IL158491A0 - 2-iminopyrrolidine derivatives - Google Patents

2-iminopyrrolidine derivatives

Info

Publication number: IL158491A0
Authority: IL; Israel
Prior art keywords: isoindol; diethoxy; imino; fluoro; tert
Prior art date: 2001-04-19

Application number

IL15849102A

Other languages

English (en)

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-19

Filing date

2002-04-19

Publication date

2004-05-12

2002-04-19 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2004-05-12 Publication of IL158491A0 publication Critical patent/IL158491A0/xx

Links

NJBMZYSKLWQXLJ-UHFFFAOYSA-N 3,4-dihydro-2h-pyrrol-5-amine Chemical class NC1=NCCC1 NJBMZYSKLWQXLJ-UHFFFAOYSA-N 0.000 title abstract 2
JKPOPBAIEHSKDF-UHFFFAOYSA-N 1-(3-tert-butyl-4-methoxy-5-piperazin-1-ylphenyl)-2-(5,6-diethoxy-4-fluoro-3-imino-1h-isoindol-2-yl)ethanone Chemical compound N=C1C=2C(F)=C(OCC)C(OCC)=CC=2CN1CC(=O)C(C=C(C=1OC)C(C)(C)C)=CC=1N1CCNCC1 JKPOPBAIEHSKDF-UHFFFAOYSA-N 0.000 abstract 1
MCSPUQNLRAUDSC-UHFFFAOYSA-N 2-[4-[3-tert-butyl-5-[2-(5,6-diethoxy-4-fluoro-3-imino-1h-isoindol-2-yl)acetyl]-2-methoxyphenyl]piperazin-1-yl]acetic acid Chemical compound N=C1C=2C(F)=C(OCC)C(OCC)=CC=2CN1CC(=O)C(C=C(C=1OC)C(C)(C)C)=CC=1N1CCN(CC(O)=O)CC1 MCSPUQNLRAUDSC-UHFFFAOYSA-N 0.000 abstract 1
QWKAUGRRIXBIPO-UHFFFAOYSA-N Atopaxar Chemical compound N=C1C=2C(F)=C(OCC)C(OCC)=CC=2CN1CC(=O)C(C=C(C=1OC)C(C)(C)C)=CC=1N1CCOCC1 QWKAUGRRIXBIPO-UHFFFAOYSA-N 0.000 abstract 1
MLZNVXAZRKOMGP-UHFFFAOYSA-N ethyl 2-[4-[3-tert-butyl-5-[2-(5,6-diethoxy-4-fluoro-3-imino-1h-isoindol-2-yl)acetyl]-2-methoxyphenyl]piperazin-1-yl]acetate Chemical compound C1CN(CC(=O)OCC)CCN1C1=CC(C(=O)CN2C(C3=C(F)C(OCC)=C(OCC)C=C3C2)=N)=CC(C(C)(C)C)=C1OC MLZNVXAZRKOMGP-UHFFFAOYSA-N 0.000 abstract 1
125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Lubricants (AREA)

IL15849102A 2001-04-19 2002-04-19 2-iminopyrrolidine derivatives IL158491A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001121829		2001-04-19
JP2001269422		2001-09-05
PCT/JP2002/003961 WO2002085855A1 (fr)	2001-04-19	2002-04-19	Derives de 2-iminopyrrolidine

Publications (1)

Publication Number	Publication Date
IL158491A0 true IL158491A0 (en)	2004-05-12

Family

ID=26613890

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15849102A IL158491A0 (en)	2001-04-19	2002-04-19	2-iminopyrrolidine derivatives
IL158491A IL158491A (en)	2001-04-19	2003-10-19	2-iminopyrrolidine derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL158491A IL158491A (en)	2001-04-19	2003-10-19	2-iminopyrrolidine derivatives

Country Status (21)

Country	Link
US (6)	US7476688B2 (fr)
EP (6)	EP1394152A4 (fr)
JP (6)	JP4445201B2 (fr)
KR (2)	KR100749795B1 (fr)
CN (3)	CN1243735C (fr)
AT (3)	ATE534627T1 (fr)
AU (1)	AU2005202135B2 (fr)
BR (1)	BR0208985A (fr)
CA (1)	CA2446924C (fr)
CZ (1)	CZ303865B6 (fr)
DE (2)	DE60231608D1 (fr)
ES (1)	ES2462995T3 (fr)
HU (1)	HUP0400467A3 (fr)
IL (2)	IL158491A0 (fr)
MX (1)	MXPA03009497A (fr)
NO (1)	NO327849B1 (fr)
NZ (1)	NZ528820A (fr)
PL (1)	PL368109A1 (fr)
RU (1)	RU2270192C2 (fr)
WO (4)	WO2002085855A1 (fr)
ZA (1)	ZA200308064B (fr)

