DK395888A - 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne - Google Patents

8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne

Info

Publication number: DK395888A
Authority: DK; Denmark
Prior art keywords: atoms; group; groups; alkyl; substituted
Prior art date: 1987-07-20

Application number

DK395888A

Other languages

English (en)

Other versions

DK395888D0 (da

Inventor

Derk Hamminga

Ineke Van Wijngaarden

Johannes Wilhelmus Cath Jansen

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-20

Filing date

1988-07-15

Publication date

1989-01-21

1988-07-15 Application filed by Duphar Int Res filed Critical Duphar Int Res

1988-07-15 Publication of DK395888D0 publication Critical patent/DK395888D0/da

1989-01-21 Publication of DK395888A publication Critical patent/DK395888A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 59
125000000217 alkyl group Chemical group 0.000 abstract 29
125000003545 alkoxy group Chemical group 0.000 abstract 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 10
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 9
125000001153 fluoro group Chemical group F* 0.000 abstract 8
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
125000006413 ring segment Chemical group 0.000 abstract 6
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 4
125000004414 alkyl thio group Chemical group 0.000 abstract 4
125000000304 alkynyl group Chemical group 0.000 abstract 4
125000004093 cyano group Chemical group *C#N 0.000 abstract 4
125000005842 heteroatom Chemical group 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 4
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical group 0.000 abstract 3
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 3
125000002837 carbocyclic group Chemical group 0.000 abstract 2
125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
125000005366 cycloalkylthio group Chemical group 0.000 abstract 2
230000003480 fibrinolytic effect Effects 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
229910019950 S—O Inorganic materials 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000005079 alkoxycarbonylmethyl group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK395888A 1987-07-20 1988-07-15 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne DK395888A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8701709		1987-07-20

Publications (2)

Publication Number	Publication Date
DK395888D0 DK395888D0 (da)	1988-07-15
DK395888A true DK395888A (da)	1989-01-21

Family

ID=19850345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK395888A DK395888A (da)	1987-07-20	1988-07-15	8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne

Country Status (11)

Country	Link
US (1)	US5100884A (da)
EP (1)	EP0300541B1 (da)
JP (1)	JPS6434984A (da)
AT (1)	ATE136032T1 (da)
AU (1)	AU613059B2 (da)
CA (1)	CA1338189C (da)
DE (1)	DE3855147D1 (da)
DK (1)	DK395888A (da)
IL (1)	IL87150A (da)
NZ (1)	NZ225421A (da)
ZA (1)	ZA885146B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0347980A1 (en) *	1988-06-20	1989-12-27	Duphar International Research B.V	8,9-Annelated beta-carbolines and 8,9-anelated-3,4-dihydro-beta-carbolines
EP0357122A3 (en) *	1988-08-29	1991-10-23	Duphar International Research B.V	Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
EP0377238A1 (en) *	1988-12-22	1990-07-11	Duphar International Research B.V	New annelated indolo (3,2-c)-lactams
EP0380155A1 (en) *	1989-01-19	1990-08-01	Duphar International Research B.V	8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
NZ314105A (en) *	1996-02-02	1997-12-19	Sumitomo Pharma	Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
MXPA01012969A (es) *	1999-06-15	2003-10-14	Bristol Myers Squibb Pharma Co	Gamma-carbolinas fusionadas de heterociclo sustituido.
US7071186B2 (en)	1999-06-15	2006-07-04	Bristol-Myers Squibb Pharma Co.	Substituted heterocycle fused gamma-carbolines
US6713471B1 (en)	1999-06-15	2004-03-30	Bristol-Myers Squibb Pharma Company	Substituted heterocycle fused gamma-carbolines
HK1049157A1 (zh) *	1999-06-30	2003-05-02	持田制药株式会社	具有螺接的三环化合物
US6858599B2 (en)	1999-06-30	2005-02-22	Mochida Pharmaceutical Co., Ltd.	Tricyclic compound having spiro union
UA74826C2 (en)	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
US6849619B2 (en) *	2000-12-20	2005-02-01	Bristol-Myers Squibb Company	Substituted pyridoindoles as serotonin agonists and antagonists
PL366233A1 (en)	2000-12-20	2005-01-24	Bristol-Myers Squibb Company	Substituted pyridoindoles as serotonin agonists and antagonists
CN1910183A (zh)	2004-01-23	2007-02-07	希龙公司	四氢咔啉化合物作为抗癌药
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
MXPA06010543A (es)	2004-03-15	2007-03-26	Ptc Therapeutics Inc	Derivados de carbolina utiles en la inhibicion de la angiogenesis.
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
WO2011082266A2 (en)	2009-12-30	2011-07-07	Arqule, Inc.	Substituted heterocyclic compounds
DE102019128072B4 (de)	2019-10-17	2021-11-18	Infineon Technologies Ag	Transistorbauelement mit einem variierenden flächenbezogenen spezifischen gaterunnerwiderstand

