IL164804A0 - Methods and compositions for diagnosing and monitoring transplant rejection - Google Patents
Methods and compositions for diagnosing and monitoring transplant rejectionInfo
- Publication number
- IL164804A0 IL164804A0 IL16480403A IL16480403A IL164804A0 IL 164804 A0 IL164804 A0 IL 164804A0 IL 16480403 A IL16480403 A IL 16480403A IL 16480403 A IL16480403 A IL 16480403A IL 164804 A0 IL164804 A0 IL 164804A0
- Authority
- IL
- Israel
- Prior art keywords
- diagnosing
- compositions
- methods
- transplant rejection
- monitoring transplant
- Prior art date
Links
- 206010052779 Transplant rejections Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/131,831 US7026121B1 (en) | 2001-06-08 | 2002-04-24 | Methods and compositions for diagnosing and monitoring transplant rejection |
| US10/325,899 US7235358B2 (en) | 2001-06-08 | 2002-12-20 | Methods and compositions for diagnosing and monitoring transplant rejection |
| PCT/US2003/012946 WO2004042346A2 (fr) | 2002-04-24 | 2003-04-24 | Methodes et compositions permettant de diagnostiquer et de surveiller le rejet d'un greffon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL164804A0 true IL164804A0 (en) | 2005-12-18 |
Family
ID=32314283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16480403A IL164804A0 (en) | 2002-04-24 | 2003-04-24 | Methods and compositions for diagnosing and monitoring transplant rejection |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7235358B2 (fr) |
| EP (4) | EP2292786B1 (fr) |
| JP (2) | JP2005536230A (fr) |
| AU (1) | AU2003299465B2 (fr) |
| CA (1) | CA2483481C (fr) |
| IL (1) | IL164804A0 (fr) |
| WO (1) | WO2004042346A2 (fr) |
Families Citing this family (237)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026121B1 (en) * | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US6905827B2 (en) * | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| AU2002332929A1 (en) | 2001-09-07 | 2003-03-24 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39 |
| US7405292B2 (en) * | 2002-02-19 | 2008-07-29 | The Children's Hospital Of Philadelphia | Cellular genes regulated by HIV-1 infection and methods of use thereof |
| FR2836573A1 (fr) * | 2002-02-27 | 2003-08-29 | France Telecom | Representation informatique d'une structure de donnees arborescente et methodes de codage/decodage associees |
| AT412678B (de) * | 2002-09-30 | 2005-05-25 | Gerhard Dr Kranner | Verfahren zur rechnergestützten erstellung von prognosen für operative systeme sowie system zur erstellung von prognosen für operative systeme |
| JP4866006B2 (ja) * | 2002-10-04 | 2012-02-01 | 田辺三菱製薬株式会社 | 抗体認識抗原 |
| US20070248978A1 (en) * | 2006-04-07 | 2007-10-25 | Expression Diagnostics, Inc. | Steroid responsive nucleic acid expression and prediction of disease activity |
| US7892745B2 (en) * | 2003-04-24 | 2011-02-22 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| EP2478912B1 (fr) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Conjugués d'auristatin avec des anticorps dirigés contre le HER2 ou le CD22 et leur usage thérapeutique |
| WO2005054503A2 (fr) * | 2003-12-03 | 2005-06-16 | Novartis Ag | Marqueurs biologiques pour le rejet de greffe |
| WO2005070086A2 (fr) | 2004-01-21 | 2005-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Procedes et compositions pour la determination de phenotype a tolerance vis-a-vis du greffon chez un sujet |
| JP4912894B2 (ja) * | 2004-02-19 | 2012-04-11 | イェール ユニバーシティー | プロテオーム技術を使用した癌タンパク質バイオマーカーの同定 |
| NZ579482A (en) | 2004-06-01 | 2011-02-25 | Genentech Inc | Antibody drug conjugates and methods |
| CA2574802A1 (fr) * | 2004-07-20 | 2006-02-02 | Isogenis, Inc. | Inhibition specifique d'auto-immunite et maladies associees a des auto-antigenes |
| EP1621550A1 (fr) * | 2004-07-29 | 2006-02-01 | Dompé S.P.A. | Cellules ciblant des tumeurs, exprimant la protéine "tumor necrosis factor-related apoptosis inducing ligand" (TRAIL) |
| CA2579093A1 (fr) * | 2004-09-03 | 2006-03-09 | Dana-Farber Cancer Institute, Inc. | Compositions et procedes de modulation de pgc-1.alpha. pour le traitement de maladies et de troubles neurologiques |
| WO2006029184A2 (fr) * | 2004-09-08 | 2006-03-16 | Expression Diagnostics, Inc. | Genes permettant de diagnostiquer et de surveiller les troubles associes a l'inflammation |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| ITFI20040243A1 (it) * | 2004-11-25 | 2005-02-25 | Paola Romagnani | Metodo diagnostico per la previsione di rigetto di organo trapiantato |
| US20060194238A1 (en) * | 2005-02-28 | 2006-08-31 | Norman Latov | Peripheral neuropathy diagnosis |
| US20060194237A1 (en) * | 2005-02-28 | 2006-08-31 | Norman Latov | Method for diagnosing peripheral neuropathy |
| USRE46843E1 (en) | 2005-03-14 | 2018-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
| EP2604703B1 (fr) | 2005-03-14 | 2017-02-01 | The Board of Trustees of the Leland Stanford Junior University | Procédés permettant d'évaluer la survie d'un greffon chez un destinataire d'une transplantation d'organe solide |
| EP1885889A4 (fr) * | 2005-05-11 | 2010-01-20 | Expression Diagnostics Inc | Procedes de surveillance de l'etat fonctionnel de transplants a l'aide de panels de genes |
| US20060269948A1 (en) * | 2005-05-16 | 2006-11-30 | Halloran Philip F | Tissue rejection |
| US8642512B2 (en) | 2005-05-17 | 2014-02-04 | Cellact Pharma Gmbh | Method of detecting early immune activation |
| MX2008013411A (es) * | 2006-04-20 | 2008-11-04 | Glaxo Group Ltd | Nuevos compuestos. |
| US20080057503A1 (en) | 2006-04-24 | 2008-03-06 | Genentech, Inc. | Methods and compositions for detecting autoimmune disorders |
| CA2650507A1 (fr) | 2006-04-27 | 2007-11-08 | Universite De Montreal | Evaluation et reduction du risque de reaction du greffon contre l'hote |
| US20070254305A1 (en) * | 2006-04-28 | 2007-11-01 | Nsabp Foundation, Inc. | Methods of whole genome or microarray expression profiling using nucleic acids prepared from formalin fixed paraffin embedded tissue |
| GB0611405D0 (en) * | 2006-06-09 | 2006-07-19 | Univ Belfast | FKBP-L: A novel inhibitor of angiogenesis |
| EP1872787A1 (fr) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Utilisation de defibrotide pour l'inhibition de l'heparanase |
| WO2008021431A2 (fr) * | 2006-08-14 | 2008-02-21 | Xdx, Inc. | Méthodes et compositions permettant de diagnostiquer et de surveiller l'état de rejet de greffe et de troubles immunitaires |
| EP2102367A2 (fr) * | 2006-11-09 | 2009-09-23 | XDX, Inc. | Procedes pour diagnostiquer et surveiller l'etat d'un lupus erythemateux systemique |
| EP1947463A1 (fr) * | 2007-01-16 | 2008-07-23 | Roche Diagnostics GmbH | Collecte d'échantillons analytiques liquides à des fins d'analyses cliniques |
