IL85473A - MUTEINS OF bFGF, A RECOMBINANT DNA ENCODING THEM, A TRANSFORMANT HARBORING A VECTOR CONTAINING THE DNA, AND A METHOD FOR PRODUCING THE MUTEINS - Google Patents

MUTEINS OF bFGF, A RECOMBINANT DNA ENCODING THEM, A TRANSFORMANT HARBORING A VECTOR CONTAINING THE DNA, AND A METHOD FOR PRODUCING THE MUTEINS

Info

Publication number
IL85473A
IL85473A IL85473A IL8547388A IL85473A IL 85473 A IL85473 A IL 85473A IL 85473 A IL85473 A IL 85473A IL 8547388 A IL8547388 A IL 8547388A IL 85473 A IL85473 A IL 85473A
Authority
IL
Israel
Prior art keywords
bfgf
muteins
mutein
amino acid
producing
Prior art date
Application number
IL85473A
Other languages
English (en)
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of IL85473A publication Critical patent/IL85473A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL85473A 1987-02-24 1988-02-19 MUTEINS OF bFGF, A RECOMBINANT DNA ENCODING THEM, A TRANSFORMANT HARBORING A VECTOR CONTAINING THE DNA, AND A METHOD FOR PRODUCING THE MUTEINS IL85473A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP4221887 1987-02-24
JP4344487 1987-02-25
JP8197787 1987-04-02
JP14751187 1987-06-12
JP20151087 1987-08-11
JP29028387 1987-11-17
JP63016260A JP2526965B2 (ja) 1987-02-24 1988-01-26 ムテイン，ｄｎａおよびその用途

Publications (1)

Publication Number Publication Date
IL85473A true IL85473A (en) 1997-03-18

Family

ID=27563743

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85473A IL85473A (en) 1987-02-24 1988-02-19 MUTEINS OF bFGF, A RECOMBINANT DNA ENCODING THEM, A TRANSFORMANT HARBORING A VECTOR CONTAINING THE DNA, AND A METHOD FOR PRODUCING THE MUTEINS

Country Status (14)

