IL73239A - N-(substituted aralkyl)phenoxypropanolamines,their manufacture and pharmaceutical compositions containing them - Google Patents

N-(substituted aralkyl)phenoxypropanolamines,their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL73239A
IL73239A IL8473239A IL7323984A IL73239A IL 73239 A IL73239 A IL 73239A IL 8473239 A IL8473239 A IL 8473239A IL 7323984 A IL7323984 A IL 7323984A IL 73239 A IL73239 A IL 73239A
Authority
IL
Israel
Prior art keywords
alkyl
optionally
group
see diagramm
mono
Prior art date
Application number
IL8473239A
Other languages
English (en)
Other versions
IL73239A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL73239A0 publication Critical patent/IL73239A0/xx
Publication of IL73239A publication Critical patent/IL73239A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
IL8473239A 1983-10-19 1984-10-15 N-(substituted aralkyl)phenoxypropanolamines,their manufacture and pharmaceutical compositions containing them IL73239A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH568483 1983-10-19
CH428884 1984-09-07

Publications (2)

Publication Number Publication Date
IL73239A0 IL73239A0 (en) 1985-01-31
IL73239A true IL73239A (en) 1989-05-15

Family

ID=25695136

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8473239A IL73239A (en) 1983-10-19 1984-10-15 N-(substituted aralkyl)phenoxypropanolamines,their manufacture and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (1) US5064863A (da)
EP (1) EP0140243B1 (da)
AT (1) ATE38510T1 (da)
AU (1) AU575590B2 (da)
CA (1) CA1262729A (da)
DE (1) DE3475066D1 (da)
DK (1) DK497284A (da)
DO (1) DOP1984004282A (da)
FI (1) FI844082A7 (da)
HU (1) HU200992B (da)
IL (1) IL73239A (da)
MC (1) MC1625A1 (da)
NO (1) NO159791C (da)
NZ (1) NZ209866A (da)
PH (1) PH21479A (da)
PT (1) PT79371B (da)
ZW (1) ZW16684A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds
EP0300290B1 (de) * 1987-07-21 1991-12-18 F. Hoffmann-La Roche Ag Phenoxypropanolamine
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
GB8905336D0 (en) * 1989-03-08 1989-04-19 Ici Plc Chemical compounds
US5177219A (en) * 1992-03-06 1993-01-05 American Home Products Corporation N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione compounds
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
IL113084A (en) * 1994-03-23 1999-01-26 Sankyo Co Thiazolidine and oxazolidine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5488064A (en) * 1994-05-02 1996-01-30 Bristol-Myers Squibb Company Benzo 1,3 dioxole derivatives
WO1996004233A1 (en) * 1994-07-29 1996-02-15 Smithkline Beecham Plc Aryloxy and arylthiopropanolamine derivatives useful as beta 3-adrenoreceptor agonists and antagonists of the beta 1 and beta 2-adrenoreceptors and pharmaceutical composition thereof
US5726165A (en) * 1994-07-29 1998-03-10 Smithkline Beecham P.L.C. Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
US5491134A (en) * 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US6075040A (en) * 1996-09-05 2000-06-13 Eli Lilly And Company Selective β3 adrenergic agonists
ES2171839T3 (es) 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
GB9703492D0 (en) * 1997-02-20 1997-04-09 Smithkline Beecham Plc Novel compounds
UY24949A1 (es) * 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
AU1572701A (en) * 1999-11-15 2001-05-30 Eli Lilly And Company Treating wasting syndromes with aryloxy propanolamines
US6239313B1 (en) * 2000-02-16 2001-05-29 Council Of Scientific And Industrial Research Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
WO2006014704A1 (en) * 2004-07-21 2006-02-09 Theravance, Inc. DIARYL ETHER β2 ADRENERGIC RECEPTOR AGONISTS

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301580A (da) * 1962-12-11
US4127675A (en) * 1968-11-12 1978-11-28 Yamanouchi Pharmaceutical Co., Ltd. 4-(Alkylamino-2-hydroxypropoxy)-indenes and method of use
BE741762A (da) * 1968-11-18 1970-05-19
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
FR2119844B1 (da) * 1970-12-28 1974-03-22 Laroche Navarro Labo
SE388849B (sv) * 1974-02-14 1976-10-18 Haessle Ab Forfarande for framstellning av nya aminer med beta-receptorstimulerande verkan
SE402764B (sv) * 1975-06-04 1978-07-17 Haessle Ab Forfarande for framstellning av nya hjertaktiva foreningar
US4165384A (en) * 1974-11-01 1979-08-21 Aktiebolaget Hassle Amide substituted phenoxy propanol amines
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
US4263325A (en) * 1977-10-05 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
IL57671A (en) * 1978-07-03 1982-11-30 Lilly Co Eli Phenethanolamines,process for their preparation and pharmaceutical and animal feed compositions containing the same
DE3012012A1 (de) * 1980-03-28 1981-10-08 Beiersdorf Ag, 2000 Hamburg Substituierte 3-aryl-2-cycloalken-1-one und verfahren zu ihrer herstellung
ZW9881A1 (en) * 1980-06-02 1981-12-23 Hoffmann La Roche Substituted phenoxyaminopropanol derivatives
DE3125870C2 (de) * 1980-07-09 1994-09-15 William John Louis 3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel
EP0052963B1 (en) * 1980-11-20 1985-02-20 Beecham Group Plc Secondary amines
IL65541A0 (en) * 1981-05-06 1982-07-30 Haessle Ab Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same
EP0099707B1 (en) * 1982-07-16 1986-12-10 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
ZA835687B (en) * 1982-08-10 1984-03-28 Hoffmann La Roche Novel phenethanolamines
GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
EP0140243A3 (en) 1986-07-02
IL73239A0 (en) 1985-01-31
PT79371A (en) 1984-11-01
HUT37743A (en) 1986-02-28
DK497284D0 (da) 1984-10-17
FI844082L (fi) 1985-04-20
US5064863A (en) 1991-11-12
NZ209866A (en) 1988-07-28
NO159791B (no) 1988-10-31
HU200992B (en) 1990-09-28
EP0140243B1 (de) 1988-11-09
AU3370684A (en) 1985-04-26
FI844082A0 (fi) 1984-10-17
DK497284A (da) 1985-04-20
ATE38510T1 (de) 1988-11-15
DE3475066D1 (de) 1988-12-15
NO159791C (no) 1989-02-08
NO844176L (no) 1985-04-22
DOP1984004282A (es) 1990-03-22
PH21479A (en) 1987-10-28
CA1262729A (en) 1989-11-07
AU575590B2 (en) 1988-08-04
FI844082A7 (fi) 1985-04-20
PT79371B (en) 1986-11-20
ZW16684A1 (en) 1985-05-15
MC1625A1 (fr) 1985-09-26
EP0140243A2 (de) 1985-05-08

Similar Documents

Publication Publication Date Title
IL73239A (en) N-(substituted aralkyl)phenoxypropanolamines,their manufacture and pharmaceutical compositions containing them
YU209680A (en) Process for preparing propenylamines
PT77410B (en) Process for the preparation of a fungicidal composition containing substituted 1-hydroxymethyltriazolyl derivatives
GB1418822A (en) Imidazo-and pyrimido-2,1-b-quinazolin-2-ones and a process for the preparation thereof
ZA887433B (en) Imidazo(1,2-b)imidazobenzothiazoles and their acids addition salts,their process and intermediates of preparation,their application as medicaments and the pharmaceutical compositions containing them
ES8308834A1 (es) Un procedimiento para la preparacion de derivados de etanolamina
JPS5283396A (en) Novel compound physiologically acceptable salts thereof process for preparing same and medical composition containing same
AU6557086A (en) New pyridine compounds with basic substituents, a process for their preparation, medicaments containing them, and their use
GB1315734A (en) Phenylalanine derivatives and a process for the manufacture thereof
ES8307713A1 (es) "procedimiento para la fabricacion de cuerpos moldeados y recubrimientos mediante reaccion de compuestos epoxidicos".
GB1448966A (en) Amine derivatives of azidophenols
ES2024332A6 (es) Procedimiento para la obtencion de nuevas sulfonamidas.
JPS5671060A (en) O-sulfonamidophenol derivative
JPS5671061A (en) O-sulfonamidophenol derivative
DK513281A (da) Fremgangsaade til fremstilling af 3-thiovinylcephalosproner
ES8203876A1 (es) Procedimiento de obtencion de nuevos a-amino derivados ci- clicos del 1-(3',4'-metilendioxifenil)etanol
SU1500287A1 (ru) Состав дл приготовлени горчичников
JPS56127376A (en) Indolizine-2-one derivative and its preparation
JPS54138536A (en) O-(n-substituted aminomethyl)phenylaceticacid and its preparation
JPS56127378A (en) 2-alkoxyindolizine derivative and its preparation
ES314635A1 (es) Procedimiento para la preparacion de nuevos derivados de azepina.
JPS5630971A (en) 2-cyclohexyl-gamma-2-phenyl-trans-4-piperidinomethyl-1,2- dioxorane and its preparation
JPS57176979A (en) Novel derivative of secalonic acid and its preparation
JPS51138621A (en) Process for preparing novel nitroso compounds
ES8203377A1 (es) Un procedimiento para la preparacion de piridazopiridacina