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2002
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Publication number	Publication date
KR100749794B1 (ko)	2007-08-17
US20050004197A1 (en)	2005-01-06
US7304083B2 (en)	2007-12-04
JP4464928B2 (ja)	2010-05-19
RU2270192C2 (ru)	2006-02-20
JP2006206595A (ja)	2006-08-10
US20090215795A1 (en)	2009-08-27
JP3795458B2 (ja)	2006-07-12
EP2385039B1 (fr)	2014-03-12
NO20034632L (no)	2003-12-19
HUP0400467A2 (hu)	2005-02-28
ES2462995T3 (es)	2014-05-27
DE60231608D1 (de)	2009-04-30
WO2002085850A1 (fr)	2002-10-31
WO2002085855A1 (fr)	2002-10-31
EP1614680A3 (fr)	2006-02-01
NO20034632D0 (no)	2003-10-16
EP1386912B1 (fr)	2009-03-18
US20050245592A1 (en)	2005-11-03
US7476688B2 (en)	2009-01-13
KR20050059343A (ko)	2005-06-17
JPWO2002085855A1 (ja)	2004-08-12
NZ528820A (en)	2007-01-26
ATE425964T1 (de)	2009-04-15
EP1391456A1 (fr)	2004-02-25
JP2006225393A (ja)	2006-08-31
EP1391451B1 (fr)	2011-11-23
CN1733725A (zh)	2006-02-15
US20040242627A1 (en)	2004-12-02
EP1394152A1 (fr)	2004-03-03
AU2005202135B2 (en)	2007-11-15
BR0208985A (pt)	2004-03-09
JP4445201B2 (ja)	2010-04-07
CN100402499C (zh)	2008-07-16
EP1391451A4 (fr)	2006-02-01
JP4220249B2 (ja)	2009-02-04
JPWO2002085850A1 (ja)	2004-08-12
JPWO2002088092A1 (ja)	2004-08-12
EP1386912A1 (fr)	2004-02-04
CN1503784A (zh)	2004-06-09
IL158491A (en)	2010-12-30
EP1391456B1 (fr)	2009-07-22
HUP0400467A3 (en)	2012-08-28
PL368109A1 (en)	2005-03-21
US20040254376A1 (en)	2004-12-16
CA2446924C (fr)	2011-02-08
EP2385039A1 (fr)	2011-11-09
MXPA03009497A (es)	2004-05-24
US20050004204A1 (en)	2005-01-06
CZ303865B6 (cs)	2013-05-29
ZA200308064B (en)	2005-04-26
EP1391456A4 (fr)	2006-02-01
JPWO2002088094A1 (ja)	2004-08-12
WO2002088094A1 (fr)	2002-11-07
KR20030090764A (ko)	2003-11-28
JP4516922B2 (ja)	2010-08-04
JP4251872B2 (ja)	2009-04-08
KR100749795B1 (ko)	2007-08-17
AU2005202135A1 (en)	2005-06-09
EP1614680B1 (fr)	2011-12-21
CA2446924A1 (fr)	2002-10-31
RU2003133664A (ru)	2005-05-10
DE60233043D1 (de)	2009-09-03
US7244730B2 (en)	2007-07-17
NO327849B1 (no)	2009-10-05
ATE534627T1 (de)	2011-12-15
EP1386912A4 (fr)	2006-02-01
AU2002255269B2 (en)	2007-03-15
ATE538090T1 (de)	2012-01-15
CN1321996C (zh)	2007-06-20
WO2002088092A1 (fr)	2002-11-07
EP1394152A4 (fr)	2005-02-02
CZ20032824A3 (en)	2004-04-14
HK1086269A1 (zh)	2006-09-15
EP1614680A2 (fr)	2006-01-11
CN1243735C (zh)	2006-03-01
CN1754880A (zh)	2006-04-05
EP1391451A1 (fr)	2004-02-25

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