IL86450A - Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds - Google Patents
Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compoundsInfo
- Publication number
- IL86450A IL86450A IL8645088A IL8645088A IL86450A IL 86450 A IL86450 A IL 86450A IL 8645088 A IL8645088 A IL 8645088A IL 8645088 A IL8645088 A IL 8645088A IL 86450 A IL86450 A IL 86450A
- Authority
- IL
- Israel
- Prior art keywords
- bis
- formula
- alkyl
- group
- iodo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20647/87A IT1205029B (it) | 1987-05-22 | 1987-05-22 | Processo per la preparazione di derivati dell'acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico e corrispondenti nuovi derivati dell'acido 5-acilamino-2,4,6-triioco o tribromo-benzzoico,ottenuti con tale processo |
| IT8847935A IT1219934B (it) | 1988-05-05 | 1988-05-05 | Processo per la preparazione di derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-brenzoico e corrispondenti derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico,ottenuti con tale processo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL86450A0 IL86450A0 (en) | 1988-11-15 |
| IL86450A true IL86450A (en) | 1994-05-30 |
Family
ID=26327605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8645088A IL86450A (en) | 1987-05-22 | 1988-05-20 | Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5066823A (fr) |
| EP (1) | EP0365541B1 (fr) |
| JP (1) | JP2585087B2 (fr) |
| KR (1) | KR960016747B1 (fr) |
| AT (1) | ATE79368T1 (fr) |
| AU (1) | AU618535B2 (fr) |
| CA (1) | CA1327600C (fr) |
| DE (1) | DE3873766T2 (fr) |
| ES (1) | ES2006951A6 (fr) |
| IE (1) | IE63232B1 (fr) |
| IL (1) | IL86450A (fr) |
| NZ (1) | NZ224743A (fr) |
| WO (1) | WO1988009328A1 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8717625D0 (en) * | 1987-07-24 | 1987-09-03 | Nycomed As | Chemical compounds |
| AU612510B2 (en) * | 1988-03-01 | 1991-07-11 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| ATE123018T1 (de) * | 1988-04-06 | 1995-06-15 | Mallinckrodt Inc | Verfahren zur herstellung von 2,4,6-triiodo-5- amino-n-alkyl-isophthalsäure. |
| IL90326A (en) * | 1988-06-02 | 1993-05-13 | Guerbet Sa | Non-ionic triiodobenzene compounds and contrast media containing them |
| FR2643077B1 (fr) * | 1989-01-23 | 1991-10-31 | Guerbet Sa | Nouveaux composes non ioniques iodes et produits de contraste les contenant |
| US5614638A (en) * | 1989-11-29 | 1997-03-25 | Bracco International B.V. | Nonionic radiographic contrast agents |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
| US5019371A (en) * | 1990-11-21 | 1991-05-28 | Mallinckrodt Medical, Inc. | Novel x-ray contrast agents, compositions and methods |
| US5356613A (en) * | 1991-03-18 | 1994-10-18 | Mallinckrodt Medical, Inc. | X-ray contrast agents, compositions and methods |
| DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
| IL110391A (en) * | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the crystallization of iopamidol |
| IT1274027B (it) * | 1994-03-03 | 1997-07-14 | Zambon Spa | Processo per la preparazione e purificazione di mezzi di contrasto iodurati |
| GB9419206D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| IT1271134B (it) * | 1994-12-01 | 1997-05-26 | Bracco Spa | Derivati iodurati del bifenile e loro impiego diagnostico |
| EP0842141A1 (fr) * | 1995-07-04 | 1998-05-20 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Procede de preparation d'iopamidol au moyen d'un monoalkylether c1-c5 d'un alkylene-glycol c2-c10 |
| IT1277339B1 (it) * | 1995-07-25 | 1997-11-10 | Bracco Spa | Processo per la produzione di agenti contrastografici iodurati |
| IT1303797B1 (it) * | 1998-11-27 | 2001-02-23 | Bracco Spa | Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide. |
| EP1186305A1 (fr) * | 2000-09-07 | 2002-03-13 | Schering Aktiengesellschaft | Nouveaux composés bromé comme agents de contraste pour la mammographie aux rayons X |
| WO2002034712A1 (fr) * | 2000-10-27 | 2002-05-02 | Takeda Chemical Industries, Ltd. | Procede de preparation de composes aromatiques substitues et produits intermediaires associes |
| CN103951586B (zh) | 2007-07-12 | 2015-05-27 | 通用电气医疗集团股份有限公司 | 造影剂 |
