IL85884A - Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides - Google Patents

Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides

Info

Publication number: IL85884A
Authority: IL; Israel
Prior art keywords: support; synthesis; peptides; synthetic resin; manufacture
Prior art date: 1987-03-30

Application number

IL85884A

Other languages

English (en)

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-30

Filing date

1988-03-28

Publication date

1992-01-15

1988-03-28 Application filed by Ciba Geigy filed Critical Ciba Geigy

1992-01-15 Publication of IL85884A publication Critical patent/IL85884A/xx

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
150000001408 amides Chemical class 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
229920003002 synthetic resin Polymers 0.000 title abstract 2
239000000057 synthetic resin Substances 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 abstract 2
NPFYZDNDJHZQKY-UHFFFAOYSA-N 4-Hydroxybenzophenone Chemical compound C1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 NPFYZDNDJHZQKY-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
239000004793 Polystyrene Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salt Chemical class 0.000 abstract 1
238000005576 amination reaction Methods 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
238000010647 peptide synthesis reaction Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229920002223 polystyrene Polymers 0.000 abstract 1
229920005990 polystyrene resin Polymers 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
239000007790 solid phase Substances 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/50—Partial depolymerisation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compositions Of Macromolecular Compounds (AREA)
Dental Preparations (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Glass Compositions (AREA)
Polyamides (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Polyesters Or Polycarbonates (AREA)
Working-Up Tar And Pitch (AREA)
Paper (AREA)

IL85884A 1987-03-30 1988-03-28 Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides IL85884A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH121487		1987-03-30

Publications (1)

Publication Number	Publication Date
IL85884A true IL85884A (en)	1992-01-15

Family

ID=4205167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL85884A IL85884A (en)	1987-03-30	1988-03-28	Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides

Country Status (19)

Country	Link
US (3)	US4859736A (da)
EP (1)	EP0285562B1 (da)
JP (1)	JP2513775B2 (da)
KR (1)	KR950013679B1 (da)
AT (1)	ATE88726T1 (da)
AU (1)	AU615181B2 (da)
CA (1)	CA1318462C (da)
DD (3)	DD284031A5 (da)
DE (1)	DE3880541D1 (da)
DK (1)	DK175042B1 (da)
ES (1)	ES2054863T3 (da)
FI (1)	FI90780C (da)
GR (1)	GR3007996T3 (da)
HU (1)	HU208155B (da)
IE (1)	IE61485B1 (da)
IL (1)	IL85884A (da)
MX (1)	MX10917A (da)
PT (1)	PT87105B (da)
YU (1)	YU62588A (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8430252D0 (en) *	1984-11-30	1985-01-09	Beecham Group Plc	Compounds
NL194729C (nl) *	1986-10-13	2003-01-07	Novartis Ag	Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
US4859736A (en) *	1987-03-30	1989-08-22	Ciba-Geigy Corporation	Synthetic polystyrene resin and its use in solid phase peptide synthesis
US5242974A (en) *	1991-11-22	1993-09-07	Affymax Technologies N.V.	Polymer reversal on solid surfaces
US5212288A (en) *	1990-02-20	1993-05-18	Syntex (U.S.A.) Inc.	Temporary minimal protection synthesis of serine-containing polypeptides
US5155166A (en) *	1990-06-18	1992-10-13	Eastman Kodak Company	Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to carboxylated particles and a kit containing same
US5071565A (en) *	1991-02-04	1991-12-10	Iowa State University Research Foundation, Inc.	Modified resins for solid-phase extraction
US5550215A (en) *	1991-11-22	1996-08-27	Holmes; Christopher P.	Polymer reversal on solid surfaces
US5268423A (en) *	1992-02-28	1993-12-07	New York University	Method for preparation of peptide synthesis resins and peptide synthesis resins
US5516891A (en) *	1992-06-16	1996-05-14	Kinerton, Ltd.	Liquid phase synthesis of peptides and peptide derivatives
IE921942A1 (en) *	1992-06-16	1993-12-29	Gary A Siwruk John S Eynon	Liquid phase synthesis of peptides and peptide derivatives
US5463564A (en)	1994-09-16	1995-10-31	3-Dimensional Pharmaceuticals, Inc.	System and method of automatically generating chemical compounds with desired properties
US6571227B1 (en)	1996-11-04	2003-05-27	3-Dimensional Pharmaceuticals, Inc.	Method, system and computer program product for non-linear mapping of multi-dimensional data
US6295514B1 (en)	1996-11-04	2001-09-25	3-Dimensional Pharmaceuticals, Inc.	Method, system, and computer program product for representing similarity/dissimilarity between chemical compounds
US6453246B1 (en)	1996-11-04	2002-09-17	3-Dimensional Pharmaceuticals, Inc.	System, method, and computer program product for representing proximity data in a multi-dimensional space
US6392010B1 (en)	1996-12-19	2002-05-21	Aventis Pharmaceuticals Inc.	Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
GB9717173D0 (en)	1997-08-13	1997-10-22	Akzo Nobel Nv	Solid phase supports
US6114468A (en) *	1998-06-01	2000-09-05	Novartis Ag	Synthetic resins for use in solid phase synthesis
US7416524B1 (en)	2000-02-18	2008-08-26	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	System, method and computer program product for fast and efficient searching of large chemical libraries
US6671627B2 (en)	2000-02-29	2003-12-30	3-D Pharmaceuticals, Inc.	Method and computer program product for designing combinatorial arrays
US7039621B2 (en)	2000-03-22	2006-05-02	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	System, method, and computer program product for representing object relationships in a multidimensional space
AU2001249805A1 (en)	2000-04-03	2001-10-15	3-Dimensional Pharmaceuticals, Inc.	Method, system, and computer program product for representing object relationships in a multidimensional space
CA2419600A1 (en) *	2000-08-22	2002-02-28	3-Dimensional Pharmaceuticals, Inc.	Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
US6678619B2 (en) *	2000-09-20	2004-01-13	Victor S. Lobanov	Method, system, and computer program product for encoding and building products of a virtual combinatorial library
WO2002061419A1 (en) *	2001-01-29	2002-08-08	3-Dimensional Pharmaceuticals, Inc.	Method, system, and computer program product for analyzing combinatorial libraries
WO2002083606A1 (en) *	2001-04-17	2002-10-24	University Of Alberta	A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
US7119145B2 (en) *	2002-01-25	2006-10-10	Phenomenex, Inc.	Surface graft modified resins and formation thereof
US6926823B2 (en) *	2002-06-03	2005-08-09	Varian, Inc.	Polymer with superior polar retention for sample pretreatment
ATE501164T1 (de) *	2003-07-04	2011-03-15	Lonza Ag	Verbessertes verfahren für festphasensynthese
EP1630600A3 (en) *	2004-07-29	2006-03-22	Rohm and Haas Electronic Materials, L.L.C.	Hot melt composition and method involving forming a masking pattern
WO2006060803A2 (en) *	2004-12-03	2006-06-08	Polnox Corporation	One pot process for making polymeric antioxidants
US8742028B2 (en) *	2009-05-06	2014-06-03	Mallinckrodt Llc	Solid support for Fmoc-solid phase synthesis of peptide acids
TW202446781A (zh)	2011-12-28	2024-12-01	日商中外製藥股份有限公司	胜肽化合物之製造方法
EP3071544B1 (en)	2013-11-22	2022-07-06	Polnox Corporation	Macromolecular antioxidants based on dual type moiety per molecule: structures methods of making and using the same
EP4166664A1 (en)	2015-03-13	2023-04-19	Chugai Seiyaku Kabushiki Kaisha	Modified aminoacyl-trna synthetase and use thereof
JP7187323B2 (ja)	2017-01-31	2022-12-12	中外製薬株式会社	無細胞翻訳系におけるペプチドの合成方法
WO2018160879A2 (en)	2017-03-01	2018-09-07	Polnox Corporation	Macromolecular corrosion (mcin) inhibitors: structures, methods of making and using the same
KR20250007021A (ko)	2017-06-09	2025-01-13	추가이 세이야쿠 가부시키가이샤	N-치환 아미노산을 포함하는 펩타이드의 합성 방법
WO2019117274A1 (ja) *	2017-12-15	2019-06-20	中外製薬株式会社	ペプチドの製造方法、及び塩基の処理方法
EP3878836B1 (en)	2018-11-07	2025-07-23	Chugai Seiyaku Kabushiki Kaisha	O-substituted serine derivative production method
WO2020111238A1 (ja)	2018-11-30	2020-06-04	中外製薬株式会社	ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
EP3939962A4 (en)	2019-03-15	2022-12-28	Chugai Seiyaku Kabushiki Kaisha	PROCESS FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE
BR112022007535A2 (pt)	2019-11-07	2022-07-12	Chugai Pharmaceutical Co Ltd	Composto peptídico cíclico tendo ação inibitória de kras
CN119912618B (zh) *	2023-10-31	2025-11-18	北京索特莱克科技发展有限公司	提锂树脂的结构、制备和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE141977C (da) *
GB1406611A (en) *	1971-08-17	1975-09-17	Leo Ab	Pharmaceutically active secondary phosphoric acid esters
DD141977A3 (de) *	1975-07-11	1980-06-04	Jens Fischer	Verfahren zur herstellung wasserunloeslicher enzym-polystyrol-komplexe
US4301045A (en) *	1977-05-02	1981-11-17	Armour Pharmaceutical Company	Synthesis of peptides
US4507230A (en) *	1982-05-12	1985-03-26	Research Corporation	Peptide synthesis reagents and method of use
US4569967A (en) *	1983-10-24	1986-02-11	The Salk Institute For Biological Studies	Synthesis of N-substituted peptide amides
US4623484A (en) *	1984-05-24	1986-11-18	Research Corporation	Process for peptide synthesis
GB2169901A (en) *	1984-12-11	1986-07-23	Lkb Biochrom Ltd	method for a solid phase synthesis of a linear combination of amino acid residues.
US4731412A (en) *	1984-12-28	1988-03-15	The Salk Institute Biotechnology/Industrial Associates, Inc.	Process and composition for amino-terminal, α-aspartyl and α-glutamyl dipeptide esters
US4716147A (en) *	1986-03-27	1987-12-29	Monsanto Company	Synthetic airial peptides
CA1329124C (en) *	1987-02-02	1994-05-03	Jerald C. Sadoff	Conjugate malaria vaccine
US4859736A (en) *	1987-03-30	1989-08-22	Ciba-Geigy Corporation	Synthetic polystyrene resin and its use in solid phase peptide synthesis

1988
- 1988-03-21 US US07/171,049 patent/US4859736A/en not_active Expired - Lifetime
- 1988-03-22 EP EP88810187A patent/EP0285562B1/de not_active Expired - Lifetime
- 1988-03-22 DE DE8888810187T patent/DE3880541D1/de not_active Expired - Lifetime
- 1988-03-22 ES ES88810187T patent/ES2054863T3/es not_active Expired - Lifetime
- 1988-03-22 AT AT88810187T patent/ATE88726T1/de not_active IP Right Cessation
- 1988-03-28 JP JP63072147A patent/JP2513775B2/ja not_active Expired - Lifetime
- 1988-03-28 PT PT87105A patent/PT87105B/pt not_active IP Right Cessation
- 1988-03-28 MX MX1091788A patent/MX10917A/es unknown
- 1988-03-28 DD DD88331994A patent/DD284031A5/de not_active IP Right Cessation
- 1988-03-28 CA CA000562701A patent/CA1318462C/en not_active Expired - Lifetime
- 1988-03-28 FI FI881451A patent/FI90780C/fi not_active IP Right Cessation
- 1988-03-28 DD DD88314098A patent/DD274033A5/de not_active IP Right Cessation
- 1988-03-28 IL IL85884A patent/IL85884A/xx not_active IP Right Cessation
- 1988-03-28 DD DD88331996A patent/DD296087A5/de not_active IP Right Cessation
- 1988-03-29 HU HU881569A patent/HU208155B/hu unknown
- 1988-03-29 IE IE94088A patent/IE61485B1/en not_active IP Right Cessation
- 1988-03-29 AU AU13814/88A patent/AU615181B2/en not_active Expired
- 1988-03-29 DK DK198801730A patent/DK175042B1/da not_active IP Right Cessation
- 1988-03-29 YU YU00625/88A patent/YU62588A/xx unknown
- 1988-03-30 KR KR1019880003482A patent/KR950013679B1/ko not_active Expired - Lifetime
1989
- 1989-05-17 US US07/353,311 patent/US5004781A/en not_active Expired - Lifetime
1991
- 1991-06-20 US US07/719,090 patent/US5093530A/en not_active Expired - Lifetime
1993
- 1993-05-28 GR GR920403072T patent/GR3007996T3/el unknown

