IL87150A - 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number: IL87150A
Authority: IL; Israel
Prior art keywords: atoms; group; groups; alkyl; substituted
Prior art date: 1987-07-20

Application number

IL87150A

Other languages

English (en)

Other versions

IL87150A0 (en

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-20

Filing date

1988-07-18

Publication date

1992-12-01

1988-07-18 Application filed by Duphar Int Res filed Critical Duphar Int Res

1988-12-30 Publication of IL87150A0 publication Critical patent/IL87150A0/xx

1992-12-01 Publication of IL87150A publication Critical patent/IL87150A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 59
125000000217 alkyl group Chemical group 0.000 abstract 29
125000003545 alkoxy group Chemical group 0.000 abstract 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 10
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 9
125000001153 fluoro group Chemical group F* 0.000 abstract 8
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
125000006413 ring segment Chemical group 0.000 abstract 6
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 4
125000004414 alkyl thio group Chemical group 0.000 abstract 4
125000000304 alkynyl group Chemical group 0.000 abstract 4
125000004093 cyano group Chemical group *C#N 0.000 abstract 4
125000005842 heteroatom Chemical group 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 4
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical group 0.000 abstract 3
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 3
125000002837 carbocyclic group Chemical group 0.000 abstract 2
125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
125000005366 cycloalkylthio group Chemical group 0.000 abstract 2
230000003480 fibrinolytic effect Effects 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
229910019950 S—O Inorganic materials 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000005079 alkoxycarbonylmethyl group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL87150A 1987-07-20 1988-07-18 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them IL87150A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8701709		1987-07-20

Publications (2)

Publication Number	Publication Date
IL87150A0 IL87150A0 (en)	1988-12-30
IL87150A true IL87150A (en)	1992-12-01

Family

ID=19850345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87150A IL87150A (en)	1987-07-20	1988-07-18	8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them

Country Status (11)

Country	Link
US (1)	US5100884A (de)
EP (1)	EP0300541B1 (de)
JP (1)	JPS6434984A (de)
AT (1)	ATE136032T1 (de)
AU (1)	AU613059B2 (de)
CA (1)	CA1338189C (de)
DE (1)	DE3855147D1 (de)
DK (1)	DK395888A (de)
IL (1)	IL87150A (de)
NZ (1)	NZ225421A (de)
ZA (1)	ZA885146B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0347980A1 (de) *	1988-06-20	1989-12-27	Duphar International Research B.V	8,9-Anellierte B-Carboline und 8,9-anellierte 3,4-dihydro-B-Carboline
EP0357122A3 (de) *	1988-08-29	1991-10-23	Duphar International Research B.V	Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
EP0377238A1 (de) *	1988-12-22	1990-07-11	Duphar International Research B.V	Annelierte Indolo(3,2-c)-lactame
EP0380155A1 (de) *	1989-01-19	1990-08-01	Duphar International Research B.V	8,9-Annelierte-1,2,3,4-tetrahydro-beta-carboline-Derivate
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
NZ314105A (en) *	1996-02-02	1997-12-19	Sumitomo Pharma	Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
ATE277048T1 (de) *	1999-06-15	2004-10-15	Bristol Myers Squibb Pharma Co	Substituierte hetercyclisch kondensierte gamma carboline
US6713471B1 (en)	1999-06-15	2004-03-30	Bristol-Myers Squibb Pharma Company	Substituted heterocycle fused gamma-carbolines
US7071186B2 (en)	1999-06-15	2006-07-04	Bristol-Myers Squibb Pharma Co.	Substituted heterocycle fused gamma-carbolines
US6858599B2 (en)	1999-06-30	2005-02-22	Mochida Pharmaceutical Co., Ltd.	Tricyclic compound having spiro union
TR200103853T2 (tr) *	1999-06-30	2002-11-21	Mochida Pharmaceutical Co., Ltd	Spiro bağlı trisiklik bileşikler.
UA74826C2 (en)	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
US6849619B2 (en) *	2000-12-20	2005-02-01	Bristol-Myers Squibb Company	Substituted pyridoindoles as serotonin agonists and antagonists
SK7042003A3 (en)	2000-12-20	2004-07-07	Bristol Myers Squibb Co	Substituted pyridoindoles as serotonin agonists and antagonists
CN1910183A (zh)	2004-01-23	2007-02-07	希龙公司	四氢咔啉化合物作为抗癌药
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
UA92317C2 (ru)	2004-03-15	2010-10-25	Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК.	Производные карболина, пригодные для ингибирования развития кровеносных сосудов
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
WO2011082266A2 (en)	2009-12-30	2011-07-07	Arqule, Inc.	Substituted heterocyclic compounds
DE102019128072B4 (de)	2019-10-17	2021-11-18	Infineon Technologies Ag	Transistorbauelement mit einem variierenden flächenbezogenen spezifischen gaterunnerwiderstand

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3299078A (en) *	1962-10-01	1967-01-17	Smith Kline French Lab	Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines
EP0017727A1 (de) *	1979-04-10	1980-10-29	Ciba-Geigy Ag	Polysubstituierte Diazatricyclen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
EP0190472B1 (de) *	1984-12-21	1989-07-12	Duphar International Research B.V	Arzneimittel mit antipsychotischer Wirkung
DK686688A (da) *	1987-12-14	1989-06-15	Duphar Int Res	8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne
EP0357122A3 (de) *	1988-08-29	1991-10-23	Duphar International Research B.V	Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung

1988
- 1988-07-07 DE DE3855147T patent/DE3855147D1/de not_active Expired - Lifetime
- 1988-07-07 EP EP88201418A patent/EP0300541B1/de not_active Expired - Lifetime
- 1988-07-07 AT AT88201418T patent/ATE136032T1/de not_active IP Right Cessation
- 1988-07-15 CA CA000572113A patent/CA1338189C/en not_active Expired - Fee Related
- 1988-07-15 NZ NZ225421A patent/NZ225421A/en unknown
- 1988-07-15 DK DK395888A patent/DK395888A/da not_active Application Discontinuation
- 1988-07-15 ZA ZA885146A patent/ZA885146B/xx unknown
- 1988-07-18 IL IL87150A patent/IL87150A/xx not_active IP Right Cessation
- 1988-07-18 JP JP63177252A patent/JPS6434984A/ja active Pending
- 1988-07-18 AU AU19152/88A patent/AU613059B2/en not_active Ceased
1989
- 1989-10-30 US US07/428,481 patent/US5100884A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU1915288A (en)	1989-01-27
DE3855147D1 (de)	1996-05-02
ATE136032T1 (de)	1996-04-15
CA1338189C (en)	1996-03-26
US5100884A (en)	1992-03-31
AU613059B2 (en)	1991-07-25
EP0300541B1 (de)	1996-03-27
EP0300541A1 (de)	1989-01-25
JPS6434984A (en)	1989-02-06
DK395888D0 (da)	1988-07-15
DK395888A (da)	1989-01-21
ZA885146B (en)	1989-03-29
IL87150A0 (en)	1988-12-30
NZ225421A (en)	1991-03-26

Legal Events

Date	Code	Title	Description
1999-07-14	RH	Patent void

Publication	Publication Date	Title
IL87150A (en)	1992-12-01	8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them
DE2966954D1 (en)	1984-06-07	Alkyl derivatives of c-076 compounds, their preparation and their use as antiparasitic agents
EP0013612A3 (en)	1980-10-15	(piperidinylalkyl)quinazoline derivatives and intermediates, process for their preparation and pharmaceutical compositions containing them
KR890001553A (ko)	1989-03-27	약학적 조성물
EP0208518A3 (en)	1988-04-20	6-phenyl-pyridazinyl compounds
DE2966344D1 (en)	1983-12-01	Xanthone and thioxanthone derivatives, their preparation and pharmaceutical compositions containing them
ES2051814T3 (es)	1994-07-01	Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro.
IL95321A0 (en)	1991-06-30	2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
PT91607A (pt)	1990-03-30	Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
PT88991A (pt)	1988-12-01	Processo para a preparacao de analogos de avermectinas e milbemicinas
ES506895A0 (es)	1982-09-01	Un metodo para la preparacion de derivados del acido prope- noico.
AU584157B2 (en)	1989-05-18	Urea derivatives
ATE120744T1 (de)	1995-04-15	Azolderivate und diese enthaltende antiulcus- zusammensetzungen.
ATE269329T1 (de)	2004-07-15	Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
YU158385A (en)	1988-04-30	Process for obtaining derivatives of 2-pyridine thioles
IL85253A0 (en)	1988-07-31	Ergoline derivatives,their preparation and pharmaceutical compositions containing them
ES8105319A1 (es)	1981-05-16	Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
GR3023066T3 (en)	1997-07-30	Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same
NZ218034A (en)	1989-07-27	Benzopyrando(2,3-c)pyrrole derivatives, intermediates and pharmaceutical compositions
IE800588L (en)	1980-09-22	Piperidinothiazolidines
JPS5610191A (en)	1981-02-02	Clavulanic acid derivative* its manufacture and composition
MY101771A (en)	1992-01-17	Antiparasitic agents and process for their preparation.
ES473414A1 (es)	1979-11-01	Un proceso para la preparacion de eteres del acido clavula- nico