| EP2093206A1 (fr) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Procédé d'iodation de composés aromatiques |
| EP2243767A1 (fr) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Procédé d'iodation de composés aromatiques |
| JP5661762B2 (ja) | 2009-07-07 | 2015-01-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | ヨウ素化剤の製造方法 |
| EP2394984A1 (fr) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Procédé d'iodation de dérivés phénoliques |
| CN107253918A (zh) * | 2017-07-27 | 2017-10-17 | 成都丽璟科技有限公司 | 一种制备碘美普尔的新方法 |
| KR102128423B1 (ko) | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
| EP4514771B1 (fr) | 2022-04-29 | 2026-04-15 | Bracco Imaging SPA | Procédé de préparation de dérivés de 2,4,6-triiodophénol |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2031724C3 (de) * | 1969-06-27 | 1979-06-28 | Nyegaard & Co. A/S., Oslo | N-substituierte Trijodbenz- bzw. Jodmethansulfon-am'ide, Verfahren zu deren Herstellung und radiologische Zusammensetzungen |
| US3660464A (en) * | 1970-06-19 | 1972-05-02 | Squibb & Sons Inc | Tri-iodinated diaminobenzoic acid derivatives |
| BE787669A (fr) * | 1971-08-17 | 1973-02-19 | Schering Ag | Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation |
| DD104193A5 (fr) * | 1972-12-22 | 1974-03-05 | ||
| CH583562A5 (fr) * | 1973-07-17 | 1977-01-14 | Bracco Ind Chimica Spa | |
| US4065553A (en) * | 1974-05-31 | 1977-12-27 | Laboratoires Andre Guerbet | X-Ray contrast media |
| CH608189A5 (fr) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| US4321368A (en) * | 1975-10-20 | 1982-03-23 | Mallinckrodt, Inc. | Glycosyl triidobenzoic acid derivatives |
| DE2629228C2 (de) * | 1976-06-25 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung |
| US4191775A (en) * | 1977-12-15 | 1980-03-04 | Imperial Chemical Industries Limited | Amide derivatives |
| DE2852094A1 (de) * | 1978-11-30 | 1980-06-12 | Schering Ag | Neue roentgenkontrastmittel |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
| DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
| US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
| FR2541272A1 (fr) * | 1983-02-23 | 1984-08-24 | Guerbet Sa | Composes bromes et produits opacifiants en contenant |
| DE3429949A1 (de) * | 1984-08-10 | 1986-02-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel |
| US4567034A (en) * | 1984-09-07 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Esters of diatrizoic acid as X-ray contrast agents |
-
1988
- 1988-05-20 EP EP88904526A patent/EP0365541B1/fr not_active Expired - Lifetime
- 1988-05-20 JP JP63504455A patent/JP2585087B2/ja not_active Expired - Lifetime
- 1988-05-20 NZ NZ224743A patent/NZ224743A/en unknown
- 1988-05-20 DE DE8888904526T patent/DE3873766T2/de not_active Expired - Lifetime
- 1988-05-20 IE IE151888A patent/IE63232B1/en not_active IP Right Cessation
- 1988-05-20 KR KR1019890700112A patent/KR960016747B1/ko not_active Expired - Lifetime
- 1988-05-20 US US07/424,216 patent/US5066823A/en not_active Expired - Lifetime
- 1988-05-20 CA CA000567436A patent/CA1327600C/fr not_active Expired - Lifetime
- 1988-05-20 IL IL8645088A patent/IL86450A/en not_active IP Right Cessation
- 1988-05-20 AU AU17978/88A patent/AU618535B2/en not_active Expired
- 1988-05-20 ES ES8801607A patent/ES2006951A6/es not_active Expired
- 1988-05-20 AT AT88904526T patent/ATE79368T1/de not_active IP Right Cessation
- 1988-05-20 WO PCT/EP1988/000453 patent/WO1988009328A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE3873766T2 (de) | 1993-02-11 |
| CA1327600C (fr) | 1994-03-08 |
| JPH02503556A (ja) | 1990-10-25 |
| KR960016747B1 (ko) | 1996-12-20 |
| NZ224743A (en) | 1991-07-26 |
| ES2006951A6 (es) | 1989-05-16 |
| WO1988009328A1 (fr) | 1988-12-01 |
| ATE79368T1 (de) | 1992-08-15 |
| AU1797888A (en) | 1988-12-21 |
| JP2585087B2 (ja) | 1997-02-26 |
| IE63232B1 (en) | 1995-04-05 |
| AU618535B2 (en) | 1992-01-02 |
| IE881518L (en) | 1988-11-22 |
| KR890701547A (ko) | 1989-12-20 |
| DE3873766D1 (de) | 1992-09-17 |
| EP0365541A1 (fr) | 1990-05-02 |
| IL86450A0 (en) | 1988-11-15 |
| US5066823A (en) | 1991-11-19 |
| EP0365541B1 (fr) | 1992-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |