IL79648A - Pharmaceutical anti-inflammatory and ischemia preventing compositions containing di-t-butylphenol derivatives,some such novel compounds and process for their preparation - Google Patents
Pharmaceutical anti-inflammatory and ischemia preventing compositions containing di-t-butylphenol derivatives,some such novel compounds and process for their preparationInfo
- Publication number
- IL79648A IL79648A IL79648A IL7964886A IL79648A IL 79648 A IL79648 A IL 79648A IL 79648 A IL79648 A IL 79648A IL 7964886 A IL7964886 A IL 7964886A IL 79648 A IL79648 A IL 79648A
- Authority
- IL
- Israel
- Prior art keywords
- ischemia
- inflammatory
- preparation
- compositions containing
- novel compounds
- Prior art date
Links
- SKDGWNHUETZZCS-UHFFFAOYSA-N 2,3-ditert-butylphenol Chemical class CC(C)(C)C1=CC=CC(O)=C1C(C)(C)C SKDGWNHUETZZCS-UHFFFAOYSA-N 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000028867 ischemia Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76416085A | 1985-08-09 | 1985-08-09 | |
| US86948886A | 1986-06-02 | 1986-06-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL79648A0 IL79648A0 (en) | 1986-11-30 |
| IL79648A true IL79648A (en) | 1991-12-12 |
Family
ID=27117408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL79648A IL79648A (en) | 1985-08-09 | 1986-08-06 | Pharmaceutical anti-inflammatory and ischemia preventing compositions containing di-t-butylphenol derivatives,some such novel compounds and process for their preparation |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0211670B1 (da) |
| JP (1) | JPH0625182B2 (da) |
| KR (1) | KR870000889B1 (da) |
| CN (1) | CN1014891B (da) |
| AR (1) | AR243173A1 (da) |
| AU (1) | AU590312B2 (da) |
| CA (1) | CA1285572C (da) |
| CY (1) | CY1619A (da) |
| DE (1) | DE3670951D1 (da) |
| DK (1) | DK169324B1 (da) |
| ES (1) | ES2001075A6 (da) |
| GR (1) | GR862081B (da) |
| HK (1) | HK94791A (da) |
| HU (1) | HU196192B (da) |
| IE (1) | IE58718B1 (da) |
| IL (1) | IL79648A (da) |
| LV (1) | LV10866B (da) |
| MX (1) | MX9203108A (da) |
| MY (1) | MY102365A (da) |
| NZ (1) | NZ217126A (da) |
| PH (1) | PH24517A (da) |
| PT (1) | PT83152B (da) |
| SG (1) | SG80391G (da) |
| SU (1) | SU1516012A3 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8512163D0 (en) * | 1985-05-14 | 1985-06-19 | Fujisawa Pharmaceutical Co | Oxothiazolidine compound |
| US5356917A (en) * | 1985-08-09 | 1994-10-18 | Eli Lilly And Company | Aryl-substituted rhodanine derivatives |
| US5691367A (en) * | 1985-08-09 | 1997-11-25 | Eli Lilly And Company | Aryl-substituted rhodanine derivatives |
| US4897406A (en) * | 1987-11-13 | 1990-01-30 | Nisshin Flour Milling Co., Ltd. | Rhodanine derivatives and pharmaceutical compositions |
| US5208250A (en) * | 1988-05-25 | 1993-05-04 | Warner-Lambert Company | Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents |
| IE62214B1 (en) * | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
| US5306822A (en) * | 1988-05-25 | 1994-04-26 | Warner-Lambert Company | Arylmethylenyl derivatives of oxazolidinone |
| NZ231534A (en) * | 1988-11-29 | 1992-02-25 | Warner Lambert Co | 3,5-di-t-butyl-4-hydroxyphenyl-triazoles, oxadiazoles and thiadiazoles; anti-inflammatory compositions |
| ES2088965T3 (es) * | 1989-04-07 | 1996-10-01 | Lilly Co Eli | Derivados de rodanina aril-sustituidos. |
| IL108962A (en) * | 1989-12-21 | 1996-12-05 | Lilly Co Eli | Use of hydroxybenzyl substituted sulfur containing heterocyclic derivatives a process for their preparation and pharmaceutical compositions containing them |
| US5216002A (en) * | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
| US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
| PT97507B (pt) * | 1990-04-27 | 1998-08-31 | Orion Yhtymae Oy | Processo para apreparacao de novos derivados de catecol farmacologicamente activos |
| DE69221794T2 (de) * | 1991-01-21 | 1998-03-19 | Shionogi Seiyaku Kk | 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga |
| US5158966A (en) * | 1991-02-22 | 1992-10-27 | The University Of Colorado Foundation, Inc. | Method of treating type i diabetes |
| US5143929A (en) * | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents |
| NZ248573A (en) * | 1992-09-10 | 1996-02-27 | Lilly Co Eli | 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions |
| EP0595546B1 (en) * | 1992-10-28 | 1996-03-20 | Shionogi & Co., Ltd. | Benzylidene derivatives |
| KR100262419B1 (ko) * | 1993-06-23 | 2000-09-01 | 나가야마 오사무 | 허혈성 질환에 유용한 벤젠 유도체 |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
| EP0722729A3 (en) * | 1995-01-23 | 1997-11-26 | Eli Lilly And Company | Aryl-substituted rhodanines for treating multiple sclerosis |
| ES2146837T3 (es) * | 1995-09-07 | 2000-08-16 | Lilly Co Eli | Procedimiento para preparar derivados de la rodanina sustituidos con bencilo. |
| AU726664B2 (en) * | 1996-07-11 | 2000-11-16 | Warner-Lambert Company | Method for treating and preventing neurodegenerative disorders by administering a thiazolidinone |
| US6005142A (en) * | 1996-09-03 | 1999-12-21 | Eli Lilly And Company | Process for preparing benzyl-substituted rhodanine derivatives |
| US6063799A (en) * | 1996-09-03 | 2000-05-16 | Eli Lilly And Company | Alternate crystal form of Tazofelone |
| WO2000018748A1 (en) * | 1998-09-30 | 2000-04-06 | Roche Diagnostics Gmbh | Rhodanine derivatives for the treatment and prevention of metabolic bone disorders |
| AU2002953533A0 (en) | 2002-12-24 | 2003-01-16 | Arthron Limited | Fc receptor modulating compounds and compositions |
| DE202006018406U1 (de) | 2006-12-05 | 2008-04-10 | Seda S.P.A. | Verpackung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1038050B (de) * | 1955-11-17 | 1958-09-04 | Farmaceutici Italia S A Soc | Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen |
| JPS5740478A (en) * | 1980-08-22 | 1982-03-06 | Ono Pharmaceut Co Ltd | Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative |
| JPS5879944A (ja) * | 1981-11-09 | 1983-05-13 | Kanegafuchi Chem Ind Co Ltd | ３，５−ジ・タ−シヤリ−・ブチルスチレン誘導体及び抗炎症、鎮痛、解熱剤並びに血小板凝集阻害剤 |
| JPS57130950A (en) * | 1981-02-05 | 1982-08-13 | Kanegafuchi Chem Ind Co Ltd | 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation |
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
-
1986
- 1986-08-06 IL IL79648A patent/IL79648A/xx not_active IP Right Cessation
- 1986-08-06 GR GR862081A patent/GR862081B/el unknown
- 1986-08-06 CA CA000515379A patent/CA1285572C/en not_active Expired - Lifetime
- 1986-08-06 PT PT83152A patent/PT83152B/pt not_active IP Right Cessation
- 1986-08-07 PH PH34111A patent/PH24517A/en unknown
- 1986-08-07 AU AU60972/86A patent/AU590312B2/en not_active Ceased
- 1986-08-07 NZ NZ217126A patent/NZ217126A/xx unknown
- 1986-08-07 DK DK376986A patent/DK169324B1/da not_active IP Right Cessation
- 1986-08-08 IE IE213786A patent/IE58718B1/en not_active IP Right Cessation
- 1986-08-08 AR AR86304842A patent/AR243173A1/es active
- 1986-08-08 EP EP86306134A patent/EP0211670B1/en not_active Expired - Lifetime
- 1986-08-08 ES ES8600951A patent/ES2001075A6/es not_active Expired
- 1986-08-08 JP JP61187645A patent/JPH0625182B2/ja not_active Expired - Fee Related
- 1986-08-08 DE DE8686306134T patent/DE3670951D1/de not_active Expired - Lifetime
- 1986-08-08 CN CN86105036A patent/CN1014891B/zh not_active Expired
- 1986-08-08 SU SU864027906A patent/SU1516012A3/ru active
- 1986-08-08 HU HU863516A patent/HU196192B/hu not_active IP Right Cessation
- 1986-08-08 KR KR1019860006534A patent/KR870000889B1/ko not_active Expired
-
1987
- 1987-09-22 MY MYPI87001858A patent/MY102365A/en unknown
-
1991
- 1991-10-04 SG SG803/91A patent/SG80391G/en unknown
- 1991-11-21 HK HK947/91A patent/HK94791A/en not_active IP Right Cessation
-
1992
- 1992-06-22 MX MX9203108A patent/MX9203108A/es unknown
- 1992-07-10 CY CY1619A patent/CY1619A/xx unknown
-
1993
- 1993-06-08 LV LVP-93-523A patent/LV10866B/lv unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG80391G (en) | 1991-11-15 |
| PT83152B (pt) | 1989-03-30 |
| PT83152A (en) | 1986-09-01 |
| NZ217126A (en) | 1989-01-27 |
| GR862081B (en) | 1986-12-24 |
| AU6097286A (en) | 1987-02-12 |
| EP0211670B1 (en) | 1990-05-09 |
| LV10866B (en) | 1996-04-20 |
| MX9203108A (es) | 1992-07-01 |
| IE58718B1 (en) | 1993-11-03 |
| KR870002109A (ko) | 1987-03-30 |
| KR870000889B1 (ko) | 1987-05-02 |
| MY102365A (en) | 1992-06-17 |
| CN1014891B (zh) | 1991-11-27 |
| AU590312B2 (en) | 1989-11-02 |
| DK376986A (da) | 1987-02-10 |
| CN86105036A (zh) | 1987-02-04 |
| EP0211670A2 (en) | 1987-02-25 |
| SU1516012A3 (ru) | 1989-10-15 |
| PH24517A (en) | 1990-07-18 |
| LV10866A (lv) | 1995-10-20 |
| DE3670951D1 (de) | 1990-06-13 |
| IL79648A0 (en) | 1986-11-30 |
| HU196192B (en) | 1988-10-28 |
| CY1619A (en) | 1992-07-10 |
| DK169324B1 (da) | 1994-10-10 |
| DK376986D0 (da) | 1986-08-07 |
| JPH0625182B2 (ja) | 1994-04-06 |
| EP0211670A3 (en) | 1987-05-06 |
| HUT42765A (en) | 1987-08-28 |
| ES2001075A6 (es) | 1988-04-16 |
| CA1285572C (en) | 1991-07-02 |
| AR243173A1 (es) | 1993-07-30 |
| JPS6242977A (ja) | 1987-02-24 |
| HK94791A (en) | 1991-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |