IL84310A0 - Benzo(5,6)cycloheptapyridines,compositions and methods of use - Google Patents
Benzo(5,6)cycloheptapyridines,compositions and methods of useInfo
- Publication number
- IL84310A0 IL84310A0 IL84310A IL8431087A IL84310A0 IL 84310 A0 IL84310 A0 IL 84310A0 IL 84310 A IL84310 A IL 84310A IL 8431087 A IL8431087 A IL 8431087A IL 84310 A0 IL84310 A0 IL 84310A0
- Authority
- IL
- Israel
- Prior art keywords
- benzo
- methods
- cycloheptapyridines
- compositions
- cyclohepta
- Prior art date
Links
- 125000005605 benzo group Chemical group 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- OZVMEJXYSDZMDV-UHFFFAOYSA-N 11h-benzo[1,2]cyclohepta[3,4-b]pyridine Chemical class C1=CC2=NC=CC=C2CC2=CC=CC=C21 OZVMEJXYSDZMDV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL101941A IL101941A0 (en) | 1986-10-31 | 1992-05-20 | Heterocyclic compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/925,342 US4826853A (en) | 1986-10-31 | 1986-10-31 | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL84310A0 true IL84310A0 (en) | 1988-03-31 |
Family
ID=25451584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL84310A IL84310A0 (en) | 1986-10-31 | 1987-10-29 | Benzo(5,6)cycloheptapyridines,compositions and methods of use |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4826853A (da) |
| EP (3) | EP0685476A1 (da) |
| JP (1) | JPH0678316B2 (da) |
| KR (1) | KR930002489B1 (da) |
| AT (1) | ATE116310T1 (da) |
| AU (1) | AU604285B2 (da) |
| CA (2) | CA1305147C (da) |
| CS (1) | CS414391A3 (da) |
| DE (1) | DE3750929T2 (da) |
| DK (1) | DK73193A (da) |
| ES (1) | ES2068179T3 (da) |
| FI (1) | FI96768C (da) |
| HK (1) | HK186396A (da) |
| IE (1) | IE65174B1 (da) |
| IL (1) | IL84310A0 (da) |
| MY (1) | MY102986A (da) |
| NZ (1) | NZ222347A (da) |
| OA (1) | OA09546A (da) |
| PH (1) | PH26184A (da) |
| SG (1) | SG44597A1 (da) |
| WO (1) | WO1988003138A1 (da) |
| ZA (1) | ZA878128B (da) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US5665726A (en) * | 1986-10-31 | 1997-09-09 | Schering Corporation | Benzo[5,6]cycloheptapyridines, compositions and methods of use |
| US5438062A (en) * | 1986-10-31 | 1995-08-01 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| SG44477A1 (en) * | 1988-04-28 | 1997-12-19 | Schering Corp | Fused polycyclic compounds compositions methods of manufacture and their use as paf antaginists anthihistamines and/or antiinflammatory agents |
| EP0411048A1 (en) * | 1988-04-28 | 1991-02-06 | Schering Corporation | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
| US4863931A (en) * | 1988-09-15 | 1989-09-05 | Schering Corporation | Antihistaminic fluoro substituted benzocycloheptapyridines |
| ES2012297A6 (es) * | 1989-04-10 | 1990-03-01 | Espnola De Especialidades Farm | Procedimiento para la obtencion de nuevos derivados imidazolicos diclorados con actividad antifungica. |
| US5095022A (en) * | 1989-07-04 | 1992-03-10 | Hokuriku Pharmaceutical Co., Ltd. | Piperidine derivatives and pharmaceutical compositions comprising the same |
| IE68935B1 (en) * | 1990-06-22 | 1996-07-24 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use |
| AU8854091A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use |
| ATE124045T1 (de) * | 1990-10-10 | 1995-07-15 | Schering Corp | Substituierte imidazobenzazepine und imidazopyridoazepine. |
| CA2093798C (en) * | 1990-10-10 | 2000-02-01 | John J. Piwinski | Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof |
| KR920014799A (ko) * | 1991-01-18 | 1992-08-25 | 나오가따 다이도 | 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제 |
| WO1992020681A1 (en) * | 1991-05-23 | 1992-11-26 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
| WO1993002081A1 (en) * | 1991-07-23 | 1993-02-04 | Schering Corporation | Novel benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use |
| JP2974529B2 (ja) * | 1992-02-20 | 1999-11-10 | 北陸製薬株式会社 | 両性型三環系化合物 |
| NZ251540A (en) * | 1992-03-27 | 1996-09-25 | Schering Corp | Bridged bis-aryl carbinol derivatives, preparation and medicaments |
| ATE140224T1 (de) * | 1992-03-27 | 1996-07-15 | Schering Corp | Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung |
| AU4244593A (en) * | 1992-05-19 | 1993-12-13 | Schering Corporation | Pentacyclic antihistamines |
| ES2042421B1 (es) | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina. |
| KR100346802B1 (ko) * | 1993-07-13 | 2002-11-29 | 얀센 파마슈티카 엔.브이. | 항앨러지성이미다조아제핀 |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
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| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
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| US6365588B1 (en) | 1993-10-15 | 2002-04-02 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
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| US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
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| US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
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| US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
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| US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
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| AU4801197A (en) * | 1996-09-13 | 1998-04-02 | Schering Corporation | Tricyclic antitumor compounds being farnesyl protein transferase inhibit ors |
| US5994364A (en) | 1996-09-13 | 1999-11-30 | Schering Corporation | Tricyclic antitumor farnesyl protein transferase inhibitors |
| US5861395A (en) * | 1996-09-13 | 1999-01-19 | Schering Corporation | Compounds useful for inhibition of farnesyl proteins transferase |
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| US5958890A (en) * | 1996-09-13 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
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| CA2294347C (en) * | 1997-06-17 | 2008-01-29 | Schering Corporation | Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives for the inhibition of farnesyl protein transferase |
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| US6689789B2 (en) | 1997-06-17 | 2004-02-10 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| US6576639B1 (en) | 1997-06-17 | 2003-06-10 | Schering Corporation | Compounds for the inhibition of farnesyl protein transferase |
| US5925648A (en) * | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
| US6632455B2 (en) | 1997-12-22 | 2003-10-14 | Schering Corporation | Molecular dispersion composition with enhanced bioavailability |
| US6686502B1 (en) | 1999-03-26 | 2004-02-03 | Ucb S.A. | Compounds and methods for treatment of asthma, allergy and inflammatory disorders |
| PE20001566A1 (es) | 1999-03-26 | 2001-02-05 | Ucb Sa | Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas |
| US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
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| AU2020372682A1 (en) * | 2019-10-31 | 2022-06-09 | Jd Bioscience Inc. | Tricyclic compound and pharmaceutical use thereof |
| WO2023071601A1 (zh) * | 2021-10-28 | 2023-05-04 | 天津市昕晨投资发展有限公司 | 地氯雷他定衍生物、其制备方法及其用途 |
| CN115141229B (zh) * | 2022-07-21 | 2023-12-12 | 华创合成制药股份有限公司 | 抗组胺类化合物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL132137C (da) * | 1963-04-24 | |||
| US3419565A (en) * | 1963-04-24 | 1968-12-31 | Schering Corp | Aza-dibenzocycloheptenes |
| US3409621A (en) * | 1966-04-01 | 1968-11-05 | Schering Corp | Piperazino-aza-dibenzo-[a, d]-cycloheptenes |
| US3717647A (en) * | 1971-04-09 | 1973-02-20 | Schering Corp | Alpha-nicotinoyl phenylacetonitriles |
| DK401476A (da) * | 1975-09-15 | 1977-03-16 | Sandoz Ag | Fremgangsmade til fremstilling af benzocycloheptapyridinforbindelser |