| US20100129361A1 (en) * | 2007-05-01 | 2010-05-27 | The Brigham And Women's Hospital | Immunosuppression with antibody against itm2a |
| US8600135B2 (en) * | 2007-06-28 | 2013-12-03 | Mayo Foundation For Medical Education And Research | System and method for automatically generating sample points from a series of medical images and identifying a significant region |
| WO2009003198A1 (fr) * | 2007-06-28 | 2008-12-31 | Mayo Foundation For Medical Education And Research | Systèmes et procédés pour détecter automatiquement un changement dans une série d'images médicales d'un sujet dans le temps |
| CA2978267A1 (fr) | 2007-08-23 | 2009-02-23 | Dfm, Llc | Procedes de traitement de patients pediatriques a l'aide de dexmedetomidine |
| MX340916B (es) * | 2008-01-18 | 2016-07-29 | President And Fellows Of Harvard College * | Metodos para detectar señales de identificacion de enfermedad o condiciones en fluidos corporales. |
| US8215329B2 (en) * | 2008-02-01 | 2012-07-10 | Woodward, Inc. | Digital closed loop proportional hydraulic pressure controller |
| CN101960021A (zh) * | 2008-02-28 | 2011-01-26 | 希森美康株式会社 | 产生il-17的辅助t细胞检测用标记及产生il-17的辅助t细胞的检测方法 |
| DK2257301T3 (da) | 2008-03-03 | 2014-04-28 | Univ Miami | Immunterapi baseret på allogene cancerceller. |
| EP2103689A1 (fr) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Oligonucléotides phosphodiesters synthétiques et leurs utilisations thérapeutiques |
| US20110171645A1 (en) * | 2008-04-09 | 2011-07-14 | The University Of British Columbia | Methods of diagnosing acute cardiac allograft rejection |
| EP2285961A4 (fr) * | 2008-05-15 | 2012-10-17 | Topigen Pharmaceuticals Inc | Oligonucléotides pour le traitement de l inflammation et de la prolifération des cellules néoplasiques |
| WO2010000320A1 (fr) * | 2008-07-03 | 2010-01-07 | Institut D'investigations Biomediques August Pi I Sunyer (Idibaps) | Procédé et kit de diagnostic/pronostic in vitro pour l'évaluation de la tolérance dans une transplantation hépatique |
| WO2010010951A1 (fr) * | 2008-07-24 | 2010-01-28 | Kuroda Masahiko | Méthode de détection de l’expression d’arnm indicateur agissant comme indicateur de maladies associées à l’endométriose, et sonde utilisée dans la méthode |
| US8285719B1 (en) | 2008-08-08 | 2012-10-09 | The Research Foundation Of State University Of New York | System and method for probabilistic relational clustering |
| WO2010021696A1 (fr) * | 2008-08-18 | 2010-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Procédés et compositions pour déterminer un phénotype tolérant à une greffe chez un sujet |
| NZ610356A (en) * | 2008-08-28 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2735590A1 (fr) * | 2008-08-29 | 2010-03-04 | Astute Medical, Inc. | Procedes et compositions pour le diagnostic et le pronostic de la blessure renale et de l'insuffisance renale |
| WO2010033722A2 (fr) | 2008-09-17 | 2010-03-25 | Isogenis, Inc. | Construction de vecteurs de délivrance de gènes basés sur un adénovirus complètement délété et ses utilisations |
| NZ607703A (en) | 2008-10-21 | 2014-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2010048347A2 (fr) * | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Procédés et compositions pour le diagnostic et le pronostic de lésion rénale et d’insuffisance rénale |
| CN102264230B (zh) | 2008-11-10 | 2014-12-10 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| MX2011005379A (es) * | 2008-11-22 | 2011-06-09 | Astute Medical Inc | Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal. |
| ES2492498T3 (es) * | 2009-01-15 | 2014-09-09 | The Board Of Trustees Of The Leland Stanford Junior University | Panel de biomarcadores para el diagnóstico y la predicción de rechazo de injerto |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| TWI387750B (zh) * | 2009-02-10 | 2013-03-01 | Nat Defense Medical Ct | Biomarker and detection method for detecting kidney disease |
| US20110045468A1 (en) * | 2009-03-02 | 2011-02-24 | Richard Robison | Polynucleotides for the identification and quantification of group a streptococcus nucleic acids |
| WO2010105275A2 (fr) | 2009-03-13 | 2010-09-16 | Cornell University | Procédé pour évaluer un état d'allogreffe humaine à partir des taux d'expression de micro-arn |
| AU2010260152A1 (en) | 2009-06-15 | 2012-02-02 | Cardiodx, Inc. | Determination of coronary artery disease risk. |
| US9290577B2 (en) | 2009-07-03 | 2016-03-22 | Avipep Pty Limited | Immuno-conjugates and methods for producing them |
| WO2011006119A2 (fr) * | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Profils d'expression génique associés à une néphropathie chronique de l'allogreffe |
| ES2356217B1 (es) * | 2009-08-04 | 2012-02-13 | Universidad De Salamanca | Método para la detección de daño renal. |
| US20110065599A1 (en) * | 2009-08-07 | 2011-03-17 | Rules-Based Medicine, Inc. | Methods and Devices for Detecting Kidney Damage |
| CA2770393A1 (fr) | 2009-08-07 | 2011-02-10 | Astute Medical, Inc. | Procedes et compositions pour le diagnostic et le pronostic d'une lesion renale et d'une insuffisance renale |
| KR20170051544A (ko) * | 2009-09-02 | 2017-05-11 | 아큐젠 피티와이 엘티디 | 개선된 핵산 정량화 방법 |
| JP2013504585A (ja) | 2009-09-09 | 2013-02-07 | セントローズ, エルエルシー | 細胞外標的化薬物複合体 |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| EP2496942B1 (fr) | 2009-11-07 | 2017-03-22 | Astute Medical, Inc. | Méthodes et compositions de diagnostic et de pronostic de lésion rénale et d'insuffisance rénale |
| US20110125791A1 (en) * | 2009-11-25 | 2011-05-26 | Microsoft Corporation | Query classification using search result tag ratios |
| EP2507630B1 (fr) | 2009-12-02 | 2017-01-25 | The Board of Trustees of The Leland Stanford Junior University | Biomarqueurs pour déterminer un xénotype tolérant à l'allogreffe |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル,インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| JP2013514788A (ja) | 2009-12-23 | 2013-05-02 | アビペップ ピーティーワイ リミテッド | イムノコンジュゲート及びその作製方法2 |
| PT2666872T (pt) * | 2010-02-05 | 2016-07-08 | Astute Medical Inc | Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal |
| AU2011213685B2 (en) * | 2010-02-05 | 2014-10-30 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3070474A3 (fr) | 2010-02-26 | 2016-12-07 | Astute Medical, Inc. | Procedes et compositions pour le diagnostic et le pronostic de lesion renale et d'insuffisance renale |
| US9746479B2 (en) | 2010-03-09 | 2017-08-29 | Cornell University | Methods and compositions to predict and detect acute rejection |
