IL86246A - Intercellular adhesion molecules and functional derivatives thereof, their production and antibodies against thereto - Google Patents

Intercellular adhesion molecules and functional derivatives thereof, their production and antibodies against thereto

Info

Publication number
IL86246A
IL86246A IL8624688A IL8624688A IL86246A IL 86246 A IL86246 A IL 86246A IL 8624688 A IL8624688 A IL 8624688A IL 8624688 A IL8624688 A IL 8624688A IL 86246 A IL86246 A IL 86246A
Authority
IL
Israel
Prior art keywords
icam
binding
antibody
cells
functional derivative
Prior art date
Application number
IL8624688A
Other languages
English (en)
Other versions
IL86246A0 (en
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of IL86246A0 publication Critical patent/IL86246A0/xx
Publication of IL86246A publication Critical patent/IL86246A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5751—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the skin, e.g. melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL8624688A 1987-05-04 1988-05-03 Intercellular adhesion molecules and functional derivatives thereof, their production and antibodies against thereto IL86246A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4596387A 1987-05-04 1987-05-04
US11579887A 1987-11-02 1987-11-02
US15594388A 1988-02-16 1988-02-16

Publications (2)

Publication Number Publication Date
IL86246A0 IL86246A0 (en) 1988-11-15
IL86246A true IL86246A (en) 1994-06-24

Family

ID=27366801

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8624688A IL86246A (en) 1987-05-04 1988-05-03 Intercellular adhesion molecules and functional derivatives thereof, their production and antibodies against thereto

Country Status (16)

Country Link
EP (1) EP0289949B1 (fr)
JP (2) JP2763030B2 (fr)
AT (1) ATE128727T1 (fr)
AU (1) AU1551888A (fr)
CA (1) CA1341399C (fr)
DE (1) DE3854536T2 (fr)
DK (1) DK174629B1 (fr)
ES (1) ES2080044T3 (fr)
FI (1) FI882037A7 (fr)
GR (1) GR3018298T3 (fr)
HK (1) HK1003117A1 (fr)
IE (1) IE69976B1 (fr)
IL (1) IL86246A (fr)
MX (1) MX9203033A (fr)
NZ (2) NZ237036A (fr)
PT (1) PT87390B (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284931A (en) * 1987-05-04 1994-02-08 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
ES2064327T3 (es) * 1987-11-02 1995-02-01 Baylor College Medicine Uso de icam-1 o de sus derivados funcionales para el tratamiento de una inflamacion no especifica.
US6218525B1 (en) 1988-02-25 2001-04-17 The General Hospital Corporation Nucleic acid encoding CD28
US5506126A (en) * 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
EP0429542B1 (fr) * 1988-08-15 1995-12-06 Brigham And Women's Hospital Inhibiteur d'adhesion de leucocytes
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
EP0362531B1 (fr) * 1988-09-01 1999-11-10 Bayer Corporation Protéine du récepteur du rhinovirus humain, qui inhibe le caractère infectieux du virus
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
ES2077572T3 (es) * 1988-09-28 1995-12-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular, y sus ligandos de fijacion.
AU4412889A (en) * 1988-09-28 1990-04-18 Dana-Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
US5081034A (en) * 1988-11-14 1992-01-14 Brigham & Women's Hospital Cloned genes which encode elam-1
CA2008368C (fr) * 1989-01-24 2003-04-08 Jeffrey Greve Molecule soluble apparentee a l'icam-i mais distincte
NO900155L (no) * 1989-01-24 1990-07-25 Molecular Therapeutics Inc Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1.
US5235049A (en) * 1989-01-24 1993-08-10 Molecular Therapeutics, Inc. Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
DE69029336T2 (de) * 1989-03-09 1997-07-03 Center For Blood Research, Inc., Boston, Mass. Interzellulares Adhäsions-Molekül-2 und seine Bindungsliganden
DE69000248T2 (de) * 1989-03-09 1993-01-07 Boehringer Ingelheim Pharma Verwendung von interzellularen adhaesions-molekuelen und deren bindungsliganden bei der behandlung von asthma.
ES2177695T3 (es) * 1989-03-16 2002-12-16 Blood Res Center Uso de derivados funcionales de la molecual de adhesion intercelular icam-1 en terapia antiviral.
US6797270B1 (en) 1989-03-16 2004-09-28 Center For Blood Research, Inc. Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy
WO1990013316A1 (fr) * 1989-04-28 1990-11-15 Baylor College Of Medicine Dissemination de cellules infectees par l'hiv-1
WO1990013281A2 (fr) * 1989-04-28 1990-11-15 Baylor College Of Medicine Procede de suppression d'une infection par l'hiv
GB9009548D0 (en) * 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
WO1991018010A1 (fr) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition d'infection virale a l'aide de peptides analogues a la molecule-1 d'adhesion intercellulaire et/ou d'analogues de ces peptides
WO1991018011A1 (fr) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition d'adhesion cellulaire a l'aide de peptides analogues a la molecule-1-d'adhesion intercellulaire et/ou d'analogues de ces peptides
DK0468257T3 (da) * 1990-07-20 2000-03-27 Bayer Ag Multimer form af human rhinovirusreceptorprotein
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5223396A (en) * 1991-05-03 1993-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. Method for detecting organ transplant rejection
US5891841A (en) * 1991-06-11 1999-04-06 The Center For Blood Research, Inc. Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof
DE69229275T2 (de) * 1991-10-04 1999-12-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville Herstellung eines arzneimittels zur behandlung von augenentzündung durch blockierung von zelladhäsionsmolekulen
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US5700658A (en) * 1992-01-27 1997-12-23 Icos Corporation ICAM-4 materials and methods
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
EP0578819A4 (fr) * 1992-01-27 1994-10-12 Icos Corp Proteine apparentee a icam.
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
US5708141A (en) * 1992-05-11 1998-01-13 Corvas International, Inc. Neutrophil inhibitors
US5580780A (en) * 1992-06-09 1996-12-03 Jalkanen; Sirpa Vascular adhesion protein-(VAP-1) and VAP-1-specific antibodies
US5602307A (en) * 1992-08-12 1997-02-11 Baylor College Of Medicine Non-human animal having predefined allele of a cellular adhesion gene
AU687755B2 (en) * 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
AU5675794A (en) * 1992-12-15 1994-07-04 Board Of Trustees Of The Leland Stanford Junior University Mucosal vascular addressin, dna and expression
DE4335273A1 (de) * 1993-10-15 1995-04-20 Univ Ludwigs Albert Peptide zur Tumortherapie
EP0757697A4 (fr) * 1994-04-12 2000-05-17 Boehringer Ingelheim Pharma Utilisation d'agents bloquant l'interaction molecule d'adhesion intercellulaire/recepteur dans le traitement d'une infection respiratoire virale
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
EP1102601B1 (fr) * 1998-08-04 2005-11-23 The Trustees Of The University Of Pennsylvania Ciblage et association prolongee de medicaments sur la surface luminaire de cellules de l'endothelium vasculaire pulmonaire
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
ATE439145T1 (de) 1999-03-19 2009-08-15 Genentech Inc Behandlung von lfa-1 assozieerten krankheiten durch gesteigerte dosen von lfa-1 antagonist
US6582698B1 (en) 1999-03-19 2003-06-24 Genentech, Inc. Treatment method
US7674466B2 (en) 1999-08-05 2010-03-09 The Trustees Of The University Of Pennsylvania Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells using antibodies that bind to ICAM-1
WO2001051084A1 (fr) * 2000-01-14 2001-07-19 Genentech, Inc. Diagnostic et traitement de troubles hepatiques inflammatoires par inhibition de la liaison de lfa-1 a icam-1
CA2454358A1 (fr) 2001-07-19 2003-07-31 Perlan Therapeutics, Inc. Proteines multimeres et methodes de production et d'utilisation de ces proteines
AU2010206195B2 (en) 2009-01-20 2016-03-10 Transgene Sa Soluble ICAM-1 as biomarker for prediction of therapeutic response
CA2825641C (fr) * 2011-02-02 2016-10-11 Medipost Co., Ltd. Utilisation d'icam-1 pour la prevention ou le traitement de maladies neurologiques

Also Published As

Publication number Publication date
GR3018298T3 (en) 1996-03-31
EP0289949B1 (fr) 1995-10-04
NZ224490A (en) 1991-11-26
PT87390B (pt) 1993-11-30
DK174629B1 (da) 2003-07-28
EP0289949A3 (en) 1990-09-26
ES2080044T3 (es) 1996-02-01
FI882037A7 (fi) 1988-11-05
HK1003117A1 (en) 1998-10-09
JP2763030B2 (ja) 1998-06-11
EP0289949A2 (fr) 1988-11-09
IE69976B1 (en) 1996-10-16
JP2874861B2 (ja) 1999-03-24
DK239488D0 (da) 1988-05-03
IE881322L (en) 1988-11-04
IL86246A0 (en) 1988-11-15
JPH10101699A (ja) 1998-04-21
FI882037A0 (fi) 1988-05-02
JPH01110700A (ja) 1989-04-27
CA1341399C (fr) 2002-11-19
DE3854536T2 (de) 1996-03-07
NZ237036A (en) 1997-09-22
PT87390A (pt) 1989-05-31
ATE128727T1 (de) 1995-10-15
DK239488A (da) 1988-11-05
AU1551888A (en) 1988-11-10
MX9203033A (es) 1992-07-01
DE3854536D1 (de) 1995-11-09

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Legal Events

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