Country Link
EP (1) EP0281822B1 (fr)
JP (1) JP2526965B2 (fr)
KR (1) KR960013574B1 (fr)
CN (1) CN1031893C (fr)
AT (1) ATE108829T1 (fr)
AU (1) AU613564B2 (fr)
CS (1) CS407691A3 (fr)
DE (1) DE3850690T2 (fr)
DK (1) DK173269B1 (fr)
ES (1) ES2056842T3 (fr)
FI (1) FI96316C (fr)
IE (1) IE64299B1 (fr)
IL (1) IL85473A (fr)
NO (1) NO180305C (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
EP0364481A4 (en) * 1987-06-18 1992-01-22 Monash University Growth factors
AU611614B2 (en) * 1987-06-18 1991-06-13 Monash University Growth factors
GB8821795D0 (en) * 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor
US5352589A (en) * 1988-09-16 1994-10-04 Farmitalia Carlo Erba S.R.L. Deletion mutant of basic fibroblast growth factor and production thereof
US5120715A (en) * 1988-12-12 1992-06-09 Takeda Chemical Industries, Ltd. Method for purifying fibroblast growth factor protein
US5464943A (en) * 1989-04-26 1995-11-07 Takeda Chemical Industries, Ltd. DNA encoding glycosylated FGF and production thereof
EP0394951A1 (fr) * 1989-04-26 1990-10-31 Takeda Chemical Industries, Ltd. bFGF glycosylé et sa production
CA2020654A1 (fr) * 1989-07-07 1991-01-08 Yohko Akiyama Compose fgf stabilise et sa production
AU7162791A (en) * 1989-12-27 1991-07-24 Miroslav Radman Novel system for isolating and producing new genes, gene products and dna sequences
WO1991009875A1 (fr) 1989-12-28 1991-07-11 Takeda Chemical Industries, Ltd. Anticorps monoclonal, hybridomes, leur production et leur utilisation
JPH047617A (ja) * 1990-04-26 1992-01-13 Canon Inc 電子機器
US5612211A (en) * 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5206354A (en) * 1990-11-23 1993-04-27 American Cyanamid Company Dna sequence encoding active fragment of fibroblast growth factor, hbf-2
CA2056142A1 (fr) 1990-11-27 1992-05-28 Hirotomo Masuya Composes a base de pyridopyridazine et leur utilisation
EP0499242B1 (fr) * 1991-02-15 1996-06-26 Takeda Chemical Industries, Ltd. Stimulation de la formation endosseuse à l'aide d'un facteur de croissance cellulaire
EP0499990B1 (fr) * 1991-02-19 1996-05-15 Takeda Chemical Industries, Ltd. Procédé pour la production des peptides sans cystéine
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
TW209174B (fr) 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
US5461029A (en) * 1992-04-24 1995-10-24 American Cyanamid Company Method of treating herpes viral infections using HBNF and MK proteins
US6805865B1 (en) * 1993-05-27 2004-10-19 Entremed, Inc. Compositions and methods for treating cancer and hyperproliferative disorders
JPH07114789B2 (ja) * 1993-08-26 1995-12-13 工業技術院長 上肢動作補助機構
WO1995008630A1 (fr) * 1993-09-24 1995-03-30 American Cyanamid Company Analogues structurels a boucle de surface de facteurs de croissance du fibroblast
JP2562413B2 (ja) * 1993-11-04 1996-12-11 株式会社東京機械製作所 版胴における刷版装着装置
IT1269321B (it) * 1994-04-15 1997-03-26 Eniricerche Spa Mutanti stabili della d-n- -carbamilasi
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
EP1168997B1 (fr) 1999-04-02 2013-04-24 KCI Licensing, Inc. Systeme de fermeture de plaies sous vide avec introduction d'un agent
HUE025872T2 (en) 2002-06-18 2016-05-30 Eisai R&D Man Co Ltd Primary, cultured adipocytes for gene therapy
CA2646065C (fr) 2006-03-20 2014-01-14 Entremed, Inc. 2-methoxyestradiol presentant une activite anti-arthritique pouvant modifier l'evolution de la maladie
CN102690782A (zh) * 2012-06-14 2012-09-26 安徽农业大学 一种成纤维细胞培养液
KR101610861B1 (ko) * 2014-07-28 2016-04-11 (주)케어젠 골분화 촉진능 및 치주인대섬유모세포 활성 촉진능을 갖는 펩타이드 및 이의 용도
CN105924532A (zh) * 2016-06-08 2016-09-07 盘古基因生物工程(南京)股份有限公司 一种可溶性碱性成纤维细胞生长因子融合蛋白表达载体及其应用
CN121518527A (zh) * 2026-01-15 2026-02-13 泰州博莱得利生物科技有限公司 一种重组猫碱性成纤维细胞生长因子溶液的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
EP0593065B1 (fr) * 1985-09-12 2002-08-21 Scios Inc. Facteurs de croissance de fibroblastes recombinants
JP2879148B2 (ja) * 1987-07-07 1999-04-05 サイオス インコーポレイテッド 組換え繊維芽細胞成長因子
WO1989004832A1 (fr) * 1987-11-24 1989-06-01 Amgen Inc. Analogues du facteur de croissance de fibroblastes

Also Published As

Publication number Publication date
CS407691A3 (en) 1992-06-17
EP0281822A2 (fr) 1988-09-14
EP0281822B1 (fr) 1994-07-20
IE64299B1 (en) 1995-07-26
CN1031893C (zh) 1996-05-29
NO880719L (no) 1988-08-25
EP0281822A3 (en) 1990-03-21
NO180305C (no) 1997-03-26
ES2056842T3 (es) 1994-10-16
IE880482L (en) 1988-08-24
DK173269B1 (da) 2000-05-29
FI880845A0 (fi) 1988-02-23
DK92688D0 (da) 1988-02-23
FI96316C (fi) 1996-06-10
KR960013574B1 (en) 1996-10-09
DE3850690T2 (de) 1995-01-05
DE3850690D1 (de) 1994-08-25
KR880010130A (ko) 1988-10-07
FI880845L (fi) 1988-08-25
JPH02193A (ja) 1990-01-05
CN88100913A (zh) 1988-09-07
ATE108829T1 (de) 1994-08-15
AU613564B2 (en) 1991-08-01
NO880719D0 (no) 1988-02-18
NO180305B (no) 1996-12-16
JP2526965B2 (ja) 1996-08-21
AU1208588A (en) 1988-08-25
FI96316B (fi) 1996-02-29
DK92688A (da) 1988-08-25

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