| WO2011119980A1 (fr) | 2010-03-25 | 2011-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarqueurs protéiques et génétiques pour le rejet de greffes d'organes |
| SI2528625T1 (sl) | 2010-04-15 | 2013-11-29 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
| US9603708B2 (en) | 2010-05-19 | 2017-03-28 | Dfm, Llc | Low crossing profile delivery catheter for cardiovascular prosthetic implant |
| CA2799540A1 (fr) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Anticorps et conjugues modifies par la cysteine |
| US20130090258A1 (en) * | 2010-06-16 | 2013-04-11 | National University Corporation Hamamatsu University School Of Medicines | Method for detecting colorectal tumor |
| NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| IN2012MN02812A (fr) | 2010-06-23 | 2015-05-22 | Astute Medical Inc | |
| TW201209171A (en) * | 2010-07-23 | 2012-03-01 | Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| EP2437192A1 (fr) * | 2010-09-16 | 2012-04-04 | Roche Diagnostics GmbH | Analyse de quantification relative d'expériences PCR à plusieurs paramètres |
| EP2637672B1 (fr) | 2010-11-12 | 2018-08-22 | Gentium S.r.l. | Défibrotide pour une utilisation dans la prophylaxie et/ou le traitement de la maladie du greffon contre l'hôte (mgch) |
| US20120121615A1 (en) | 2010-11-17 | 2012-05-17 | Flygare John A | Alaninyl maytansinol antibody conjugates |
| US9487838B2 (en) | 2010-12-28 | 2016-11-08 | Qiagen Hamburg Gmbh | Oligonucleotide probe for the detection of adenovirus |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US8962261B2 (en) | 2011-04-06 | 2015-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Autoantibody biomarkers for IGA nephropathy |
| JP6038121B2 (ja) | 2011-04-21 | 2016-12-07 | ガーバン インスティテュート オブ メディカル リサーチ | 修飾された可変ドメイン分子及びその製造及び使用の方法b |
| US8679767B2 (en) | 2011-05-12 | 2014-03-25 | Genentech, Inc. | Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides |
| BR112014009050B1 (pt) | 2011-10-14 | 2022-06-21 | Medimmune Limited | Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas |
| ES2734494T3 (es) | 2011-12-08 | 2019-12-10 | Astute Medical Inc | Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal |
| WO2013130093A1 (fr) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151665A2 (fr) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Polynucléotides modifiés destinés à la production de protéines associées à une maladie humaine |
| US9445897B2 (en) | 2012-05-01 | 2016-09-20 | Direct Flow Medical, Inc. | Prosthetic implant delivery device with introducer catheter |
| US20150142460A1 (en) * | 2012-05-24 | 2015-05-21 | Allegheny-Singer Research Institute | Method and system for ordering and arranging a data set for a severity and heterogeneity approach to preventing events including a disease stratification scheme |
| ES2660969T5 (es) | 2012-06-22 | 2021-09-03 | Gentium S R L | Método basado en euglobulina para determinar la actividad biológica de defibrotida |
| US9535071B2 (en) | 2012-09-07 | 2017-01-03 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| RU2506592C1 (ru) * | 2012-10-11 | 2014-02-10 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) | Способ выбора тактики хирургического лечения больных с периимплантным воспалением в области крупных суставов |
| RS57694B1 (sr) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pirolobenzodiazepin - anti-psma konjugati antitela |
| HRP20182129T1 (hr) | 2012-10-12 | 2019-02-08 | Adc Therapeutics Sa | Konjugati protutijelo - pirolobenzodiazepin |
| ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
| EP2906297B1 (fr) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Conjugués anticorps - pyrrolobenzodiazépine |
| EP2906296B1 (fr) | 2012-10-12 | 2018-03-21 | ADC Therapeutics SA | Conjugués anticorps - pyrrolobenzodiazépine |
| JP6392765B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa | ピロロベンゾジアゼピン−抗体結合体 |
| MX338711B (es) | 2012-10-12 | 2016-04-28 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| CN110627797A (zh) | 2012-12-21 | 2019-12-31 | 麦迪穆有限责任公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| CN105189507A (zh) | 2012-12-21 | 2015-12-23 | 斯皮罗根有限公司 | 吡咯并苯并二氮杂卓及其结合物 |
| TR201807542T4 (tr) | 2013-01-17 | 2018-06-21 | Astute Medical Inc | Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler. |
| US9758828B2 (en) | 2013-01-31 | 2017-09-12 | Cornell University | Methods to detect, treat and prevent acute cellular rejection in kidney allografts |
| US10210312B2 (en) * | 2013-02-03 | 2019-02-19 | Youscript Inc. | Systems and methods for quantification and presentation of medical risk arising from unknown factors |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| AU2014229529B2 (en) | 2013-03-13 | 2018-02-15 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| MX362970B (es) | 2013-03-13 | 2019-02-28 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| TWI680766B (zh) | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
| WO2014152031A1 (fr) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Purification d'acide ribonucléique |
| WO2014152027A1 (fr) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Procédés de fabrication pour la production de transcrits d'arn |
| US10590161B2 (en) | 2013-03-15 | 2020-03-17 | Modernatx, Inc. | Ion exchange purification of mRNA |
| EP2971165A4 (fr) | 2013-03-15 | 2016-11-23 | Moderna Therapeutics Inc | Elimination de fragments d'adn dans des procédés de production d'arnm |
| US20160040236A1 (en) * | 2013-03-15 | 2016-02-11 | Biogen Ma Inc. | Systems and methods for characterization of multiple sclerosis |
| WO2014204991A1 (fr) * | 2013-06-17 | 2014-12-24 | Verinata Health, Inc. | Méthode pour déterminer les variations du nombre de copies dans des chromosomes sexuels |
| CA2917348A1 (fr) | 2013-07-11 | 2015-01-15 | Moderna Therapeutics, Inc. | Compositions comprenant des polynucleotides synthetiques codant pour des proteines liees a crispr et des arnsg synthetiques et methodes d'utilisation |
| US12073480B2 (en) * | 2013-07-12 | 2024-08-27 | D2L Corporation | System and method for evaluating assessments |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| EP3052511A4 (fr) | 2013-10-02 | 2017-05-31 | Moderna Therapeutics, Inc. | Molécules de polynucléotides et leurs utilisations |
| WO2015052535A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2015052534A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
| EP3054983B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépines |
| AU2014348566B2 (en) * | 2013-11-13 | 2019-02-28 | Five3 Genomics, Llc | Systems and methods for transmission and pre-processing of sequencing data |
| JP6671292B2 (ja) | 2013-12-16 | 2020-03-25 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