| US4335036A (en) | 1980-05-30 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Plasticized polyvinyl butyral employing propylene oxide oligomers |
| US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
| US4355036A (en) * | 1980-06-19 | 1982-10-19 | Schering Corporation | Tricyclic-substituted piperidine antihistamines |
| WO1985003707A1 (en) * | 1984-02-15 | 1985-08-29 | Schering Corporation | 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| EP0208855B1 (en) * | 1985-05-13 | 1991-03-06 | Schering Corporation | process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions |
| US4804666A (en) * | 1985-08-14 | 1989-02-14 | Schering Corporation | Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines |
-
1986
- 1986-10-31 US US06/925,342 patent/US4826853A/en not_active Expired - Fee Related
-
1987
- 1987-10-29 IL IL84310A patent/IL84310A0/xx not_active IP Right Cessation
- 1987-10-29 MY MYPI87002990A patent/MY102986A/en unknown
- 1987-10-29 NZ NZ222347A patent/NZ222347A/xx unknown
- 1987-10-29 WO PCT/US1987/002777 patent/WO1988003138A1/en not_active Ceased
- 1987-10-29 PH PH36002A patent/PH26184A/en unknown
- 1987-10-29 SG SG1996003470A patent/SG44597A1/en unknown
- 1987-10-29 ZA ZA878128A patent/ZA878128B/xx unknown
- 1987-10-29 EP EP94108677A patent/EP0685476A1/en not_active Withdrawn
- 1987-10-29 EP EP87908033A patent/EP0330673A1/en active Pending
- 1987-10-29 DE DE3750929T patent/DE3750929T2/de not_active Expired - Fee Related
- 1987-10-29 JP JP63500276A patent/JPH0678316B2/ja not_active Expired - Lifetime
- 1987-10-29 AU AU83362/87A patent/AU604285B2/en not_active Ceased
- 1987-10-29 IE IE291387A patent/IE65174B1/en not_active IP Right Cessation
- 1987-10-29 ES ES87115890T patent/ES2068179T3/es not_active Expired - Lifetime
- 1987-10-29 EP EP87115890A patent/EP0270818B1/en not_active Expired - Lifetime
- 1987-10-29 KR KR1019880700738A patent/KR930002489B1/ko not_active Expired - Fee Related
- 1987-10-29 AT AT87115890T patent/ATE116310T1/de not_active IP Right Cessation
- 1987-10-30 CA CA000550729A patent/CA1305147C/en not_active Expired - Lifetime
-
1989
- 1989-04-17 FI FI891806A patent/FI96768C/fi not_active IP Right Cessation
- 1989-04-28 OA OA59569A patent/OA09546A/en unknown
-
1991
- 1991-12-30 CS CS914143A patent/CS414391A3/cs unknown
-
1992
- 1992-02-07 CA CA000616309A patent/CA1321589C/en not_active Expired - Fee Related
-
1993
- 1993-06-21 DK DK073193A patent/DK73193A/da not_active Application Discontinuation
-
1996
- 1996-10-03 HK HK186396A patent/HK186396A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0685476A1 (en) | 1995-12-06 |
| DE3750929T2 (de) | 1995-06-01 |
| IE65174B1 (en) | 1995-10-04 |
| ZA878128B (en) | 1988-04-29 |
| JPH0678316B2 (ja) | 1994-10-05 |
| EP0270818B1 (en) | 1994-12-28 |
| DK73193D0 (da) | 1993-06-21 |
| ES2068179T3 (es) | 1995-04-16 |
| NZ222347A (en) | 1990-03-27 |
| FI891806L (fi) | 1989-04-17 |
| AU8336287A (en) | 1988-05-25 |
| PH26184A (en) | 1992-03-18 |
| CA1305147C (en) | 1992-07-14 |
| IE872913L (en) | 1988-04-30 |
| MY102986A (en) | 1993-03-31 |
| DK73193A (da) | 1993-06-21 |
| AU604285B2 (en) | 1990-12-13 |
| CA1321589C (en) | 1993-08-24 |
| OA09546A (en) | 1993-01-31 |
| KR930002489B1 (ko) | 1993-04-02 |
| FI96768C (fi) | 1996-08-26 |
| JPH02500910A (ja) | 1990-03-29 |
| DE3750929D1 (de) | 1995-02-09 |
| FI96768B (fi) | 1996-05-15 |
| SG44597A1 (en) | 1997-12-19 |
| FI891806A0 (fi) | 1989-04-17 |
| US4826853A (en) | 1989-05-02 |
| WO1988003138A1 (en) | 1988-05-05 |
| HK186396A (en) | 1996-10-11 |
| CS414391A3 (en) | 1992-09-16 |
| ATE116310T1 (de) | 1995-01-15 |
| KR880701716A (ko) | 1988-11-04 |
| EP0330673A1 (en) | 1989-09-06 |
| EP0270818A1 (en) | 1988-06-15 |
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Legal Events
| Date | Code | Title | Description |
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| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |