IL159256A0 - Piperidine derivatives useful as modulators of chemokine receptor activity - Google Patents

Piperidine derivatives useful as modulators of chemokine receptor activity

Info

Publication number: IL159256A0
Authority: IL; Israel
Prior art keywords: modulators; chemokine receptor; receptor activity; derivatives useful; piperidine derivatives
Prior art date: 2001-07-02

Application number

IL15925602A

Other languages

English (en)

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-02

Filing date

2002-07-01

Publication date

2004-06-01

2001-07-02 Priority claimed from GB0116179A external-priority patent/GB0116179D0/en

2001-09-25 Priority claimed from GB0123037A external-priority patent/GB0123037D0/en

2002-07-01 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-06-01 Publication of IL159256A0 publication Critical patent/IL159256A0/xx

Links

102000009410 Chemokine receptor Human genes 0.000 title 1
108050000299 Chemokine receptor Proteins 0.000 title 1
150000003053 piperidines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Neurology (AREA)
Immunology (AREA)
Diabetes (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)

IL15925602A 2001-07-02 2002-07-01 Piperidine derivatives useful as modulators of chemokine receptor activity IL159256A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0116179A GB0116179D0 (en)	2001-07-02	2001-07-02	Chemical compounds
GB0123037A GB0123037D0 (en)	2001-09-25	2001-09-25	Chemical compounds
PCT/SE2002/001311 WO2003004487A1 (en)	2001-07-02	2002-07-01	Piperidine derivatives useful as modulators of chemokine receptor activity

Publications (1)

Publication Number	Publication Date
IL159256A0 true IL159256A0 (en)	2004-06-01

Family

ID=26246268

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15925602A IL159256A0 (en)	2001-07-02	2002-07-01	Piperidine derivatives useful as modulators of chemokine receptor activity

Country Status (25)

Country	Link
US (1)	US7307090B2 (ar)
EP (2)	EP1604982A1 (ar)
JP (1)	JP3857270B2 (ar)
KR (1)	KR20040013090A (ar)
CN (1)	CN1545509A (ar)
AR (1)	AR042401A1 (ar)
AT (1)	ATE319703T1 (ar)
BR (1)	BR0210733A (ar)
CA (1)	CA2452597A1 (ar)
CO (1)	CO5540307A2 (ar)
CY (1)	CY1106095T1 (ar)
DE (1)	DE60209736T2 (ar)
DK (1)	DK1404667T3 (ar)
ES (1)	ES2258642T3 (ar)
HU (1)	HUP0401886A2 (ar)
IL (1)	IL159256A0 (ar)
IS (1)	IS7094A (ar)
MX (1)	MXPA03011722A (ar)
NO (1)	NO20035729L (ar)
NZ (1)	NZ530202A (ar)
PL (1)	PL368041A1 (ar)
PT (1)	PT1404667E (ar)
RU (1)	RU2004100839A (ar)
SA (1)	SA02230184B1 (ar)
WO (1)	WO2003004487A1 (ar)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR033517A1 (es) *	2000-04-08	2003-12-26	Astrazeneca Ab	Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0120461D0 (en)	2001-08-22	2001-10-17	Astrazeneca Ab	Novel compounds
GB0122503D0 (en) *	2001-09-18	2001-11-07	Astrazeneca Ab	Chemical compounds
AU2003209204A1 (en) *	2002-01-10	2003-07-30	University Of Washington	Hydrogels formed by non-covalent linkages
AU2003209388A1 (en) *	2002-01-29	2003-09-02	Merck And Co., Inc.	Substituted imidazoles as cannabinoid receptor modulators
SE0200843D0 (sv) *	2002-03-19	2002-03-19	Astrazeneca Ab	Chemical compounds
SE0200844D0 (sv)	2002-03-19	2002-03-19	Astrazeneca Ab	Chemical compounds
WO2003080586A1 (en) *	2002-03-21	2003-10-02	Abbott Laboratories	N-sulfonylurea apoptosis promoters
US7030115B2 (en) *	2002-03-21	2006-04-18	Abbott Laboratories	N-sulfonylurea apoptosis promoters
PE20040167A1 (es)	2002-03-28	2004-05-26	Novartis Ag	Amidas del acido sulfamico
SE0202838D0 (sv) *	2002-09-24	2002-09-24	Astrazeneca Ab	Chemical compounds
US20040192738A1 (en) *	2003-03-18	2004-09-30	Aventis Pharma Deutschland Gmbh	2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it
SE0300957D0 (sv) *	2003-04-01	2003-04-01	Astrazeneca Ab	Chemical compounds
SE0302956D0 (sv) *	2003-11-07	2003-11-07	Astrazeneca Ab	Chemical compounds
SE0400925D0 (sv) *	2004-04-06	2004-04-06	Astrazeneca Ab	Chemical compounds
SE0403003D0 (sv) *	2004-12-09	2004-12-09	Astrazeneca Ab	Chemical compound 1
WO2006071958A1 (en)	2004-12-29	2006-07-06	Millennium Pharmaceuticals, Inc.	Compounds useful as chemokine receptor antagonists
WO2006071875A1 (en) *	2004-12-29	2006-07-06	Millennium Pharmaceuticals, Inc.	Compounds useful as chemokine receptor antagonists
EP1888527A1 (en) *	2005-05-27	2008-02-20	AstraZeneca AB	Piperidines for the treatment of chemokine mediated diseases
TW200722419A (en) *	2005-05-27	2007-06-16	Astrazeneca Ab	Chemical compounds
JP2009501793A (ja)	2005-07-21	2009-01-22	アストラゼネカ・アクチエボラーグ	新規ピペリジン誘導体
US20090143413A1 (en) *	2005-11-29	2009-06-04	Adams Alan D	Thiazole Derivatives as CXCR3 Receptor Modulators
KR20080108422A (ko) *	2006-02-10	2008-12-15	얀센 파마슈티카 엔.브이.	Ｃｘｃｒ3 수용체 길항제로서 피페리딘 유도체
CN101378756A (zh) *	2006-02-10	2009-03-04	詹森药业有限公司	作为cxcr3受体拮抗剂的哌啶衍生物
BRPI0817211A2 (pt)	2007-09-20	2017-05-16	Irm Llc	composto composições como moduladores da atividade de gpr119
EP3623374B1 (en)	2008-12-03	2021-09-08	The Scripps Research Institute	Stem cell cultures
DK3297438T3 (da)	2015-05-21	2022-01-17	Chemocentryx Inc	Ccr2-modulatorer
CA3293051A1 (en)	2017-09-25	2026-03-02	Chemocentryx, Inc.	Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN112105353B (zh)	2018-01-08	2024-04-19	凯莫森特里克斯股份有限公司	Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en)	2018-01-08	2019-09-05	Chemocentryx, Inc.	Methods of treating solid tumors with ccr2 antagonists
TWI730297B (zh) *	2018-02-27	2021-06-11	日商組合化學工業股份有限公司	巰基酚化合物的製造方法及巰基酚化合物的中間體

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1250719A (ar)	1969-03-19	1971-10-20
US4556660A (en)	1982-07-12	1985-12-03	Janssen Pharmaceutica N.V.	N-(Bicyclic heterocyclyl)-4-piperidinamines
DK139684A (da)	1983-04-11	1984-10-12	Janssen Pharmaceutica Nv	N-aryl-alpha-amino-carboxamider
US4634704A (en)	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695575A (en) *	1984-11-13	1987-09-22	Janssen Pharmaceutica, N.V.	4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
US4588722A (en)	1984-01-09	1986-05-13	Janssen Pharmaceutica N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en)	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
TW221996B (ar)	1991-11-14	1994-04-01	Glaxo Group Ltd
GB9319534D0 (en)	1993-09-22	1993-11-10	Boots Co Plc	Therapeutic agents
US5889006A (en) *	1995-02-23	1999-03-30	Schering Corporation	Muscarinic antagonists
IL117149A0 (en)	1995-02-23	1996-06-18	Schering Corp	Muscarinic antagonists
US5696267A (en)	1995-05-02	1997-12-09	Schering Corporation	Substituted oximes, hydrazones and olefins as neurokinin antagonists
AU5966096A (en)	1995-06-09	1997-01-09	Eli Lilly And Company	Methods of treating cold and allergic rhinitis
TW531537B (en) *	1995-12-27	2003-05-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
US5952349A (en) *	1996-07-10	1999-09-14	Schering Corporation	Muscarinic antagonists for treating memory loss
ES2182104T3 (es)	1996-07-10	2003-03-01	Schering Corp	Piperidinas 1,4-disustituidas como antagonistas muscarinicos.
EP0821954A1 (en)	1996-08-01	1998-02-04	Eli Lilly And Company	Method for treating mental retardation
JP3390179B2 (ja)	1996-08-15	2003-03-24	シェーリングコーポレイション	エーテルムスカリン様アンタゴニスト
US5977138A (en) *	1996-08-15	1999-11-02	Schering Corporation	Ether muscarinic antagonists
SK285631B6 (sk)	1996-09-10	2007-05-03	Dr. Karl Thomae Gmbh	Modifikované aminokyseliny, farmaceutický prostriedok s ich obsahom a ich použitie
CA2296314A1 (en)	1997-07-25	1999-02-04	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
TR200002182T2 (tr)	1998-01-27	2000-12-21	Aventis Pharmaceuticals Products Inc.	İkame edilmiş aksozaherosayklil faktör xa inhibitörleri
JP2002501898A (ja)	1998-02-02	2002-01-22	メルクエンドカムパニーインコーポレーテッド	ケモカイン受容体活性の環状アミン調節剤
TWI245763B (en)	1998-04-02	2005-12-21	Janssen Pharmaceutica Nv	Biocidal benzylbiphenyl derivatives
WO1999055674A1 (en)	1998-04-28	1999-11-04	Dainippon Pharmaceutical Co., Ltd.	1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
US6066636A (en) *	1998-06-30	2000-05-23	Schering Corporation	Muscarinic antagonists
EP1091956B1 (en)	1998-06-30	2004-08-04	Schering Corporation	Muscarinic antagonists
GB9919776D0 (en)	1998-08-31	1999-10-27	Zeneca Ltd	Compoujnds
JP2003529531A (ja)	1998-11-25	2003-10-07	アヴェンティスファーマシューティカルズインコーポレイテッド	置換オキソアザへテロシクリルＸａ因子阻害剤
US6331545B1 (en) *	1998-12-18	2001-12-18	Soo S. Ko	Heterocycyclic piperidines as modulators of chemokine receptor activity
US6387930B1 (en) *	1999-05-04	2002-05-14	Schering Corporation	Piperidine derivatives useful as CCR5 antagonists
KR100439357B1 (ko) *	1999-05-04	2004-07-07	쉐링 코포레이션	Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체
SE9902551D0 (sv)	1999-07-02	1999-07-02	Astra Pharma Prod	Novel compounds
CN1420882A (zh)	1999-07-28	2003-05-28	阿温蒂斯药物公司	取代的氧代氮杂杂环基化合物
IT1307809B1 (it)	1999-10-21	2001-11-19	Menarini Ricerche Spa	Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono.
AR033517A1 (es) *	2000-04-08	2003-12-26	Astrazeneca Ab	Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0013060D0 (en)	2000-05-31	2000-07-19	Astrazeneca Ab	Chemical compounds
AU2001280187A1 (en)	2000-08-28	2002-03-13	Toray Industries, Inc.	Cyclic amine derivatives
GB0021670D0 (en)	2000-09-04	2000-10-18	Astrazeneca Ab	Chemical compounds
GB0107907D0 (en)	2001-03-29	2001-05-23	Smithkline Beecham Plc	Novel compounds
AR033452A1 (es)	2001-03-29	2003-12-17	Schering Corp	Antagonistas de ccr5 utiles para el tratamiento del sida
GB0108876D0 (en)	2001-04-09	2001-05-30	Novartis Ag	Organic Compounds
GB0120461D0 (en)	2001-08-22	2001-10-17	Astrazeneca Ab	Novel compounds
AR036366A1 (es)	2001-08-29	2004-09-01	Schering Corp	Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit
GB0122503D0 (en)	2001-09-18	2001-11-07	Astrazeneca Ab	Chemical compounds
SE0200844D0 (sv)	2002-03-19	2002-03-19	Astrazeneca Ab	Chemical compounds
SE0200843D0 (sv)	2002-03-19	2002-03-19	Astrazeneca Ab	Chemical compounds
SE0202838D0 (sv)	2002-09-24	2002-09-24	Astrazeneca Ab	Chemical compounds
SE0300850D0 (sv)	2003-03-25	2003-03-25	Astrazeneca Ab	Chemical compounds
SE0300957D0 (sv)	2003-04-01	2003-04-01	Astrazeneca Ab	Chemical compounds
SE0301368D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	Chemical compounds
RU2006100190A (ru)	2003-06-13	2006-08-10	Шеринг Акциенгезельшафт (De)	Производные хинолиламида в качестве антагонистов ccr-5

2002
- 2002-07-01 AT AT02747793T patent/ATE319703T1/de not_active IP Right Cessation
- 2002-07-01 DE DE60209736T patent/DE60209736T2/de not_active Expired - Lifetime
- 2002-07-01 JP JP2003510654A patent/JP3857270B2/ja not_active Expired - Fee Related
- 2002-07-01 CA CA002452597A patent/CA2452597A1/en not_active Abandoned
- 2002-07-01 RU RU2004100839/04A patent/RU2004100839A/ru not_active Application Discontinuation
- 2002-07-01 PT PT02747793T patent/PT1404667E/pt unknown
- 2002-07-01 WO PCT/SE2002/001311 patent/WO2003004487A1/en not_active Ceased
- 2002-07-01 PL PL02368041A patent/PL368041A1/xx not_active Application Discontinuation
- 2002-07-01 EP EP05018449A patent/EP1604982A1/en not_active Withdrawn
- 2002-07-01 EP EP02747793A patent/EP1404667B1/en not_active Expired - Lifetime
- 2002-07-01 HU HU0401886A patent/HUP0401886A2/hu unknown
- 2002-07-01 BR BR0210733-3A patent/BR0210733A/pt not_active IP Right Cessation
- 2002-07-01 MX MXPA03011722A patent/MXPA03011722A/es active IP Right Grant
- 2002-07-01 NZ NZ530202A patent/NZ530202A/en unknown
- 2002-07-01 US US10/480,625 patent/US7307090B2/en not_active Expired - Fee Related
- 2002-07-01 KR KR10-2004-7000023A patent/KR20040013090A/ko not_active Ceased
- 2002-07-01 CN CNA028162714A patent/CN1545509A/zh active Pending
- 2002-07-01 ES ES02747793T patent/ES2258642T3/es not_active Expired - Lifetime
- 2002-07-01 IL IL15925602A patent/IL159256A0/xx unknown
- 2002-07-01 DK DK02747793T patent/DK1404667T3/da active
- 2002-07-02 AR ARP020102488A patent/AR042401A1/es not_active Application Discontinuation
- 2002-07-02 SA SA02230184A patent/SA02230184B1/ar unknown
2003
- 2003-12-19 NO NO20035729A patent/NO20035729L/no not_active Application Discontinuation
- 2003-12-29 CO CO03112957A patent/CO5540307A2/es not_active Application Discontinuation
- 2003-12-30 IS IS7094A patent/IS7094A/is unknown
2006
- 2006-06-07 CY CY20061100755T patent/CY1106095T1/el unknown

