ATE269329T1 - Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung - Google Patents

Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung

Info

Publication number: ATE269329T1
Authority: AT; Austria
Prior art keywords: onenes; group; isoindol; benz; quinolin
Prior art date: 1998-10-13

Application number

AT99120342T

Other languages

English (en)

Inventor

Francesco Makovec

Andrea Cappelli

Paganico Civitella

Maurizio Anzini

Salvatore Vomero

Lucio Claudio Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-13

Filing date

1999-10-12

Publication date

2004-07-15

1999-10-12 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE269329T1 publication Critical patent/ATE269329T1/de

Links

230000003042 antagnostic effect Effects 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical class CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 title 1
-1 3-quinuclidyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000954 anitussive effect Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000003474 anti-emetic effect Effects 0.000 abstract 1
239000002111 antiemetic agent Substances 0.000 abstract 1
229940125683 antiemetic agent Drugs 0.000 abstract 1
239000003434 antitussive agent Substances 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

AT99120342T 1998-10-13 1999-10-12 Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung ATE269329T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1998TO000871A IT1303123B1 (it)	1998-10-13	1998-10-13	Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed

Publications (1)

Publication Number	Publication Date
ATE269329T1 true ATE269329T1 (de)	2004-07-15

Family

ID=11417108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99120342T ATE269329T1 (de)	1998-10-13	1999-10-12	Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung

Country Status (10)

Country	Link
US (2)	US6323216B1 (de)
EP (1)	EP1018512B1 (de)
JP (1)	JP2000119270A (de)
AT (1)	ATE269329T1 (de)
AU (1)	AU754739B2 (de)
CA (1)	CA2285817C (de)
DE (1)	DE69918046T2 (de)
ES (1)	ES2218930T3 (de)
IT (1)	IT1303123B1 (de)
PT (1)	PT1018512E (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004506686A (ja) *	2000-08-21	2004-03-04	ジョージタウン　ユニバーシティ	モノアミン輸送体のモジュレーターとしての２，３−二置換キヌクリジン、及びこれに基づく治療及び診断法
WO2004094418A1 (en) *	2003-04-21	2004-11-04	Pfizer Inc.	Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity
SE0400970D0 (sv)	2004-04-14	2004-04-14	Astrazeneca Ab	Nicotinic acetylcholine receptor ligands
US8697722B2 (en) *	2007-11-02	2014-04-15	Sri International	Nicotinic acetylcholine receptor modulators
UA103026C2 (ru) *	2008-07-29	2013-09-10	Ацьенде Кимике Риуните Анджелини Франческо А.К.Р.А.Ф. С.П.А.	Соединение с серотонинергической активностью, способ его получения и фармацевтическая композиция, которая его содержит
WO2011085389A1 (en) *	2010-01-11	2011-07-14	Astraea Therapeutics, Llc	Nicotinic acetylcholine receptor modulators
MX2021005314A (es)	2018-11-09	2021-08-24	Vivace Therapeutics Inc	Compuestos biciclicos.
PL3956033T3 (pl)	2019-04-16	2025-06-09	Vivace Therapeutics, Inc.	Związki bicykliczne

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5200413A (en)	1987-01-05	1993-04-06	Beecham Group P.L.C.	Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis
GB9009542D0 (en) *	1990-04-27	1990-06-20	Beecham Group Plc	Novel compounds
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists
JPH06506443A (ja) *	1991-01-09	1994-07-21	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アザ二環式およびアザ三環式誘導体、その製法および中間体ならびに該化合物含有の医薬組成物
US5260303A (en)	1991-03-07	1993-11-09	G. D. Searle & Co.	Imidazopyridines as serotonergic 5-HT3 antagonists
US5280028A (en)	1992-06-24	1994-01-18	G. D. Searle & Co.	Benzimidazole compounds
IT1265057B1 (it)	1993-08-05	1996-10-28	Dompe Spa	Tropil 7-azaindolil-3-carbossiamidi
WO1995009168A1 (en)	1993-09-30	1995-04-06	Tokyo Tanabe Company Limited	Indoline compound and 5-ht3 receptor antagonist containing the same as active ingredient
FR2710915B1 (fr)	1993-10-04	1995-11-24	Synthelabo	Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique.
EP0647639A1 (de)	1993-10-11	1995-04-12	Sanofi	Heteroarylpiperidinen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammenstellungen
US5399562A (en)	1994-02-04	1995-03-21	G. D. Searle & Co.	Indolones useful as serotonergic agents
GB9410441D0 (en) *	1994-05-25	1994-07-13	Erba Carlo Spa	Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation

1998
- 1998-10-13 IT IT1998TO000871A patent/IT1303123B1/it active IP Right Grant
1999
- 1999-10-12 CA CA002285817A patent/CA2285817C/en not_active Expired - Fee Related
- 1999-10-12 ES ES99120342T patent/ES2218930T3/es not_active Expired - Lifetime
- 1999-10-12 EP EP99120342A patent/EP1018512B1/de not_active Expired - Lifetime
- 1999-10-12 AU AU53597/99A patent/AU754739B2/en not_active Ceased
- 1999-10-12 DE DE69918046T patent/DE69918046T2/de not_active Expired - Fee Related
- 1999-10-12 JP JP11289461A patent/JP2000119270A/ja active Pending
- 1999-10-12 PT PT99120342T patent/PT1018512E/pt unknown
- 1999-10-12 AT AT99120342T patent/ATE269329T1/de not_active IP Right Cessation
- 1999-10-13 US US09/417,098 patent/US6323216B1/en not_active Expired - Fee Related
2001
- 2001-10-02 US US09/967,972 patent/US6413978B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1018512B1 (de)	2004-06-16
DE69918046T2 (de)	2005-07-14
DE69918046D1 (de)	2004-07-22
ES2218930T3 (es)	2004-11-16
IT1303123B1 (it)	2000-10-30
AU754739B2 (en)	2002-11-21
CA2285817C (en)	2008-12-16
JP2000119270A (ja)	2000-04-25
US6323216B1 (en)	2001-11-27
US6413978B1 (en)	2002-07-02
US20020042426A1 (en)	2002-04-11
PT1018512E (pt)	2004-08-31
AU5359799A (en)	2000-04-20
EP1018512A1 (de)	2000-07-12
ITTO980871A1 (it)	2000-04-13
CA2285817A1 (en)	2000-04-13

Legal Events

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2005-04-15

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Publication of translation of european patent specification

Ref document number: 1018512

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2005-07-15

EEFA

Change of the company name

2009-07-15

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Ceased due to non-payment of the annual fee

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DE69415614D1 (de)	1999-02-11	N-acylierte trizyklische Azaheteroringe verwendbar als Vasopressin-Antagonisten
ES2164657T3 (es)	2002-03-01	Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
FI931370A0 (fi)	1993-03-26	Kvaeve innehaollande analoger av icke-aromatiska heterocykliska foereningar med en fusionerad ring
DE69329386D1 (de)	2000-10-12	Substituierte benzylaminoquinuclidine als substanz p antagonisten
CA2207784A1 (en)	1998-12-13	Certain pyrrolopyridine derivatives; novel crf1 specific ligands
DE69019020D1 (de)	1995-06-08	Tricyclische kondensierte Pyrimidin-Derivate, ihre Herstellung und Verwendung.
ATE269329T1 (de)	2004-07-15	Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
ATE109136T1 (de)	1994-08-15	Substituierte cyclohexene mit zentraler nervensystem-wirkung.
ATE102626T1 (de)	1994-03-15	Heterocyclische verbindungen, ihre darstellung und verwendung.
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HRP20000027B1 (en)	2006-07-31	Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds
NO885224L (no)	1989-05-25	Fremgangsmaate for fremstilling av 1,4-disubstituerte-piperidinylderivater.
GR82272B (de)	1984-12-13
FR2626279B1 (fr)	1990-07-13	Nouveaux derives de l'indolo(3,2,1-de)(1,4)-oxazino(2,3,4-ij)(1,5) naphthyridine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
DK0746556T3 (da)	2002-12-16	Tricycliske forbindelser med affinitet for 5-HT1A-receptoren
DE69406763D1 (de)	1997-12-18	Pyridazinon Derivate, Herstellungsverfahren und Verwendung
ATE108444T1 (de)	1994-07-15	3-isoxazolonderivate, ihre herstellung und ihre anwendung in der therapeutik.
GB2009732A (en)	1979-06-20	Disubstituted Piperazines