IL61175A - 4-(3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-hydroxypropyl)delta 2-1,2,4-oxadiazolin-5-one derivatives,process for their preparation and pharmaceutical compositions containing them - Google Patents

4-(3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-hydroxypropyl)delta 2-1,2,4-oxadiazolin-5-one derivatives,process for their preparation and pharmaceutical compositions containing them

Info

Publication number: IL61175A
Authority: IL; Israel
Prior art keywords: oxadiazolin; isoquinolyl; tetrahydro; hydroxypropyl; delta
Prior art date: 1979-10-11

Application number

IL61175A

Other languages

English (en)

Other versions

IL61175A0 (en

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-11

Filing date

1980-09-30

Publication date

1984-08-31

1980-09-30 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1980-11-30 Publication of IL61175A0 publication Critical patent/IL61175A0/xx

1984-08-31 Publication of IL61175A publication Critical patent/IL61175A/xx

Links

PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical class O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL61175A 1979-10-11 1980-09-30 4-(3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-hydroxypropyl)delta 2-1,2,4-oxadiazolin-5-one derivatives,process for their preparation and pharmaceutical compositions containing them IL61175A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU79CI1973A HU179951B (en)	1979-10-11	1979-10-11	Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof

Publications (2)

Publication Number	Publication Date
IL61175A0 IL61175A0 (en)	1980-11-30
IL61175A true IL61175A (en)	1984-08-31

Family

ID=10994764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL61175A IL61175A (en)	1979-10-11	1980-09-30	4-(3-(1,2,3,4-tetrahydro-2-isoquinolyl)-2-hydroxypropyl)delta 2-1,2,4-oxadiazolin-5-one derivatives,process for their preparation and pharmaceutical compositions containing them

Country Status (23)

Country	Link
US (1)	US4365064A (cs)
JP (1)	JPS5661375A (cs)
AT (1)	AT375369B (cs)
BE (1)	BE885633A (cs)
CA (1)	CA1154019A (cs)
CH (1)	CH649547A5 (cs)
CS (1)	CS241032B2 (cs)
DD (1)	DD153550A5 (cs)
DE (1)	DE3037432A1 (cs)
DK (1)	DK149854C (cs)
ES (1)	ES8106725A1 (cs)
FI (2)	FI71932C (cs)
FR (1)	FR2467203A1 (cs)
GB (1)	GB2059967B (cs)
HU (1)	HU179951B (cs)
IL (1)	IL61175A (cs)
IT (1)	IT1129305B (cs)
NL (1)	NL8005586A (cs)
NO (1)	NO154795C (cs)
PL (3)	PL132131B1 (cs)
SE (1)	SE452158B (cs)
SU (1)	SU1087519A1 (cs)
YU (1)	YU41738B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU180708B (en) *	1979-10-11	1983-04-29	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 1,2,4-oxadiazine derivatives
JP2003528073A (ja) *	2000-03-20	2003-09-24	エヌ・ジーンリサーチラボラトリーズインコーポレイテッド	プロペンカルボン酸アミドキシム誘導体、その製法、及びこの誘導体を含有する医薬組成物
US9604930B2 (en)	2012-12-21	2017-03-28	Epizyme, Inc.	Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
US10118918B2 (en)	2012-12-21	2018-11-06	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
US9365555B2 (en) *	2012-12-21	2016-06-14	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
US9908887B2 (en)	2012-12-21	2018-03-06	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
JP2016505002A (ja)	2012-12-21	2016-02-18	エピザイム，インコーポレイティド	ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用
AU2015301196A1 (en)	2014-08-04	2017-01-12	Epizyme, Inc.	PRMT5 inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1529700A (fr) *	1967-04-11	1968-06-21	Dausse Sa Lab	Tertioaminoalcoyl oxadiazolinones et leur procédé de préparation
FR1575552A (cs) *	1967-12-07	1969-07-25
US4038279A (en) *	1972-12-23	1977-07-26	Boehringer Ingelheim Gmbh	N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US3994891A (en) *	1974-12-20	1976-11-30	Armour Pharmaceutical Company	Tetrahydroisoquinoline compounds
US4187220A (en) *	1977-08-30	1980-02-05	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU180708B (en) *	1979-10-11	1983-04-29	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 1,2,4-oxadiazine derivatives

1979
- 1979-10-11 HU HU79CI1973A patent/HU179951B/hu not_active IP Right Cessation
1980
- 1980-09-30 IL IL61175A patent/IL61175A/xx unknown
- 1980-10-03 DE DE19803037432 patent/DE3037432A1/de not_active Withdrawn
- 1980-10-06 CS CS806737A patent/CS241032B2/cs unknown
- 1980-10-07 SE SE8007025A patent/SE452158B/sv not_active IP Right Cessation
- 1980-10-09 IT IT68555/80A patent/IT1129305B/it active
- 1980-10-09 NL NL8005586A patent/NL8005586A/nl not_active Application Discontinuation
- 1980-10-09 FR FR8021624A patent/FR2467203A1/fr active Granted
- 1980-10-09 JP JP14066880A patent/JPS5661375A/ja active Pending
- 1980-10-09 AT AT0501380A patent/AT375369B/de not_active IP Right Cessation
- 1980-10-10 GB GB8032828A patent/GB2059967B/en not_active Expired
- 1980-10-10 SU SU802993201A patent/SU1087519A1/ru active
- 1980-10-10 BE BE0/202406A patent/BE885633A/fr not_active IP Right Cessation
- 1980-10-10 DD DD80224478A patent/DD153550A5/de not_active IP Right Cessation
- 1980-10-10 ES ES495819A patent/ES8106725A1/es not_active Expired
- 1980-10-10 YU YU2594/80A patent/YU41738B/xx unknown
- 1980-10-10 PL PL1980232293A patent/PL132131B1/pl unknown
- 1980-10-10 PL PL1980232292A patent/PL131451B1/pl unknown
- 1980-10-10 NO NO803044A patent/NO154795C/no unknown
- 1980-10-10 FI FI803220A patent/FI71932C/fi not_active IP Right Cessation
- 1980-10-10 DK DK429780A patent/DK149854C/da not_active IP Right Cessation
- 1980-10-10 CH CH7599/80A patent/CH649547A5/de not_active IP Right Cessation
- 1980-10-10 CA CA000362217A patent/CA1154019A/en not_active Expired
- 1980-10-10 PL PL1980227209A patent/PL131375B1/pl unknown
- 1980-10-10 FI FI803219A patent/FI71318C/fi not_active IP Right Cessation
- 1980-10-14 US US06/196,583 patent/US4365064A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL131375B1 (en)	1984-11-30
CS241032B2 (en)	1986-03-13
DK429780A (da)	1981-04-12
IT8068555A0 (it)	1980-10-09
AT375369B (de)	1984-07-25
NL8005586A (nl)	1981-04-14
FR2467203B1 (cs)	1985-03-22
YU41738B (en)	1987-12-31
PL132131B1 (en)	1985-02-28
FI71318C (fi)	1986-12-19
PL232292A1 (cs)	1982-04-26
DK149854B (da)	1986-10-13
GB2059967A (en)	1981-04-29
NO803044L (no)	1981-04-13
CA1154019A (en)	1983-09-20
FI71932C (fi)	1987-03-09
ES495819A0 (es)	1981-09-16
JPS5661375A (en)	1981-05-26
DK149854C (da)	1987-04-21
FR2467203A1 (fr)	1981-04-17
PL232293A1 (cs)	1982-04-26
DD153550A5 (de)	1982-01-13
SU1087519A1 (ru)	1984-04-23
CH649547A5 (de)	1985-05-31
FI71318B (fi)	1986-09-09
IL61175A0 (en)	1980-11-30
FI803219L (fi)	1981-04-12
US4365064A (en)	1982-12-21
ES8106725A1 (es)	1981-09-16
PL227209A1 (cs)	1981-12-11
GB2059967B (en)	1983-06-02
HU179951B (en)	1983-01-28
CS673780A2 (en)	1985-06-13
FI803220L (fi)	1981-04-12
PL131451B1 (en)	1984-11-30
NO154795C (no)	1986-12-29
SE8007025L (sv)	1981-04-12
YU259480A (en)	1984-02-29
IT1129305B (it)	1986-06-04
NO154795B (no)	1986-09-15
ATA501380A (de)	1983-12-15
BE885633A (fr)	1981-02-02
FI71932B (fi)	1986-11-28
SE452158B (sv)	1987-11-16
DE3037432A1 (de)	1981-05-27

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DE3070073D1 (en)	1985-03-14	1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
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IL59719A (en)	1984-01-31	2-(pyrid-2-yl)tetrahydrothiophene derivatives,process for their preparation and pharmaceutical compositions comprising the same
IL60548A (en)	1983-07-31	N-alkanesulfonyl-n-(6-methyl-ergol-8-enyl(and 8-ergolinyl)methyl)aminoethyl derivatives,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en)	1983-06-09	Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
DE3060365D1 (en)	1982-06-24	Cystamine derivatives, their preparation and pharmaceutical compositions containing them
DE2860796D1 (en)	1981-09-24	Tantomeric arylaminoimidazoline derivatives, their preparation and pharmaceutical formulations for analgetic application containing them
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