Also Published As

Publication number	Publication date
ATE319703T1 (de)	2006-03-15
HUP0401886A2 (hu)	2004-12-28
CN1545509A (zh)	2004-11-10
DE60209736T2 (de)	2006-11-02
EP1604982A1 (en)	2005-12-14
SA02230184B1 (ar)	2007-03-25
PT1404667E (pt)	2006-07-31
RU2004100839A (ru)	2005-06-20
US20040235894A1 (en)	2004-11-25
US7307090B2 (en)	2007-12-11
EP1404667B1 (en)	2006-03-08
WO2003004487A1 (en)	2003-01-16
CA2452597A1 (en)	2003-01-16
NO20035729D0 (no)	2003-12-19
PL368041A1 (en)	2005-03-21
CO5540307A2 (es)	2005-07-29
JP3857270B2 (ja)	2006-12-13
DK1404667T3 (da)	2006-07-10
NO20035729L (no)	2004-02-23
BR0210733A (pt)	2004-07-20
EP1404667A1 (en)	2004-04-07
AR042401A1 (es)	2005-06-22
MXPA03011722A (es)	2004-03-19
IS7094A (is)	2003-12-30
KR20040013090A (ko)	2004-02-11
NZ530202A (en)	2005-06-24
CY1106095T1 (el)	2011-06-08
HK1062559A1 (en)	2004-11-12
DE60209736D1 (de)	2006-05-04
JP2004536112A (ja)	2004-12-02
ES2258642T3 (es)	2006-09-01

Publication	Publication Date	Title
IL159256A0 (en)	2004-06-01	Piperidine derivatives useful as modulators of chemokine receptor activity
EP1656138A4 (en)	2007-04-18	SUBSTITUTED CYCLOALKYAMINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
AU2002326948A1 (en)	2003-04-01	Piperizinones as modulators of chemokine receptor activity
AU2003218028A8 (en)	2003-09-22	Cyclic derivatives as modulators of chemokine receptor activity
AU2056800A (en)	2000-07-03	Heterocyclic piperidines as modulators of chemokine receptor activity
IL228794A0 (en)	2013-12-31	Cyclic derivatives as modulators of chemokine-binding receptor activity
AU2002357692A1 (en)	2003-05-26	Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
AU2002241724A1 (en)	2002-07-01	Diamines as modulators of chemokine receptor activity
MXPA03008109A (es)	2003-12-12	Moduladores de la actividad de receptores de quimiocinas.
IL164909A0 (en)	2005-12-18	Tetrahydropyranyl cyclopentyll tetrahydropidopyridine modulators of chemokine receptor activity
IL161699A0 (en)	2004-09-27	Piperidine derivatives and their use as modulators of chemokine receptor activity (especially ccr5)
AU1201401A (en)	2001-04-30	Benzylcycloalkyl amines as modulators of chemokine receptor activity
PL377768A1 (pl)	2006-02-20	Nowe pochodne piperydyny jako modulatory receptora CCR5 dla chemokin
IL161594A0 (en)	2004-09-27	Piperidine derivatives and their use as modulators of chemokine receptor activity (especially ccr5)
IL163896A0 (en)	2005-12-18	Piperidine or 8-aza-bicycloÄ3.2.1Üoct-3-yl derivatives useful as modulators of chemokine receptoractivity (especially ccr5)
EP1620391A4 (en)	2007-10-31	CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
AU2003212770A1 (en)	2003-09-29	Piperidine derivatives useful as modulators of chemokine receptor activity
AU7135901A (en)	2002-01-02	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2003288854A1 (en)	2004-07-14	Novel piperidine derivatives as modulators of chemokine receptor ccr5
EP1631286A4 (en)	2007-08-29	N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
SI1404667T1 (sl)	2006-08-31	Piperidinski derivati uporabni kot modulatorji kemokinske receptorske aktivnosti
AU2003301095A1 (en)	2004-07-22	4(spiropiperidinyl)methyl substituted pyrrolidines as modulators of chemokine receptor activity
PL375901A1 (en)	2005-12-12	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2002321969A1 (en)	2003-03-10	Piperidine derivatives useful as modulators of chemokine receptor activity
AU2002249713A1 (en)	2002-10-15	Novel piperidine derivatives as modulators of chemokine receptor