Also Published As

Publication number	Publication date
DK173088A (da)	1988-10-01
DD296087A5 (de)	1991-11-21
FI881451A7 (fi)	1988-10-01
JPS63260946A (ja)	1988-10-27
HU208155B (en)	1993-08-30
US5004781A (en)	1991-04-02
DK173088D0 (da)	1988-03-29
IE880940L (en)	1988-09-30
DK175042B1 (da)	2004-05-10
AU1381488A (en)	1988-09-29
FI90780B (fi)	1993-12-15
KR880011210A (ko)	1988-10-27
YU62588A (en)	1990-10-31
EP0285562B1 (de)	1993-04-28
AU615181B2 (en)	1991-09-26
EP0285562A3 (en)	1990-01-10
HUT46713A (en)	1988-11-28
ES2054863T3 (es)	1994-08-16
PT87105A (pt)	1988-04-01
FI881451A0 (fi)	1988-03-28
PT87105B (pt)	1992-07-31
KR950013679B1 (ko)	1995-11-13
MX10917A (es)	1993-12-01
DD284031A5 (de)	1990-10-31
JP2513775B2 (ja)	1996-07-03
US5093530A (en)	1992-03-03
DD274033A5 (de)	1989-12-06
IE61485B1 (en)	1994-11-02
CA1318462C (en)	1993-05-25
EP0285562A2 (de)	1988-10-05
DE3880541D1 (de)	1993-06-03
GR3007996T3 (da)	1993-08-31
FI90780C (fi)	1994-03-25
US4859736A (en)	1989-08-22
ATE88726T1 (de)	1993-05-15

Legal Events

Date	Code	Title
1998-02-08	HC	Change of name of proprietor(s)
1998-09-24	KB	Patent renewed
2006-07-05	KB	Patent renewed
2008-12-29	EXP	Patent expired

Publication	Publication Date	Title
IL85884A (en)	1992-01-15	Synthetic resin,its manufacture and its use as support for the synthesis of peptides and peptide amides
DE68911280D1 (de)	1994-01-20	Flüssigphaseverfahren zur Herstellung von Methanol aus Synthesegas.
FI961234L (fi)	1996-03-15	Adipiinihapon syntetisointi biomassaperäisistä hiililähteistä
PH22841A (en)	1989-01-19	Novel polypeptides pharmaceutical compositions comprising said polypeptides and their use
DE69118806D1 (de)	1996-05-23	Katalysator zur Synthese von kristallinem 3,4-Polyisopren
DE59409672D1 (de)	2001-04-12	Festphasensynthese von Oligoribonucleotiden
ES8403863A1 (es)	1984-03-01	Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico.
DE3870309D1 (de)	1992-05-27	Neue festphasen-peptidsynthesemethoden.
NZ239575A (en)	1993-07-27	Process for the preparation of peptides with c-terminal aza-amino amide by solid phase synthesis
HUT65752A (en)	1994-07-28	Process for producing peptides
KR840002346A (ko)	1984-06-25	펩타이드의 제조방법
DE69409454D1 (de)	1998-05-14	Verfahren zur Herstellung von Dimethyl 2,6 naphthalen-dicarboxylat
JPS6416792A (en)	1989-01-20	Guanidine related compound containing tetraphenylborate ion, its production and use thereof in peptide synthesis
DK0410278T3 (da)	1994-05-24	Reninhæmmende aminooligohydroxyderivater
SE9402253D0 (sv)	1994-06-27	Process
DE69007577D1 (de)	1994-04-28	Verfahren zur Synthese von niedrigen Olefinen aus Methanol.
DE69428401D1 (de)	2001-10-31	Verfahren zur Herstellung von alpha-Aminosäureamiden zur Verwendung in der Peptidsynthese
MX9207372A (es)	1993-06-01	Sal hidrocloruro de un ester alquilico de un oligopeptido o de un aminoacido y procedimiento para su preparacion.
ES2052447A1 (es)	1994-07-01	Peptidos hemorreguladores.
ATE85972T1 (de)	1993-03-15	Verfahren zur herstellung von methylhydrochinon.
ES457069A1 (es)	1978-11-01	Un metodo mejorado para preparar un polipeptido.
IT1240610B (it)	1993-12-17	Nuovo derivato del 9h-xantene utile per la sintesi in fase solida di peptidi in forma di ammidi c-terminali
JPS5363339A (en)	1978-06-06	Synthesis of peptides
DE3679528D1 (de)	1991-07-04	Kompositplasmide zur synthese von aminosaeuren.