 A IL15754302 A IL 15754302A IL 157543 A0 IL157543 A0 IL 157543A0
Authority
IL
Israel
Prior art keywords
cyclopropaheterocycles
reverse transcriptase
transcriptase inhibitors
nucleoside reverse
nucleoside
Prior art date
Application number
IL15754302A
Other languages
English (en)
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of IL157543A0 publication Critical patent/IL157543A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
IL15754302A 2001-03-05 2002-03-04 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors IL157543A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100733A SE0100733D0 (sv) 2001-03-05 2001-03-05 Non-nucleoside reverse transcriptase inhibitors
PCT/EP2002/002328 WO2002070516A2 (en) 2001-03-05 2002-03-04 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
IL157543A0 true IL157543A0 (en) 2004-03-28

Family

ID=20283208

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15754302A IL157543A0 (en) 2001-03-05 2002-03-04 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors
IL157543A IL157543A (en) 2001-03-05 2003-08-21 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157543A IL157543A (en) 2001-03-05 2003-08-21 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors

Country Status (21)

Country Link
US (3) US6716850B2 (de)
EP (1) EP1373261B1 (de)
JP (2) JP4463478B2 (de)
KR (1) KR100884494B1 (de)
CN (2) CN1264839C (de)
AR (1) AR035941A1 (de)
AT (1) ATE508128T1 (de)
AU (1) AU2002308231B2 (de)
BR (1) BR0207886A (de)
CA (1) CA2438524C (de)
DE (1) DE60239924D1 (de)
DK (1) DK1373261T3 (de)
ES (1) ES2364926T3 (de)
IL (2) IL157543A0 (de)
MX (1) MXPA03008040A (de)
MY (1) MY137083A (de)
PL (1) PL207392B1 (de)
RU (1) RU2281284C2 (de)
SE (1) SE0100733D0 (de)
TW (1) TWI228990B (de)
WO (1) WO2002070516A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1534276B1 (de) * 2002-09-05 2008-11-05 Medivir AB Nicht-nucleoside revers-transcriptase inhibitoren
US20050130974A1 (en) * 2003-10-17 2005-06-16 Rigel Pharmaceuticals, Inc. Benzothiazole compositions and their use as ubiquitin ligase inhibitors
SE0400021D0 (sv) * 2004-01-08 2004-01-08 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
JP4762917B2 (ja) * 2004-01-08 2011-08-31 メディヴィル・アクチボラグ 非ヌクレオシド逆転写酵素インヒビター
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
ATE552245T1 (de) 2006-05-15 2012-04-15 Merck Sharp & Dohme Antidiabetische bicyclische verbindungen
US9670203B2 (en) * 2013-06-28 2017-06-06 Beigene, Ltd. Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
US9670231B2 (en) 2013-06-28 2017-06-06 Beigene, Ltd. Fused tricyclic amide compounds as multiple kinase inhibitors
WO2015089842A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis
TWI909513B (zh) 2019-01-25 2025-12-21 英屬開曼群島商百濟神州有限公司 作為ｂ-ｒａｆ激酶二聚體抑制劑之化合物及其製備方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA973885A (en) * 1969-08-22 1975-09-02 Universal Oil Products Company Vinylation of aromatic compounds
US3803175A (en) 1969-08-22 1974-04-09 Universal Oil Prod Co Preparation of coumarin compounds
US4931221A (en) * 1988-12-30 1990-06-05 Ppg Industries, Inc. Photochromic spiropyran compounds
IL102548A (en) 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
CA2115427C (en) * 1991-08-14 2000-05-02 Stanford Salvatore Pelosi Jr. Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
CZ286265B6 (cs) * 1991-08-14 2000-03-15 Procter And Gamble Pharmaceuticals Cyklické sloučeniny močoviny a farmaceutický prostředek, který je obsahuje
CA2168447C (en) * 1993-08-24 2006-07-11 Peter Thomas Lind Compounds and methods for inhibition of hiv and related viruses
BR9906933A (pt) * 1998-01-16 2001-11-27 Medivir Ab Antiviróticos
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
WO1999051613A1 (en) 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US7186736B1 (en) 1999-03-20 2007-03-06 Parker Hughes Institute NNI for treatment of multi-drug resistant HIV
US6207688B1 (en) 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
US6469034B1 (en) 1999-06-23 2002-10-22 Parker Hughes Institute Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase
US6124324A (en) 1999-06-23 2000-09-26 Hughes Institute Thiophene-ethyl thiourea compounds and use

Also Published As

Publication number Publication date
RU2003129513A (ru) 2005-03-20
HK1063784A1 (en) 2005-01-14
MY137083A (en) 2008-12-31
EP1373261B1 (de) 2011-05-04
BR0207886A (pt) 2004-08-17
US6716850B2 (en) 2004-04-06
PL364414A1 (en) 2004-12-13
JP4463478B2 (ja) 2010-05-19
JP2009102436A (ja) 2009-05-14
CA2438524C (en) 2011-11-29
CN101081843A (zh) 2007-12-05
WO2002070516A2 (en) 2002-09-12
US6894177B2 (en) 2005-05-17
IL157543A (en) 2010-11-30
JP2004529112A (ja) 2004-09-24
PL207392B1 (pl) 2010-12-31
ATE508128T1 (de) 2011-05-15
US20030069224A1 (en) 2003-04-10
MXPA03008040A (es) 2004-05-24
KR20030086601A (ko) 2003-11-10
US20030187266A1 (en) 2003-10-02
RU2281284C2 (ru) 2006-08-10
CA2438524A1 (en) 2002-09-12
DK1373261T3 (da) 2011-08-29
US20050240035A1 (en) 2005-10-27
CN1494545A (zh) 2004-05-05
CN101081843B (zh) 2010-10-13
KR100884494B1 (ko) 2009-02-18
AR035941A1 (es) 2004-07-28
ES2364926T3 (es) 2011-09-16
HK1111155A1 (en) 2008-08-01
US7405310B2 (en) 2008-07-29
TWI228990B (en) 2005-03-11
EP1373261A2 (de) 2004-01-02
AU2002308231B2 (en) 2007-05-10
CN1264839C (zh) 2006-07-19
DE60239924D1 (de) 2011-06-16
WO2002070516A3 (en) 2003-02-06
SE0100733D0 (sv) 2001-03-05

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