IL24513A - Iron-containing therapeutic preparations - Google Patents

Iron-containing therapeutic preparations

Info

Publication number: IL24513A
Authority: IL; Israel
Prior art keywords: iron; mol; dextrin; preparation; acid
Prior art date: 1964-11-04

Application number

IL2451365A

Other languages

English (en)

Original Assignee

Hausmann Ag Labor

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1964-11-04

Filing date

1965-10-25

Publication date

1969-06-25

1965-10-25 Application filed by Hausmann Ag Labor filed Critical Hausmann Ag Labor

1969-06-25 Publication of IL24513A publication Critical patent/IL24513A/en

Links

XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 61
229910052742 iron Inorganic materials 0.000 title claims description 31
238000002360 preparation method Methods 0.000 title claims description 17
230000001225 therapeutic effect Effects 0.000 title description 2
239000000243 solution Substances 0.000 claims description 18
229920001353 Dextrin Polymers 0.000 claims description 17
239000004375 Dextrin Substances 0.000 claims description 17
235000019425 dextrin Nutrition 0.000 claims description 17
239000003795 chemical substances by application Substances 0.000 claims description 16
229920002307 Dextran Polymers 0.000 claims description 14
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 11
RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 11
239000002253 acid Substances 0.000 claims description 11
239000000174 gluconic acid Substances 0.000 claims description 11
235000012208 gluconic acid Nutrition 0.000 claims description 11
229960004887 ferric hydroxide Drugs 0.000 claims description 9
IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 claims description 9
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
238000000034 method Methods 0.000 claims description 8
239000000600 sorbitol Substances 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 7
239000003513 alkali Substances 0.000 claims description 4
239000007864 aqueous solution Substances 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
238000009835 boiling Methods 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 2
229940082629 iron antianemic preparations Drugs 0.000 claims description 2
239000012670 alkaline solution Substances 0.000 claims 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
239000000047 product Substances 0.000 description 13
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
238000006243 chemical reaction Methods 0.000 description 6
239000002244 precipitate Substances 0.000 description 5
239000011541 reaction mixture Substances 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
150000002506 iron compounds Chemical class 0.000 description 4
229910052708 sodium Inorganic materials 0.000 description 4
239000011734 sodium Substances 0.000 description 4
229910021578 Iron(III) chloride Inorganic materials 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 2
150000004698 iron complex Chemical class 0.000 description 2
235000014413 iron hydroxide Nutrition 0.000 description 2
NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 2
229920001542 oligosaccharide Polymers 0.000 description 2
150000002482 oligosaccharides Chemical class 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000007858 starting material Substances 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
229910001854 alkali hydroxide Inorganic materials 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000009918 complex formation Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
229960005191 ferric oxide Drugs 0.000 description 1
231100000086 high toxicity Toxicity 0.000 description 1
238000005984 hydrogenation reaction Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
239000002609 medium Substances 0.000 description 1
230000027939 micturition Effects 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IL2451365A 1964-11-04 1965-10-25 Iron-containing therapeutic preparations IL24513A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DEL49194A DE1293144B (de)	1964-11-04	1964-11-04	Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid

Publications (1)

Publication Number	Publication Date
IL24513A true IL24513A (en)	1969-06-25

Family

ID=7272836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL2451365A IL24513A (en)	1964-11-04	1965-10-25	Iron-containing therapeutic preparations

Country Status (7)

Country	Link
CH (1)	CH475007A (de)
DE (1)	DE1293144B (de)
DK (1)	DK116688B (de)
ES (1)	ES319085A1 (de)
GB (1)	GB1076219A (de)
IL (1)	IL24513A (de)
NL (1)	NL6514241A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6039681B2 (ja) *	1976-01-01	1985-09-07	日本臓器製薬株式会社	デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤
HU187167B (en) *	1982-10-15	1985-11-28	Richter Gedeon Vegyeszet	Process for producing pharmaceutical solution of new type polynuclear iron/iii/ mixed complex activity
DK172860B1 (da)	1998-03-25	1999-08-16	Pharmacosmos Holding As	Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman
ATE335008T1 (de) *	2002-04-09	2006-08-15	Pharmacosmos Holding As	Eisen-dextrin verbindung zur behandlung von anämien durch eisenmangel
AU2004319676B2 (en) *	2004-05-17	2011-01-06	Cilag Ag	Method for producing iron (III) gluconate complex
BRPI0924653B8 (pt)	2009-03-25	2021-05-25	Pharmacosmos Holding As	composto de ferro-oligossacarídeo, composição e uso de deste composto
EP2997968A1 (de)	2014-09-22	2016-03-23	Ioulia Tseti	Eisen-(III)-Hydroxidkomplexe mit aktivierten Glucosesirups und Verfahren zur Herstellung davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1172250B (de) *	1958-02-13	1964-06-18	Hausmann Ag Labor	Verfahren zur Herstellung von therapeutisch verwendbaren Eisen(ó¾)-Dextran-Komplex-verbindungen
CH366537A (de) *	1958-02-13	1963-01-15	Hausmann Ag Labor	Verfahren zur Herstellung eines therapeutisch anwendbaren Eisen-Polyisomaltosat-Komplexes

1964
- 1964-11-04 DE DEL49194A patent/DE1293144B/de active Pending
1965
- 1965-10-25 DK DK545765A patent/DK116688B/da unknown
- 1965-10-25 IL IL2451365A patent/IL24513A/en unknown
- 1965-10-29 ES ES0319085A patent/ES319085A1/es not_active Expired
- 1965-11-02 GB GB4635665A patent/GB1076219A/en not_active Expired
- 1965-11-03 NL NL6514241A patent/NL6514241A/xx unknown
- 1965-11-03 CH CH1515165A patent/CH475007A/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CH475007A (de)	1969-07-15
ES319085A1 (es)	1966-04-16
DK116688B (da)	1970-02-02
GB1076219A (en)	1967-07-19
NL6514241A (de)	1966-05-05
DE1293144B (de)	1969-04-24

Publication	Publication Date	Title
Kalckar	1939	The nature of phosphoric esters formed in kidney extracts
US2820740A (en)	1958-01-21	Therapeutic preparations of iron
DE1668033C2 (de)	1983-02-10	Eisenkomplexverbindungen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
US4180567A (en)	1979-12-25	Iron preparations and methods of making and administering the same
US4927756A (en)	1990-05-22	Water soluble iron dextran and a process for its manufacture
WO2004037865A1 (de)	2004-05-06	Wasserlösliche eisen-kohlenhydrat-komplexe, deren herstellung und diese enthaltende arzneimittel
DE1468540A1 (de)	1969-02-20	Verfahren zur Herstellung von Erdalkalisalzen von Aluminiumhydroxysaeurechelaten
US3686397A (en)	1972-08-22	Parenteral iron preparations
DE2324470C3 (de)	1980-04-24	Hydrolysierte Stärkehydroxypropyläther, Verfahren zu deren Herstellung und ihre Verwendung
US3830824A (en)	1974-08-20	Physiological organic acid silver allantoinates
AU2004319676A1 (en)	2005-11-24	Method for producing iron (III) gluconate complex
US3639588A (en)	1972-02-01	Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids
US3070595A (en)	1962-12-25	Process for producing polysulfuric acid esters of polysaccharides
US2710860A (en)	1955-06-14	Nikethamide adenylate
DE1293144B (de)	1969-04-24	Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid
US3578655A (en)	1971-05-11	Carbohydrate agent of high water retention power,process of making same,and composition containing same
US3666749A (en)	1972-05-30	Iron dextran complex and process for making same
US3352893A (en)	1967-11-14	Method of producing hydroxy aluminum disalicylate
US505986A (en)	1893-10-03	Pio marfori
USRE27240E (en)	1971-11-23	Therapeutic preparation of iron
DE938502C (de)	1956-02-02	Verfahren zur Herstellung einer kolloidalen Eisenzubereitung
DE2226267B2 (de)	1977-06-02	Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittel
US3907869A (en)	1975-09-23	Method of producing calcium pangamate
US3109019A (en)	1963-10-29	Process for preparing a water-soluble sodium salt of acetylsalicylic acid
CA1078735A (en)	1980-06-03	Process for the production of a stabilized solution of theophylline