| EP3082876B1 (fr) | 2013-12-16 | 2018-01-17 | Genentech, Inc. | Composés conjugués anticorps-médicament dimérique à base de 1-(chlorométhyl)-2,3-dihydro-1 h-benzo [e]indole, et méthodes d'utilisation et de traitement |
| WO2015095227A2 (fr) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Composés peptidomimétiques et conjugués anticorps-médicament de ceux-ci |
| US9982301B2 (en) | 2014-01-07 | 2018-05-29 | Cornell University | Urine mRNA profile and acute dysfunction of kidney allograft |
| US10451636B2 (en) | 2014-04-09 | 2019-10-22 | The Regents Of The University Of California | Protein biomarkers for immune assessment and prediction of transplant rejection |
| US10394828B1 (en) * | 2014-04-25 | 2019-08-27 | Emory University | Methods, systems and computer readable storage media for generating quantifiable genomic information and results |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| WO2015196128A2 (fr) | 2014-06-19 | 2015-12-23 | Moderna Therapeutics, Inc. | Molécules d'acide nucléique alternatives et leurs utilisations |
| US10407683B2 (en) | 2014-07-16 | 2019-09-10 | Modernatx, Inc. | Circular polynucleotides |
| KR20170055474A (ko) * | 2014-07-31 | 2017-05-19 | 아카데미아 시니카 | 길항 pd-1 압타머 및 암 요법 관련 적용에서의 그의 적용 |
| JP2017525534A (ja) | 2014-08-15 | 2017-09-07 | ディーエフエム、 エルエルシー | 人工インプラント送出デバイス |
| EP3193940A1 (fr) | 2014-09-10 | 2017-07-26 | Medimmune Limited | Pyrrolobenzodiazépines et leurs conjugués |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| WO2016040825A1 (fr) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés |
| SG11201701128YA (en) | 2014-09-12 | 2017-03-30 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| CN107073136A (zh) | 2014-09-17 | 2017-08-18 | 健泰科生物技术公司 | 吡咯并苯并二氮杂卓及其抗体二硫化物偶联物 |
| US10417225B2 (en) * | 2015-09-18 | 2019-09-17 | Splunk Inc. | Entity detail monitoring console |
| CN107148285B (zh) | 2014-11-25 | 2022-01-04 | Adc治疗股份有限公司 | 吡咯并苯并二氮杂䓬-抗体缀合物 |
| EP3026122A1 (fr) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Procédé à base cellulaire pour déterminer la puissance de défibrotide |
| AU2015358532C1 (en) | 2014-12-03 | 2020-10-29 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| WO2016118852A1 (fr) * | 2015-01-23 | 2016-07-28 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Utilisation d'éomesodermine afin de déterminer le risque d'un rejet d'allogreffe |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| US10989716B2 (en) | 2015-05-01 | 2021-04-27 | The University Of British Columbia | Biomarkers for the detection of acute rejection in heart transplantation |
| CN107921148A (zh) | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
| EP3350333B2 (fr) | 2015-09-17 | 2025-08-06 | ModernaTX, Inc. | Polynucléotides contenant une région de queue de stabilisation |
| WO2017049286A1 (fr) | 2015-09-17 | 2017-03-23 | Moderna Therapeutics, Inc. | Polynucléotides contenant un lieur morpholino |
| CR20180243A (es) | 2015-10-02 | 2018-07-31 | Genentech Inc | Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| EP3365025B1 (fr) | 2015-10-20 | 2020-07-15 | Genentech, Inc. | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN108700598A (zh) | 2016-03-25 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 多路总抗体和抗体缀合的药物量化测定法 |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP3465221B1 (fr) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Procédé bioanalytique pour la caractérisation de conjugués anticorps-médicament spécifiques d'un site |
| EP3466444B1 (fr) * | 2016-06-02 | 2025-07-23 | Riken | Composition d'adjuvant et son utilisation |
| EP3465201A4 (fr) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | Prise en charge de lésions rénales aiguës au moyen de la protéine de liaison de facteur de croissance insulinomimétique 7 et de l'inhibiteur tissulaire de métalloprotéinase 2 |
| WO2017214024A1 (fr) | 2016-06-06 | 2017-12-14 | Genentech, Inc. | Médicaments conjugués d'anticorps silvestrol et procédés d'utilisation |
| WO2017223176A1 (fr) | 2016-06-24 | 2017-12-28 | Modernatx, Inc. | Procédés et appareil de filtration |
| CN109689111B (zh) | 2016-08-11 | 2024-04-05 | 基因泰克公司 | 吡咯并苯并二氮杂䓬前药及其抗体缀合物 |
| JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| US20180166170A1 (en) * | 2016-12-12 | 2018-06-14 | Konstantinos Theofilatos | Generalized computational framework and system for integrative prediction of biomarkers |
| US20200174014A1 (en) | 2016-12-19 | 2020-06-04 | Osaka University | METHOD FOR IN VITRO EARLY DIAGNOSIS OF ANTIBODY MEDIATED REJECTION AFTER ORGAN TRANSPLANTATION USING IgM-TYPE MEMORY B CELL DIFFERENTIATION CULTURE SYSTEM |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| RS61795B1 (sr) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin antitela |
| TW202428301A (zh) | 2017-02-28 | 2024-07-16 | 法商賽諾菲公司 | 治療性rna |
| TW201837467A (zh) | 2017-03-01 | 2018-10-16 | 美商建南德克公司 | 用於癌症之診斷及治療方法 |
| CN110582505B (zh) | 2017-04-18 | 2021-04-02 | 免疫医疗有限公司 | 吡咯并苯并二氮杂*缀合物 |
| WO2018193102A1 (fr) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Polythérapie avec un conjugué anticorps anti-axl-médicament |
| CA3064804A1 (fr) | 2017-06-14 | 2018-12-20 | Adc Therapeutics Sa | Regimes posologiques pour l'administration d'un cam anti-cd19 |
| KR102270107B1 (ko) | 2017-08-18 | 2021-06-30 | 메디뮨 리미티드 | 피롤로벤조디아제핀 컨쥬게이트 |
| EP3684773B1 (fr) | 2017-09-20 | 2026-04-29 | pH Pharma Co., Ltd. | Analogues de thailanstatine |
| US11093518B1 (en) | 2017-09-23 | 2021-08-17 | Splunk Inc. | Information technology networked entity monitoring with dynamic metric and threshold selection |
| US11106442B1 (en) | 2017-09-23 | 2021-08-31 | Splunk Inc. | Information technology networked entity monitoring with metric selection prior to deployment |
| US11159397B2 (en) | 2017-09-25 | 2021-10-26 | Splunk Inc. | Lower-tier application deployment for higher-tier system data monitoring |
| CN107967938A (zh) * | 2017-11-21 | 2018-04-27 | 成都天奥电子股份有限公司 | 一种心脏病患者定位监护管理系统 |
| WO2019107673A1 (fr) * | 2017-11-29 | 2019-06-06 | 서울대학교병원 | Marqueur biologique permettant de surveiller le rejet médié par des anticorps lors d'une transplantation incompatible avec le groupe sanguin abo |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| WO2019173283A1 (fr) | 2018-03-05 | 2019-09-12 | Marquette University | Procédé et appareil de prédiction du niveau d'hémoglobine non invasifs |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| WO2020002602A1 (fr) * | 2018-06-29 | 2020-01-02 | bioMérieux | Procédé pour déterminer in vitro ou ex vivo le statut immunitaire d'un individu |
| FR3085689A1 (fr) * | 2018-09-12 | 2020-03-13 | Biomerieux | Procede pour determiner in vitro ou ex vivo le statut immunitaire d'un individu |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| JP7708662B2 (ja) | 2018-10-24 | 2025-07-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | コンジュゲート化された化学的分解誘導物質および使用方法 |
| JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック, インコーポレイテッド | Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
| US11263116B2 (en) | 2019-01-24 | 2022-03-01 | International Business Machines Corporation | Champion test case generation |
| US11099975B2 (en) | 2019-01-24 | 2021-08-24 | International Business Machines Corporation | Test space analysis across multiple combinatoric models |
| US11106567B2 (en) | 2019-01-24 | 2021-08-31 | International Business Machines Corporation | Combinatoric set completion through unique test case generation |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| CN113631560B (zh) | 2019-03-15 | 2025-02-18 | 麦迪穆有限责任公司 | 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物 |
| EP3736570A1 (fr) * | 2019-05-09 | 2020-11-11 | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | Procédé pour le diagnostic, la sous-classification et le pronostic d'une lésion rénale aiguë en détectant cct7 |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| US12221622B2 (en) | 2019-05-10 | 2025-02-11 | The Regents Of The University Of California | Modified pluripotent cells |
| US10970195B2 (en) * | 2019-06-13 | 2021-04-06 | International Business Machines Corporation | Reduction of test infrastructure |
| US11422924B2 (en) | 2019-06-13 | 2022-08-23 | International Business Machines Corporation | Customizable test set selection using code flow trees |
| US11232020B2 (en) | 2019-06-13 | 2022-01-25 | International Business Machines Corporation | Fault detection using breakpoint value-based fingerprints of failing regression test cases |
| CN114787351A (zh) * | 2019-10-15 | 2022-07-22 | 加利福尼亚大学董事会 | 通过Fc隔离的移植细胞保护 |
| CN110923356B (zh) * | 2019-12-30 | 2022-08-12 | 广西大学 | 一种水稻抗稻瘿蚊主效基因Gm5的分子标记引物及其标记方法和应用 |
| DE102020205364B4 (de) * | 2020-04-28 | 2022-01-20 | Universität Rostock | Verfahren zur Überwachung des Verlaufs einer Kardiomyozyten-Transplantation und Methode zur Bestimmung, ob ein Proband für einer Kardiomyozyten-Transplantation geeignet ist |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| EP3985395A1 (fr) * | 2020-10-16 | 2022-04-20 | Mukocell GmbH | Procédé de production de tissu de muqueuse buccale transplantable |
| CN116507727A (zh) * | 2020-11-06 | 2023-07-28 | 住友制药株式会社 | Rps25基因的表达和/或功能调节剂 |
| US11676072B1 (en) | 2021-01-29 | 2023-06-13 | Splunk Inc. | Interface for incorporating user feedback into training of clustering model |
| CN113435168B (zh) * | 2021-06-10 | 2024-03-22 | 上海美吉生物医药科技有限公司 | 胶图自动编辑方法、系统、终端及介质 |
| EP4426727A2 (fr) | 2021-11-03 | 2024-09-11 | Hangzhou Dac Biotech Co., Ltd. | Conjugaison spécifique d'un anticorps |
| WO2024138128A2 (fr) | 2022-12-23 | 2024-06-27 | Genentech, Inc. | Conjugués d'agent de dégradation de céréblon et leurs utilisations |
| KR20260012304A (ko) | 2023-04-17 | 2026-01-26 | 피크 바이오, 인크. | 항체 및 항체-약물 접합체 및 사용 방법 및 합성 공정 및 중간체 |
| WO2025183579A1 (fr) * | 2024-02-29 | 2025-09-04 | Ramalhete Lus Manuel Pires | Procédé de pronostic pour déterminer une probabilité de rejet d'allogreffe |
| WO2026006689A2 (fr) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Conjugués anticorps-dégradeur de bcl-xl et leurs utilisations |
| WO2026006688A2 (fr) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Conjugués d'anticorps de dégradation et leurs utilisations |
Family Cites Families (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212071A (en) | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
| US5981481A (en) | 1974-12-06 | 1999-11-09 | The Johns Hopkins University | Human C3b/C4b receptor (CR1) |
| US4350593A (en) | 1977-12-19 | 1982-09-21 | Becton, Dickinson And Company | Assembly, compositions and method for separating blood |
| US4190535A (en) | 1978-02-27 | 1980-02-26 | Corning Glass Works | Means for separating lymphocytes and monocytes from anticoagulated blood |
| US4215051A (en) * | 1979-08-29 | 1980-07-29 | Standard Oil Company (Indiana) | Formation, purification and recovery of phthalic anhydride |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4358535A (en) | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US4762780A (en) | 1984-04-17 | 1988-08-09 | The Regents Of The University Of California | Method and composition for screening and diagnosing "HCMV" |
| US4582789A (en) | 1984-03-21 | 1986-04-15 | Cetus Corporation | Process for labeling nucleic acids using psoralen derivatives |
| US4818418A (en) | 1984-09-24 | 1989-04-04 | Becton Dickinson And Company | Blood partitioning method |
| US4751001A (en) | 1984-09-24 | 1988-06-14 | Becton Dickinson And Company | Blood partitioning apparatus |
| US5264351A (en) | 1984-11-05 | 1993-11-23 | The Board Of Regents For The University Of Oklahoma | Monoclonal antibodies against autoimmune RNA proteins |
| US5053134A (en) | 1984-12-04 | 1991-10-01 | Becton Dickinson And Company | Lymphocyte collection tube |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US6040166A (en) | 1985-03-28 | 2000-03-21 | Roche Molecular Systems, Inc. | Kits for amplifying and detecting nucleic acid sequences, including a probe |
| US6197563B1 (en) | 1985-03-28 | 2001-03-06 | Roche Molecular Systems, Inc. | Kits for amplifying and detecting nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| EP0217102B1 (fr) | 1985-08-28 | 1992-01-08 | Yeda Research And Development Company, Ltd. | Gène de (2'-5') oligo A synthétase induit par l'interféron, mARN, cADN et enzymes à activité de (2'-5') oligo A synthétase |
| US5011684A (en) | 1985-09-05 | 1991-04-30 | Beth Israel Hospital Association | Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance |
| US4789630A (en) | 1985-10-04 | 1988-12-06 | Cetus Corporation | Ionic compounds containing the cationic meriquinone of a benzidine |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| CA1284931C (fr) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Procede de detection de variations specifiques de nucleotides et de polymorphismes genetiques dans les acides nucleiques |
| US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5418149A (en) | 1990-07-24 | 1995-05-23 | Hoffmann-La Roche Inc. | Reduction of non-specific amplification glycosylase using DUTP and DNA uracil |
| US5561058A (en) | 1986-08-22 | 1996-10-01 | Hoffmann-La Roche Inc. | Methods for coupled high temperatures reverse transcription and polymerase chain reactions |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5693517A (en) | 1987-06-17 | 1997-12-02 | Roche Molecular Systems, Inc. | Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions |
| US5405774A (en) | 1986-08-22 | 1995-04-11 | Hoffmann-La Roche Inc. | DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17 |
| US5352600A (en) | 1986-08-22 | 1994-10-04 | Hoffmann-La Roche Inc. | Purified thermostable enzyme |
| US5618711A (en) | 1986-08-22 | 1997-04-08 | Hoffmann-La Roche Inc. | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase |
| US5310652A (en) | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| US5407800A (en) | 1986-08-22 | 1995-04-18 | Hoffmann-La Roche Inc. | Reverse transcription with Thermus thermophilus polymerase |
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| US5374553A (en) | 1986-08-22 | 1994-12-20 | Hoffmann-La Roche Inc. | DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima |
| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US6127155A (en) | 1986-08-22 | 2000-10-03 | Roche Molecular Systems, Inc. | Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents |
| US5079352A (en) | 1986-08-22 | 1992-01-07 | Cetus Corporation | Purified thermostable enzyme |
| US5795762A (en) | 1986-08-22 | 1998-08-18 | Roche Molecular Systems, Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5063162A (en) | 1987-04-24 | 1991-11-05 | Hoffmann-La Roche Inc. | Process for isolating nucleic acids utilizing protease digestion |
| CA1297431C (fr) | 1987-04-24 | 1992-03-17 | F. Hoffmann-La Roche Ag | Procede pour l'isolation d'acides nucleiques |
| US4908318A (en) | 1987-09-04 | 1990-03-13 | Integrated Genetics, Inc. | Nucleic acid extraction methods |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US5120525A (en) | 1988-03-29 | 1992-06-09 | Immunomedics, Inc. | Radiolabeled antibody cytotoxic therapy of cancer |
| US5693760A (en) | 1988-04-14 | 1997-12-02 | Incyte Pharmaceuticals, Inc. | Method of causing selective immunosuppression using HL-60 related lectins |
| US5075216A (en) | 1988-09-23 | 1991-12-24 | Cetus Corporation | Methods for dna sequencing with thermus aquaticus dna polymerase |
| US5091310A (en) | 1988-09-23 | 1992-02-25 | Cetus Corporation | Structure-independent dna amplification by the polymerase chain reaction |
| US5142033A (en) | 1988-09-23 | 1992-08-25 | Hoffmann-La Roche Inc. | Structure-independent DNA amplification by the polymerase chain reaction |
| US5066584A (en) | 1988-09-23 | 1991-11-19 | Cetus Corporation | Methods for generating single stranded dna by the polymerase chain reaction |
| US5389512A (en) | 1988-10-07 | 1995-02-14 | Hoffman-La Roche Inc. | Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5340720A (en) | 1989-11-29 | 1994-08-23 | University Of Kansas | Methods of diagnosing and monitoring rheumatic diseases |
| US5215882A (en) | 1989-11-30 | 1993-06-01 | Ortho Diagnostic Systems, Inc. | Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays |
| CA2033692A1 (fr) | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Systemes de transfert d'energie |
| DK0515506T3 (da) | 1990-02-16 | 2000-05-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af carcinogene humane papillomavirus |
| US5344755A (en) | 1990-04-21 | 1994-09-06 | The United States Of America As Represented By The Department Of Health And Human Services | Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals |
| US5350683A (en) * | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| US5130423A (en) | 1990-07-13 | 1992-07-14 | Microprobe Corporation | Non-corrosive compositions and methods useful for the extraction of nucleic acids |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| CA2092317A1 (fr) | 1990-09-28 | 1992-03-29 | David H. Gelfand | Polymerase d'acide nucleique purifiee et thermostable, obtenue a partir de thermosipho africanus |
| DE4034036C2 (de) | 1990-10-26 | 1994-03-03 | Diagen Inst Molekularbio | Vorrichtung und Verfahren zur Isolierung von Nukleinsäuren aus Zellsuspensionen |
| ATE126599T1 (de) | 1991-01-22 | 1995-09-15 | Akzo Nobel Nv | Verfahren zur bestimmung von anti-rns- antikörpern. |
| JPH06506358A (ja) | 1991-03-28 | 1994-07-21 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | ナチュラルキラー細胞に特異的なdnaおよびアミノ酸配列 |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| DE69213112T2 (de) | 1991-06-20 | 1997-04-03 | Hoffmann La Roche | Verbesserte Methoden zur Nukleinsäure-Amplifizierung |
| US5445940A (en) | 1991-08-28 | 1995-08-29 | Brigham & Women's Hospital | Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease |
| HUT69725A (en) * | 1991-10-01 | 1995-09-28 | Gen Hospital Corp | Process for producing compositions for preventing allograft rejection |
| US5346994A (en) * | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| DE69207580T2 (de) | 1992-03-23 | 1996-08-08 | Hoffmann La Roche | Verfahren zum DNS-Nachweis |
| WO1993025713A1 (fr) | 1992-06-17 | 1993-12-23 | Arch Development Corporation | Compositions et procedes de detection de rearrangements et de translocations de genes |
| GB2268935B (en) | 1992-06-24 | 1996-10-23 | Nat Heart & Lung Inst | Diagnosis of rejection of transplanted organs |
| EP0590327B1 (fr) | 1992-09-11 | 2003-04-09 | F. Hoffmann-La Roche Ag | Détection d'acides nucléiques dans le sang |
| US5565339A (en) | 1992-10-08 | 1996-10-15 | Hoffmann-La Roche Inc. | Compositions and methods for inhibiting dimerization of primers during storage of polymerase chain reaction reagents |
| US5420039A (en) * | 1992-12-31 | 1995-05-30 | Cem Corporation | Control of continuous microwave digestion process |
| AU6230594A (en) * | 1993-02-01 | 1994-08-29 | University Of Iowa Research Foundation, The | Quartenary amine surfactants and methods of using same in isolation of rna |
| US6403304B1 (en) | 1993-04-06 | 2002-06-11 | Forsyth Dental Infirmary For Children | Human osteoclast-specific and -related DNA sequences |
| US5491086A (en) | 1993-05-14 | 1996-02-13 | Hoffmann-La Roche Inc. | Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5459037A (en) | 1993-11-12 | 1995-10-17 | The Scripps Research Institute | Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995016353A1 (fr) | 1993-12-14 | 1995-06-22 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Traitement systemique par genes des affections des tissus conjonctifs |
| DK145393D0 (da) | 1993-12-23 | 1993-12-23 | Stig Haunsoe | Proteinmarkoerer til forudsigelse af akut allotransplantatafstoedning |
| US5811284A (en) | 1993-12-29 | 1998-09-22 | Schering Corporation | Nucleic acids encoding kp43 protein and antigenic fragments thereof |
| US5512462A (en) | 1994-02-25 | 1996-04-30 | Hoffmann-La Roche Inc. | Methods and reagents for the polymerase chain reaction amplification of long DNA sequences |
| US6190872B1 (en) | 1994-05-06 | 2001-02-20 | Gus J. Slotman | Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5658744A (en) | 1994-07-22 | 1997-08-19 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of identifying patients having an altered immune status |
| US6010847A (en) | 1994-08-18 | 2000-01-04 | Akzo Nobel N.V. | Oligonucleotides that can be used in the amplification and detection of CMV nucleic acid |
| US5491063A (en) | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| US5571673A (en) | 1994-11-23 | 1996-11-05 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| US5506145A (en) * | 1994-12-02 | 1996-04-09 | Bull; Brian S. | Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements |
| US5834248A (en) | 1995-02-10 | 1998-11-10 | Millennium Pharmaceuticals Inc. | Compositions and methods using rchd534, a gene uregulated by shear stress |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| DE69621507T2 (de) | 1995-03-28 | 2003-01-09 | Japan Science And Technology Corp., Kawaguchi | Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen |
| US6251597B1 (en) | 1996-03-29 | 2001-06-26 | Millennium Pharmaceuticals, Inc. | Methods for detecting fohy030 |
| US5569583A (en) | 1995-04-25 | 1996-10-29 | Health Research Inc. | Rapid and sensitive detection of cytomegalovirus |
| US5635365A (en) | 1995-08-07 | 1997-06-03 | Emory University | Noninvasive diagnosis for allograft rejection |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5665551A (en) | 1995-09-13 | 1997-09-09 | Roche Molecular Systems, Inc. | Purified nucleic acid encoding a thermostable pyrophosphatase |
| US5750345A (en) * | 1995-10-31 | 1998-05-12 | Evanston Hospital Corporation | Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders |
| US5973137A (en) | 1996-02-13 | 1999-10-26 | Gentra Systems, Inc. | Low pH RNA isolation reagents, method, and kit |
| US6099823A (en) | 1996-02-16 | 2000-08-08 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
| CA2247246A1 (fr) | 1996-02-16 | 1997-08-21 | Millennium Pharmaceuticals, Inc. | Compositions et procedes de traitement et de diagnostic des maladies cardio-vasculaires |
| US5958342A (en) | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
| CZ293215B6 (cs) | 1996-08-06 | 2004-03-17 | F. Hoffmann-La Roche Ag | Rekombinantní tepelně stálá DNA polymeráza, způsob její přípravy a prostředek, který ji obsahuje |
| US6146828A (en) | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6274312B1 (en) | 1996-12-11 | 2001-08-14 | Schering Corporation | Intracellular regulatory molecules; related reagents |
| US6060240A (en) | 1996-12-13 | 2000-05-09 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
| EP0866071B1 (fr) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Amorces modifiées |
| US6190857B1 (en) | 1997-03-24 | 2001-02-20 | Urocor, Inc. | Diagnosis of disease state using MRNA profiles in peripheral leukocytes |
| US6090556A (en) | 1997-04-07 | 2000-07-18 | Japan Science & Technology Corporation | Method for quantitatively determining the expression of a gene |
| US5958688A (en) | 1997-04-28 | 1999-09-28 | The Trustees Of The University Of Pennsylvania | Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics |
| US5994076A (en) | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| US6010853A (en) | 1997-05-29 | 2000-01-04 | Dana-Farber Cancer Institute | Siva genes, novel genes involved in CD27-mediated apoptosis |
| US6228628B1 (en) | 1997-07-09 | 2001-05-08 | Roche Molecular Systems | Mutant chimeric DNA polymerase |
| WO1999010536A1 (fr) | 1997-08-22 | 1999-03-04 | Yale University | Procede d'etude des modifications de l'expression des genes dans les granulocytes |
| US20030104371A1 (en) * | 1997-09-24 | 2003-06-05 | Strom Terry B. | Methods of evaluating transplant rejection |
| US6187534B1 (en) | 1997-09-24 | 2001-02-13 | Cornell Research Foundation, Inc. | Methods of evaluating transplant rejection |
| DE69829402T2 (de) | 1997-10-31 | 2006-04-13 | Affymetrix, Inc. (a Delaware Corp.), Santa Clara | Expressionsprofile in adulten und fötalen organen |
| US6248528B1 (en) | 1998-04-06 | 2001-06-19 | Millennium Pharmaceuticals, Inc. | Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| US6048695A (en) | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
| US6218122B1 (en) | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| AU5583799A (en) * | 1998-08-25 | 2000-03-14 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US6248527B1 (en) | 1998-10-21 | 2001-06-19 | Millennium Pharmaceuticals, Inc. | Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E |
| US6203987B1 (en) * | 1998-10-27 | 2001-03-20 | Rosetta Inpharmatics, Inc. | Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns |
| WO2000028090A2 (fr) | 1998-11-12 | 2000-05-18 | Nyxis, Inc. | Essais diagnostiques du cancer |
| US6177254B1 (en) | 1998-12-15 | 2001-01-23 | Jerome Bernard Rattner | Nucleolus autoantigenic marker for systemic lupus erthyematosus |
| US6222093B1 (en) * | 1998-12-28 | 2001-04-24 | Rosetta Inpharmatics, Inc. | Methods for determining therapeutic index from gene expression profiles |
| US6087112A (en) | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6150121A (en) | 1999-02-16 | 2000-11-21 | Wisconsin Alumni Research Foundation | Assessing immunological state of transplant recipients |
| US6280941B1 (en) | 1999-03-29 | 2001-08-28 | Cedars-Sinai Medical Center | Genetic marker test for lupus |
| WO2000058473A2 (fr) * | 1999-03-31 | 2000-10-05 | Curagen Corporation | Acides nucleiques comprenant des phases de lecture ouverte codant des polypeptides; «orfx» |
| US6162604A (en) | 1999-04-01 | 2000-12-19 | Jacob; Chaim O. | Methods for determining genetic predisposition to autoimmune diseases by genotyping apoptotic genes |
| US6242185B1 (en) | 1999-04-01 | 2001-06-05 | Incyte Genomics, Inc. | Purified nucleic acid encoding transcription factor regulatory protein |
| US6245526B1 (en) | 1999-05-26 | 2001-06-12 | Incyte Pharmaceuticals, Inc. | Lipid metabolism transcription factor |
| US6132997A (en) * | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
| US6168933B1 (en) | 1999-06-08 | 2001-01-02 | Incyte Pharmaceuticals, Inc. | Phospholipid transfer protein |
| CA2378008A1 (fr) | 1999-06-28 | 2001-04-12 | Source Precision Medicine, Inc. | Systemes et techniques permettant de caracteriser un etat ou un agent biologique par expression genique calibree |