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3299078A (en) *	1962-10-01	1967-01-17	Smith Kline French Lab	Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines
DK72180A (da) *	1979-04-10	1980-10-11	Ciba Geigy Ag	Fremgangsmaade til fremstilling af diazatricycler samt salte deraf
EP0185429A1 (en) *	1984-12-21	1986-06-25	Duphar International Research B.V	New bicyclic heteroaryl piperazines
DK686688A (da) *	1987-12-14	1989-06-15	Duphar Int Res	8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne
EP0357122A3 (en) *	1988-08-29	1991-10-23	Duphar International Research B.V	Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties

1988
- 1988-07-07 EP EP88201418A patent/EP0300541B1/en not_active Expired - Lifetime
- 1988-07-07 AT AT88201418T patent/ATE136032T1/de not_active IP Right Cessation
- 1988-07-07 DE DE3855147T patent/DE3855147D1/de not_active Expired - Lifetime
- 1988-07-15 CA CA000572113A patent/CA1338189C/en not_active Expired - Fee Related
- 1988-07-15 ZA ZA885146A patent/ZA885146B/xx unknown
- 1988-07-15 NZ NZ225421A patent/NZ225421A/en unknown
- 1988-07-15 DK DK395888A patent/DK395888A/da not_active Application Discontinuation
- 1988-07-18 IL IL87150A patent/IL87150A/xx not_active IP Right Cessation
- 1988-07-18 AU AU19152/88A patent/AU613059B2/en not_active Ceased
- 1988-07-18 JP JP63177252A patent/JPS6434984A/ja active Pending
1989
- 1989-10-30 US US07/428,481 patent/US5100884A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0300541A1 (en)	1989-01-25
IL87150A0 (en)	1988-12-30
CA1338189C (en)	1996-03-26
ATE136032T1 (de)	1996-04-15
IL87150A (en)	1992-12-01
US5100884A (en)	1992-03-31
AU1915288A (en)	1989-01-27
EP0300541B1 (en)	1996-03-27
JPS6434984A (en)	1989-02-06
DE3855147D1 (de)	1996-05-02
NZ225421A (en)	1991-03-26
ZA885146B (en)	1989-03-29
AU613059B2 (en)	1991-07-25
DK395888D0 (da)	1988-07-15

Legal Events

Date	Code	Title	Description
1993-11-01	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK395888A (da)	1989-01-21	8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne
DK34793A (da)	1993-03-25	Vandoploeseligt, farmaceutisk acceptabelt salt af et monoacylderivat af rapamycin, fremgangsmaade til dets fremstilling og injicerbart, farmaceutisk praeparat indeholdende det
DE69122941D1 (de)	1996-12-05	Piperazinderivate
KR890001553A (ko)	1989-03-27	약학적 조성물
EP0208518A3 (en)	1988-04-20	6-phenyl-pyridazinyl compounds
DE2966344D1 (en)	1983-12-01	Xanthone and thioxanthone derivatives, their preparation and pharmaceutical compositions containing them
PT790248E (pt)	2003-08-29	Derivados de 3-aza-piperidona-(tetra-hidropirimidin-2-ona) e 3-oxa-piperidona(1,3 oxazin-2-ona) sua preparacao e uso como antagonistas de taquicinina/neurocinina
ES2051814T3 (es)	1994-07-01	Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro.
IL95321A0 (en)	1991-06-30	2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
PT91607A (pt)	1990-03-30	Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
PT88991A (pt)	1988-12-01	Processo para a preparacao de analogos de avermectinas e milbemicinas
ATE27817T1 (de)	1987-07-15	Phenylpiperazin-derivate und verfahren zu deren herstellung.
ATE154351T1 (de)	1997-06-15	2,3-diphenyl-5-pyrrolyl-furan derivate, verfahren und zwischenprodukte für ihre herstellung und ihre verwendung als entzündungshemmende, antiallergische und blutplättchenaggregationshemmende mittel
DE69018324D1 (de)	1995-05-11	Azolderivate und diese enthaltende Antiulcus-Zusammensetzungen.
EA200101204A1 (ru)	2002-06-27	Новые бициклические соединения аминопиразинона, способ их получения и содержащие их фармацевтические композиции
ATE269329T1 (de)	2004-07-15	Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
YU158385A (en)	1988-04-30	Process for obtaining derivatives of 2-pyridine thioles
IL85253A0 (en)	1988-07-31	Ergoline derivatives,their preparation and pharmaceutical compositions containing them
HUT60261A (en)	1992-08-28	Process for producing piperazine derivatives and pharmaceutical compositions comprising same
NZ218034A (en)	1989-07-27	Benzopyrando(2,3-c)pyrrole derivatives, intermediates and pharmaceutical compositions
NZ217026A (en)	1989-02-24	Pyrimido (1,2-b) benzothiazole derivatives and pharmaceutical compositions
ES2025140B3 (es)	1992-03-16	Herbicidas heterociclicos.
JPS5610191A (en)	1981-02-02	Clavulanic acid derivative* its manufacture and composition