| US6245527B1 (en) | 1999-06-30 | 2001-06-12 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| PL354286A1 (en) * | 1999-08-23 | 2003-12-29 | Dana-Farber Cancer Institutedana-Farber Cancer Institute | Pd-1, a receptor for b7-4, and uses therefor |
| US6225093B1 (en) | 1999-09-07 | 2001-05-01 | Decode Genetics Ehf. | Detection of C4A deletion by long range PCR |
| WO2001038585A2 (fr) * | 1999-11-24 | 2001-05-31 | The Regents Of The University Of California | Matrices polymeres et procedes d'utilisation de molecules de sondes marquees pour identifier et quantifier l'expression des molecules cibles |
| GB9928136D0 (en) | 1999-11-29 | 2000-01-26 | Rose Marlene L | Organ rejection and associated conditions |
| WO2001047944A2 (fr) | 1999-12-28 | 2001-07-05 | Curagen Corporation | Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation correspondants |
| US20020132753A1 (en) | 2000-01-31 | 2002-09-19 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| AU3095801A (en) | 2000-01-31 | 2001-08-07 | Human Genome Sciences Inc | Nucleic acids, proteins, and antibodies |
| WO2001055301A2 (fr) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Acides nucleiques, proteines et anticorps |
| AU3087801A (en) | 2000-02-04 | 2001-08-14 | Molecular Dynamics Inc | Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells |
| WO2001060860A2 (fr) | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes, compositions, kits, et procedes d'identification, d'evaluation, de prevention, et de traitement du cancer de la prostate |
| US20040038339A1 (en) | 2000-03-24 | 2004-02-26 | Peter Kufer | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| US6900015B2 (en) | 2000-04-24 | 2005-05-31 | Beth Israel Deaconess Medical Center, Inc. | Measurement of protective genes in allograft rejection |
| DE10021834A1 (de) | 2000-05-06 | 2001-11-15 | Lynx Therapeutics Gmbh | mRNA Moleküle zur Verwendung als Indikatoren für den Aktivierungs- und Funktionszustand von T-Lymphozyten |
| EP1284747A2 (fr) | 2000-05-12 | 2003-02-26 | Beth Israel Deaconess Medical Center, Inc. | Compositions et procedes pour obtenir une suppression immune |
| WO2002000677A1 (fr) | 2000-06-07 | 2002-01-03 | Human Genome Sciences, Inc. | Acides nucleiques, proteines et anticorps |
| WO2002002807A2 (fr) | 2000-06-30 | 2002-01-10 | Epigenomics Ag | Diagnostic des maladies associees a la signalisation cellulaire |
| AU2126502A (en) | 2000-10-03 | 2002-04-15 | Gene Logic, Inc. | Gene expression profiles in granulocytic cells |
| EP1334113A4 (fr) | 2000-10-20 | 2007-08-08 | Expression Diagnostics Inc | Evaluation du niveau d'expression leucocytaire |
| US7235358B2 (en) | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US7026121B1 (en) * | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| EP1410011B1 (fr) * | 2001-06-18 | 2011-03-23 | Rosetta Inpharmatics LLC | Diagnostic et prevision du cancer du sein chez des patients |
| WO2003004612A2 (fr) * | 2001-07-02 | 2003-01-16 | Yale University | Inhibiteur de l'activation des leucocytes t |
| US6964850B2 (en) * | 2001-11-09 | 2005-11-15 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| EP1990055A3 (fr) * | 2001-11-29 | 2011-11-16 | Therakos, Inc. | Procédés pour prétraiter un sujet au moyen d'une photophérèse extracorporelle et/ou de cellules apoptotiques |
| US20040072181A1 (en) * | 2002-01-22 | 2004-04-15 | Whitehead Alexander Steven | Methods for determining drug responsiveness |
| DE10234524A1 (de) * | 2002-07-24 | 2004-02-12 | Oligene Gmbh | Nukleinsäurearray |
| US7118865B2 (en) | 2002-08-16 | 2006-10-10 | Regents Of The University Of Minnesota | Methods for diagnosing severe systemic lupus erythematosus |
| US20070248978A1 (en) * | 2006-04-07 | 2007-10-25 | Expression Diagnostics, Inc. | Steroid responsive nucleic acid expression and prediction of disease activity |
| CA2528162A1 (fr) | 2003-06-04 | 2004-12-16 | The Government Of The United States As Represented By The Secretary Of T He Department Of Health And Human Services, Centers For Disease Control | Micro-reseau pni et son utilisation |
| US20050281815A1 (en) * | 2004-02-26 | 2005-12-22 | Dani Eshel | CD40 splice variants and their uses |
| WO2006029184A2 (fr) * | 2004-09-08 | 2006-03-16 | Expression Diagnostics, Inc. | Genes permettant de diagnostiquer et de surveiller les troubles associes a l'inflammation |
| EP1885889A4 (fr) * | 2005-05-11 | 2010-01-20 | Expression Diagnostics Inc | Procedes de surveillance de l'etat fonctionnel de transplants a l'aide de panels de genes |
| WO2008021431A2 (fr) * | 2006-08-14 | 2008-02-21 | Xdx, Inc. | Méthodes et compositions permettant de diagnostiquer et de surveiller l'état de rejet de greffe et de troubles immunitaires |
-
2002
- 2002-12-20 US US10/325,899 patent/US7235358B2/en not_active Expired - Lifetime
-
2003
- 2003-04-24 WO PCT/US2003/012946 patent/WO2004042346A2/fr not_active Ceased
- 2003-04-24 EP EP10183179A patent/EP2292786B1/fr not_active Expired - Lifetime
- 2003-04-24 AU AU2003299465A patent/AU2003299465B2/en not_active Ceased
- 2003-04-24 IL IL16480403A patent/IL164804A0/xx unknown
- 2003-04-24 EP EP03799755A patent/EP1585972B1/fr not_active Expired - Lifetime
- 2003-04-24 US US10/511,937 patent/US7691569B2/en not_active Expired - Lifetime
- 2003-04-24 EP EP08016970.9A patent/EP2194145B1/fr not_active Expired - Lifetime
- 2003-04-24 CA CA2483481A patent/CA2483481C/fr not_active Expired - Fee Related
- 2003-04-24 JP JP2004549874A patent/JP2005536230A/ja active Pending
- 2003-04-24 EP EP10157687A patent/EP2253719B1/fr not_active Expired - Lifetime
-
2009
- 2009-08-19 US US12/544,182 patent/US7785797B2/en not_active Expired - Fee Related
- 2009-10-26 JP JP2009245982A patent/JP2010022375A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2292786A2 (fr) | 2011-03-09 |
| US20100099098A1 (en) | 2010-04-22 |
| EP1585972A2 (fr) | 2005-10-19 |
| JP2005536230A (ja) | 2005-12-02 |
| EP2253719A2 (fr) | 2010-11-24 |
| AU2003299465A1 (en) | 2004-06-07 |
| EP1585972B1 (fr) | 2013-03-20 |
| EP2292786A3 (fr) | 2011-04-13 |
| CA2483481A1 (fr) | 2004-05-21 |
| EP1585972A4 (fr) | 2007-11-21 |
| US7235358B2 (en) | 2007-06-26 |
| EP2194145A1 (fr) | 2010-06-09 |
| CA2483481C (fr) | 2016-06-28 |
| AU2003299465B2 (en) | 2007-02-15 |
| US20070031890A1 (en) | 2007-02-08 |
| WO2004042346A2 (fr) | 2004-05-21 |
| EP2194145B1 (fr) | 2013-06-05 |
| US7785797B2 (en) | 2010-08-31 |
| US20060088836A1 (en) | 2006-04-27 |
| EP2292786B1 (fr) | 2012-10-03 |
| AU2003299465B9 (en) | 2004-06-07 |
| US7691569B2 (en) | 2010-04-06 |
| EP2253719A3 (fr) | 2010-12-01 |
| WO2004042346A3 (fr) | 2005-11-24 |
| JP2010022375A (ja) | 2010-02-04 |
| EP2253719B1 (fr) | 2013-03-20 |
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